Research graph
References from Conformational switching and spatial heterogeneity: Decoding SERPINE1/PAI-1as a multifaceted driver of tumor progression and therapy resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Plasminogen Activator Inhibitor-1 as a Therapeutic Target for Healthy Longevity, Immunosenescence, and Age-Related Disease: Translational Development of the Small-Molecule Inhibitor Tm5614
10.3390/cells15100941 · 2026 · External reference
The Role of Plasminogen Activator Inhibitor Type 1 (Pai-1) in Placenta-Mediated Pregnancy Complications: A Systematic Review
10.1055/s-0041-1742082 · 2022 · External reference
Plasminogen Activator Inhibitor-1 as an Oncologic Target: Biology, Therapeutic Inhibitors, and Clinical Translation
10.3389/fonc.2026.1737975 · 2026 · External reference
A Cross-Sectional Study on the Expression of Fibrinolytic System Components and Metalloproteinase-9 in Women with Early-Stage and Metastases Breast Cancer in Tucumán, Argentina
2025 · External reference
Absence of Host Plasminogen Activator Inhibitor 1 Prevents Cancer Invasion and Vascularization
10.1038/nm0898-923 · 1998 · External reference
Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy
10.3390/cancers14194706 · 2022 · External reference
Biomarker: Predictive or Prognostic?
10.1200/jco.2015.63.3651 · 2015 · External reference
Paracrine Regulation and Immune System Pathways in the Inflammatory Tumor Microenvironment of Lung Cancer: Insights into Oncogenesis and Immunotherapeutic Strategies
10.3390/cancers16061113 · 2024 · External reference
Therapeutic Potential of Plasminogen Activator Inhibitor-1 Inhibitors
10.1177/1753944710379126 · 2010 · External reference
The Inhibitory Effect of Oridonin on Colon Cancer Was Mediated by Deactivation of Tgf-Β1/Smads-Pai-1 Signaling Pathway in Vitro and Vivo
10.2147/ott.s220401 · 2019 · External reference
Mechanisms of Metastatic Colorectal Cancer
10.1038/s41575-024-00934-z · 2024 · External reference
Cholest-4-En-3-One Attenuates Tgf-Β Responsiveness by Inducing Tgf-Β Receptors Degradation in Mv1lu Cells and Colorectal Adenocarcinoma Cells
10.1080/10799893.2016.1203944 · 2017 · External reference
Evidence for a Rapid Inhibitor to Tissue Plasminogen Activator in Plasma
10.1016/0049-3848(83)90407-3 · 1983 · External reference
Association between Pai-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort
10.3390/ijms24098041 · 2023 · External reference
High Expression of Cathepsin B and Plasminogen Activator Inhibitor Type-1 Are Strong Predictors of Survival in Glioblastomas
10.1007/s00401-009-0592-2 · 2009 · External reference
Synthesis and Secretion of Plasminogen Activator Inhibitor-1 by Human Preadipocytes
10.1210/jcem.84.9.5987 · 1999 · External reference
Collagens in Cancer: Structural Regulators and Guardians of Cancer Progression
10.1158/0008-5472.can-22-2034 · 2023 · External reference
The Low Density Lipoprotein Receptor-Related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1
10.1074/jbc.m313004200 · 2004 · External reference
Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin Ii–Induced Abdominal Aortic Aneurysm
10.1161/01.res.0000061571.49375.e1 · 2003 · External reference
The Pro-or Antiangiogenic Effect of Plasminogen Activator Inhibitor 1 Is Dose Dependent
10.1096/fj.01-0552com · 2002 · External reference
Serpine1 and Sma Expression at the Invasive Front Predict Extracapsular Spread and Survival in Oral Squamous Cell Carcinoma
10.1038/bjc.2014.500 · 2014 · External reference
Act001 Suppresses the Malignant Progression of Small-Cell Lung Cancer by Inhibiting Lactate Production and Promoting Anti-Tumor Immunity
10.1111/1759-7714.70028 · 2025 · External reference
Circulating Levels of Pai-1 and Serpine1 4g/4g Polymorphism Are Predictive of Poor Prognosis in Hcc Patients Undergoing Tace
