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References from Antiviral Drug- and Multidrug Resistance in Cytomegalovirus Infected SCT Patients. Local targets link to admitted publications; unresolved targets remain external evidence.
CMV: prevention
10.1111/ajt.12006 · 2013 · External reference
10.1128/aac.49.3.873-883.2005
10.1128/aac.49.3.873-883.2005 · External reference
Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs
10.1016/j.humimm.2004.02.007 · 2004 · External reference
Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes
10.1182/blood.v96.9.3286 · 2000 · External reference
Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients
10.1053/srin.2002.36447 · 2002 · External reference
A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotype
10.1016/j.antiviral.2009.10.004 · 2010 · External reference
Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies
10.1086/656717 · 2010 · External reference
10.1016/j.antiviral.2013.10.011
10.1016/j.antiviral.2013.10.011 · External reference
Pre-emptive treatment of cytomegalovirus infection in kidney transplant recipients with letermovir: results of a phase 2a study
10.1111/tri.12225 · 2014 · External reference
Unresolved reference
2009 · External reference
Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double blind, placebo controlled, randomised trial
10.1016/s1473-3099(11)70024-x · 2011 · External reference
Efficacy and safety of maribavir dose 100mg orally twice daily for the prevention of cytomegalovirus disease in liver transplant recipients: a randomized, double-blind, multicenter controlled trial
10.1111/j.1600-6143.2012.04231.x · 2012 · External reference
Antiviral drug resistance of human cytomegalovirus
10.1128/cmr.00009-10 · 2010 · External reference
Innate nuclear sensor IFI16 translocates into the cytoplasm during early stage on in vitro human cytomegalovirus infection and is entrapped in the egressing virions during late stage
10.1128/jvi.00384-14 · 2014 · External reference
How I treat cytomegalovirus in hematopoietic cell transplant recipients
10.1182/blood-2008-10-143560 · 2009 · External reference
International consensus guidelines on the management of cytomegalovirus in solid organ transplantation
10.1097/tp.0b013e3181cee42f · 2010 · External reference
Incidence and outcome of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients
10.1097/tp.0b013e31821fad25 · 2011 · External reference
10.1517/14656560802678138
10.1517/14656560802678138 · External reference
The biology og cytomegalovirus drug resistance
10.1097/qco.0b013e32834cfb58 · 2011 · External reference
Antiviral strategies to combat cytomegalovirus infections in transplant recipients
10.1016/j.coph.2008.07.002 · 2008 · External reference
Drug targets in cytomegalovirus infection
10.2174/187152609787847758 · 2009 · External reference
Emergence of drug resistant cytomegalovirus in the era of valganciclovir prophylaxis: therapeutic implications and outcomes
10.1111/j.1399-0012.2007.00761.x · 2008 · External reference
10.1128/jcm.37.7.2291-2296.1999
10.1128/jcm.37.7.2291-2296.1999 · External reference
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI-)-treated patients and NRTI-naïve patients
10.1086/597808 · 2009 · External reference
10.1101/gr.6468307
10.1101/gr.6468307 · External reference
Dynamics of the emergence of a drug resistant human cytomegalovirus strain in a pediatric stem cell transplant recipient detected by a new real-time PCR approach
10.2353/jmoldx.2009.080153 · 2009 · External reference
Detection of ganciclovir resistance mutations of cytomegalovirus (CMV) DNA in leucozytes of patients with fatal disseminated CMV diseases
10.1093/infdis/173.3.523 · 1996 · External reference
Rate of emergence of cytomegalovirus (CMV) mutations in leucocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis
10.1086/324672 · 2001 · External reference
Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
10.1093/infdis/171.3.576 · 1995 · External reference
Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates
10.1093/infdis/172.1.239 · 1995 · External reference
Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients
10.1086/516446 · 1997 · External reference
Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients
10.1097/00002030-199802000-00001 · 1998 · External reference
Rapid simultaneous detection by real-time PCR of cytomegalovirus UL97 mutations in codons 460 and 520 conferring ganciclovir resistance
10.1128/jcm.01141-06 · 2006 · External reference
Rapid semiquantitative real-time PCR for the detection of human cytomegalovirus UL97 mutations conferring ganciclovir resistance
10.1177/135965350801300308 · 2008 · External reference
10.1034/j.1399-3062.1999.010204.x · 1999 · Admitted local publication
A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates
10.1128/aac.44.3.688-692.2000 · 2000 · External reference
Analysis and characterization of antiviral-drug-resistant cytomegalovirus isolates from solid organ transplant recipients
10.1086/342844 · 2002 · External reference
A simplified assay for screening of drug resistance of cell-associated cytomegalovirus strains
1998 · External reference
Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness
10.1128/aac.00165-09 · 2009 · External reference
10.1038/358162a0
10.1038/358162a0 · External reference
10.1128/jvi.72.7.5927-5936.1998
10.1128/jvi.72.7.5927-5936.1998 · External reference
10.1093/nar/gni035
10.1093/nar/gni035 · External reference
Characterization of human citomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of bacterial artificial chromosom containing the HCMV genome
10.1086/505882 · 2006 · External reference
10.1128/jvi.73.10.8320-8329.1999
10.1128/jvi.73.10.8320-8329.1999 · External reference
Two-step mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli
