Research graph
References from Immunosenescence in tumor progression: from synergistic mechanisms to therapeutic strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Age-Related Survival Disparities in Advanced Renal Carcinoma in the Immune Checkpoint Inhibitor Era using the SEER Database and Meta-analysis
10.1038/s41598-025-06297-y · 2025 · External reference
The effects of exercise training for eight weeks on immune cell characteristics among breast cancer survivors
10.3389/fspor.2023.1163182 · 2023 · External reference
Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation
10.1186/s12979-025-00542-8 · 2025 · External reference
Systemic effect of radiotherapy before or after nivolumab in lung cancer: an observational, retrospective, multicenter study
10.1177/03008916211004733 · 2022 · External reference
Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues
10.3389/fragi.2025.1684051 · 2025 · External reference
Alternative Chemotherapies: Angiotensin-Converting Enzyme Inhibitors Reduce Myeloid-Derived Suppressor Cells to Benefit Older Patients with Colorectal Cancer
10.31083/j.fbl2801002 · 2023 · External reference
Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+T cells
10.1007/s00262-025-03960-1 · 2025 · External reference
Aging-related biomarkers in testicular cancer survivors after different oncologic treatments
10.1002/cam4.70200 · 2024 · External reference
Age-associated clonal B cells drive B cell lymphoma in mice
10.1038/s43587-024-00671-7 · 2024 · External reference
Hyperactive Dendritc Cells Redirect Aged Antitumor Immunity
10.1158/0008-5472.can-24-2650 · 2024 · External reference
Developing and experimental validating a T cell senescence-related gene signature to predict prognosis and immunotherapeutic sensitivity in non-small cell lung cancer
10.1016/j.gene.2025.149233 · 2025 · External reference
iPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3
10.1186/s13287-025-04761-0 · 2025 · External reference
Therapy-induced senescent cancer cells as bidirectional regulators of antitumor immunity and resistance in the tumor microenvironment
10.1038/s41419-026-08688-z · 2026 · External reference
Depletion of preexisting B-cell lymphoma 2-expressing senescent cells before vaccination impacts antigen-specific antitumor immune responses in old mice
10.1111/acel.14007 · 2023 · External reference
Inflammaging: Experimental Insights and Translational Advances
10.1002/eji.70239 · 2026 · External reference
Deregulated Expression of Immune Checkpoints on Circulating CD4 T Cells May Complicate Clinical Outcome and Response to Treatment with Checkpoint Inhibitors in Multiple Myeloma Patients
10.3390/ijms22179298 · 2021 · External reference
Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection
10.1186/s12979-025-00535-7 · 2025 · External reference
Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment
10.7150/thno.91119 · 2024 · External reference
Ageing, immune fitness and cancer
10.1038/s41568-025-00858-z · 2025 · External reference
Aging Leads to Increased Monocytes and Macrophages With Altered CSF-1 Receptor Expression and Earlier Tumor-Associated Macrophage Expansion in Murine Mesothelioma
10.3389/fragi.2022.848925 · 2022 · External reference
Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficacy studies in preclinical models
10.1038/s41418-025-01447-1 · 2025 · External reference
Circulating T-cell Immunosenescence in Patients with Advanced Non-small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy
10.1158/1078-0432.ccr-20-1420 · 2021 · External reference
Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment
2025 · External reference
Toward precision interventions and metrics of inflammaging
10.1038/s43587-025-00938-7 · 2025 · External reference
Transient hepatic reconstitution of trophic factors enhances aged immunity
10.1038/s41586-025-09873-4 · 2026 · External reference
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study
10.1186/s12979-023-00399-9 · 2023 · External reference
Immunosenescence: signaling pathways, diseases and therapeutic targets
10.1038/s41392-025-02371-z · 2025 · External reference
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity
10.1136/jitc-2020-001536 · 2021 · External reference
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