10.1016/j.tranon.2015.05.002 · 2015 · External reference
Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization
10.1021/jm049766q · 2004 · External reference
Allele-Specific Increase in Basal Transcription of the Plasminogen-Activator Inhibitor 1 Gene Is Associated with Myocardial Infarction
1995 · External reference
Plasma Plasminogen Activator Inhibitor-1 (Pai-1) Levels in Breast Cancer–Relationship with Clinical Outcome
2014 · External reference
Structure and Expression of the Human Gene Encoding Plasminogen Activator Inhibitor, Pai-1
10.1016/0378-1119(89)90519-2 · 1989 · External reference
Significance of Pai-1 on the Development of Skin Cancer: Optimal Targets for Cancer Therapies
2025 · External reference
Phase Iii Study Investigating the Safety and Efficacy of Tm5614 in Combination with Nivolumab for the Treatment of Unresectable Malignant Melanoma: Protocol
10.1111/exd.70202 · 2026 · External reference
A Phase Ii Multicentre Study of Plasminogen Activator Inhibitor-1 Inhibitor (Tm5614) Plus Nivolumab for Treating Anti-Programmed Cell Death 1 Antibody-Refractory Malignant Melanoma: Tm5614-Mm Trial
10.1093/bjd/ljae231 · 2024 · External reference
Serpin Structure, Mechanism, and Function
10.1021/cr010170+ · 2002 · External reference
The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (Pai-1) for the Low Density Lipoprotein Receptor-Related Protein (Lrp1) Is Composed of Four Basic Residues
10.1074/jbc.m115.688820 · 2016 · External reference
Cdna Cloning of Human Plasminogen Activator-Inhibitor from Endothelial Cells
10.1172/jci112761 · 1986 · External reference
Quantitative Stain-Free Imaging and Digital Profiling of Collagen Structure Reveal Diverse Survival of Triple Negative Breast Cancer Patients
10.1186/s13058-020-01282-x · 2020 · External reference
Matrix Metalloproteinases’ Role in Tumor Microenvironment
10.1007/978-3-030-40146-7_5 · 2020 · External reference
Understanding and Treating Intrauterine Adhesions: Insights into Molecular Mechanisms and Innovative Therapies
2025 · External reference
The Consensus Molecular Subtypes of Colorectal Cancer
10.1038/nm.3967 · 2015 · External reference
Serpine1 as an Independent Prognostic Marker and Therapeutic Target for Nicotine-Related Oral Carcinoma
10.21053/ceo.2022.01480 · 2023 · External reference
Glial-Cell-Line-Derived Neurotrophic Factor Promotes Glioblastoma Cell Migration and Invasion Via the Smad2/3-Serpine1-Signaling Axis
10.3390/ijms251810229 · 2024 · External reference
Thermodynamics and Selection of the Plasminogen Activator Inhibitor-1 Latency Transition
10.1016/j.jbc.2025.110896 · 2025 · External reference
Unresolved reference
External reference
Effect of Tiplaxtinin (Pai-039), an Orally Bioavailable Pai-1 Antagonist, in a Rat Model of Thrombosis
10.1111/j.1538-7836.2008.03063.x · 2008 · External reference
A Randomized Double-Blind Placebo-Controlled Trial of an Inhibitor of Plasminogen Activator Inhibitor-1 (Tm5614) in Mild to Moderate Covid-19
10.1038/s41598-023-50445-1 · 2024 · External reference
Impact of Mesenchymal Stem Cell Secreted Pai-1 on Colon Cancer Cell Migration and Proliferation
10.1016/j.bbrc.2013.05.013 · 2013 · External reference
Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing Serpine1 at Breast Cancer Metastatic Sites
10.1111/cas.70050 · 2025 · External reference
Tumor Necrosis Factor Α Activates the Human Plasminogen Activator Inhibitor-1 Gene through a Distal Nuclear Factor Κb Site
10.1074/jbc.m310438200 · 2004 · External reference
Targeting of Glioma Stem-Like Cells with a Parthenolide Derivative Act001 through Inhibition of Aebp1/Pi3k/Akt Signaling
10.7150/thno.49250 · 2021 · External reference
Lcrmp-1 Induces Tumor Angiogenesis by Transcriptionally Upregulating Serpine1 in Lung Adenocarcinoma
