Research graph
References from Towards personalized treatment in juvenile idiopathic arthritis: moving beyond the trial-and-error strategy. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence and incidence of juvenile idiopathic arthritis: a systematic review
10.1016/j.jbspin.2013.09.003 · 2014 · External reference
Juvenile idiopathic arthritis
10.1038/s41572-021-00332-8 · 2022 · External reference
Toward new classification criteria for juvenile idiopathic arthritis: first steps of the Pediatric Rheumatology International Trials Organization International Consensus
10.3899/jrheum.180168 · 2019 · External reference
Predictive, personalized, preventive, and participatory (P4) cancer medicine
10.1038/nrclinonc.2010.227 · 2011 · External reference
Precision and personalized medicine: what their current definition says and silences about the model of health they promote and implications for the development of personalized health
10.3389/fsoc.2023.1112159 · 2023 · External reference
Personomics: the missing link in the evolution from precision medicine to personalized medicine
10.3390/jpm7040011 · 2017 · External reference
2021 American College of Rheumatology guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for oligoarthritis, temporomandibular joint arthritis, and systemic juvenile idiopathic arthritis
10.1002/acr.24853 · 2022 · External reference
2019 American College of Rheumatology/Arthritis Foundation guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for non-systemic polyarthritis, sacroiliitis, and enthesitis
10.1002/acr.23870 · 2019 · External reference
Treatment of non-systemic juvenile idiopathic arthritis
10.1038/s41584-024-01079-8 · 2024 · External reference
Juvenile idiopathic arthritis
10.1056/nejmra2402073 · 2025 · External reference
Patterns and determinants of response to novel therapies in juvenile and adult-onset polyarthritis
10.1093/rheumatology/kead490 · 2024 · External reference
How common is remission in rheumatoid factor–positive juvenile idiopathic arthritis patients? The multicenter Pediatric Rheumatology Academy (PeRA) research group experience
10.1186/s12969-023-00860-5 · 2023 · External reference
Effects of biologic therapies on temporomandibular joint inflammation in juvenile idiopathic arthritis
2025 · External reference
Hip involvement in juvenile idiopathic arthritis: a roadmap from arthritis to total hip arthroplasty or how can we prevent hip damage?
10.3389/fped.2021.747779 · 2021 · External reference
Tumor necrosis factor inhibitors for juvenile idiopathic arthritis–associated uveitis
2022 · External reference
Juvenile idiopathic arthritis and associated uveitis: a review of pathogenesis, diagnosis, and management
10.4103/sjopt.sjopt_153_24 · 2025 · External reference
Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomized, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial
10.1136/ard-2022-222849 · 2023 · External reference
Ixekizumab in children with active psoriatic and enthesitis-related juvenile idiopathic arthritis (COSPIRIT-JIA): a multicentre, open-label, 16-week Bayesian trial including a randomized reference group to adalimumab
10.1016/s2665-9913(25)00346-7 · 2026 · External reference
Development of inflammatory bowel disease in children with juvenile idiopathic arthritis treated with biologics
10.1097/mpg.0000000000003656 · 2023 · External reference
Inflammatory bowel disease in children: current diagnosis and treatment strategies
2025 · External reference
The impact of body mass index on disease activity and growth outcomes in juvenile idiopathic arthritis
10.1007/s00431-025-06084-x · 2025 · External reference
Low etanercept concentrations in children with obesity and juvenile idiopathic arthritis
2021 · External reference
New developments in ultrasound and magnetic resonance imaging of pediatric rheumatic diseases
10.1016/j.berh.2025.102069 · 2025 · External reference
Low prevalence of subclinical synovitis in patients with juvenile idiopathic arthritis in long-term clinical remission on medication
10.1007/s10067-023-06729-y · 2024 · External reference
Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis but do not predict a flare of synovitis
10.1136/annrheumdis-2011-201264 · 2013 · External reference
Flares of disease in children with clinically inactive juvenile idiopathic arthritis are not correlated with ultrasound findings
10.3899/jrheum.170681 · 2018 · External reference
Baseline ultrasound examination as a possible predictor of relapse in patients affected by juvenile idiopathic arthritis
10.1136/annrheumdis-2017-211696 · 2018 · External reference
Patients with juvenile idiopathic arthritis in clinical remission with positive power Doppler signal in joint ultrasonography have an increased rate of clinical flare: a prospective study
