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References from Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1194/jlr.r800058-jlr200 · External reference
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport
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Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
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10.1194/jlr.m200108-jlr200 · External reference
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Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
10.1186/1476-511x-13-136 · 2014 · External reference
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10.1007/s00109-004-0631-3
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10.1038/nrn2620
10.1038/nrn2620 · External reference
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
1996 · External reference
10.1007/s00109-016-1427-y
10.1007/s00109-016-1427-y · External reference
Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress
10.1161/01.atv.0000128849.12617.f4 · 2004 · External reference
High-density lipoprotein heterogeneity and function in reverse cholesterol transport
10.1097/mol.0b013e328338472d · 2010 · External reference
HDL and atherosclerosis: Insights from inherited HDL disorders
10.1016/j.bbalip.2014.07.015 · 2015 · External reference
Distinct roles of apolipoproteins A1 and E in the modulation of high-density lipoprotein composition and function
10.1021/acs.biochem.6b00389 · 2016 · External reference
Complement factor H binds to human serum apolipoprotein E and mediates complement regulation on high density lipoprotein particles
10.1074/jbc.m115.669226 · 2015 · External reference
Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism
10.1016/s0021-9150(03)00139-4 · 2003 · External reference
A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E
10.1016/s0022-2275(20)33338-1 · 1999 · External reference
Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice
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10.1074/jbc.272.46.29113 · External reference
A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different binding specificities for orphan receptors HNF-4, ARP-1, and EAR-2
10.1074/jbc.273.7.4188 · 1998 · External reference
10.1074/jbc.m005468200
10.1074/jbc.m005468200 · External reference
Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain
10.1523/jneurosci.21-03-00812.2001 · 2001 · External reference
10.1074/jbc.m110.179572
10.1074/jbc.m110.179572 · External reference
STAT1 interacts with RXRalpha to upregulate ApoCII gene expression in macrophages
10.1371/journal.pone.0040463 · 2012 · External reference
10.1371/journal.pmed.1002146
10.1371/journal.pmed.1002146 · External reference
Association of apolipoprotein E genotypes with lipid levels and coronary risk
10.1001/jama.298.11.1300 · 2007 · External reference
10.1194/jlr.r800069-jlr200
10.1194/jlr.r800069-jlr200 · External reference
10.1074/jbc.m112.439570
10.1074/jbc.m112.439570 · External reference
Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4
10.1021/bi1017655 · 2010 · External reference
Molecular mechanism of apolipoprotein E binding to lipoprotein particles
10.1021/bi9000694 · 2009 · External reference
10.1021/acs.biochem.5b00681
10.1021/acs.biochem.5b00681 · External reference
10.1074/jbc.273.41.26388
10.1074/jbc.273.41.26388 · External reference
Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice
10.1172/jci119501 · 1997 · External reference
Abnormal in vivo metabolism of apolipoprotein E4 in humans
10.1172/jci112645 · 1986 · External reference
10.1152/ajpcell.00210.2004
10.1152/ajpcell.00210.2004 · External reference
Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages
10.1172/jci119887 · 1998 · External reference
Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype
10.1172/jci113107 · 1987 · External reference
10.1038/ejhg.2008.202
10.1038/ejhg.2008.202 · External reference
10.1016/s0022-2275(20)32417-2
10.1016/s0022-2275(20)32417-2 · External reference
Unraveling hyperlipidemia type III (dysbetalipoproteinemia), slowly
10.1038/ejhg.2008.222 · 2009 · External reference
10.1161/hq0202.102919
10.1161/hq0202.102919 · External reference
10.1007/s10157-013-0918-1
10.1007/s10157-013-0918-1 · External reference
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein E
10.4137/ccrep.s12209 · 2013 · External reference
10.1007/s10157-013-0886-5
10.1007/s10157-013-0886-5 · External reference
Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203–299 promotes hepatic very low density lipoprotein-triglyceride secretion
10.1074/jbc.m100418200 · 2001 · External reference
Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
10.1194/jlr.m200313-jlr200 · 2003 · External reference
Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
10.1074/jbc.m413458200 · 2005 · External reference
10.1016/j.bcp.2012.09.006
10.1016/j.bcp.2012.09.006 · External reference
Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein
10.1021/bi700232g · 2007 · External reference
10.1016/j.atherosclerosis.2012.11.013
10.1016/j.atherosclerosis.2012.11.013 · External reference