10.1038/s42003-025-09071-y · 2025 · External reference
Immune-Related Gene Serpine1 Is a Novel Biomarker for Diffuse Lower-Grade Gliomas Via Large-Scale Analysis
2021 · External reference
The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
10.3390/ijms23010337 · 2021 · External reference
A Novel Inhibitor of Plasminogen Activator Inhibitor-1 Provides Antithrombotic Benefits Devoid of Bleeding Effect in Nonhuman Primates
10.1038/jcbfm.2009.272 · 2010 · External reference
Lncrna H19 Acts as a Cerna to Promote Glioblastoma Malignancy by Sponging Mir-19b-3p and Upregulating Serpine1
10.1186/s12935-025-03868-x · 2025 · External reference
Pan-Cancer Analysis of Serpine1 with a Concentration on Immune Therapeutic and Prognostic in Gastric Cancer
10.1111/jcmm.18579 · 2024 · External reference
From Cms to Icms/Imf: Developing Roadmap to Precision Therapy in Colorectal Cancer
10.3390/ijms262211086 · 2025 · External reference
Vitronectin Inhibits Plasminogen Activator Inhibitor-1-Induced Signalling and Chemotaxis by Blocking Plasminogen Activator Inhibitor-1 Binding to the Low-Density Lipoprotein Receptor-Related Protein
10.1016/j.biocel.2008.07.006 · 2009 · External reference
Cellular Senescence in Human Liver under Normal Aging and Cancer
10.1016/j.xgen.2025.101133 · 2026 · External reference
Tgf-Β Induces P53/Smads Complex Formation in the Pai-1 Promoter to Activate Transcription
10.1038/srep35483 · 2016 · External reference
The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in Copd and Other Chronic Lung Diseases
10.3390/ijms22126351 · 2021 · External reference
Analysing the Role of Serpine1 Network in the Pathogenesis of Human Glioblastoma
2022 · External reference
Secretory Serpine1 Expression Is Increased by Antiplatelet Therapy, Inducing Mmp1 Expression and Increasing Colon Cancer Metastasis
10.3390/ijms23179596 · 2022 · External reference
Exploring a Possible Association between the Occurrence of the Serpine1-675 4g/5g (Rs1799889) Polymorphism and the Increased Risk of Esophageal Cancer in the Caucasian Population
2021 · External reference
Demonstration of a Fast-Acting Inhibitor of Plasminogen Activators in Human Plasma
10.1182/blood.v64.4.907.907 · 1984 · External reference
The Plasminogen Activator Inhibitor-1 Paradox in Cancer: A Mechanistic Understanding
10.1007/s10555-019-09806-4 · 2019 · External reference
Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
10.1016/j.celrep.2018.10.082 · 2018 · External reference
Prognostic Role of Tumor-Associated Proteases in Colorectal Cancer
10.1007/s10517-013-1952-4 · 2013 · External reference
The Apparent Upa/Pai-1 Paradox in Cancer: More Than Meets the Eye
2013 · External reference
Proteases and Glioma Angiogenesis
10.1111/j.1750-3639.2005.tb00118.x · 2005 · External reference
Single-Cell Transcriptome Sequencing Reveals New Epithelial-Stromal Associated Mesenchymal-Like Subsets in Recurrent Gliomas
10.1186/s40478-025-02036-6 · 2025 · External reference
Identification and Validation of Serpine1 as a Prognostic and Immunological Biomarker in Pan-Cancer and in Ccrcc
2023 · External reference
A Spatially Resolved Transcriptome Landscape During Thyroid Cancer Progression
2025 · External reference
Landscape of Small Nucleic Acid Therapeutics: Moving from the Bench to the Clinic as Next-Generation Medicines
10.1038/s41392-024-02112-8 · 2025 · External reference
Pan-Cancer Analysis of Serpine Family Genes as Biomarkers of Cancer Prognosis and Response to Therapy
10.3389/fmolb.2023.1277508 · 2024 · External reference
Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor Pai-1 in 8377 Breast Cancer Patients
10.1093/jnci/94.2.116 · 2002 · External reference
Detection of an Unusually Stable Fibrinolytic Inhibitor Produced by Bovine Endothelial Cells