10.1158/2326-6066.cir-24-0463 · 2024 · External reference
Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: a global-scale, cross-sectional, and large-sample informatics study
10.1097/js9.0000000000001479 · 2024 · External reference
Exercise training partially rescues impaired mucosal associated invariant t-cell mobilization in breast cancer survivors compared to healthy older women
10.1016/j.exger.2021.111454 · 2021 · External reference
Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells
10.1021/acsnano.3c08559 · 2024 · External reference
Effects of Korean red ginseng on T-cell repopulation after autologous hematopoietic stem cell transplantation in childhood cancer patients
10.1016/j.jgr.2023.09.001 · 2024 · External reference
From infection to immune exhaustion: The Epstein-Barr virus and its contribution to Immunosenescence
10.1016/j.bbcan.2025.189421 · 2025 · External reference
A modulatory effect of L-arginine supplementation on anticancer effects of chemoimmunotherapy in colon cancer-bearing aged mice
10.1016/j.intimp.2022.109423 · 2022 · External reference
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
10.1016/j.xcrm.2025.102484 · 2025 · External reference
Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors
10.3389/fimmu.2025.1484303 · 2025 · External reference
Who should be treated with pembrolizumab in addition to standard of care in advanced cervical cancer?
10.1007/s12032-021-01623-6 · 2022 · External reference
Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage
10.1111/acel.70364 · 2026 · External reference
Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship
10.1038/s41408-024-01071-1 · 2024 · External reference
Association of T Cell Senescence with Radiation Pneumonitis in Patients with Non-small Cell Lung Cancer
10.1016/j.ijrobp.2022.07.018 · 2023 · External reference
An Insight into Immunological Therapeutic Approach against Cancer: Potential Anti-Cancer Vaccines
10.2174/0113892029319505240821063238 · 2025 · External reference
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
10.1016/j.immuni.2025.03.005 · 2025 · External reference
Spontaneous Physical Activity in Obese Condition Favours Antitumour Immunity Leading to Decreased Tumour Growth in a Syngeneic Mouse Model of Carcinogenesis
10.3390/cancers14010059 · 2022 · External reference
Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity
10.1136/jitc-2020-001846 · 2021 · External reference
Atezolizumab plus Bevacizumab versus Sorafenib for Unresectable Hepatocellular Carcinoma: Results from Older Adults Enrolled in the IMbrave150 Randomized Clinical Trial
10.1159/000525671 · 2022 · External reference
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
10.7554/elife.83272 · 2022 · External reference
Research on the anti-ageing mechanism of Prunella vulgaris L
2023 · External reference
Potential biomarkers for predicting the risk of thyroid cancer in immunosenescence: a population-based and externally validated multi omics study
10.3389/fonc.2024.1525767 · 2025 · External reference
Aging and cancer: current understandings and future perspectives
10.1038/s41392-026-02756-8 · 2026 · External reference
Identification of immunosenescence of unconventional T cells in hepatocellular carcinoma
10.1016/j.compbiolchem.2024.108148 · 2024 · External reference
Study of calcitriol anti-aging effects on human natural killer cells in vitro
10.1080/21655979.2021.1972076 · 2021 · External reference
Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender
10.1111/cei.13606 · 2021 · External reference
Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers
10.1371/journal.pone.0269960 · 2022 · External reference
Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results
10.1038/s41591-025-03873-7 · 2025 · External reference
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges
10.1186/s13045-025-01735-w · 2025 · External reference
Turning to immunosuppressive tumors: Deciphering the immunosenescence-related microenvironment and prognostic characteristics in pancreatic cancer, in which GLUT1 contributes to gemcitabine resistance
10.1016/j.heliyon.2024.e36684 · 2024 · External reference
Characteristics and postoperative dynamic changes in circulating CD4+ helper T lymphocytes in patients with breast cancer
