Research graph
References from γδ T Cells in Cancer Immunotherapy, 2000–2025: A Bibliometric Analysis and Clinical-Trial Evidence Map. Local targets link to admitted publications; unresolved targets remain external evidence.
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Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy
10.1016/j.jcyt.2024.04.072 · 2024 · External reference
Delta One T cells for immunotherapy of chronic lymphocytic leukemia: clinical-grade expansion/differentiation and preclinical proof of concept
10.1158/1078-0432.ccr-16-0597 · 2016 · External reference
Chimeric antigen receptor T cell immunotherapy for autoimmune rheumatic disorders: where are we now?
10.3390/cells14161242 · 2025 · External reference
bibliometrix: An R-tool for comprehensive science mapping analysis
10.1016/j.joi.2017.08.007 · 2017 · External reference
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
10.1126/science.285.5428.727 · 1999 · External reference
Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
10.26508/lsa.202000680 · 2020 · External reference
Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses
10.1073/pnas.0810059106 · 2009 · External reference
Chimeric antigen receptor-engineered human gamma delta T cells: enhanced cytotoxicity with retention of cross presentation
10.1016/j.ymthe.2017.12.001 · 2018 · External reference
NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions
10.1016/j.celrep.2021.109871 · 2021 · External reference
CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature
10.1002/asi.20317 · 2006 · External reference
Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis
10.1016/j.atherosclerosis.2014.03.007 · 2014 · External reference
A cell for the ages: human γδ T cells across the lifespan
10.3390/ijms21238903 · 2020 · External reference
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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
10.1038/nature14282 · 2015 · External reference
Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity
10.1074/jbc.m111.327650 · 2012 · External reference
γδ T cells support pancreatic oncogenesis by restraining αβ T cell activation
10.1016/j.cell.2016.07.046 · 2016 · External reference
Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell-mediated antitumor immune response
10.1126/scitranslmed.abj0835 · 2021 · External reference
Clinical applications of gamma delta T cells with multivalent immunity
10.3389/fimmu.2014.00636 · 2014 · External reference
Off-the-shelf’ allogeneic CAR T cells: development and challenges
10.1038/s41573-019-0051-2 · 2020 · External reference
Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments
10.1016/j.cell.2016.08.030 · 2016 · External reference
How to conduct a bibliometric analysis: an overview and guidelines
10.1016/j.jbusres.2021.04.070 · 2021 · External reference
A simple and robust single-step method for CAR-Vδ1 γδT cell expansion and transduction for cancer immunotherapy
10.3389/fimmu.2022.863155 · 2022 · External reference
Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells
10.1084/jem.20021500 · 2003 · External reference
Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells
10.1126/science.279.5357.1737 · 1998 · External reference
γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs
10.1182/blood-2012-05-432427 · 2012 · External reference
Current concerns and future directions of large language model ChatGPT in medicine: a machine-learning-driven global-scale bibliometric analysis
10.1097/js9.0000000000003668 · 2026 · External reference
Artificial intelligence AlphaFold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation
10.1186/s12943-024-02140-6 · 2024 · External reference
Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset
10.1182/blood-2012-05-430470 · 2012 · External reference
γδ T cell update: adaptive orchestrators of immune surveillance
10.4049/jimmunol.1800934 · 2019 · External reference
TCRγ4δ1-engineered αβT cells exhibit effective antitumor activity
10.2119/molmed.2016.00023 · 2016 · External reference
Improved survival with ipilimumab in patients with metastatic melanoma
10.1056/nejmoa1003466 · 2010 · External reference
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Flanking V and J sequences of complementary determining region 3 of T-cell receptor (TCR) δ1 (CDR3δ1) determine the structure and function of TCRγ4δ1
10.1074/jbc.m111.239624 · 2011 · External reference
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
10.1038/s42255-025-01276-z · 2025 · External reference
Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma
10.1007/s00262-006-0199-6 · 2007 · External reference
The NKG2D ligand ULBP4 binds to TCRγ9/δ2 and induces cytotoxicity to tumor cells through both TCRγδ and NKG2D
10.1182/blood-2008-12-196287 · 2009 · External reference
Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
10.1182/blood.v96.2.384.013k07_384_392 · 2000 · External reference
Cutting edge: bispecific γδ T cell engager containing heterodimeric BTN2A1 and BTN3A1 promotes targeted activation of Vγ9Vδ2+ T cells in the presence of costimulation by CD28 or NKG2D
10.4049/jimmunol.2200185 · 2022 · External reference
Engineered drug resistant γδ T cells kill glioblastoma cell lines during a chemotherapy challenge: a strategy for combining chemo- and immunotherapy
10.1371/journal.pone.0051805 · 2013 · External reference
A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2 T cells for the treatment of CD1d-expressing hematological malignancies