10.1073/pnas.80.10.2956 · 1983 · External reference
Cebpb-Mediated Upregulation of Serpina1 Promotes Colorectal Cancer Progression by Enhancing Stat3 Signaling
10.1038/s41420-024-01990-9 · 2024 · External reference
Targeting Colorectal Cancer Stem Cells as an Effective Treatment for Colorectal Cancer
10.1177/1533033819892261 · 2020 · External reference
Structural Determinants of Smad Function in Tgf-Β Signaling
10.1016/j.tibs.2015.03.012 · 2015 · External reference
Fibrinolytic System and Cancer: Diagnostic and Therapeutic Applications
10.3390/ijms22094358 · 2021 · External reference
Gene Polymorphisms and Signaling Defects
2013 · External reference
Role of Pai-1 in the Progression and Treatment Resistance of Non-Small Cell Lung Cancer
2025 · External reference
Sk-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis
10.1158/1535-7163.mct-13-0041 · 2013 · External reference
Control of Type Iv Collagenase Activity by Components of the Urokinase–Plasmin System: A Regulatory Mechanism with Cell-Bound Reactants
10.1093/emboj/16.9.2319 · 1997 · External reference
Plasminogen Activator Inhibitor-1 Is Internalized by Endothelial Cells Via a Pinocytosis-Like Mechanism and Evades Degradation
2026 · External reference
Overview: Pai-1 Inhibitors and Clinical Applications
10.1016/j.bj.2025.100874 · 2025 · External reference
Hemostasis and Cancer: Impact of Haemostatic Biomarkers for the Prediction of Clinical Outcomes in Patients with Cancer
10.1111/jth.15880 · 2022 · External reference
Structural Basis of Latency in Plasminogen Activator Inhibitor-1
10.1038/355270a0 · 1992 · External reference
Plasminogen Activator Inhibitor-1 (Pai-1) Blockers Suppress Intestinal Polyp Formation in Min Mice
10.1093/carcin/bgn028 · 2008 · External reference
A Stromal Pai1-Tpa Axis Orchestrates Immunosuppression in Pancreatic Cancer
10.1126/sciadv.aea6734 · 2026 · External reference
Serpine1 Drives Molecular Synergies in Colorectal Cancer
10.1152/ajpcell.00759.2025 · 2026 · External reference
Combined Inactivation of Tp53 and Mir34a Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of Il6r and Pai1
10.1053/j.gastro.2018.08.011 · 2018 · External reference
Therapeutic Targeting of Tgfβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas
10.1158/1078-0432.ccr-17-3024 · 2019 · External reference
Linc02257 Regulates Malignant Phenotypes of Colorectal Cancer Via Interacting with Mir-1273g-3p and Yb1
10.1038/s41419-024-07259-4 · 2024 · External reference
Upa/Upar and Serpine1 in Head and Neck Cancer: Role in Tumor Resistance, Metastasis, Prognosis and Therapy
10.18632/oncotarget.10344 · 2016 · External reference
Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis
10.1038/s41556-023-01241-6 · 2023 · External reference
Transposon Mutagenesis Identifies Genes That Cooperate with Mutant Pten in Breast Cancer Progression
10.1073/pnas.1613859113 · 2016 · External reference
Small Molecules Inhibitors of Plasminogen Activator Inhibitor-1 - an Overview
10.1016/j.ejmech.2015.01.010 · 2015 · External reference
Serpine1 Identified as Potential Therapeutic Target through Rna-Seq of Clinically Relevant Invasive Glioblastoma Cells Isolated from Patients by 5-Ala Based Methodology
10.1093/neuonc/noy129.020 · 2018 · External reference
An Integrative View of Serpins in Health and Disease: The Contribution of Serpina3
2021 · External reference
Tm5614, an Inhibitor of Plasminogen Activator Inhibitor-1, Exerts an Antitumor Effect on Chronic Myeloid Leukemia
10.1620/tjem.2022.j036 · 2022 · External reference
Interaction between Lung Cancer Cells and Astrocytes Via Specific Inflammatory Cytokines in the Microenvironment of Brain Metastasis
10.1007/s10585-010-9354-8 · 2011 · External reference
Identification of Serpine1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling
