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References from A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.sbi.2011.05.001
10.1016/j.sbi.2011.05.001 · External reference
10.1007/s10295-011-0970-3
10.1007/s10295-011-0970-3 · External reference
Systems metabolic engineering, industrial biotechnology and microbial cell factories
10.1186/1475-2859-11-156 · 2012 · External reference
Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory
10.1371/journal.pone.0054144 · 2013 · External reference
10.1007/s10295-011-0954-3
10.1007/s10295-011-0954-3 · External reference
Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives
10.4014/jmb.1401.01031 · 2014 · External reference
10.1016/j.cbpa.2009.11.028
10.1016/j.cbpa.2009.11.028 · External reference
10.1146/annurev-biochem-030409-143718
10.1146/annurev-biochem-030409-143718 · External reference
10.1038/nature06450
10.1038/nature06450 · External reference
10.1016/j.copbio.2008.08.008
10.1016/j.copbio.2008.08.008 · External reference
10.1002/bit.22660
10.1002/bit.22660 · External reference
10.1016/j.ymben.2011.06.005
10.1016/j.ymben.2011.06.005 · External reference
Metabolic engineering of Escherichia coli for enhanced production of (R)- and (S)-3-hydroxybutyrate
10.1128/aem.02667-08 · 2009 · External reference
10.1073/pnas.1003366107
10.1073/pnas.1003366107 · External reference
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
10.1016/j.ymben.2008.07.007 · 2009 · External reference
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae
10.1002/bit.22668 · 2010 · External reference
10.1146/annurev-biochem-030409-143718
10.1146/annurev-biochem-030409-143718 · External reference
10.1126/science.1190719
10.1126/science.1190719 · External reference
10.1038/nmeth.2894
10.1038/nmeth.2894 · External reference
10.1073/pnas.1004716107
10.1073/pnas.1004716107 · External reference
Unresolved reference
2013 · External reference
Engineering solventogenic clostridia
10.1016/j.copbio.2008.08.003 · 2008 · External reference
Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine
10.1186/1475-2859-12-110 · 2013 · External reference
Construction of artificial biosynthetic pathways for resveratrol glucoside derivatives
10.4014/jmb.1401.01031 · 2014 · External reference
10.1016/j.copbio.2009.08.007
10.1016/j.copbio.2009.08.007 · External reference
A blood-based proteomic classifier for the molecular characterization of pulmonary nodules
2013 · External reference
10.1371/journal.pone.0076694
10.1371/journal.pone.0076694 · External reference
10.1371/journal.pcbi.1003370
10.1371/journal.pcbi.1003370 · External reference
10.1038/nrmicro2717
10.1038/nrmicro2717 · External reference
Application of plant and bacterial enzymes in the biocatalysis of paclitaxel (110.3)
10.1096/fasebj.28.1_supplement.110.3 · 2014 · External reference
10.1016/j.copbio.2013.03.022
10.1016/j.copbio.2013.03.022 · External reference
10.1002/biot.200900234
10.1002/biot.200900234 · External reference
10.1007/s10529-012-1038-9
10.1007/s10529-012-1038-9 · External reference
10.1038/nbt.1672
10.1038/nbt.1672 · External reference
Path2Models: large-scale generation of computational models from biochemical pathway maps
10.1186/1752-0509-7-116 · 2013 · External reference
MetaNetX.org: a website and repository for accessing, analysing and manipulating metabolic networks
10.1093/bioinformatics/btt036 · 2013 · External reference
10.1073/pnas.232349399
10.1073/pnas.232349399 · External reference
Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes
10.1038/ng1432 · 2004 · External reference
Designing novel cellulase systems through agent-based modeling and global sensitivity analysis
2014 · External reference
Bacterial cell factories for recombinant protein production; expanding the catalogue
10.1186/1475-2859-12-113 · 2013 · External reference
Novel soluble expression technologies derived from unique properties of halophilic proteins
10.1007/s00253-010-2832-8 · 2010 · External reference
10.1021/ja205783f
10.1021/ja205783f · External reference
10.1007/978-1-61779-433-9_17
10.1007/978-1-61779-433-9_17 · External reference
10.1016/j.ymben.2008.08.006