2023 · External reference
Aged AβPPswe/PS1ΔE9 mice as a useful animal model for studying the link between immunological senescence and diseases
10.1016/j.imlet.2024.106842 · 2024 · External reference
piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer
10.1186/s12943-026-02568-y · 2026 · External reference
Lymph node paracortex-inspired on-a-chip recapitulating immunosenescence: a cancer vaccine immunogenicity and antitumoral efficacy screening platform
10.1039/d5lc00533g · 2026 · External reference
At the Crossroads of TNF a Signaling and Cancer
2024 · External reference
History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications
2023 · External reference
Lymph nodes link sex-biased immune aging to compromised antigen recognition
2025 · External reference
The Impact of Age on the Effectiveness of Immune Checkpoint Inhibitors Therapy in Patients with Metastatic Non-Small-Cell Lung Cancer
10.3390/geriatrics10040085 · 2025 · External reference
Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC
10.1126/sciadv.adh0708 · 2023 · External reference
Critical role of the CD44low CD62Llow CD8+ T cell subset in restorinng antitumor immunnity in aged mice
2021 · External reference
Distinctive Role of the Systemic Inflammatory Profile in Non-Small-Cell Lung Cancer Younger and Elderly Patients Treated with a PD-1 Immune Checkpoint Blockade: A Real-World Retrospective Multi-Institutional Analysis
10.3390/life11111235 · 2021 · External reference
The Correlation between Peripheral Blood Index and Immune Cell Expansion in Vietnamese Elderly Lung Cancer Patients
10.3390/ijms24054284 · 2023 · External reference
Targeting immunosenescence and inflammaging: advancing longevity research
10.1038/s12276-025-01527-9 · 2025 · External reference
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial
10.1186/s12979-022-00266-z · 2022 · External reference
Peripheral blood TCR clonotype diversity as an age- associated marker of breast cancer progression
2023 · External reference
Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage
10.3390/biology11040504 · 2022 · External reference
History of the discovery and development of Biomodulina T (InmunyVital), a useful immunomodulator with a broad range of clinical applications
10.1016/j.intimp.2023.110167 · 2023 · External reference
Aging Phenotypes and Restoring Functional Deficits in Older Adults With Hematologic Malignancy
10.6004/jnccn.2020.7686 · 2021 · External reference
Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy
10.1186/s13014-022-02153-9 · 2022 · External reference
Senescent T Cells as a Resistance Mechanism to Lung Cancer Immunotherapy
10.1158/1078-0432.ccr-20-3507 · 2021 · External reference
Recent advances in exercise effects on immunosenescence and management of diseases
10.1016/j.intimp.2025.115971 · 2026 · External reference
Curcumin restores the engraftment capacity of aged hematopoietic stem cells and also reduces PD-1 expression on cytotoxic T cells
10.1002/term.3180 · 2021 · External reference
GM-CSF and IL-7 fusion cytokine engineered tumor vaccine generates long-term Th-17 memory cells and increases overall survival in aged syngeneic mouse models of glioblastoma
10.1111/acel.13864 · 2023 · External reference
Mechanisms of Age Differences in the Effectiveness of Phototherapy of Glioblastoma
10.24976/discov.med.202537193.27 · 2025 · External reference
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cells
10.1007/s11357-022-00515-5 · 2022 · External reference
Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments
10.3389/fimmu.2023.1258291 · 2023 · External reference
Associations among cytokines, EGF and lymphocyte subpopulations in patients diagnosed with advanced lung cancer
10.1007/s00262-020-02823-1 · 2021 · External reference
Sialic acid-mediated photochemotherapy enhances infiltration of CD8D T cells from tumor-draining lymph nodes into tumors of immunosenescent mice
10.1016/j.apsb.2022.06.005 · 2023 · External reference
Regulators of CD8+ T cell exhaustion
10.1038/s41577-025-01221-x · 2026 · External reference
Tumour-infiltrating immune cells in tonsillar cancer: no tissue-level signs of inflammageing in the elderly
10.1080/00016489.2025.2575865 · 2025 · External reference