10.3390/cancers11111651 · 2019 · External reference
Activity of Plasminogen Activator Inhibitor-1 in Blood of Patients with Metabolic Syndrome Depending on a Stage of Diabetic Retinopathy
2018 · External reference
Circulating Mir-10b, Soluble Urokinase-Type Plasminogen Activator Receptor, and Plasminogen Activator Inhibitor-1 as Predictors of Non-Small Cell Lung Cancer Progression and Treatment Response
10.3233/cbm-220222 · 2024 · External reference
Act001 Inhibits Tumor Progression and Modulates Immune Responses in Non-Small Cell Lung Cancer
10.1002/jcla.70066 · 2025 · External reference
Serpine1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-“Activated” Keratinocytes
10.1089/wound.2013.0512 · 2014 · External reference
Low Molecular Weight Antagonists of Plasminogen Activator Inhibitor-1: Therapeutic Potential in Cardiovascular Disease
10.4172/2324-8769.1000102 · 2012 · External reference
Stromal Coexpression of Upa/Pai-1 Protein Predicts Poor Disease Outcome in Endocrine-Treated Postmenopausal Patients with Receptor-Positive Early Breast Cancer
10.1016/j.breast.2019.05.007 · 2019 · External reference
Expression of Plasminogen Activator Inhibitor Type 1 by Human Prostate Carcinoma Cells Inhibits Primary Tumor Growth, Tumor-Associated Angiogenesis, and Metastasis to Lung and Liver in an Athymic Mouse Model
10.1172/jci118323 · 1995 · External reference
Obesity Promotes Radioresistance through Serpine1-Mediated Aggressiveness and DNA Repair of Triple-Negative Breast Cancer
10.1038/s41419-023-05576-8 · 2023 · External reference
Plasminogen Activator Inhibitor-1 Mediates Tolerance to Anti–Pd-1 Immunotherapy in Non–Small Cell Lung Cancer
10.1158/1535-7163.mct-24-0890 · 2026 · External reference
Deep Molecular Response in Patients with Chronic Phase Chronic Myeloid Leukemia Treated with the Plasminogen Activator Inhibitor-1 Inhibitor Tm5614 Combined with a Tyrosine Kinase Inhibitor
10.1002/cam4.5292 · 2023 · External reference
Serpine1 Maintained Expression by Nr4a1 Promotes Invasion and Migration of Glioblastoma in Hypoxic Microenvironment
10.3389/fonc.2025.1750546 · 2026 · External reference
Pai-1 Mediates Acquired Resistance to Met-Targeted Therapy in Non-Small Cell Lung Cancer
10.1371/journal.pone.0300644 · 2024 · External reference
Genetic Variants in Rassf1 (Rs2073498), Serpine1 (Rs1799889), and Efna1 (Rs12904) Are Associated with Susceptibility in Mexican Patients with Colorectal Cancer: Clinical Associations and Their Analysis in Silico
10.3390/genes16020223 · 2025 · External reference
Inhibition of Pai-1 Blocks Pd-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune Checkpoint Blockade
10.1016/j.jid.2021.03.030 · 2021 · External reference
Serpine1 Facilitates Metastasis in Gastric Cancer through Anoikis Resistance and Tumor Microenvironment Remodeling
10.1002/smll.202500136 · 2025 · External reference
Good or Bad: Paradox of Plasminogen Activator Inhibitor 1 (Pai-1) in Digestive System Tumors
10.1016/j.canlet.2023.216117 · 2023 · External reference
Integrated Multi-Omics and Single-Cell Analysis Identify Serpine1 as a Key Mediator of the Inflammatory Tumor Microenvironment in Pdac
2025 · External reference
Pai-1 Polymorphisms Have Significant Associations with Cancer Risk, Especially Feminine Cancer
10.1177/15330338211037813 · 2021 · External reference
Pai-1 4g/5g Polymorphism Contributes to Cancer Susceptibility: Evidence from Meta-Analysis
2013 · External reference
Diverse Roles of Serpine1 in Regulating Cellular Proliferation and Invasion
10.3892/ijo.2026.5871 · 2026 · External reference
Oxymatrine Inhibits the Migration of Human Colorectal Carcinoma Rko Cells Via Inhibition of Pai-1 and the Tgf-Β1/Smad Signaling Pathway
10.3892/or.2016.5292 · 2017 · External reference
The Expression of Serpine1 in Colon Cancer and Its Regulatory Network and Prognostic Value
