Research graph
References from Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering. Local targets link to admitted publications; unresolved targets remain external evidence.
Physical and chemical mutagenesis
2003 · External reference
10.1113/jphysiol.2003.049494
10.1113/jphysiol.2003.049494 · External reference
10.1016/j.cbpa.2010.10.007
10.1016/j.cbpa.2010.10.007 · External reference
10.1038/nmeth.1332
10.1038/nmeth.1332 · External reference
DNA transposons: nature and applications in genomics
10.2174/138920210790886871 · 2010 · External reference
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice
10.1126/science.1193004 · 2010 · External reference
Studies reveal potential pitfalls of RNAi
10.1038/nrd1221 · 2003 · External reference
10.1038/nature07758
10.1038/nature07758 · External reference
Adenovirus vectors: promise and possible pitfalls
2012 · External reference
10.1126/science.1233151
10.1126/science.1233151 · External reference
10.1016/0168-9525(96)10019-6
10.1016/0168-9525(96)10019-6 · External reference
10.1038/nmeth.1656
10.1038/nmeth.1656 · External reference
10.1038/nrg3686
10.1038/nrg3686 · External reference
10.1128/mcb.16.5.2164
10.1128/mcb.16.5.2164 · External reference
10.1146/annurev.biochem.052308.093131
10.1146/annurev.biochem.052308.093131 · External reference
10.1128/mcb.15.4.1968
10.1128/mcb.15.4.1968 · External reference
10.1038/cr.2008.1
10.1038/cr.2008.1 · External reference
10.1073/pnas.0611478104
10.1073/pnas.0611478104 · External reference
10.1101/gr.099747.109
10.1101/gr.099747.109 · External reference
10.1093/nar/gkq720
10.1093/nar/gkq720 · External reference
10.1016/j.tibtech.2013.04.004
10.1016/j.tibtech.2013.04.004 · External reference
Repair of double-stranded DNA breaks by homologous DNA fragments during transfer of DNA into mouse L cells
1990 · External reference
10.1128/mcb.21.8.2671-2682.2001
10.1128/mcb.21.8.2671-2682.2001 · External reference
Genetic steps of mammalian homologous repair with distinct mutagenic consequences
10.1128/mcb.24.21.9305-9316.2004 · 2004 · External reference
10.1016/j.cell.2013.04.025
10.1016/j.cell.2013.04.025 · External reference
Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems
10.1038/srep05705 · 2014 · External reference
10.1038/nature03556
10.1038/nature03556 · External reference
10.1172/jci35798
10.1172/jci35798 · External reference
10.1038/nature10177
10.1038/nature10177 · External reference
10.1182/blood-2011-02-335554
10.1182/blood-2011-02-335554 · External reference
10.1038/nature10424
10.1038/nature10424 · External reference
10.1111/j.1365-313x.2009.04041.x
10.1111/j.1365-313x.2009.04041.x · External reference
10.1093/jxb/erv537
10.1093/jxb/erv537 · External reference
10.1534/genetics.108.089037
10.1534/genetics.108.089037 · External reference
10.1093/nar/gkm632
10.1093/nar/gkm632 · External reference
Modern approaches for the biological control of vertebrate pests: an Australian perspective
10.1016/j.biocontrol.2009.06.014 · 2010 · External reference
Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster
10.1534/genetics.111.127506 · 2011 · External reference
10.1371/journal.pone.0074254
10.1371/journal.pone.0074254 · External reference
10.1126/science.aaa5945
10.1126/science.aaa5945 · External reference
10.1038/nbt.3439
10.1038/nbt.3439 · External reference
10.1101/089946
10.1101/089946 · External reference
Homing endonuclease structure and function
10.1017/s0033583505004063 · 2005 · External reference
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy
10.2174/156652311794520111 · 2011 · External reference
10.1139/g2012-049
10.1139/g2012-049 · External reference
10.1186/1759-8753-5-7
10.1186/1759-8753-5-7 · External reference
Hybrid restriction enzymes: zinc finger fusions to FokI cleavage domain
10.1073/pnas.93.3.1156 · 1996 · External reference
10.1146/annurev.biochem.70.1.313
10.1146/annurev.biochem.70.1.313 · External reference
10.1038/mt.2008.114
10.1038/mt.2008.114 · External reference
Genome engineering with zinc-finger nucleases
2011 · External reference
10.1126/science.1178811
10.1126/science.1178811 · External reference
10.1534/genetics.110.120717
10.1534/genetics.110.120717 · External reference