10.1016/j.ymben.2008.08.006 · External reference
Fatty acid production in genetically modified cyanobacteria
10.1073/pnas.1103014108 · 2011 · External reference
Bio-based production of chemicals, materials and fuels — Corynebacterium glutamicum as versatile cell factory
10.1016/j.copbio.2011.11.012 · 2012 · External reference
The damaging effects of short chain fatty acids on Escherichia coli membranes
10.1007/s00253-013-5113-5 · 2013 · External reference
Understanding biocatalyst inhibition by carboxylic acids
10.3389/fmicb.2013.00272 · 2013 · External reference
10.1073/pnas.1102444108
10.1073/pnas.1102444108 · External reference
Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and changes in the cell's transcriptional program
10.1128/aem.69.8.4951-4965.2003 · 2003 · External reference
10.1128/aem.00694-11
10.1128/aem.00694-11 · External reference
10.1038/nbt.2149
10.1038/nbt.2149 · External reference
10.1038/nbt.2689
10.1038/nbt.2689 · External reference
10.1038/nmeth.1318
10.1038/nmeth.1318 · External reference
10.1371/journal.pone.0069032
10.1371/journal.pone.0069032 · External reference
Unresolved reference
2014 · External reference
10.1038/nature10317
10.1038/nature10317 · External reference
10.1016/j.nbt.2014.03.002
10.1016/j.nbt.2014.03.002 · External reference
Promoter methylation and transgene copy numbers predict unstable protein production in recombinant Chinese hamster ovary cell lines
10.1002/bit.23216 · 2011 · External reference
10.1007/s00253-011-3654-z
10.1007/s00253-011-3654-z · External reference
Human cells: new platform for recombinant therapeutic protein production
10.1016/j.pep.2012.04.023 · 2012 · External reference
Mammalian cell protein expression for biopharmaceutical production
10.1016/j.biotechadv.2011.08.022 · 2012 · External reference
Insect cells as factories for biomanufacturing
10.1016/j.biotechadv.2011.09.014 · 2012 · External reference
10.1002/bit.24920
10.1002/bit.24920 · External reference
10.1016/j.ymben.2012.04.005
10.1016/j.ymben.2012.04.005 · External reference
In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene
10.1186/1752-0509-4-7 · 2010 · External reference
10.1002/bit.22673
10.1002/bit.22673 · External reference
10.1002/bit.23334
10.1002/bit.23334 · External reference
10.1021/ci2000659
10.1021/ci2000659 · External reference
Computational framework for predictive biodegradation
10.1002/bit.22489 · 2009 · External reference
10.1093/nar/30.1.47
10.1093/nar/30.1.47 · External reference
10.1093/bioinformatics/btn471
10.1093/bioinformatics/btn471 · External reference
FMM: a web server for metabolic pathway reconstruction and comparative analysis
10.1093/nar/gkp264 · 2009 · External reference
Supervised de novo reconstruction of metabolic pathways from metabolome-scale compound sets
10.1093/bioinformatics/btt244 · 2013 · External reference
META. 1. A program for the evaluation of metabolic transformation of chemicals
10.1021/ci00022a014 · 1994 · External reference
MRSD: a web server for metabolic route search and design
10.1093/bioinformatics/btr160 · 2011 · External reference
10.1093/nar/gkt234
10.1093/nar/gkt234 · External reference
10.1002/cbdv.200590064
10.1002/cbdv.200590064 · External reference
Microbial pathway prediction: a functional group approach
10.1021/ci034018f · 2003 · External reference
PathPred: an enzyme-catalyzed metabolic pathway prediction server
10.1093/nar/gkq318 · 2010 · External reference
Rahnuma: hypergraph-based tool for metabolic pathway prediction and network comparison
10.1093/bioinformatics/btp269 · 2009 · External reference
10.1016/j.copbio.2008.07.009
10.1016/j.copbio.2008.07.009 · External reference
10.1093/bioinformatics/bti213
10.1093/bioinformatics/bti213 · External reference
10.1093/nar/gku362
10.1093/nar/gku362 · External reference
10.1016/j.sbi.2011.05.003
10.1016/j.sbi.2011.05.003 · External reference
Directed evolution of fungal laccases
10.2174/138920211795564322 · 2011 · External reference
Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein–ligand interactions based on crystal structures of the ligand-bound enzyme