Preoperative PD-1+CD4+ lymphocytes reflect immunological and physical frailty and are associated with postoperative infectious complications following gastrectomy for gastric cancer
10.3892/ol.2025.15321 · 2025 · External reference
Tumor Microenvironment-Regulating Immunosenescence-Independent Nanostimulant Synergizing with Near-Infrared Light Irradiation for Antitumor Immunity
10.1021/acsami.0c20063 · 2021 · External reference
T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy
10.1038/s41392-026-02923-x · 2026 · External reference
Association of Tumor Microenvironment with Biological and Chronological Age in Head and Neck Cancer
10.3390/cancers15153834 · 2023 · External reference
Impact of older age in patients receiving atezolizumab and bevacizumab for hepatocellular carcinoma
10.1111/liv.15405 · 2022 · External reference
Shorter telomere length increases the risk of lymphocyte immunodeficiency: A Mendelian randomization study
10.1002/iid3.1251 · 2024 · External reference
Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer
10.1038/s41435-023-00197-9 · 2023 · External reference
Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity
2024 · External reference
Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer
10.1007/s11357-024-01064-9 · 2024 · External reference
hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis
10.3389/fimmu.2021.780897 · 2021 · External reference
Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade
10.1038/s41467-023-38810-0 · 2023 · External reference
Negative Influence of Aging on Differentiation and Proliferation of CD8+ T-Cells in Dogs
10.3390/vetsci10090541 · 2023 · External reference
Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin
10.3389/fimmu.2023.1183709 · 2023 · External reference
The effect of metformin on senescence of T lymphocytes
10.1186/s12979-023-00394-0 · 2023 · External reference
Dysregulation of peripheral and intratumoral KLRG1+CD8+ T cells is associated with immune evasion in patients with non-small-cell lung cancer
10.1016/j.tranon.2024.101968 · 2024 · External reference
Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma
10.1186/s12575-025-00278-1 · 2025 · External reference
Characteristics of circulating adaptive immune cells in patients with colorectal cancer
2022 · External reference
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity
10.1038/s41467-025-56002-w · 2025 · External reference
Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP
2025 · External reference
Reconstructing the immunosenescence core pathway reveals global characteristics in pan-cancer
10.1007/s00262-023-03521-4 · 2023 · External reference
Single-Cell and Bulk Transcriptomics Reveal the Immunosenescence Signature for Prognosis and Immunotherapy in Lung Cancer
10.3390/cancers17010085 · 2025 · External reference
Correction of age-associated defects in dendritic cells enables CD4+T cells to eradicate tumors
10.1016/j.cell.2024.05.026 · 2024 · External reference
Identifying an immunosenescence-associated gene signature in gastric cancer by integrating bulk and single-cell sequencing data
2024 · External reference
An Immunosenescence-Related Gene Signature to Evaluate the Prognosis, Immunotherapeutic Response, and Cisplatin Sensitivity of Bladder Cancer
10.1155/2022/2143892 · 2022 · External reference
Construction and experimental validation of a B cell senescence-related gene signature to evaluate prognosis and immunotherapeutic sensitivity in bladder cancer
10.1007/s10142-022-00936-7 · 2023 · External reference
Prognostic value of CD28-CD57+CD8+ T cells for early immunotherapy response in hepatocellular carcinoma: a prospective observational study
2025 · External reference
Alterations and Clinical Value of Peripheral Lymphocyte Subsets and Inflammatory Factors in Paragangliomas
2024 · External reference
Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy
10.1158/2767-9764.crc-25-0268 · 2025 · External reference
Machine learning-derived immunosenescence index for predicting outcome and drug sensitivity in patients with skin cutaneous melanoma
10.1038/s41435-024-00278-3 · 2024 · External reference
Global, Regional, and National Burden of Cancer in the Elderly Population, 1990–2021: Analysis of Data From the Global Burden of Disease Study 2021
10.1002/mdr2.70031 · 2025 · External reference