10.1038/nbt.1767
10.1038/nbt.1767 · External reference
10.1093/nar/gkq704
10.1093/nar/gkq704 · External reference
10.1146/annurev-genet-110410-132430
10.1146/annurev-genet-110410-132430 · External reference
10.1126/science.1225829
10.1126/science.1225829 · External reference
10.1038/nbt.2508
10.1038/nbt.2508 · External reference
10.1016/0092-8674(95)90027-6
10.1016/0092-8674(95)90027-6 · External reference
10.1101/cshperspect.a003616
10.1101/cshperspect.a003616 · External reference
10.1371/journal.pone.0069032
10.1371/journal.pone.0069032 · External reference
Host factors influencing the retrohoming pathway of group II intron RmInt1, which has an intron-encoded protein naturally devoid of endonuclease activity
10.1371/journal.pone.0162275 · 2016 · External reference
Rules for DNA target-site recognition by a lactococcal group II intron enable retargeting of the intron to specific DNA sequences
10.1101/gad.14.5.559 · 2000 · External reference
10.1038/nbt1201-1162
10.1038/nbt1201-1162 · External reference
Mobile group II intron targeting: applications in prokaryotes and perspectives in eukaryotes
10.2741/2442 · 2007 · External reference
10.1146/annurev.genet.40.110405.090451
10.1146/annurev.genet.40.110405.090451 · External reference
10.1016/j.molcel.2010.09.019
10.1016/j.molcel.2010.09.019 · External reference
10.1016/j.molcel.2012.07.029
10.1016/j.molcel.2012.07.029 · External reference
In vivo cleavage of transgene donors promote nuclease-mediated targeted integration
10.1002/bit.24733 · 2013 · External reference
10.1101/gr.145441.112
10.1101/gr.145441.112 · External reference
A frameshift mutation in MC4R associated with dominantly inherited human obesity
10.1038/2404 · 1998 · External reference
10.1038/35079114
10.1038/35079114 · External reference
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors
10.1371/journal.pbio.0050109 · 2007 · External reference
10.1038/mt.2013.111
10.1038/mt.2013.111 · External reference
10.1016/j.stemcr.2014.10.013
10.1016/j.stemcr.2014.10.013 · External reference
10.7554/elife.04766
10.7554/elife.04766 · External reference
Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors
10.7554/elife.12213 · 2016 · External reference
10.1038/nbt.2842
10.1038/nbt.2842 · External reference
10.1016/j.cell.2014.05.010
10.1016/j.cell.2014.05.010 · External reference
Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis
10.1186/1759-8753-5-2 · 2014 · External reference
10.1038/nm.3793
10.1038/nm.3793 · External reference
Towards a new era in medicine: therapeutic genome editing
10.1186/s13059-015-0859-y · 2015 · External reference
10.1038/mt.2016.10
10.1038/mt.2016.10 · External reference
10.1038/nprot.2016.104
10.1038/nprot.2016.104 · External reference
10.1101/gr.138792.112
10.1101/gr.138792.112 · External reference
Genome editing techniques and their therapeutic applications
2016 · External reference
CRISPR/Cas9: a historical and chemical biology perspective of targeted genome engineering
10.1039/c6cs00197a · 2016 · External reference
10.1007/s12185-016-2017-z
10.1007/s12185-016-2017-z · External reference
In vivo delivery systems for therapeutic genome editing
2016 · External reference
10.1038/365566a0
10.1038/365566a0 · External reference
Targeting DNA with triplex-forming oligonucleotides to modify gene sequence
10.1016/j.biochi.2008.04.004 · 2008 · External reference
DNA-guided genome editing using structure-guided endonucleases
10.1186/s13059-016-1055-4 · 2016 · External reference
An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease
10.1186/s13059-016-1038-5 · 2016 · External reference
DNA and protein requirements for substrate conformational changes necessary for human flap endonuclease-1-catalyzed reaction
10.1074/jbc.m115.698993 · 2016 · External reference
Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds
10.1093/nar/gkp1171 · 2010 · External reference
Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
10.1038/nsb840 · 2002 · External reference
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
10.1093/nar/gkq283 · 2010 · External reference
Homing endonucleases: from genetic anomalies to programmable genomic clippers
