Research graph
References from Systems-level bioinformatics analysis of hsa-miR-132–3p targets identifies a conserved neuroimmune regulatory module relevant to Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Predicting effective microRNA target sites in mammalian mRNAs
10.7554/elife.05005 · 2015 · External reference
2026 Alzheimer's disease facts and figures
2026 · External reference
An automated method for finding molecular complexes in large protein interaction networks
10.1186/1471-2105-4-2 · 2003 · External reference
ImmPort, toward repurposing of open access immunological assay data for translational and clinical research
10.1038/sdata.2018.15 · 2018 · External reference
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
10.1093/bioinformatics/btp101 · 2009 · External reference
InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation
10.1093/nar/gks1147 · 2013 · External reference
miRDB: an online database for prediction of functional microRNA targets
10.1093/nar/gkz757 · 2020 · External reference
UpSetR: an R package for the visualization of intersecting sets and their properties
10.1093/bioinformatics/btx364 · 2017 · External reference
miRTarBase 2025: updates to the collection of experimentally validated microRNA-target interactions
10.1093/nar/gkae1072 · 2025 · External reference
The reactome pathway knowledgebase
10.1093/nar/gkx1132 · 2018 · External reference
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data
2019 · External reference
MicroRNAs: roles in regulating neuroinflammation
10.1177/1073858417721150 · 2018 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
10.1093/bioinformatics/btz931 · 2020 · External reference
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
10.1016/j.neuron.2013.04.014 · 2013 · External reference
Microglia in Alzheimer's disease
2018 · External reference
Mapping the human miRNA interactome by CLASH reveals frequent noncanonical targeting
10.1016/j.cell.2013.03.043 · 2013 · External reference
Innate immune activation in neurodegenerative disease
2015 · External reference
Immune attack: the role of inflammation in Alzheimer disease
10.1038/nrn3880 · 2015 · External reference
microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice
10.1038/srep30953 · 2016 · External reference
Memory formation and retention are affected in adult miR-132/212 knockout mice
10.1016/j.bbr.2015.03.032 · 2015 · External reference
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
10.1038/ng.803 · 2011 · External reference
A unique microglia type associated with restricting development of Alzheimer's disease
10.1016/j.cell.2017.05.018 · 2017 · External reference
Alzheimer disease
10.1038/s41572-021-00269-y · 2021 · External reference
miRBase: from microRNA sequences to function
10.1093/nar/gky1141 · 2019 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
Massive mining of publicly available RNA-seq data from human and mouse
10.1038/s41467-018-03751-6 · 2018 · External reference
Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles
10.1182/blood-2013-03-492801 · 2013 · External reference
miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator
10.1038/ncb2054 · 2010 · External reference
Alteration of the microRNA network during the progression of Alzheimer's disease
10.1002/emmm.201201974 · 2013 · External reference
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data
10.1093/nar/gkt1248 · 2014 · External reference
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
10.1152/physiolgenomics.00242.2007 · 2008 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Distribution of miRNA expression across human tissues
10.1093/nar/gkw116 · 2016 · External reference
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
10.1073/pnas.1015691107 · 2010 · External reference
MicroRNAs as regulatory elements in immune system logic
10.1038/nri.2016.40 · 2016 · External reference
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
10.1038/ng.801 · 2011 · External reference
microRNA regulation of inflammatory responses
2012 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
2020 · External reference
microRNAs and neurodegenerative diseases
2022 · External reference
How neuroinflammation contributes to neurodegeneration
10.1126/science.aag2590 · 2016 · External reference
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search
10.1093/nar/gkw1012 · 2017 · External reference
Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins
10.1042/bj20100024 · 2010 · External reference
miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity
10.1371/journal.pone.0062509 · 2013 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations
10.1093/nar/gku631 · 2014 · External reference
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
10.1016/j.cell.2009.01.038 · 2009 · External reference
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
10.15252/emmm.201606520 · 2016 · External reference
Alzheimer's disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex
10.1111/j.1460-9568.2012.08220.x · 2012 · External reference
MicroRNA-132 potentiates cholinergic anti-inflammatory signaling
10.1016/j.immuni.2009.09.019 · 2009 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
TarBase-v9.0 extends experimentally supported miRNA-gene interactions to cell-types and virally encoded miRNAs
10.1093/nar/gkad1071 · 2024 · External reference
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
10.1093/hmg/ddv377 · 2015 · External reference
miRWalk: An online resource for prediction of microRNA binding sites
10.1371/journal.pone.0206239 · 2018 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any of 14286 organisms
10.1093/nar/gkac1000 · 2023 · External reference
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
10.1073/pnas.0605298103 · 2006 · External reference
Characterization of extracellular circulating microRNA
10.1093/nar/gkr254 · 2011 · External reference
Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
miR-212/132 expression and functions: within and beyond the neuronal compartment
10.1093/nar/gks151 · 2012 · External reference
Unresolved reference
2016 · External reference
De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease
10.1093/hmg/ddt164 · 2013 · External reference
Unresolved reference
2023 · External reference
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation
2010 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
