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References from From dysbiosis to precision supportive care: the gut microbiota–immune axis in pediatric acute lymphoblastic leukemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Chemotherapy induced gastrointestinal toxicities
10.1016/bs.acr.2022.02.007 · 2022 · External reference
Para-probiotics as novel anti-inflammatory agents: insight into health benefits and therapeutic applications
10.2174/0113816128411949250909113034 · 2026 · External reference
Instrumental variable methods for causal inference
10.1002/sim.6128 · 2014 · External reference
Hypoglycemic effect of the polysaccharides from Astragalus membranaceus on type 2 diabetic mice based on the “gut microbiota–mucosal barrier
10.1039/d2fo02300h · 2022 · External reference
Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy
10.1186/s12885-020-6654-5 · 2020 · External reference
Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: the impact of the gut microbiota
10.1002/ijc.32942 · 2020 · External reference
Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant
10.1056/nejmoa1910437 · 2019 · External reference
Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis
10.1016/j.cmet.2025.12.017 · 2026 · External reference
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease
10.1038/s41577-023-00874-w · 2023 · External reference
Safety of levofloxacin as an antibiotic prophylaxis in the induction phase of children newly diagnosed with acute lymphoblastic leukemia: an interim analysis of a randomized, open-label trial in Brazil
10.1016/j.bjid.2023.102745 · 2023 · External reference
The effects of LactoCare synbiotic administration on chemotherapy-induced nausea, vomiting, diarrhea, and constipation in children with ALL: a double-blind randomized clinical trial
10.1002/pbc.30328 · 2023 · External reference
Clinical and microbiologic outcomes of quinolone prophylaxis in children with acute myeloid leukemia
10.1097/inf.0000000000000591 · 2015 · External reference
Fecal microbiota transplantation promotes gut microbiome recovery in pediatric hematopoietic stem cell transplant recipients
2026 · External reference
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
10.1038/nature12721 · 2013 · External reference
Microbiota influences on hematopoiesis and blood cancers: new horizons?
10.1158/2643-3230.bcd-22-0172 · 2023 · External reference
The potential of the gut microbiota and butyrate to enhance CAR T-cell therapy in non-Hodgkin lymphoma
10.1158/1078-0432.ccr-25-1676 · 2026 · External reference
Lactobacillus bloodstream infections genetically related to probiotic use in pediatric hematopoietic cell transplant patients
10.1017/ice.2021.515 · 2023 · External reference
A causal mechanism for childhood acute lymphoblastic leukaemia
10.1038/s41568-018-0015-6 · 2018 · External reference
A gut microbial signature for combination immune checkpoint blockade across cancer types
10.1038/s41591-024-02823-z · 2024 · External reference
Fecal microbiota transplantation in hematopoietic cell transplant and cellular therapy recipients: lessons learned and the path forward
10.1080/19490976.2023.2229567 · 2023 · External reference
The role of butyrate in surgical and oncological outcomes in colorectal cancer
10.1152/ajpgi.00316.2020 · 2021 · External reference
Gut microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia
10.1093/cid/ciy153 · 2018 · External reference
Intestinal barrier functions in hematologic and oncologic diseases
10.1186/s12967-023-04091-w · 2023 · External reference
Treatment of pediatric acute lymphoblastic leukemia: a historical perspective
10.3390/cancers16040723 · 2024 · External reference
Microbiome-based modeling of CAR-T therapy response in lymphoma: insights from shotgun metagenomics sequencing
10.1111/ejh.70121 · 2026 · External reference
Gut microbiome and nutrition-related predictors of response to immunotherapy in cancer: making sense of the puzzle
10.1038/s44276-023-00008-8 · 2023 · External reference
12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46+ ILC3 development
10.1126/sciadv.adz8405 · 2026 · External reference
Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia
10.1002/cncr.28688 · 2014 · External reference
Pediatric acute lymphoblastic leukemia
10.3324/haematol.2020.247031 · 2020 · External reference
Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation
10.1186/s40168-019-0745-z · 2019 · External reference
JBI Manual for Evidence Synthesis
2024 · External reference
Metabolic tug-of-war: microbial metabolism shapes colonization resistance against enteric pathogens
10.1016/j.chembiol.2024.12.005 · 2025 · External reference
Significance of Th17 and Treg in treatment efficacy and outcome in pediatric acute lymphoblastic leukemia
10.3390/ijms241512323 · 2023 · External reference
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
10.1038/s41575-019-0258-z · 2020 · External reference
Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies
10.1038/s41390-022-02104-w · 2022 · External reference
Roles of secretory immunoglobulin A in host-microbiota interactions in the gut ecosystem
10.3389/fmicb.2022.880484 · 2022 · External reference
Extremophyte-derived exosome-like nanovesicles remodel intestinal barrier dysfunction by multi-dimensional intervention: physical barrier repair with immune homeostasis and microbiome regulation
2026 · External reference
A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders
10.1038/s41421-025-00789-x · 2025 · External reference
Study on the effect of molecular weight on the gut microbiota fermentation properties of blackberry polysaccharides in vitro
10.1021/acs.jafc.2c03091 · 2022 · External reference
Gut microbiome-targeted therapeutics for chronic kidney disease: comparative efficacy of probiotic and microbial preparations