10.1007/978-1-62703-968-0_1 · 2014 · External reference
Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)
2016 · External reference
Fine-tuning next-generation genome editing tools
10.1016/j.tibtech.2016.03.007 · 2016 · External reference
Tapping natural reservoirs of homing endonucleases for targeted gene modification
10.1073/pnas.1107719108 · 2011 · External reference
10.1093/nar/gks365
10.1093/nar/gks365 · External reference
REBASE: restriction enzymes and methyltransferases
10.1093/nar/gkg069 · 2003 · External reference
10.1016/j.str.2016.03.024
10.1016/j.str.2016.03.024 · External reference
10.1093/nar/gkt1224
10.1093/nar/gkt1224 · External reference
10.1371/journal.pone.0100948
10.1371/journal.pone.0100948 · External reference
10.1371/journal.pone.0110852
10.1371/journal.pone.0110852 · External reference
10.1016/j.tig.2008.08.007
10.1016/j.tig.2008.08.007 · External reference
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption
10.1038/nmeth.2177 · 2012 · External reference
10.1093/nar/gku573
10.1093/nar/gku573 · External reference
Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease
10.1073/pnas.1616343114 · 2016 · External reference
10.1038/nrg2842
10.1038/nrg2842 · External reference
10.1038/nbt1319
10.1038/nbt1319 · External reference
10.1038/nbt1317
10.1038/nbt1317 · External reference
10.1182/blood-2013-08-521229
10.1182/blood-2013-08-521229 · External reference
10.1056/nejmoa1300662
10.1056/nejmoa1300662 · External reference
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
10.1038/nmeth.1670 · 2011 · External reference
10.1371/journal.pone.0056633
10.1371/journal.pone.0056633 · External reference
10.1007/s12033-014-9751-3
10.1007/s12033-014-9751-3 · External reference
10.1038/nbt.1755
10.1038/nbt.1755 · External reference
10.1038/nmeth.2364
10.1038/nmeth.2364 · External reference
10.1093/nar/gks608
10.1093/nar/gks608 · External reference
10.1038/nbt.1927
10.1038/nbt.1927 · External reference
10.1016/j.stem.2014.06.016
10.1016/j.stem.2014.06.016 · External reference
10.1038/nbt.3127
10.1038/nbt.3127 · External reference
The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs
10.1534/g3.114.011445 · 2014 · External reference
CRISPR-Cas systems and RNA-guided interference
10.1002/wrna.1159 · 2013 · External reference
10.1038/nprot.2013.143
10.1038/nprot.2013.143 · External reference
10.1093/nar/gkv878
10.1093/nar/gkv878 · External reference
10.1534/genetics.115.182162
10.1534/genetics.115.182162 · External reference
10.4161/rna.24203
10.4161/rna.24203 · External reference
10.1073/pnas.1313587110
10.1073/pnas.1313587110 · External reference
10.1038/nature14592
10.1038/nature14592 · External reference
10.1016/j.cell.2013.02.022
10.1016/j.cell.2013.02.022 · External reference
10.1073/pnas.1208507109
10.1073/pnas.1208507109 · External reference
10.1038/nmeth.2598
10.1038/nmeth.2598 · External reference
10.1038/nbt.2675
10.1038/nbt.2675 · External reference
10.1128/aem.03786-13
10.1128/aem.03786-13 · External reference
Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models
10.4103/1008-682x.153851 · 2015 · External reference
A generic strategy for CRISPR-Cas9-mediated gene tagging
10.1038/ncomms10237 · 2015 · External reference
10.1016/j.cell.2014.11.052
10.1016/j.cell.2014.11.052 · External reference
10.1016/j.copbio.2016.06.003
10.1016/j.copbio.2016.06.003 · External reference
10.1016/j.stem.2016.01.022
10.1016/j.stem.2016.01.022 · External reference
10.1016/j.cell.2013.12.001
10.1016/j.cell.2013.12.001 · External reference
10.1038/nbt.2908
10.1038/nbt.2908 · External reference
10.1126/science.1231143
10.1126/science.1231143 · External reference
10.1016/j.cell.2014.09.014
10.1016/j.cell.2014.09.014 · External reference
10.1038/ncomms7244
10.1038/ncomms7244 · External reference
CrisprGE: a central hub of CRISPR/Cas-based genome editing
10.1093/database/bav055 · 2015 · External reference
10.1056/nejmcibr1601383
10.1056/nejmcibr1601383 · External reference
10.1111/febs.13586
10.1111/febs.13586 · External reference
10.1038/522020a
10.1038/522020a · External reference
10.1016/j.cell.2013.08.021
10.1016/j.cell.2013.08.021 · External reference
10.1038/nmeth.2857
10.1038/nmeth.2857 · External reference
