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References from Mechanistic Role of eIF4E in the Hallmarks of Cancer: A Translational Control Perspective. Local targets link to admitted publications; unresolved targets remain external evidence.
Comparison of Akt/mTOR signaling in primary breast tumors and matched distant metastases
10.1002/cncr.23456 · 2008 · External reference
eIF4F-mediated dysregulation of mRNA translation in cancer
10.1261/rna.080340.124 · 2025 · External reference
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): A proof-of-principle clinical trial with ribavirin
10.1182/blood-2009-02-205153 · 2009 · External reference
A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E
10.3324/haematol.2014.111245 · 2015 · External reference
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs
10.1073/pnas.1203853109 · 2012 · External reference
Targeting the translation machinery in cancer
10.1038/nrd4505 · 2015 · External reference
Targeting the oncogene eIF4E in cancer: From the bench to clinical trials
2011 · External reference
10.1002/bies.202300145
10.1002/bies.202300145 · 2024 · External reference
Ribavirin as an anti-cancer therapy: Acute myeloid leukemia and beyond?
10.3109/10428194.2010.496506 · 2010 · External reference
Emerging Roles of m7G-Cap Hypermethylation and Nuclear Cap-Binding Proteins in Bypassing Suppression of eIF4E-Dependent Translation
10.3390/v17030372 · 2025 · External reference
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E
10.1111/jcmm.14043 · 2019 · External reference
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol
10.1371/journal.pone.0005223 · 2009 · External reference
CELF1 is a non-canonical eIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs
10.1093/nar/gkag123 · 2026 · External reference
Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line
10.3892/mmr.2015.4468 · 2015 · External reference
Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction
10.1021/jm300037x · 2012 · External reference
Abstract 1302: Targeting hormone receptor-dependent cancers with potent, selective and orally-available small molecule inhibitors of eIF4E
10.1158/1538-7445.am2019-1302 · 2019 · External reference
Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: A survival mechanism for carcinoma cells
10.1083/jcb.200112015 · 2002 · External reference
Targets and mechanisms for the regulation of translation in malignant transformation
10.1038/sj.onc.1207544 · 2004 · External reference
Tackling the complexity of cancer with generative models
10.1016/j.cell.2026.03.027 · 2026 · External reference
Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1)
10.1042/bc20070121 · 2008 · External reference
N7-Methylguanine-Related Gene Signature Highlights EIF4E as a Novel Therapeutic Target in HER2-Negative Breast Cancer
10.1111/jcmm.70808 · 2025 · External reference
Advances in understanding and targeting eIF4E activity
10.1042/bst20241045 · 2025 · External reference
MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop
10.1111/cas.14778 · 2021 · External reference
Ribavirin as a tri-targeted antitumor repositioned drug
10.3892/or.2015.3816 · 2015 · External reference
Translational downregulation of Twist1 expression by antiproliferative gene, B-cell translocation gene 2, in the triple negative breast cancer cells
10.1038/s41419-019-1640-z · 2019 · External reference
Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells
10.1007/s10549-008-9956-x · 2009 · External reference
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
10.1126/science.1187532 · 2010 · External reference
Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer
10.1002/ijc.30199 · 2016 · External reference
Microbiome Dynamics in Breast Cancer: Mechanisms, Therapeutic Impacts and Research gaps
10.1016/j.critrevonc.2025.104879 · 2025 · External reference
The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation
10.1593/neo.10144 · 2010 · External reference
eIF4E-eIF4G complex inhibition synergistically enhances the effect of sorafenib in hepatocellular carcinoma
10.1097/cad.0000000000001074 · 2021 · External reference
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo
2019 · External reference
Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells
10.1111/jcmm.16135 · 2021 · External reference
Oblique-incidence reflectivity difference technology identifies the antiviral drug Ribavirin as an inhibitor of lung tumor progression by targeting AMPK signaling
10.1016/j.jpha.2025.101306 · 2026 · External reference
Expression analysis and clinical significance of eIF4E, VEGF-C, E-cadherin and MMP-2 in colorectal adenocarcinoma
10.18632/oncotarget.13453 · 2016 · External reference
Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: Inhibitors of multi-pathways involve in cancer
10.1016/j.ejmech.2010.04.038 · 2010 · External reference
eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
10.1158/0008-5472.can-08-3472 · 2009 · External reference
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
10.1172/jci32044 · 2007 · External reference
Programmed cell death network in cancer drug resistance: A framework for therapeutic intervention
10.1016/j.drup.2026.101387 · 2026 · External reference
Hallmarks of cancer: New dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
Hallmarks of cancer—Then and now, and beyond
10.1016/j.cell.2025.12.049 · 2026 · External reference
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
10.1038/ni.2291 · 2012 · External reference
A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer
10.1158/1078-0432.ccr-11-0430 · 2011 · External reference
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
10.1016/j.ccr.2010.01.021 · 2010 · External reference
Oncogenic AKTivation of translation as a therapeutic target
10.1038/bjc.2011.241 · 2011 · External reference
Co-targeting hallmarks of cancer for therapeutic benefit in ovarian cancer: A scoping review
10.1016/j.ijgc.2026.104651 · 2026 · External reference
Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide
10.1371/journal.pone.0081669 · 2013 · External reference
Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target
10.1002/med.21260 · 2012 · External reference
Mnk kinase pathway: Cellular functions and biological outcomes
10.4331/wjbc.v5.i3.321 · 2014 · External reference
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap
10.1073/pnas.0406927102 · 2004 · External reference
The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells
10.1096/fj.201700780r · 2018 · External reference
Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
10.1128/jvi.78.20.11030-11039.2004 · 2004 · External reference
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors
10.1158/0008-5472.can-07-0752 · 2007 · External reference
Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells
10.18632/oncotarget.24354 · 2018 · External reference
Role of eIF4E on epithelial‐mesenchymal transition, invasion, and chemoresistance of prostate cancer cells
10.1002/cac2.12011 · 2020 · External reference
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer
10.1371/journal.pone.0227768 · 2020 · External reference
Identification of a first-in-class small-molecule inhibitor of the EIF4E-RBM38 complex that enhances wild-type TP53 protein translation for tumor growth suppression
10.1158/1535-7163.mct-22-0627 · 2023 · External reference
Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression
10.1158/0008-5472.can-18-2209 · 2019 · External reference
Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor
10.1016/s0021-9258(18)49896-1 · 1991 · External reference
eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production
10.1080/19491034.2024.2360196 · 2024 · External reference
HIF-1α pathway: Role, regulation and intervention for cancer therapy
10.1016/j.apsb.2015.05.007 · 2015 · External reference
Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer
10.1172/jci199838 · 2026 · External reference
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
10.1016/j.cell.2006.11.046 · 2007 · External reference
Translation initiation and its relationship with metabolic mechanisms in cancer development, progression and chemoresistance
10.1016/bs.apcsb.2022.05.011 · 2022 · External reference
COX-2 expression in dysplasia of the head and neck: Correlation with elF4E
10.1002/1097-0142(20011001)92:7<1888::aid-cncr1706>3.0.co;2-z · 2001 · External reference
Chemical Probes for Studying the Eukaryotic Translation Initiation Factor 4E (eIF4E)-Regulated Translatome in Cancer
10.1021/acsptsci.4c00674 · 2025 · External reference
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
10.1074/jbc.m506551200 · 2005 · External reference
The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
10.1124/mol.106.033308 · 2007 · External reference
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
10.1038/onc.2014.146 · 2015 · External reference
The role of translation in neoplastic transformation from a pathologist’s point of view
10.1038/sj.onc.1207552 · 2004 · External reference
The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial
10.1158/1078-0432.ccr-25-2112 · 2025 · External reference
Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E
10.1038/bjc.1998.356 · 1998 · External reference
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
10.1172/jci46323 · 2011 · External reference
Cancer in 4D: Toward Spatiotemporal Hallmark Ecosystems
10.1016/j.trecan.2026.01.004 · 2026 · External reference
Signalling to eIF4E in cancer
10.1042/bst20150126 · 2015 · External reference
Translational control in cancer
10.1038/nrc2824 · 2010 · External reference
LMP1 promotes nasal NK/T-cell lymphoma cell function by eIF4E via NF-κB pathway
10.3892/or.2015.4305 · 2015 · External reference
Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38
2021 · External reference
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase
10.1016/j.yexcr.2013.05.029 · 2013 · External reference
Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1
10.1038/sj.onc.1203446 · 2000 · External reference
Inhibition of eIF4E signaling by ribavirin selectively targets lung cancer and angiogenesis
10.1016/j.bbrc.2020.05.127 · 2020 · External reference
Ribavirin augments doxorubicin’s efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation
10.1002/jbt.22007 · 2018 · External reference
Ribavirin targets eIF4E dependent Akt survival signaling
10.1016/j.bbrc.2008.07.163 · 2008 · External reference
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
10.1038/ncomms11776 · 2016 · External reference
The hallmarks of oncogenic signaling: From pathways to resistance in cancer therapy
10.1016/j.drup.2026.101355 · 2026 · External reference
PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific molecular heterogeneity in the Nigerian breast cancer landscape
2026 · External reference
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia
10.1021/acs.jmedchem.4c03158 · 2025 · External reference
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations
2024 · External reference
Targeting eIF4E inhibits growth, survival and angiogenesis in retinoblastoma and enhances efficacy of chemotherapy
10.1016/j.biopha.2017.10.034 · 2017 · External reference
Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma
10.1016/j.lungcan.2009.02.001 · 2009 · External reference
4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation
10.18632/oncotarget.7824 · 2016 · External reference
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer
10.1158/0008-5472.can-18-1220 · 2019 · External reference
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway
10.18632/oncotarget.8497 · 2016 · External reference
The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
10.4161/cbt.10.7.12965 · 2010 · External reference
Update on the Development of MNK Inhibitors as Therapeutic Agents
10.1021/acs.jmedchem.1c00368 · 2022 · External reference
The Translational Regulation in mTOR Pathway
10.3390/biom12060802 · 2022 · External reference
Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T
10.3748/wjg.v9.i8.1707 · 2003 · External reference
Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: Small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection
10.1128/jvi.79.11.6882-6889.2005 · 2005 · External reference
MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
10.1172/jci91258 · 2017 · External reference
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: Prognostic markers for breast cancer
10.1186/1471-2407-6-231 · 2006 · External reference
The mechanism of the PI3K-AKT-mTOR signaling pathway in renal cell carcinoma: Current developments and future prospects
10.3389/fonc.2026.1745024 · 2026 · External reference