10.1186/s12969-017-0208-7 · 2017 · External reference
Serum calprotectin (S100A8/A9), clinical and ultrasound assessment in patients with juvenile idiopathic arthritis
10.55563/clinexprheumatol/5tckci · 2021 · External reference
Serum calprotectin and joint ultrasound in the definition of disease relapse in non-systemic juvenile idiopathic arthritis: a prospective longitudinal study
2024 · External reference
Ultrasound-detected tenosynovitis in ankles with clinical arthritis and short-term outcome of patients with new-onset juvenile idiopathic arthritis
2024 · External reference
A prediction rule for polyarticular extension in oligoarticular-onset juvenile idiopathic arthritis
10.55563/clinexprheumatol/uxnm7j · 2021 · External reference
Novel biomarkers for prediction of outcome and therapeutic response in juvenile idiopathic arthritis
10.1080/1744666x.2021.1945441 · 2021 · External reference
Phagocyte-specific S100 proteins and high-sensitivity C-reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study
10.1136/annrheumdis-2012-201329 · 2012 · External reference
A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein
10.1093/rheumatology/ket152 · 2013 · External reference
MRP8/14 serum levels as predictors of response to starting and stopping anti–tumor necrosis factor treatment in juvenile idiopathic arthritis
10.1186/s13075-015-0723-1 · 2015 · External reference
10.1002/art.40727
10.1002/art.40727 · 2019 · External reference
Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial
10.1136/annrheumdis-2021-222029 · 2022 · External reference
The role of serum calprotectin in defining disease outcomes in non-systemic juvenile idiopathic arthritis: a pilot study
10.3390/ijms24021671 · 2023 · External reference
S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis
10.1186/s13075-024-03347-0 · 2024 · External reference
Diagnostic accuracy of serum calprotectin measured by chemiluminescent immunoassay and enzyme immunoassay in juvenile idiopathic arthritis: a proof-of-concept study
10.3389/fped.2024.1422916 · 2024 · External reference
Circulating complexes between tumor necrosis factor-alpha and etanercept predict long-term efficacy of etanercept in juvenile idiopathic arthritis
10.1111/apa.13319 · 2016 · External reference
Association of pharmacologic markers of anti–tumor necrosis factor-alpha activity and etanercept effectiveness in juvenile idiopathic arthritis
10.1002/prp2.70166 · 2025 · External reference
The utility of miR-16, miR-146a, and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring
10.1186/s12969-025-01136-w · 2025 · External reference
Genetic variants and therapeutic response to anti–tumor necrosis factor-alpha agents in juvenile idiopathic arthritis: an updated systematic review and meta-analysis
10.1097/rhu.0000000000001835 · 2022 · External reference
Identification and validation of an interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
10.1016/j.ard.2025.03.007 · 2025 · External reference
Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study
10.1136/ard.2006.061853 · 2007 · External reference
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression
10.1002/art.27284 · 2010 · External reference
Immunometabolic analysis of synovial fluid from juvenile idiopathic arthritis patients
10.4049/immunohorizons.2200052 · 2022 · External reference
Th17 and Th1 lymphocytes in oligoarticular juvenile idiopathic arthritis
10.3389/fimmu.2019.00450 · 2019 · External reference
Joint-specific memory, resident memory T cells, and the rolling window of opportunity in arthritis
10.1038/s41584-024-01107-7 · 2024 · External reference
Histological synovitis score in juvenile idiopathic arthritis and other pediatric synovial inflammatory conditions
10.1016/j.prp.2024.155588 · 2024 · External reference
Diagnostic and prognostic role of synovial tissue analysis in juvenile idiopathic arthritis: a monocentric study
10.1136/rmdopen-2023-003296 · 2023 · External reference
Distinct synovial immunopathologic characteristics of juvenile-onset spondyloarthritis and other forms of juvenile idiopathic arthritis
10.1002/art.22024 · 2006 · External reference
Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups
10.1136/ard.2010.148635 · 2011 · External reference
Two broad categories overlapping with rheumatoid arthritis observed in synovial biopsies from patients with juvenile idiopathic arthritis
10.1002/art.42922 · 2024 · External reference
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
10.1126/scitranslmed.adt6050 · 2025 · External reference
Spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis
2025 · External reference
Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease
10.1186/ar4434 · 2014 · External reference
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis
10.1038/s41467-025-60987-9 · 2025 · External reference
Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization
10.1186/s10020-025-01348-6 · 2025 · External reference
2019 American College of Rheumatology/Arthritis Foundation guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for non-systemic polyarthritis, sacroiliitis, and enthesitis
10.1002/acr.23870 · ExternalCitation · doi-reference
2021 American College of Rheumatology guideline for the treatment of juvenile idiopathic arthritis: therapeutic approaches for oligoarthritis, temporomandibular joint arthritis, and systemic juvenile idiopathic arthritis
10.1002/acr.24853 · ExternalCitation · doi-reference
Distinct synovial immunopathologic characteristics of juvenile-onset spondyloarthritis and other forms of juvenile idiopathic arthritis
10.1002/art.22024 · ExternalCitation · doi-reference
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression
10.1002/art.27284 · ExternalCitation · doi-reference
10.1002/art.40727
10.1002/art.40727 · ExternalCitation · doi-reference
Two broad categories overlapping with rheumatoid arthritis observed in synovial biopsies from patients with juvenile idiopathic arthritis
10.1002/art.42922 · ExternalCitation · doi-reference
Association of pharmacologic markers of anti–tumor necrosis factor-alpha activity and etanercept effectiveness in juvenile idiopathic arthritis
10.1002/prp2.70166 · ExternalCitation · doi-reference
The impact of body mass index on disease activity and growth outcomes in juvenile idiopathic arthritis
10.1007/s00431-025-06084-x · ExternalCitation · doi-reference
Low prevalence of subclinical synovitis in patients with juvenile idiopathic arthritis in long-term clinical remission on medication
10.1007/s10067-023-06729-y · ExternalCitation · doi-reference
Identification and validation of an interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
10.1016/j.ard.2025.03.007 · ExternalCitation · doi-reference
New developments in ultrasound and magnetic resonance imaging of pediatric rheumatic diseases
10.1016/j.berh.2025.102069 · ExternalCitation · doi-reference
Prevalence and incidence of juvenile idiopathic arthritis: a systematic review
10.1016/j.jbspin.2013.09.003 · ExternalCitation · doi-reference
Histological synovitis score in juvenile idiopathic arthritis and other pediatric synovial inflammatory conditions
10.1016/j.prp.2024.155588 · ExternalCitation · doi-reference
Ixekizumab in children with active psoriatic and enthesitis-related juvenile idiopathic arthritis (COSPIRIT-JIA): a multicentre, open-label, 16-week Bayesian trial including a randomized reference group to adalimumab
10.1016/s2665-9913(25)00346-7 · ExternalCitation · doi-reference
Predictive, personalized, preventive, and participatory (P4) cancer medicine
10.1038/nrclinonc.2010.227 · ExternalCitation · doi-reference
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis
10.1038/s41467-025-60987-9 · ExternalCitation · doi-reference
Juvenile idiopathic arthritis
10.1038/s41572-021-00332-8 · ExternalCitation · doi-reference
Treatment of non-systemic juvenile idiopathic arthritis
10.1038/s41584-024-01079-8 · ExternalCitation · doi-reference
Joint-specific memory, resident memory T cells, and the rolling window of opportunity in arthritis
10.1038/s41584-024-01107-7 · ExternalCitation · doi-reference
Juvenile idiopathic arthritis
10.1056/nejmra2402073 · ExternalCitation · doi-reference
Novel biomarkers for prediction of outcome and therapeutic response in juvenile idiopathic arthritis
10.1080/1744666x.2021.1945441 · ExternalCitation · doi-reference
Patterns and determinants of response to novel therapies in juvenile and adult-onset polyarthritis
10.1093/rheumatology/kead490 · ExternalCitation · doi-reference
A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein
10.1093/rheumatology/ket152 · ExternalCitation · doi-reference
Development of inflammatory bowel disease in children with juvenile idiopathic arthritis treated with biologics
10.1097/mpg.0000000000003656 · ExternalCitation · doi-reference
Genetic variants and therapeutic response to anti–tumor necrosis factor-alpha agents in juvenile idiopathic arthritis: an updated systematic review and meta-analysis
10.1097/rhu.0000000000001835 · ExternalCitation · doi-reference
Circulating complexes between tumor necrosis factor-alpha and etanercept predict long-term efficacy of etanercept in juvenile idiopathic arthritis
10.1111/apa.13319 · ExternalCitation · doi-reference
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
10.1126/scitranslmed.adt6050 · ExternalCitation · doi-reference
Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis but do not predict a flare of synovitis
10.1136/annrheumdis-2011-201264 · ExternalCitation · doi-reference
Phagocyte-specific S100 proteins and high-sensitivity C-reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study
10.1136/annrheumdis-2012-201329 · ExternalCitation · doi-reference
Baseline ultrasound examination as a possible predictor of relapse in patients affected by juvenile idiopathic arthritis
10.1136/annrheumdis-2017-211696 · ExternalCitation · doi-reference
Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial
10.1136/annrheumdis-2021-222029 · ExternalCitation · doi-reference
Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomized, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial
10.1136/ard-2022-222849 · ExternalCitation · doi-reference
Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study
10.1136/ard.2006.061853 · ExternalCitation · doi-reference
Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups
10.1136/ard.2010.148635 · ExternalCitation · doi-reference
Diagnostic and prognostic role of synovial tissue analysis in juvenile idiopathic arthritis: a monocentric study
10.1136/rmdopen-2023-003296 · ExternalCitation · doi-reference
Synovial membrane protein expression differs between juvenile idiopathic arthritis subtypes in early disease
10.1186/ar4434 · ExternalCitation · doi-reference
Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization
10.1186/s10020-025-01348-6 · ExternalCitation · doi-reference
Patients with juvenile idiopathic arthritis in clinical remission with positive power Doppler signal in joint ultrasonography have an increased rate of clinical flare: a prospective study
10.1186/s12969-017-0208-7 · ExternalCitation · doi-reference
How common is remission in rheumatoid factor–positive juvenile idiopathic arthritis patients? The multicenter Pediatric Rheumatology Academy (PeRA) research group experience
10.1186/s12969-023-00860-5 · ExternalCitation · doi-reference
The utility of miR-16, miR-146a, and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring
10.1186/s12969-025-01136-w · ExternalCitation · doi-reference
MRP8/14 serum levels as predictors of response to starting and stopping anti–tumor necrosis factor treatment in juvenile idiopathic arthritis
10.1186/s13075-015-0723-1 · ExternalCitation · doi-reference
S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis
10.1186/s13075-024-03347-0 · ExternalCitation · doi-reference
Th17 and Th1 lymphocytes in oligoarticular juvenile idiopathic arthritis
10.3389/fimmu.2019.00450 · ExternalCitation · doi-reference
Hip involvement in juvenile idiopathic arthritis: a roadmap from arthritis to total hip arthroplasty or how can we prevent hip damage?
10.3389/fped.2021.747779 · ExternalCitation · doi-reference
Diagnostic accuracy of serum calprotectin measured by chemiluminescent immunoassay and enzyme immunoassay in juvenile idiopathic arthritis: a proof-of-concept study
10.3389/fped.2024.1422916 · ExternalCitation · doi-reference
Precision and personalized medicine: what their current definition says and silences about the model of health they promote and implications for the development of personalized health
10.3389/fsoc.2023.1112159 · ExternalCitation · doi-reference
The role of serum calprotectin in defining disease outcomes in non-systemic juvenile idiopathic arthritis: a pilot study
10.3390/ijms24021671 · ExternalCitation · doi-reference
Personomics: the missing link in the evolution from precision medicine to personalized medicine
10.3390/jpm7040011 · ExternalCitation · doi-reference
Flares of disease in children with clinically inactive juvenile idiopathic arthritis are not correlated with ultrasound findings
10.3899/jrheum.170681 · ExternalCitation · doi-reference
Toward new classification criteria for juvenile idiopathic arthritis: first steps of the Pediatric Rheumatology International Trials Organization International Consensus
10.3899/jrheum.180168 · ExternalCitation · doi-reference
Immunometabolic analysis of synovial fluid from juvenile idiopathic arthritis patients
10.4049/immunohorizons.2200052 · ExternalCitation · doi-reference
Juvenile idiopathic arthritis and associated uveitis: a review of pathogenesis, diagnosis, and management
10.4103/sjopt.sjopt_153_24 · ExternalCitation · doi-reference
Serum calprotectin (S100A8/A9), clinical and ultrasound assessment in patients with juvenile idiopathic arthritis
10.55563/clinexprheumatol/5tckci · ExternalCitation · doi-reference
A prediction rule for polyarticular extension in oligoarticular-onset juvenile idiopathic arthritis
10.55563/clinexprheumatol/uxnm7j · ExternalCitation · doi-reference