10.1007/s10787-025-02044-x · 2025 · External reference
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
10.1038/s41588-021-00968-y · 2022 · External reference
Pediatric acute lymphoblastic leukemia patients exhibit distinctive alterations in the gut microbiota
10.3389/fcimb.2020.558799 · 2020 · External reference
Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage
10.1200/go.21.00266 · 2022 · External reference
Microbiota predict infections and acute graft-versus-host disease after pediatric allogeneic hematopoietic stem cell transplantation
10.1093/infdis/jiad190 · 2023 · External reference
Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as a predictor of mortality in children
10.1182/blood.2023020026 · 2023 · External reference
Recent advances in lipopolysaccharide recognition systems
10.3390/ijms21020379 · 2020 · External reference
Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis
10.1080/19490976.2020.1870402 · 2021 · External reference
Fecal microbiota transplantation donor screening updates and research gaps for solid organ transplant recipients
10.1128/jcm.00161-21 · 2022 · External reference
Unresolved reference
External reference
Distinct effects of a dairy probiotic drink and physical exercise on gut microbiota in pediatric acute lymphoblastic leukemia patients in remission: a randomized clinical trial
10.3389/fmicb.2026.1791192 · 2026 · External reference
The microbiome in childhood acute lymphoblastic leukemia
10.3390/cancers13194947 · 2021 · External reference
Baseline gut microbiome alpha diversity predicts chemotherapy-induced gastrointestinal symptoms in patients with breast cancer
10.1038/s41523-024-00707-6 · 2024 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
Gut microbiome immaturity and childhood acute lymphoblastic leukaemia
10.1038/s41568-023-00584-4 · 2023 · External reference
Microbial tryptophan catabolites in health and disease
10.1038/s41467-018-05470-4 · 2018 · External reference
Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial
10.1016/j.cmi.2016.11.001 · 2017 · External reference
Relapsed acute lymphoblastic leukemia
10.1007/s12098-023-04635-4 · 2024 · External reference
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
10.1038/s41591-022-01702-9 · 2022 · External reference
Changes in gut microbiota predict neutropenia after induction treatment in childhood acute lymphoblastic leukemia
10.1182/bloodadvances.2024013986 · 2025 · External reference
A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
10.1038/s41591-023-02234-6 · 2023 · External reference
Temporal development of the gut microbiome in early childhood from the TEDDY study
10.1038/s41586-018-0617-x · 2018 · External reference
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
10.3389/fimmu.2023.1127743 · 2023 · External reference
The gut connection: a narrative review on the in-depth analysis of gut microbiota and metabolites in depression
10.2174/0127724328332998250118182255 · 2026 · External reference
Effects of high-inorganic-phosphorus diet on intestinal mucosal injury and immune alteration in mice
10.3390/nu18101590 · 2026 · External reference
The Integrative Human Microbiome Project
10.1038/s41586-019-1238-8 · 2019 · External reference
Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells
10.1093/discim/kyaf020 · 2026 · External reference
10.1186/s12885-022-09522-3
10.1186/s12885-022-09522-3 · 2022 · External reference
ALLTogether recommendations for biobanking samples from patients with acute lymphoblastic leukaemia: a modified Delphi study
10.1038/s41416-025-02958-x · 2025 · External reference
Infectious complications during early treatment of childhood acute lymphoblastic leukemia-a comparison between the ALLTogether and NOPHO ALL-2008 protocols
10.1002/pbc.32120 · 2026 · External reference
Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut
10.1086/599346 · 2009 · External reference
Early discontinuation of empirical antibiotics versus extended treatment in children with cancer and high-risk febrile neutropenia in Denmark: an open-label, randomised controlled trial
10.1016/s2352-4642(26)00039-8 · 2026 · External reference
Reading and conducting instrumental variable studies: guide, glossary, and checklist
10.1136/bmj-2023-078093 · 2024 · External reference
Microbial metagenomic shifts in children with acute lymphoblastic leukaemia during induction therapy and predictive biomarkers for infection
10.1186/s12941-024-00717-z · 2024 · External reference
Intestinal mucositis, systemic inflammation and bloodstream infections following high-dose methotrexate treatment in childhood acute lymphoblastic leukaemia: comparison between the NOPHO ALL 2008 protocol and the ALLTogether1 protocol
10.1002/ijc.35136 · 2025 · External reference
Interactions between gut microbiota and acute childhood leukemia
10.3389/fmicb.2019.01300 · 2019 · External reference
Next-generation sequencing: insights to advance clinical investigations of the microbiome
10.1172/jci154944 · 2022 · External reference
The role of inflammasomes in human diseases and their potential as therapeutic targets
10.1038/s41392-023-01687-y · 2024 · External reference
Treatment delay and the risk of relapse in pediatric acute lymphoblastic leukemia
10.1080/08880018.2016.1276235 · 2017 · External reference
Remodeling the gut ecosystem and its mechanism: natural products in the treatment of ulcerative colitis via regulating gut microbiota and metabolites
10.1016/j.intimp.2026.116378 · 2026 · External reference
Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: a review
10.1016/j.biopha.2023.114985 · 2023 · External reference
NLRP3 inflammasome promotes the progression of acute myeloid leukemia via IL-1β pathway
2021 · External reference