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10.1016/j.atherosclerosis.2011.06.057 · External reference
10.3109/07853890.2010.549143
10.3109/07853890.2010.549143 · External reference
Apolipoprotein E mimetics and cholesterol-lowering properties
10.2165/11594190-000000000-00000 · 2011 · External reference
10.1258/ebm.2011.011169
10.1258/ebm.2011.011169 · External reference
A human apolipoprotein E mimetic peptide reduces atherosclerosis in aged apolipoprotein E null mice
2016 · External reference
10.1038/nrneurol.2012.263
10.1038/nrneurol.2012.263 · External reference
10.1101/cshperspect.a006312
10.1101/cshperspect.a006312 · External reference
New insights on apoliprotein E involvement in brain lipid homeostasis
2016 · External reference
Astrocytes: regulation of brain homeostasis via apolipoprotein E
10.1016/j.biocel.2004.10.004 · 2005 · External reference
10.1073/pnas.0600549103
10.1073/pnas.0600549103 · External reference
Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele
10.1176/ajp.2006.163.9.1603 · 2006 · External reference
10.1073/pnas.151254698
10.1073/pnas.151254698 · External reference
10.1074/jbc.270.16.9039
10.1074/jbc.270.16.9039 · External reference
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
10.1042/bj3480359 · 2000 · External reference
The interaction of amyloid-beta with ApoE
2005 · External reference
10.1073/pnas.1434398100
10.1073/pnas.1434398100 · External reference
Gender differences in cognitive decline and Alzheimer's disease
2015 · External reference
Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Abeta deposition and learning and memory in mouse models of Alzheimer's disease
2015 · External reference
10.1371/journal.pone.0148099
10.1371/journal.pone.0148099 · External reference
10.1038/npp.2015.95
10.1038/npp.2015.95 · External reference
10.1016/j.nbd.2013.12.016
10.1016/j.nbd.2013.12.016 · External reference
10.1111/j.1471-4159.2010.06756.x
10.1111/j.1471-4159.2010.06756.x · External reference
The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
10.1038/srep30654 · 2016 · External reference
10.1074/jbc.m113.538124
10.1074/jbc.m113.538124 · External reference
10.1016/j.neuroscience.2012.03.013
10.1016/j.neuroscience.2012.03.013 · External reference
10.1074/jbc.m602440200
10.1074/jbc.m602440200 · External reference
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
10.1186/1750-1326-4-35 · 2009 · External reference
10.1111/febs.13725
10.1111/febs.13725 · External reference
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function
10.1074/jbc.m109.014464 · 2009 · External reference
10.1074/jbc.m110.217380
10.1074/jbc.m110.217380 · External reference
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10.1073/pnas.0508693102 · External reference
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10.1021/jm3008618 · External reference
The receptor-binding region of human apolipoprotein E has direct anti-infective activity
10.1086/499280 · 2006 · External reference
10.1016/s0140-6736(96)10149-5
10.1016/s0140-6736(96)10149-5 · External reference
Amplification of herpes simplex type 1 and human herpes type 5 viral DNA from formalin-fixed Alzheimer brain tissue
10.1016/j.neulet.2005.07.052 · 2005 · External reference
Hematogenous vertical transmission of herpes simplex virus type 1 in mice
10.1128/jvi.80.6.2823-2831.2006 · 2006 · External reference
HSV-1 and Alzheimer's disease: more than a hypothesis
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10.1073/pnas.0803526105
10.1073/pnas.0803526105 · External reference
HIV entry inhibitors: mechanisms of action and resistance pathways
10.1093/jac/dkl027 · 2006 · External reference
Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis
10.1074/jbc.m009915200 · 2001 · External reference
10.1016/s0196-9781(00)00165-0
10.1016/s0196-9781(00)00165-0 · External reference
Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity
10.1111/j.1742-4658.2007.05981.x · 2007 · External reference
10.1038/ng0996-55
10.1038/ng0996-55 · External reference
The receptor binding domain of apolipoprotein E is responsible for its antioxidant activity
10.1021/bi0472696 · 2005 · External reference
10.1002/mnfr.200700322
10.1002/mnfr.200700322 · External reference
10.1007/s12263-012-0282-x
10.1007/s12263-012-0282-x · External reference
Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice
10.1016/j.atherosclerosis.2010.02.027 · 2010 · External reference
Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice
10.1007/s00109-011-0771-1 · 2011 · External reference
Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages
10.1017/s0007114507669219 · 2007 · External reference
Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression
10.1016/j.bbrc.2007.03.150 · 2007 · External reference
10.1161/atvbaha.111.222745
10.1161/atvbaha.111.222745 · External reference
Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity
10.1006/cimm.1994.1302 · 1994 · External reference
APOE genotype and stress response - a mini review
10.1186/s12944-016-0288-2 · 2016 · External reference