10.2144/000112096 · 2006 · External reference
En passant mutagenesis: a two step markerless recombination system
10.1007/978-1-60761-652-8_30 · 2010 · External reference
High impact of an expanded restriction fragment length polymorphism assay on detection of gancoclovir- resistant UL97 mutants of human cytomegalovirus
10.1128/aac.47.1.442-443.2003 · 2003 · External reference
Dynamics of coexisting HCMV UL97- and UL54 drug resistance assicoated mutations in patients after haematopoetic cell transplantation
10.1016/j.jcv.2013.01.003 · 2013 · External reference
Emergence and persistence of multiple antiviral-resistant CMV strains in a highly imunocompromised child
10.1016/j.jcv.2007.07.003 · 2007 · External reference
10.1099/vir.0.83286-0
10.1099/vir.0.83286-0 · External reference
Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance
10.1128/aac.00186-10 · 2010 · External reference
Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir
10.1016/s1386-6532(99)00031-1 · 1999 · External reference
Resistance pattern of cytomegalovirus (CMV) after oral valganciclovir therapy in transplant recipients at high-risk for CMV infection
10.1016/j.antiviral.2008.11.003 · 2009 · External reference
Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir
10.1086/338362 · 2002 · External reference
High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes
10.1086/514041 · 1997 · External reference
Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma
10.1172/jci117648 · 1995 · External reference
Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene
10.1128/aac.49.7.2710-2715.2005 · 2005 · External reference
Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. The Cytomegalovirus and Viral Resistance Study Group Report Number 8
10.1016/s0002-9394(01)01161-8 · 2001 · External reference
Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants
10.1016/s0140-6736(00)02607-6 · 2000 · External reference
Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients
10.1016/j.jcv.2006.11.005 · 2007 · External reference
Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis
10.1016/j.jcv.2010.01.009 · 2010 · External reference
10.1128/aac.39.5.1204
10.1128/aac.39.5.1204 · External reference
High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy
10.1086/338143 · 2002 · External reference
GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97is partially reconstituted by a second mutation at D605E
10.1016/s0166-3542(01)00202-9 · 2002 · External reference
10.1016/s0166-0934(97)00093-1
10.1016/s0166-0934(97)00093-1 · External reference
10.1128/jvi.69.2.796-800.1995
10.1128/jvi.69.2.796-800.1995 · External reference
A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir
10.1128/aac.44.1.183-185.2000 · 2000 · External reference
Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system
10.1016/s0166-3542(01)00211-x · 2002 · External reference
10.1016/s0166-3542(98)00051-5
10.1016/s0166-3542(98)00051-5 · External reference
Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient
10.1128/aac.49.4.1580-1583.2005 · 2005 · External reference
The Cys607Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients
10.1128/aac.42.2.444 · 1998 · External reference
Generation and characterisation of defined HCMV UL97- and UL54-mutants conferring drug resistance
10.1016/j.antiviral.2013.09.026 · 2013 · External reference
Identification of newly detected, drug-related HCMV UL97- and UL54- mutations using a modified plaque reduction assay
2015 · External reference
Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus
10.1086/375743 · 2003 · External reference
Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates
10.1128/aac.00633-06 · 2007 · External reference
Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease
10.1086/517302 · 1997 · External reference
A novel mutation in theUL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet
10.1177/135965350601100416 · 2006 · External reference
A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture
10.1006/viro.1998.9299 · 1998 · External reference
Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus
10.1016/j.jcv.2008.04.005 · 2008 · External reference
Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity
10.1016/s1386-6532(01)00160-3 · 2001 · External reference
How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients
10.1128/jcm.43.1.208-213.2005 · 2005 · External reference
Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS
10.1128/jvi.70.3.1390-1395.1996 · 1996 · External reference
Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
10.1086/368385 · 2003 · External reference
10.1086/587106
10.1086/587106 · External reference
Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy
10.1086/515648 · 1998 · External reference
Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
10.1128/aac.00736-07 · 2007 · External reference
A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance
10.1086/317618 · 2000 · External reference
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives
10.1128/aac.37.1.19 · 1993 · External reference
Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain
10.1086/346240 · 2003 · External reference
A comprehensive restriction analysis of the UL97 region allows early detection of ganciclovir-resistant human cytomegalovirus in an immunocompromised child
10.1086/314877 · 1999 · External reference
Differentiation between polymorphism and resistance-associated mutations in human cytomegalovirus DNA polymerase
10.1128/aac.00259-10 · 2010 · External reference
A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients
10.1007/s00705-012-1479-4 · 2013 · External reference
Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model
10.1016/j.antiviral.2013.02.002 · 2013 · External reference
