Research graph
References from Advances in the development of SUMO specific protease (SENP) inhibitors. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1007/s00018-007-7137-4
10.1007/s00018-007-7137-4 · External reference
10.1111/j.1742-4658.2008.06459.x
10.1111/j.1742-4658.2008.06459.x · External reference
10.1016/j.tibs.2009.01.004
10.1016/j.tibs.2009.01.004 · External reference
SUMOylation and De-SUMOylation: wrestling with life's processes
10.1074/jbc.r800050200 · 2009 · External reference
10.1038/nrm3011
10.1038/nrm3011 · External reference
10.1038/nature08765
10.1038/nature08765 · External reference
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
10.1038/sj.emboj.7600552 · 2005 · External reference
10.1021/ja9088549
10.1021/ja9088549 · External reference
SUMO—nonclassical ubiquitin
10.1146/annurev.cellbio.16.1.591 · 2000 · External reference
10.1016/s0092-8674(02)00630-x
10.1016/s0092-8674(02)00630-x · External reference
10.1042/bj20100158
10.1042/bj20100158 · External reference
10.1038/nrm2293
10.1038/nrm2293 · External reference
10.1016/j.sbi.2007.08.018
10.1016/j.sbi.2007.08.018 · External reference
A mechanistic view of the role of E3 in sumoylation
10.1371/journal.pcbi.1000913 · 2010 · External reference
A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes
10.1038/ng1391 · 2004 · External reference
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus
10.1074/jbc.m402273200 · 2004 · External reference
10.1016/j.tibs.2007.05.002
10.1016/j.tibs.2007.05.002 · External reference
10.1016/j.tcb.2007.08.002
10.1016/j.tcb.2007.08.002 · External reference
10.1002/iub.113
10.1002/iub.113 · External reference
10.1038/aja.2008.45
10.1038/aja.2008.45 · External reference
10.1038/nrm3478
10.1038/nrm3478 · External reference
10.1016/j.bbrc.2005.09.090
10.1016/j.bbrc.2005.09.090 · External reference
10.1074/jbc.m110.205153
10.1074/jbc.m110.205153 · External reference
Engineering pre-SUMO4 as efficient substrate of SENP2
10.1093/protein/gzu004 · 2014 · External reference
SUMO protease SENP1 induces isomerization of the scissile peptide bond
10.1038/nsmb1172 · 2006 · External reference
Crystal structure of the SENP1 mutant C603S–SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
10.1042/bj20060526 · 2006 · External reference
A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2–SUMO complex
10.1016/j.str.2004.05.023 · 2004 · External reference
10.1038/nsmb1168
10.1038/nsmb1168 · External reference
Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7
10.1074/jbc.m805655200 · 2008 · External reference
The structure of SENP1–SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing
10.1042/bj20052030 · 2006 · External reference
10.1016/j.cell.2007.08.045
10.1016/j.cell.2007.08.045 · External reference
10.1016/j.molcel.2010.03.005
10.1016/j.molcel.2010.03.005 · External reference
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms
10.1074/jbc.m110.134874 · 2010 · External reference
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development
10.1128/mcb.25.12.5171-5182.2005 · 2005 · External reference
10.1593/neo.06445
10.1593/neo.06445 · External reference
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors
10.1210/jc.2004-1337 · 2005 · External reference
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors
10.1016/j.canlet.2011.05.019 · 2011 · External reference
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9
10.1007/s13277-014-2598-1 · 2014 · External reference
De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
10.1161/circresaha.111.300179 · 2013 · External reference
10.1016/j.yjmcc.2011.11.011
10.1016/j.yjmcc.2011.11.011 · External reference
10.1210/me.2008-0219
10.1210/me.2008-0219 · External reference
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
10.1128/mcb.24.13.6021-6028.2004 · 2004 · External reference
10.1146/annurev.med.54.101601.152418
10.1146/annurev.med.54.101601.152418 · External reference
Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies
10.2217/14796694.3.3.329 · 2007 · External reference
10.1016/j.bbrc.2004.09.068
10.1016/j.bbrc.2004.09.068 · External reference
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity
10.1016/j.bbrc.2007.06.103 · 2007 · External reference
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
10.1016/j.cell.2007.07.044 · 2007 · External reference
10.1016/j.ccr.2013.12.008
10.1016/j.ccr.2013.12.008 · External reference
SUMO-specific protease 1 promotes prostate cancer progression and metastasis
10.1038/onc.2012.250 · 2013 · External reference
10.1074/jbc.m412185200
10.1074/jbc.m412185200 · External reference
10.1371/journal.pbio.0060310
10.1371/journal.pbio.0060310 · External reference
10.1038/cdd.2010.168
10.1038/cdd.2010.168 · External reference
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of beta-catenin
10.7314/apjcp.2012.13.8.3583 · 2012 · External reference
SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell
10.1007/s13277-014-2239-8 · 2014 · External reference
SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress
10.1074/jbc.m109.071431 · 2010 · External reference
Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation
10.3892/or.2013.2318 · 2013 · External reference
Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells
10.3892/etm.2014.1644 · 2014 · External reference
Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation
2008 · External reference
10.1038/emboj.2009.210
10.1038/emboj.2009.210 · External reference
SENP5 mediates breast cancer invasion via a TGFbetaRI SUMOylation cascade
10.18632/oncotarget.1783 · 2014 · External reference
10.1128/mcb.24.1.84-95.2004
10.1128/mcb.24.1.84-95.2004 · External reference
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases
10.1002/cbic.200400236 · 2005 · External reference
Glycine fluoromethylketones as SENP-specific activity based probes
10.1002/cbic.201100645 · 2012 · External reference
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors
10.1016/j.chembiol.2011.04.010 · 2011 · External reference
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
10.1016/j.chembiol.2011.05.008 · 2011 · External reference
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors
10.1016/j.bmcl.2011.08.101 · 2011 · External reference
10.1007/978-1-59745-566-4_18
10.1007/978-1-59745-566-4_18 · 2009 · External reference
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
10.1016/j.bmcl.2012.06.084 · 2012 · External reference
Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression
10.1371/journal.pone.0037693 · 2012 · External reference
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: virtual screening, synthesis and biological evaluation
10.1016/j.bmcl.2012.09.037 · 2012 · External reference
Identification and characterization of a new chemotype of noncovalent SENP inhibitors
10.1021/cb400177q · 2013 · External reference
10.1021/ci4007134
10.1021/ci4007134 · External reference
Important role of SUMOylation of spliceosome factors in prostate cancer cells
10.1021/pr4012848 · 2014 · External reference
10.1016/j.ymeth.2014.07.007
10.1016/j.ymeth.2014.07.007 · External reference
10.1016/j.drudis.2013.01.007
10.1016/j.drudis.2013.01.007 · External reference
Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1
10.1021/ci4002487 · 2013 · External reference
10.1002/minf.201200124
10.1002/minf.201200124 · External reference