2023 · External reference
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Scoping studies: advancing the methodology
10.1186/1748-5908-5-69 · 2010 · External reference
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient
10.1038/s41467-024-45449-y · 2024 · External reference
Bibliometric analysis of γδ T cells as immune regulators in cancer prognosis
2022 · External reference
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
10.1038/s41590-020-00848-3 · 2021 · External reference
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma
10.1136/jitc-2021-003441 · 2021 · External reference
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia
10.1056/nejmoa1709866 · 2018 · External reference
Phase I/II trial of LAVA-1207, a novel bispecific gamma-delta T-cell engager alone, or with low dose IL-2 or pembrolizumab, in metastatic castration resistant prostate cancer (mCRPC)
10.1200/jco.2024.42.16_suppl.tps2672 · 2024 · External reference
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
10.1038/s41590-018-0253-5 · 2018 · External reference
Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes
10.1038/s41423-022-00894-x · 2022 · External reference
Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma
10.1056/nejmoa1707447 · 2017 · External reference
Allogeneic CD20-targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B-cell lymphoma models
10.1002/cti2.1373 · 2022 · External reference
Tumor-restricted activation of Vγ9Vδ2 T cells via bispecific Evobodies: a novel strategy for safe and potent immunotherapy in ovarian cancer
2025 · External reference
Function of γδ T cells in tumor immunology and their application to cancer therapy
10.1038/s12276-021-00576-0 · 2021 · External reference
Human Vδ2 T cells are a major source of interleukin-9
10.1073/pnas.1607136113 · 2016 · External reference
Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes
10.1073/pnas.1818488116 · 2019 · External reference
Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells
10.1016/j.neo.2024.101072 · 2024 · External reference
Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
10.1126/science.aay5516 · 2020 · External reference
Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia
10.3389/fimmu.2020.01347 · 2020 · External reference
Management of immune-related adverse events in patients treated with chimeric antigen receptor T-cell therapy: ASCO guideline
10.1200/jco.21.01992 · 2021 · External reference
Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies
10.1038/s41573-019-0038-z · 2020 · External reference
Mechanisms of resistance to CAR T cell therapy
2019 · External reference
γδ T cells in cancer
10.1038/nri3904 · 2015 · External reference
Dysfunctional tumor-infiltrating Vδ1+ T lymphocytes in microsatellite-stable colorectal cancer
10.1038/s41467-024-51025-1 · 2024 · External reference
GMP-grade manufacturing of T cells engineered to express a defined γδTCR
10.3389/fimmu.2018.01062 · 2018 · External reference
β-Catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer
10.1158/2326-6066.cir-22-0644 · 2023 · External reference
Natural and synthetic non-peptide antigens recognized by human γδ T cells
10.1038/375155a0 · 1995 · External reference
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
10.1056/nejmoa1200690 · 2012 · External reference
PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation
10.7326/m18-0850 · 2018 · External reference
Human Vγ9/Vδ2 T cells: innate adaptors of the immune system
10.1016/j.cellimm.2015.01.008 · 2015 · External reference
Software survey: VOSviewer, a computer program for bibliometric mapping
10.1007/s11192-009-0146-3 · 2010 · External reference
Six-of-the-best: unique contributions of γδ T cells to immunology
10.1038/nri3384 · 2013 · External reference
γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice
10.1371/journal.pone.0109416 · 2014 · External reference
A Phase I Trial of Allogeneic γδ T Lymphocytes From Haploidentical Donors in Patients With Refractory or Relapsed Acute Myeloid Leukemia
10.1016/j.clml.2023.02.003 · 2023 · External reference
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
10.1038/s41392-023-01646-7 · 2023 · External reference
γδ T cells for immune therapy of patients with lymphoid malignancies
10.1182/blood-2002-12-3665 · 2003 · External reference
Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen
10.1016/j.immuni.2019.09.006 · 2019 · External reference
Lysis of a broad range of epithelial tumour cells by human γδ T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition
10.1111/j.1365-3083.2007.01963.x · 2007 · External reference
An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
10.1126/scitranslmed.aax9364 · 2019 · External reference
The role of γδ T lymphocytes in atherosclerosis
2024 · External reference
γδ T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition
10.1038/s41423-025-01258-x · 2025 · External reference
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
10.1038/s41586-023-06525-3 · 2023 · External reference
CDR3δ-grafted γ9δ2T cells mediate effective antitumor reactivity
10.1038/cmi.2011.28 · 2012 · External reference
γδ T cells: Major advances in basic and clinical research in tumor immunotherapy
10.1097/cm9.0000000000002781 · 2024 · External reference
Bibliometric methods in management and organization
10.1177/1094428114562629 · 2015 · External reference