10.1038/nbt.2808
10.1038/nbt.2808 · External reference
10.1038/nmeth.2681
10.1038/nmeth.2681 · External reference
10.1016/j.cell.2015.09.038
10.1016/j.cell.2015.09.038 · External reference
C-Brick: a new standard for assembly of biological parts using Cpf1
2016 · External reference
10.1038/nature17945
10.1038/nature17945 · External reference
10.1038/nbt.3620
10.1038/nbt.3620 · External reference
10.1038/nbt.3609
10.1038/nbt.3609 · External reference
10.1038/nature14299
10.1038/nature14299 · External reference
10.1126/science.aad5227
10.1126/science.aad5227 · External reference
10.1038/nature17946
10.1038/nature17946 · External reference
10.1016/s1097-2765(02)00742-6
10.1016/s1097-2765(02)00742-6 · External reference
10.1016/j.cell.2016.02.054
10.1016/j.cell.2016.02.054 · External reference
Triplex forming oligonucleotides: sequence-specific tools for gene targeting
10.1093/hmg/10.20.2243 · 2001 · External reference
10.1016/s0006-3495(04)74356-8
10.1016/s0006-3495(04)74356-8 · External reference
Peptide nucleic acid - an opportunity for bio nanotechnology
10.2533/chimia.2014.264 · 2014 · External reference
Structure and function of type II restriction endonucleases
10.1093/nar/29.18.3705 · 2001 · External reference
Type II restriction endonucleases: structure and mechanism
10.1007/s00018-004-4513-1 · 2005 · External reference
10.1021/bc200480m
10.1021/bc200480m · External reference
RNA triplexes: from structural principles to biological and biotech applications
10.1002/wrna.1261 · 2012 · External reference
10.1038/nbt.3547
10.1038/nbt.3547 · External reference
Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies
10.1038/536136a · 2016 · External reference
10.1128/mcb.21.12.3926-3934.2001
10.1128/mcb.21.12.3926-3934.2001 · External reference
Enhancement of plasmid-mediated gene therapy for Duchenne muscular dystrophy by directed plasmid integration
10.1073/pnas.0504505102 · 2006 · External reference
Cre-stimulated recombination at loxP containing DNA sequences placed into the mammalian genome
10.1093/nar/17.1.147 · 1989 · External reference
10.1073/pnas.090527097
10.1073/pnas.090527097 · External reference
10.1146/annurev.biochem.73.011303.073908
10.1146/annurev.biochem.73.011303.073908 · External reference
10.1016/j.jmb.2005.11.098
10.1016/j.jmb.2005.11.098 · External reference
Therapeutic applications of the phiC31 integrase system
10.2174/156652311797415818 · 2011 · External reference
10.1371/journal.pone.0096279
10.1371/journal.pone.0096279 · External reference
Insertion of a reversible redox switch into a rare-cutting DNA endonuclease
10.1021/bi015944v · 2002 · External reference
A homing endonuclease with a switch: characterization of a twintron encoded homing endonuclease
10.1016/j.fgb.2014.01.004 · 2014 · External reference
10.1371/journal.pone.0150097
10.1371/journal.pone.0150097 · External reference
Unresolved reference
2016 · External reference
Database for mobile group II introns
10.1093/nar/gkg049 · 2003 · External reference
Database for bacterial group II introns
10.1093/nar/gkr1043 · 2012 · External reference
A pipeline of programs for collecting and analyzing group II intron retroelement sequences from GenBank
10.1186/1759-8753-4-28 · 2013 · External reference
10.1016/j.mito.2007.09.005
10.1016/j.mito.2007.09.005 · External reference
A novel multifunctional factor involved in trans-splicing of chloroplast introns in Chlamydomonas
10.1093/nar/gkj429 · 2006 · External reference
Contribution of base pairing interactions between group II intron fragments during trans-splicing in vivo
10.1261/rna.028886.111 · 2011 · External reference
10.1371/journal.pone.0003121
10.1371/journal.pone.0003121 · External reference
Enhanced group II intron retrohoming in magnesium-deficient E. coli via selection of mutations in the ribozyme core
10.1073/pnas.1315742110 · 2013 · External reference
10.1371/journal.pgen.1005422
10.1371/journal.pgen.1005422 · External reference
10.1534/genetics.113.155853
10.1534/genetics.113.155853 · External reference
10.1101/gr.171322.113
10.1101/gr.171322.113 · External reference
Development of a mono-promoter-driven CRISPR/Cas9 system in mammalian cells