10.1186/s12876-022-02625-y · 2023 · External reference
Targeting Serpine1 Enhances Pd-1 Blockade Response by Modulating Macrophage Infiltration and Polarization through the Stat3-Ccl2 Axis in Non-Small Cell Lung Cancer
10.1016/j.intimp.2026.116577 · 2026 · External reference
Tumor-Secreted Pai-1 Promotes Breast Cancer Metastasis Via the Induction of Adipocyte-Derived Collagen Remodeling
10.1186/s12964-019-0373-z · 2019 · External reference
Methionine Drives Lung Adenocarcinoma Progression Via Regulation of Bach1-Serpine1
10.1016/j.bbamcr.2026.120151 · 2026 · External reference
Modeling Oxaliplatin Resistance in Colorectal Cancer Reveals a Serpine1-Based Gene Signature (Resist-M) and Therapeutic Strategies for Pro-Metastatic Cms4 Subtype
10.1038/s41419-025-07855-y · 2025 · External reference
A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles
10.1055/a-2698-4219 · 2025 · External reference
Act001, a Novel Pai-1 Inhibitor, Exerts Synergistic Effects in Combination with Cisplatin by Inhibiting Pi3k/Akt Pathway in Glioma
10.1038/s41419-019-1986-2 · 2019 · External reference
Statins Affect Human Glioblastoma and Other Cancers through Tgf-Β Inhibition
10.18632/oncotarget.26733 · 2019 · External reference
The Role of Tgf-Β/Smad Signaling in Hepatocellular Carcinoma: From Mechanism to Therapy and Prognosis
10.7150/ijbs.89568 · 2024 · External reference
Serpina1 Promotes the Invasion, Metastasis, and Proliferation of Pancreatic Ductal Adenocarcinoma Via the Pi3k/Akt/Nf-Κb Pathway
10.1016/j.bcp.2024.116580 · 2024 · External reference
Pkm2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
10.1016/j.cell.2012.07.018 · 2012 · External reference
The Influence of 4g/5g Polymorphism in the Plasminogen-Activator-Inhibitor-1 Promoter on Covid-19 Severity and Endothelial Dysfunction
10.3389/fimmu.2024.1445294 · 2024 · External reference
A Five-Gene Signature Is a Prognostic Biomarker in Pan-Cancer and Related with Immunologically Associated Extracellular Matrix
10.1002/cam4.3986 · 2021 · External reference
Six5-Activated Linc01468 Promotes Lung Adenocarcinoma Progression by Recruiting Serbp1 to Regulate Serpine1 Mrna Stability and Recruiting Usp5 to Facilitate Pai1 Protein Deubiquitylation
10.1038/s41419-022-04717-9 · 2022 · External reference
Ret Regulates Human Medullary Thyroid Cancer Cell Proliferation through Cdk5 and Stat3 Activation
10.3390/biom11060860 · 2021 · External reference
A Dual Role for Erk-1/2 in the Regulation of Plasmin Activity and Cell Migration in Metastatic Nsclc-H1299 Cells
10.1007/s00204-023-03600-6 · 2023 · External reference
Data Mining Combines Bioinformatics Discover Immunoinfiltration-Related Gene Serpine1 as a Biomarker for Diagnosis and Prognosis of Stomach Adenocarcinoma
10.1038/s41598-023-28234-7 · 2023 · External reference
Therapy-Induced Senescent Tumor Cell-Derived Extracellular Vesicles Promote Colorectal Cancer Progression through Serpine1-Mediated Nf-Κb P65 Nuclear Translocation
10.1186/s12943-024-01985-1 · 2024 · External reference
Knockdown of Serpine1 Reverses Resistance of Triple‑Negative Breast Cancer to Paclitaxel Via Suppression of Vegfa
2020 · External reference
Microrna-6084 Orchestrates Angiogenesis and Liver Metastasis in Colorectal Cancer Via Extracellular Vesicles
10.1172/jci.insight.189503 · 2025 · External reference
How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration
10.1038/nsb943 · 2003 · External reference
The Pleiotropic Roles of Adipocyte Secretome in Remodeling Breast Cancer
10.1186/s13046-022-02408-z · 2022 · External reference
Plasminogen Activator Inhibitor 1 Promotes Immunosuppression in Human Non-Small Cell Lung Cancers by Enhancing Tgf-Β1 Expression in Macrophage
10.1159/000486025 · 2018 · External reference