10.1111/j.1742-4658.2011.08411.x · 2012 · External reference
Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis
10.1021/sb300037w · 2012 · External reference
Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes
10.1111/febs.12459 · 2013 · External reference
Enhancement of riboflavin production with Bacillus subtilis by expression and site-directed mutagenesis of zwf and gnd gene from Corynebacterium glutamicum
10.1016/j.biortech.2010.11.120 · 2011 · External reference
Directed evolution of a cellobiose utilization pathway in Saccharomyces cerevisiae by simultaneously engineering multiple proteins
10.1186/1475-2859-12-61 · 2013 · External reference
Development of an NADPH-dependent homophenylalanine dehydrogenase by protein engineering
10.1021/sb400093x · 2013 · External reference
10.1016/b978-0-12-381270-4.00019-6
10.1016/b978-0-12-381270-4.00019-6 · External reference
10.1126/science.1190239
10.1126/science.1190239 · External reference
10.1038/nchembio.1498
10.1038/nchembio.1498 · External reference
10.1002/jcc.20290
10.1002/jcc.20290 · External reference
10.1002/jcc.21256
10.1002/jcc.21256 · External reference
10.1002/jcc.21287
10.1002/jcc.21287 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
Development and validation of a modular, extensible docking program: DOCK 5
10.1007/s10822-006-9060-4 · 2006 · External reference
10.1093/bioinformatics/btt055
10.1093/bioinformatics/btt055 · External reference
10.1006/jmbi.1993.1626
10.1006/jmbi.1993.1626 · External reference
Unresolved reference
External reference
10.1002/jcc.20289
10.1002/jcc.20289 · External reference
10.1038/nprot.2009.2
10.1038/nprot.2009.2 · External reference
10.1093/nar/gku340
10.1093/nar/gku340 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
Rational redesign of glucose oxidase for improved catalytic function and stability
10.1371/journal.pone.0037924 · 2012 · External reference
Rational engineering of mannosyl binding in the distal glycone subsites of Cellulomonas fimi endo-beta-1,4-mannanase: mannosyl binding promoted at subsite-2 and demoted at subsite-3
10.1021/bi100097f · 2010 · External reference
Engineering the substrate specificity of a thermophilic penicillin acylase from Thermus thermophilus
10.1128/aem.03215-12 · 2013 · External reference
10.1002/jcc.21334
10.1002/jcc.21334 · External reference
Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors
10.1016/j.bmc.2014.04.018 · 2014 · External reference
10.1002/bip.360221211
10.1002/bip.360221211 · External reference
10.1016/s0959-440x(00)00194-9
10.1016/s0959-440x(00)00194-9 · External reference
Modifying the catalytic preference of tributyrin in Bacillus thermocatenulatus lipase through in-silico modeling of enzyme–substrate complex
10.1093/protein/gzt004 · 2013 · External reference
10.1016/j.cell.2014.02.033
10.1016/j.cell.2014.02.033 · External reference
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker
10.1093/nar/gkr1321 · 2012 · External reference
10.1021/sb400021j
10.1021/sb400021j · External reference
10.1038/nbt.2461
10.1038/nbt.2461 · External reference
10.1038/nbt.1568
10.1038/nbt.1568 · External reference
Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes
10.1038/nbt1226 · 2006 · External reference
10.1007/s00253-013-5062-z
10.1007/s00253-013-5062-z · External reference
10.1016/j.ymben.2012.03.004
10.1016/j.ymben.2012.03.004 · External reference
10.1002/anie.201202441
10.1002/anie.201202441 · External reference
10.1002/bit.10803
10.1002/bit.10803 · External reference
OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions
10.1371/journal.pcbi.1000744 · 2010 · External reference
OptORF: optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains
10.1186/1752-0509-4-53 · 2010 · External reference
10.1371/journal.pcbi.1003487
10.1371/journal.pcbi.1003487 · External reference
Genome-scale modeling using flux ratio constraints to enable metabolic engineering of clostridial metabolism in silico
10.1186/1752-0509-6-42 · 2012 · External reference
Deriving metabolic engineering strategies from genome-scale modeling with flux ratio constraints
10.1002/biot.201200234 · 2013 · External reference