10.1038/srep18341 · 2015 · External reference
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
2016 · External reference
10.1073/pnas.1501698112
10.1073/pnas.1501698112 · External reference
10.1038/nbt.3155
10.1038/nbt.3155 · External reference
10.1038/nbt.3149
10.1038/nbt.3149 · External reference
10.1016/j.cell.2012.03.017
10.1016/j.cell.2012.03.017 · External reference
10.1073/pnas.0909444107
10.1073/pnas.0909444107 · External reference
10.1073/pnas.0913923107
10.1073/pnas.0913923107 · External reference
10.1002/anie.201202134
10.1002/anie.201202134 · External reference
10.1038/nbt.3245
10.1038/nbt.3245 · External reference
10.1038/ncomms7256
10.1038/ncomms7256 · External reference
10.1038/nbt.3081
10.1038/nbt.3081 · External reference
The molecular perspective: ultraviolet light and pyrimidine dimers
10.1634/theoncologist.6-3-298 · 2001 · External reference
10.1039/b201230h
10.1039/b201230h · External reference
10.1038/nchembio.1793
10.1038/nchembio.1793 · External reference
10.1038/nchembio.2179
10.1038/nchembio.2179 · External reference
10.1038/nbt.2909
10.1038/nbt.2909 · External reference
10.1016/j.cell.2006.07.025
10.1016/j.cell.2006.07.025 · External reference
An FKBP destabilization domain modulates protein levels in Plasmodium falciparum
10.1038/nmeth1132 · 2007 · External reference
10.1371/journal.pgen.1000376
10.1371/journal.pgen.1000376 · External reference
10.1101/023366
10.1101/023366 · External reference
Naturally occurring off-switches for CRISPR-Cas9
10.1016/j.cell.2016.11.017 · 2016 · External reference
RNA modularity for synthetic biology
10.12703/p5-46 · 2013 · External reference
10.1038/346818a0
10.1038/346818a0 · External reference
10.1126/science.2200121
10.1126/science.2200121 · External reference
10.1007/s00239-015-9723-7
10.1007/s00239-015-9723-7 · External reference
10.1038/gt.2009.81
10.1038/gt.2009.81 · External reference
10.1038/nrd4359
10.1038/nrd4359 · External reference
10.1016/b978-0-12-381286-5.00001-9
10.1016/b978-0-12-381286-5.00001-9 · External reference
10.1126/science.231.4745.1577
10.1126/science.231.4745.1577 · External reference
Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?
10.12688/f1000research.8601.1 · 2016 · External reference
10.1038/nchembio.1386
10.1038/nchembio.1386 · External reference
10.1038/nchembio.1846
10.1038/nchembio.1846 · External reference
Sequence requirements of the hammerhead RNA self-cleavage reaction
10.1021/bi00499a018 · 1990 · External reference
10.1261/rna.031401.111
10.1261/rna.031401.111 · External reference
10.1016/j.jmb.2015.05.005
10.1016/j.jmb.2015.05.005 · External reference
Maxizyme technology
2004 · External reference
Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
10.1038/nsb959 · 2003 · External reference
Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme
10.1021/bi972493z · 1998 · External reference
10.1021/sb500270h
10.1021/sb500270h · External reference
10.1016/0092-8674(85)90200-4
10.1016/0092-8674(85)90200-4 · External reference
10.1073/pnas.0703961104
10.1073/pnas.0703961104 · External reference
10.1371/journal.pone.0054741
10.1371/journal.pone.0054741 · External reference
Spiegelzymes® mirror-image hammerhead ribozymes and mirror-image DNAzymes, an alternative to siRNAs and microRNAs to cleave mRNAs in vivo?
10.1371/journal.pone.0086673 · 2014 · External reference
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
10.1182/blood.v81.12.3271.3271 · 1993 · External reference
Thermozymes: synthetic RNA thermometers based on ribozyme activity
10.4161/rna.24482 · 2013 · External reference
Emerging applications of riboswitches — from antibacterial targets to molecular tools
10.1007/s13353-016-0341-x · 2016 · External reference
Riboswitches: still a lot of undiscovered country
10.1261/rna.050765.115 · 2015 · External reference
10.1126/science.1190713
10.1126/science.1190713 · External reference
10.1126/science.1129666
10.1126/science.1129666 · External reference
An allosteric hammerhead ribozyme
1995 · External reference
10.1186/1472-6750-2-21 · 2002 · Admitted local publication
10.1002/cbic.200700478
10.1002/cbic.200700478 · External reference
10.1002/anie.200703700
10.1002/anie.200703700 · External reference
