Research graph
References from Gene regulatory co-expression networks decipher potential lncRNA-miRNA-mRNA interactions modulating transcription regulation in neurodegeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies
10.1038/s41576-023-00592-y · 2023 · External reference
MicroRNA response elements-mediated miRNA-miRNA interactions in prostate cancer
2012 · External reference
Overlap between neurodegenerative disorders
10.1111/j.1440-1789.2005.00605.x · 2005 · External reference
Alzheimer’s disease
10.1016/s0140-6736(06)69113-7 · 2006 · External reference
Parkinson’s disease
10.1016/s0140-6736(21)00218-x · 2021 · External reference
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
10.1038/s41586-022-04436-3 · 2022 · External reference
HuR interacts with lincBRN1a and lincBRN1b during neuronal stem cells differentiation
10.1080/15476286.2019.1637698 · 2019 · External reference
Neurodegenerative diseases
2011 · External reference
Positive association between MIC gene polymorphism and tuberculosis in Chinese population
10.1016/j.imlet.2019.07.008 · 2019 · External reference
Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage
10.1186/s12951-026-04099-6 · 2026 · External reference
Integration of neural networks in brain–computer interface applications: research frontiers and trend analysis based on Python
10.1016/j.engappai.2025.110654 · 2025 · External reference
T cell senescence induced by DNMT1 deletion mediates cardiac transplant tolerance via altered CDKN1A methylation
10.1016/j.ymthe.2026.02.015 · 2026 · External reference
cytoHubba: identifying hub objects and sub-networks from complex interactome
10.1186/1752-0509-8-s4-s11 · 2014 · External reference
Genome-wide prediction of cauliflower miRNAs and lncRNAs and their roles in post-transcriptional gene regulation
10.1007/s00425-021-03689-y · 2021 · External reference
The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants
10.1093/nar/gkp1137 · 2010 · External reference
Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease
10.1093/hmg/7.1.43 · 1998 · External reference
Twelve years of SAMtools and BCFtools
2021 · External reference
A comparative study of statistical methods used to identify dependencies between gene expression signals
10.1093/bib/bbt051 · 2014 · External reference
The 1000 genomes project: welcome to a new world
10.3747/pdi.2015.00261 · 2015 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response
2024 · External reference
Pathology of Neurodegenerative Diseases
10.1101/cshperspect.a028035 · 2017 · External reference
Gene expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
Amyotrophic lateral sclerosis
10.1016/s0140-6736(22)01272-7 · 2022 · External reference
Most mammalian mRNAs are conserved targets of microRNAs
10.1101/gr.082701.108 · 2009 · External reference
The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease
2022 · External reference
Molecular crosstalk between miRNAs and lncRNAs in neurodegenerative disease pathways
10.1007/s11033-025-11187-7 · 2026 · External reference
A one-pot isothermal Fluorogenic Mango II arrays-based assay for label-free detection of miRNA
10.1016/j.talanta.2024.126920 · 2025 · External reference
Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer’s Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS
10.3390/biom15081188 · 2025 · External reference
Comparison of Aβ levels in the brain of familial and sporadic Alzheimer’s disease
10.1016/j.neuint.2009.03.007 · 2009 · External reference
miRTarBase: a database curates experimentally validated microRNA–target interactions
10.1093/nar/gkq1107 · 2011 · External reference
Possible regulatory mechanisms of typical and atypical absence seizures through an equivalent projection from the subthalamic nucleus to the cortex: Evidence in a computational model
2025 · External reference
Developing a PPI inhibitor-based therapy for STXBP1 haploinsufficiency-associated epileptic disorders
2014 · External reference
dynGENIE3: dynamical GENIE3 for the inference of gene networks from time series expression data
10.1038/s41598-018-21715-0 · 2018 · External reference
RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility
10.1093/nar/gkab997 · 2022 · External reference
CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40
10.1038/s41598-024-75636-2 · 2024 · External reference
The mutational constraint spectrum quantified from variation in 141,456 humans
10.1038/s41586-020-2308-7 · 2020 · External reference
ClinVar: public archive of relationships among sequence variation and human phenotype
10.1093/nar/gkt1113 · 2014 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS
10.1073/pnas.1300894110 · 2013 · External reference
The Sequence Read Archive
10.1093/nar/gkq1019 · 2011 · External reference
Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for Alzheimer’s disease
10.55782/ane-2022-025 · 2022 · External reference
The role of microRNAs in neurodegenerative diseases: a review
10.1007/s10565-022-09761-x · 2023 · External reference
Inferring Latent MicroRNA-Disease Associations on a Gene-Mediated Tripartite Heterogeneous Multiplexing Network
10.1109/tcbb.2022.3143770 · 2022 · External reference
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
10.1093/nar/gkz114 · 2019 · External reference
Familial and sporadic Alzheimer’s disease
10.1212/wnl.46.2.406 · 1996 · External reference
mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA
10.2174/1568009623666230817102104 · 2024 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
On the classification of long non-coding RNAs
10.4161/rna.24604 · 2013 · External reference
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
10.1038/s41586-022-04424-7 · 2022 · External reference
ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context
10.1186/1471-2105-7-s1-s7 · 2006 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
Apoptosis in neurodegenerative disorders
10.1038/35040009 · 2000 · External reference
STRING: a database of predicted functional associations between proteins
10.1093/nar/gkg034 · 2003 · External reference
LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathway
10.1186/s10020-025-01363-7 · 2025 · External reference
NCodR: A multi-class support vector machine classification to distinguish non-coding RNAs in Viridiplantae
10.1017/qpb.2022.18 · 2022 · External reference
Genome-wide identification of miRNAs and lncRNAs in Cajanus cajan
10.1186/s12864-017-4232-2 · 2017 · External reference
Transcriptome datasets of neural progenitors and neurons differentiated from induced pluripotent stem cells of healthy donors and Parkinson’s disease patients with mutations in the PARK2 gene
10.1016/j.dib.2022.107958 · 2022 · External reference
The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis
10.1007/s12035-024-04059-x · 2024 · External reference
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
10.1212/01.wnl.0000231510.89311.8b · 2006 · External reference
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in neurodegenerative diseases
10.1016/j.neuri.2024.100176 · 2024 · External reference
The miRNome of Alzheimer’s disease: consistent downregulation of the miR-132/212 cluster
10.1016/j.neurobiolaging.2016.09.019 · 2017 · External reference
Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson’s disease
10.1186/s40035-017-0081-9 · 2017 · External reference
How Amyotrophic Lateral Sclerosis Got Its Name
2001 · External reference
Parkinson’s disease
10.1016/s0140-6736(04)16305-8 · 2004 · External reference
JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease
10.1038/s41467-023-43728-8 · 2023 · External reference
dbSNP: the NCBI database of genetic variation
10.1093/nar/29.1.308 · 2001 · External reference
Orchestration of a blood-derived and ADARB1-centred network in Alzheimer’s and Parkinson’s disease
10.1016/j.cellsig.2023.110845 · 2023 · External reference
miRWalk: an online resource for prediction of microRNA binding sites
10.1371/journal.pone.0206239 · 2018 · External reference
Application of precision medicine in neurodegenerative diseases
2018 · External reference
Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated Glia
2019 · External reference
Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases
10.1007/s12035-014-8803-9 · 2015 · External reference
REVIEWThe Gene Defects Responsible for Familial Alzheimer’s Disease
10.1006/nbdi.1996.0016 · 1996 · External reference
Non-coding RNAs in Parkinson’s disease: Regulating SNCA and alpha-synuclein aggregation
10.1016/j.prp.2024.155511 · 2024 · External reference
Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
10.1038/s41467-018-02980-z · 2018 · External reference
pmiRScan: a LightGBM based method for prediction of animal pre-miRNAs
10.1007/s10142-025-01527-y · 2025 · External reference
HyLnc: a hybrid deep learning and feature-based approach for long non-coding RNA prediction
10.1080/15476286.2026.2731913 · 2026 · External reference
Long non-coding RNA TTN-AS1 promotes acute liver injury in sepsis: a novel potential monitoring and therapeutic target
10.1016/j.ejphar.2026.179060 · 2026 · External reference
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
10.1093/nar/gkq603 · 2010 · External reference
Molecular mechanisms of long noncoding RNAs
10.1016/j.molcel.2011.08.018 · 2011 · External reference
Disrupting USP14-mediated PARP1 dynamics reinstates MIC-A/B–driven antigen-independent CD8 + T cell killing in glioma
2026 · External reference
The NONRATT023402.2/rno-miR-3065-5p/NGFR axis affects levodopa-induced dyskinesia in a rat model of Parkinson’s disease
10.1038/s41420-023-01644-2 · 2023 · External reference
miRDB: A microRNA target prediction and functional annotation database with a wiki interface
10.1261/rna.965408 · 2008 · External reference
Apolipoprotein E in sporadic Alzheimer’s disease: Allelic variation and receptor interactions
10.1016/0896-6273(93)90070-8 · 1993 · External reference
Early-Onset Familial Alzheimer’s Disease (EOFAD
10.1017/s0317167100013949 · 2012 · External reference
NIDM: network impulsive dynamics on multiplex biological network for disease-gene prediction
2021 · External reference
Elucidating the Mechanism of Buyanghuanwu Decoction Acting on Pulmonary Fibrosis Based on Network Pharmacology and Animal Studies
10.2174/1386207326666230823093958 · 2024 · External reference
New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer
10.1016/j.jare.2024.08.029 · 2025 · External reference
Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention
10.1080/10408398.2025.2568606 · 2026 · External reference
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
SNAP-25: a biomarker of synaptic loss in neurodegeneration
10.1016/j.cca.2025.120236 · 2025 · External reference
Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke
10.1016/j.redox.2024.103086 · 2024 · External reference
Competing endogenous RNAs crosstalk in hippocampus: a potential mechanism for neuronal developing defects in down syndrome
10.1007/s12031-024-02205-7 · 2024 · External reference
NPInter v5.0: ncRNA interaction database in a new era
10.1093/nar/gkac1002 · 2023 · External reference
Predicting potential miRNA-disease associations by combining gradient boosting decision tree with logistic regression
10.1016/j.compbiolchem.2020.107200 · 2020 · External reference
Joint masking and self-supervised strategies for inferring small molecule-miRNA associations
10.1016/j.omtn.2023.102103 · 2024 · External reference
