Research graph
References from Modern multidisciplinary management of brain metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG
2018 · External reference
Epidemiology of Brain Metastases and Leptomeningeal Disease
10.1093/neuonc/noab101 · 2021 · External reference
Brain metastases
10.1038/s41572-018-0055-y · 2019 · External reference
Presentation, patterns of care, and survival in patients with brain metastases: what has changed in the last 20 years?
10.1002/cncr.25707 · 2011 · External reference
Estimating the risk of brain metastasis for patients newly diagnosed with cancer
10.1038/s43856-024-00445-7 · 2024 · External reference
Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain
10.1056/nejmoa1805453 · 2018 · External reference
Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC
10.1056/nejmoa2306434 · 2023 · External reference
Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial
10.1038/s41591-024-03261-7 · 2024 · External reference
Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases
10.1093/neuonc/noaa030 · 2020 · External reference
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
10.1158/2159-8290.cd-15-0369 · 2015 · External reference
Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
10.1016/s1470-2045(09)70263-3 · 2009 · External reference
Twice-daily tapering dexamethasone treatment during cranial radiation for newly diagnosed brain metastases
10.1007/bf00165531 · 1991 · External reference
Dose-effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors: a randomized study of doses of 4, 8, and 16 mg per day
10.1212/wnl.44.4.675 · 1994 · External reference
Letter: When Less is More: Dexamethasone Dosing for Brain Tumors
10.1093/neuros/nyz186 · 2019 · External reference
Bone health in patients with brain tumors
10.1016/j.surneu.2006.11.065 · 2007 · External reference
Prophylaxis Against Pneumocystis jirovecii Pneumonia in Adults
10.1001/jama.2023.9844 · 2023 · External reference
Anticonvulsant prophylaxis and steroid use in adults with metastatic brain tumors: summary of SNO and ASCO endorsement of the Congress of Neurological Surgeons guidelines
10.1093/neuonc/noz034 · 2019 · External reference
Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors
10.1093/neuonc/noaa298 · 2021 · External reference
Is it worth reorganising cancer services on the basis of multidisciplinary teams (MDTs)? A systematic review of the objectives and organisation of MDTs and their impact on patient outcomes
10.1016/j.healthpol.2014.09.006 · 2015 · External reference
Impact of multidisciplinary team on the pattern of care for brain metastasis from breast cancer
10.3389/fonc.2023.1160802 · 2023 · External reference
Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
10.1200/jco.2011.38.0527 · 2012 · External reference
Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA)
10.1001/jamaoncol.2016.3834 · 2017 · External reference
10.1016/j.ijrobp.2022.03.020
10.1016/j.ijrobp.2022.03.020 · 2022 · External reference
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline
10.1200/jco.21.02314 · 2022 · External reference
Defining the role of surgery for patients with multiple brain metastases
10.1007/s11060-024-04739-7 · 2024 · External reference
Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline
10.1016/j.prro.2011.12.004 · 2012 · External reference
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors
10.1093/neuros/nyy542 · 2019 · External reference
Hypofractionated stereotactic radiotherapy versus whole-brain radiotherapy following brain metastasis resection: Results of the ESTRON randomized phase 2 trial
10.1093/neuonc/noaf182 · 2025 · External reference
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial
10.1016/s1470-2045(17)30414-x · 2017 · External reference
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC.3): a multicentre, randomised, controlled, phase 3 trial
10.1016/s1470-2045(17)30441-2 · 2017 · External reference
NG99: Brain tumours (primary) and brain metastases in adults
2018 · External reference
Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline
10.1016/j.prro.2022.02.003 · 2022 · External reference
EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours ✩
10.1016/j.annonc.2021.07.016 · 2021 · External reference
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial
10.1001/jama.2016.9839 · 2016 · External reference
Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial
10.1001/jama.2026.0076 · 2026 · External reference
Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience
10.1016/j.ijrobp.2019.03.052 · 2019 · External reference
Single-Isocenter Multitarget Stereotactic Radiosurgery Is Safe and Effective in the Treatment of Multiple Brain Metastases
10.1016/j.adro.2019.08.013 · 2020 · External reference
