Research graph
References from Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution. Local targets link to admitted publications; unresolved targets remain external evidence.
Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination
10.1016/j.chom.2018.08.001 · 2018 · External reference
Mycobacterium tuberculosis biology, pathogenicity and interaction with the host
10.1038/s41579-025-01201-x · 2025 · External reference
Unresolved reference
2019 · External reference
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment
10.1084/jem.20030846 · 2003 · External reference
Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
10.1016/j.chom.2007.09.006 · 2007 · External reference
Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection
10.1371/journal.ppat.1002769 · 2012 · External reference
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
10.1371/journal.pone.0001403 · 2008 · External reference
Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell
10.1371/journal.ppat.1003282 · 2013 · External reference
Dual RNA-Sequencing of Mycobacterium tuberculosis-Infected Cells from a Murine Infection Model
10.1016/j.xpro.2020.100123 · 2020 · External reference
Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator
10.1371/journal.pone.0211003 · 2019 · External reference
Heterogeneity in tuberculosis
10.1038/nri.2017.69 · 2017 · External reference
Types and functions of heterogeneity in mycobacteria
10.1038/s41579-022-00721-0 · 2022 · External reference
Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity
10.1038/nature22361 · 2017 · External reference
Single-cell tracking reveals antibiotic-induced changes in mycobacterial energy metabolism
10.1128/mbio.02236-14 · 2015 · External reference
Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms
10.1016/j.chom.2014.11.016 · 2015 · External reference
Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress
10.15252/embj.2019101876 · 2019 · External reference
Mycobacterium tuberculosis Reporter Strains as Tools for Drug Discovery and Development
10.1002/iub.1862 · 2018 · External reference
Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny
10.1084/jem.20172020 · 2018 · External reference
Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy
10.1371/journal.ppat.1010459 · 2022 · External reference
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung
10.1084/jem.20210615 · 2021 · External reference
Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection
10.1371/journal.ppat.1004394 · 2014 · External reference
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
10.1073/pnas.2235593100 · 2003 · External reference
Protein Export into and across the Atypical Diderm Cell Envelope of Mycobacteria
10.1128/microbiolspec.gpp3-0043-2018 · 2019 · External reference
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue
10.1073/pnas.1635213100 · 2003 · External reference
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
10.1046/j.1365-2958.2003.03844.x · 2004 · External reference
Mutually dependent secretion of proteins required for mycobacterial virulence
10.1073/pnas.0504922102 · 2005 · External reference
Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation
10.1086/345862 · 2003 · External reference
Mycobacterial PE/PPE proteins at the host-pathogen interface
10.1155/2011/497203 · 2011 · External reference
EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity
10.1371/journal.ppat.1000957 · 2010 · External reference
Correlative 3D imaging method for analysing lesion architecture in susceptible mice infected with Mycobacterium tuberculosis
10.1242/dmm.052185 · 2025 · External reference
Polar localization of virulence-related Esx-1 secretion in mycobacteria
10.1371/journal.ppat.1000285 · 2009 · External reference
Development and application of unstable GFP variants to kinetic studies of mycobacterial gene expression
10.1016/s0167-7012(03)00044-7 · 2003 · External reference
Hue-shifted monomeric variants of Clavularia cyan fluorescent protein: identification of the molecular determinants of color and applications in fluorescence imaging
10.1186/1741-7007-6-13 · 2008 · External reference
New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria
10.1128/aem.64.6.2240-2246.1998 · 1998 · External reference
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
10.1073/pnas.2122161119 · 2022 · External reference
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages
10.1038/s41564-023-01335-9 · 2023 · External reference
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis
10.1111/cmi.12726 · 2017 · External reference
Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence
10.1371/journal.ppat.1006363 · 2017 · External reference
Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells
10.1186/s12915-017-0471-6 · 2018 · External reference
The cell wall lipid PDIM contributes to phagosomal escape and host cell exit of Mycobacterium tuberculosis
10.1128/mbio.00148-17 · 2017 · External reference
Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity
10.1128/iai.00097-11 · 2011 · External reference
Fluorogenic probes for live-cell imaging of the cytoskeleton
10.1038/nmeth.2972 · 2014 · External reference
Mycobacterium tuberculosis phagosome Ca(2+) leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages
2025 · External reference
Phenotypic variation of Salmonella in host tissues delays eradication by antimicrobial chemotherapy
10.1016/j.cell.2014.06.045 · 2014 · External reference
Mtb-Timer: a fluorescent reporter to visualize Mycobacterium tuberculosis replication and antibiotic responses
10.1128/msystems.01796-25 · 2026 · External reference
Type VII secretion systems: structure, functions and transport models
10.1038/s41579-021-00560-5 · 2021 · External reference
Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection
10.1073/pnas.002024599 · 2002 · External reference
A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component
10.1128/iai.01824-14 · 2014 · External reference
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
10.1128/iai.74.1.88-98.2006 · 2006 · External reference
Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinum
10.1073/pnas.2123100119 · 2022 · External reference
The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum
10.1128/mbio.02819-22 · 2022 · External reference
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
10.1016/j.cell.2025.09.005 · 2025 · External reference
Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis
10.1128/jb.00142-12 · 2012 · External reference
Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish
10.1038/nprot.2013.068 · 2013 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Genome-wide mapping of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis
10.1016/j.celrep.2013.10.031 · 2013 · External reference
ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes
10.1128/mbio.01467-18 · 2018 · External reference
Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions
2013 · External reference
Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids
10.1371/journal.ppat.1000289 · 2009 · External reference
