Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Chagas disease research and development: Is there light at the end of the tunnel?. Local targets link to admitted publications; unresolved targets remain external evidence.
Chagas' disease
10.1056/nejmra1410150 · 2015 · External reference
10.1016/j.idc.2012.03.002
10.1016/j.idc.2012.03.002 · External reference
Chagas disease in Spain, the United States and other non-endemic countries
10.1016/j.actatropica.2009.07.019 · 2010 · External reference
Chagas disease in Australia and New Zealand: risks and needs for public health interventions
10.1111/tmi.12235 · 2014 · External reference
Unresolved reference
External reference
Increased mortality attributed to Chagas disease: a systematic review and meta-analysis
10.1186/s13071-016-1315-x · 2016 · External reference
Mortality due to Chagas disease in Brazil from 1979 to 2009: trends and regional differences
10.3855/jidc.2459 · 2012 · External reference
10.1371/journal.pntd.0000114
10.1371/journal.pntd.0000114 · External reference
Global economic burden of Chagas disease: a computational simulation model
10.1016/s1473-3099(13)70002-1 · 2013 · External reference
Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis
10.1111/1471-0528.12396 · 2014 · External reference
Oral transmission of Chagas' disease
2011 · External reference
Alternative transmission mechanisms of Trypanosoma cruzi in Brazil and proposals for their prevention
2011 · External reference
The main sceneries of Chagas disease transmission. The vectors, blood and oral transmissions — a comprehensive review
10.1590/0074-0276140362 · 2015 · External reference
10.1007/978-1-4419-9206-2_10
10.1007/978-1-4419-9206-2_10 · 2003 · External reference
Reactivation of Chagas disease: implications for global health
10.1016/j.pt.2015.06.006 · 2015 · External reference
Mode of death on Chagas heart disease: comparison with other etiologies. A subanalysis of the REMADHE prospective trial
10.1371/journal.pntd.0002176 · 2013 · External reference
The present situation, challenges, and perspectives regarding the production and utilization of effective drugs against human Chagas disease
10.1590/0037-8682-0248-2013 · 2014 · External reference
Toxic profile of benznidazole in patients with chronic Chagas disease: risk factors and comparison of the product from two different manufacturers
10.1128/aac.04660-14 · 2015 · External reference
Safety profile of nifurtimox and treatment interruption for chronic Chagas disease in Colombian adults
10.4269/ajtmh.15-0256 · 2015 · External reference
Nova tripanozomiase humana: Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem
10.1590/s0074-02761909000200008 · 1909 · External reference
10.1155/2014/912965
10.1155/2014/912965 · External reference
Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead
10.1016/j.ajpath.2014.12.023 · 2015 · External reference
Parasite persistence correlates with disease severity and localization in chronic Chagas' disease
10.1086/314889 · 1999 · External reference
The role of parasite persistence in pathogenesis of Chagas heart disease
10.1111/j.1365-3024.2009.01108.x · 2009 · External reference
10.1111/cmi.12584
10.1111/cmi.12584 · External reference
The indeterminate form of human chronic Chagas' disease: a clinical epidemiological review
10.1590/s0037-86821989000300007 · 1989 · External reference
Morbidity in Chagas' disease. IV. Longitudinal study of 10years in Pains and Iguatama, Minas Gerais, Brazil
10.1590/s0074-02761985000100011 · 1985 · External reference
Cardiac morbidity and mortality due to Chagas' disease: prospective electrocardiographic study of a Brazilian community
10.1161/01.cir.75.6.1140 · 1987 · External reference
Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults
10.1371/journal.pntd.0002907 · 2014 · External reference
Long-term follow-up of a patient since the acute phase of Chagas disease (South American trypanosomiasis): further treatment and cure of the infection
10.1590/0037-8682-0073-2015 · 2015 · External reference
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial
10.7326/0003-4819-144-10-200605160-00006 · 2006 · External reference
Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up
10.1016/0002-8703(94)90521-5 · 1994 · External reference
Evaluation and treatment of Chagas disease in the United States: a systematic review
10.1001/jama.298.18.2171 · 2007 · External reference
A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention
10.1590/0074-0276130122 · 2013 · External reference
Course of chronic Trypanosoma cruzi infection after treatment based on parasitological and serological tests: a systematic review of follow-up studies
10.1371/journal.pone.0139363 · 2015 · External reference
10.1038/srep35351
10.1038/srep35351 · External reference
Lineage analysis of circulating Trypanosoma cruzi parasites and their association with clinical forms of Chagas disease in Bolivia
10.1371/journal.pntd.0000687 · 2010 · External reference
10.1590/s0074-02762004000100001
10.1590/s0074-02762004000100001 · External reference
10.1586/14787210.2015.1056158
10.1586/14787210.2015.1056158 · External reference
Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection
2014 · External reference
Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas
10.1371/journal.pntd.0003312 · 2014 · External reference
International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients
10.1371/journal.pntd.0000931 · 2011 · External reference
Analytical validation of quantitative real-time PCR methods for quantification of Trypanosoma cruzi DNA in blood samples from Chagas disease patients
10.1016/j.jmoldx.2015.04.010 · 2015 · External reference
Antibody levels correlate with detection of Trypanosoma cruzi DNA by sensitive polymerase chain reaction assays in seropositive blood donors and possible resolution of infection over time
10.1111/j.1537-2995.2012.03902.x · 2013 · External reference
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
10.1586/14787210.2014.899150 · 2014 · External reference
Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review
10.1586/14787210.2013.824718 · 2013 · External reference
Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment
10.1186/1471-2334-14-302 · 2014 · External reference
10.1371/journal.pone.0079629
10.1371/journal.pone.0079629 · External reference
10.1371/journal.pntd.0001587
10.1371/journal.pntd.0001587 · External reference
Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors
10.1161/circulationaha.112.123612 · 2013 · External reference
10.1056/nejmoa1313122
10.1056/nejmoa1313122 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Randomized trial of benznidazole for chronic Chagas' cardiomyopathy
10.1056/nejmoa1507574 · 2015 · External reference
Clinical candidate VT-1161's antiparasitic effect in vitro, activity in a murine model of Chagas disease, and structural characterization in complex with the target enzyme CYP51 from Trypanosoma cruzi
10.1128/aac.02287-15 · 2015 · External reference
10.1021/jm500448u
10.1021/jm500448u · External reference
10.1177/1087057114550585
10.1177/1087057114550585 · External reference
Antitrypanosomal treatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas disease
10.1128/aac.00689-15 · 2015 · External reference
10.1128/aac.00520-15
10.1128/aac.00520-15 · External reference
Translational challenges of animal models in Chagas disease drug development: a review
10.2147/dddt.s90208 · 2015 · External reference
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions
10.1007/s00436-008-0992-6 · 2008 · External reference
Persistence of PCR positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes
10.1093/jac/dkn092 · 2008 · External reference
Impact of benznidazole on infection course in mice experimentally infected with Trypanosoma cruzi I, II, and IV
10.4269/ajtmh.13-0690 · 2015 · External reference
10.1038/nature19339
10.1038/nature19339 · External reference
10.1371/journal.ppat.1005058
10.1371/journal.ppat.1005058 · External reference
Chagas disease has not been controlled in Ecuador
10.1371/journal.pone.0158145 · 2016 · External reference
Barriers to treatment access for Chagas disease in Mexico
10.1371/journal.pntd.0002488 · 2013 · External reference