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial
10.1016/s1470-2045(17)30441-2 · 2017 · External reference
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial
10.1016/s1470-2045(17)30414-x · 2017 · External reference
Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care
10.1038/s41571-025-01013-1 · 2025 · External reference
The Impact of Sequencing PD-1/PD-L1 Inhibitors and Stereotactic Radiosurgery for Patients with Brain Metastasis
10.1093/neuonc/noz046 · 2019 · External reference
Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data
10.1016/j.radonc.2018.08.025 · 2019 · External reference
Concurrent versus non-concurrent immune checkpoint inhibition with stereotactic radiosurgery for metastatic brain disease: a systematic review and meta-analysis
10.1007/s11060-018-03020-y · 2019 · External reference
Radiation dose-volume effects in the brain
10.1016/j.ijrobp.2009.02.091 · 2010 · External reference
Radiation Necrosis in Neuro-Oncology: Diagnostic Complexity and Precision Radiotherapy Strategies
10.3390/cancers17213542 · 2025 · External reference
Immune checkpoint inhibitor therapy may increase the incidence of treatment-related necrosis after stereotactic radiosurgery for brain metastases: a systematic review and meta-analysis
10.1007/s00330-020-07514-0 · 2021 · External reference
Final results of a randomized, controlled, phase 3 trial comparing resection and post-operative stereotactic radiation versus resection and cesium-131 tile-based radiation for treatment of newly diagnosed brain metastases
2026 · External reference
Intraoperative, interstitial brachytherapy in newly diagnosed brain metastases through cesium-131 collagen tile implant: A multi-institutional case series
2026 · External reference
Survival and quality of life after first-time diagnosis of brain metastases: a multicenter, prospective, observational study
2025 · External reference
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Whole Brain Radiation Therapy in Adults with Newly Diagnosed Metastatic Brain Tumors
10.1093/neuros/nyy541 · 2019 · External reference
Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
10.1001/jama.295.21.2483 · 2006 · External reference
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial
10.1001/jama.2016.9839 · 2016 · External reference
Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
10.1200/jco.2010.30.1655 · 2011 · External reference
Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial
10.1093/neuonc/not114 · 2013 · External reference
Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001
10.1200/jco.19.02767 · 2020 · External reference
Ipilimumab plus nivolumab versus nivolumab alone in patients with melanoma brain metastases (ABC): 7-year follow-up of a multicentre, open-label, randomised, phase 2 study
10.1016/s1470-2045(24)00735-6 · 2025 · External reference
Efficacy of immune checkpoint inhibitors (ICI) in patients (pts) with central nervous system (CNS) metastases (mets) from solid tumors: A systematic review and meta-analysis
2025 · External reference
Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials
10.1016/j.jtho.2026.01.001 · 2026 · External reference
Overall Survival with Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC
10.1056/nejmoa2503001 · 2025 · External reference
Repotrectinib in ROS1 Fusion-Positive Non-Small-Cell Lung Cancer
10.1056/nejmoa2302299 · 2024 · External reference
Taletrectinib: TRUST in the Continued Evolution of Treatments for ROS1 Fusion-Positive Lung Cancer
10.1200/jco.24.01062 · 2024 · External reference
Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial
10.1200/jco.20.00775 · 2020 · External reference
Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO)
10.1093/neuonc/now241 · 2017 · External reference
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Steroids in the Treatment of Adults With Metastatic Brain Tumors
10.1093/neuros/nyy546 · 2019 · External reference
Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update
10.1200/jco.2016.70.1474 · 2017 · External reference
Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial
10.1016/s1470-2045(18)30060-3 · 2018 · External reference
Early palliative care for patients with metastatic non-small-cell lung cancer
10.1056/nejmoa1000678 · 2010 · External reference
Palliative Care for Patients With Cancer: ASCO Guideline Update
10.1200/jco.24.00542 · 2024 · External reference
Association Between Palliative Care and Patient and Caregiver Outcomes: A Systematic Review and Meta-analysis
10.1001/jama.2016.16840 · 2016 · External reference
Leptomeningeal metastatic disease: new frontiers and future directions
10.1038/s41571-024-00970-3 · 2025 · External reference
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis
10.1200/jco.22.01148 · 2022 · External reference
