Research graph
References from FoldX as Protein Engineering Tool: Better Than Random Based Approaches?. Local targets link to admitted publications; unresolved targets remain external evidence.
Home blood glucose biosensors: a commercial perspective
10.1016/j.bios.2004.11.012 · 2005 · External reference
10.1016/j.ctrv.2009.02.001
10.1016/j.ctrv.2009.02.001 · External reference
10.1128/mr.60.2.280-300.1996
10.1128/mr.60.2.280-300.1996 · External reference
10.1126/science.1188934
10.1126/science.1188934 · External reference
10.1016/j.tibtech.2006.12.005
10.1016/j.tibtech.2006.12.005 · External reference
10.1016/j.bios.2016.08.028
10.1016/j.bios.2016.08.028 · External reference
10.3390/s100504558
10.3390/s100504558 · External reference
10.1586/14737159.2014.888313
10.1586/14737159.2014.888313 · External reference
High thermal stability is essential for tumor targeting of antibody fragments
1999 · External reference
The challenge of enzyme cost in the production of lignocellulosic biofuels
10.1002/bit.24370 · 2012 · External reference
10.1039/c3cs60075k
10.1039/c3cs60075k · External reference
Challenges in the development of an efficient enzymatic process in the pharmaceutical industry
10.1016/j.tetasy.2004.07.050 · 2004 · External reference
10.1016/j.cbpa.2013.03.017
10.1016/j.cbpa.2013.03.017 · External reference
Solvent tolerant lipases: a review
10.1016/j.procbio.2014.10.019 · 2015 · External reference
The dependence of enzyme activity on temperature: determination and validation of parameters
10.1042/bj20061143 · 2007 · External reference
10.1042/bj20091254
10.1042/bj20091254 · External reference
10.1111/febs.14152
10.1111/febs.14152 · External reference
10.1177/0748730407311855
10.1177/0748730407311855 · External reference
Enzymatic procedures for the synthesis of water-soluble retinol derivatives in organic media
10.1016/s0141-0229(02)00289-2 · 2003 · External reference
Temperature effects in enzyme kinetics
10.1016/0076-6879(79)63012-4 · 1979 · External reference
The temperature dependence of enzyme rate enhancements
10.1021/ja991280p · 1999 · External reference
10.1128/mmbr.65.1.1-43.2001
10.1128/mmbr.65.1.1-43.2001 · External reference
The temperature optima of enzymes: a new perspective on an old phenomenon
10.1016/s0968-0004(01)01803-5 · 2001 · External reference
10.1002/cbic.200300660
10.1002/cbic.200300660 · External reference
Enhancing thermostability of a Rhizomucor miehei lipase by engineering a disulfide bond and displaying on the yeast cell surface
10.1007/s00253-009-2067-8 · 2009 · External reference
Enhancement of the thermostability of subtilisin E by introduction of a disulfide bond engineered on the basis of structural comparison with a thermophilic serine protease
10.1016/s0021-9258(19)39230-0 · 1990 · External reference
Nanostructures for enzyme stabilization
10.1016/j.ces.2005.05.067 · 2006 · External reference
10.1073/pnas.95.2.520
10.1073/pnas.95.2.520 · External reference
10.1126/science.1107387
10.1126/science.1107387 · External reference
Exploring nonnatural evolutionary pathways by saturation mutagenesis: rapid improvement of protein function
10.1007/pl00006593 · 1999 · External reference
Directed evolution study of temperature adaptation in a psychrophilic enzyme
10.1006/jmbi.2000.3612 · 2000 · External reference
Rigidity versus flexibility: the dilemma of understanding protein thermal stability
10.1111/febs.13343 · 2015 · External reference
Immobilization can improve the stability of hybridoma antibody productivity in serum-free media
10.1002/bit.260361010 · 1990 · External reference
10.1002/adfm.201002251
10.1002/adfm.201002251 · External reference
10.1002/elsc.201600042
10.1002/elsc.201600042 · External reference
Improving the stability of cellulase by immobilization on modified polyvinyl alcohol coated chitosan beads
10.1016/j.molcatb.2006.10.005 · 2007 · External reference
10.1016/j.bbrc.2007.01.183
10.1016/j.bbrc.2007.01.183 · External reference
Effect of immobilization on thermostability of lipase from Candida rugosa
10.1016/s1369-703x(02)00138-9 · 2003 · External reference
Thermostability of soluble and immobilized α-amylase from Bacillus licheniformis
10.1002/bit.260400309 · 1992 · External reference
Effect of immobilization on pH and thermal stability of Aspergillus ficuum phytase
10.1016/s0141-0229(99)00076-9 · 1999 · External reference
A first continuous 4-aminoantipyrine (4-AAP)-based screening system for directed esterase evolution
10.1007/s00253-015-6612-3 · 2015 · External reference
10.1093/protein/gzs065
10.1093/protein/gzs065 · External reference
10.1002/anie.201301362
10.1002/anie.201301362 · External reference
Directed evolution of a thermostable esterase
10.1073/pnas.95.22.12809 · 1998 · External reference
Engineering proteins for thermostability: the use of sequence alignments versus rational design and directed evolution
10.1016/s0958-1669(00)00229-9 · 2001 · External reference
10.1016/j.bioeng.2004.12.003
10.1016/j.bioeng.2004.12.003 · External reference
Directed evolution and structural analysis of alkaline pectate lyase from the alkaliphilic bacterium Bacillus sp. strain N16-5 to improve its thermostability for efficient ramie degumming
10.1128/aem.01017-15 · 2015 · External reference
10.1006/jmbi.2000.4265
10.1006/jmbi.2000.4265 · External reference
10.1016/j.jmb.2007.10.075
10.1016/j.jmb.2007.10.075 · External reference
10.1093/bioinformatics/btr254
10.1093/bioinformatics/btr254 · External reference
Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis
10.1006/abbi.2001.2635 · 2002 · External reference
Engineering disulfide bonds in Selenomonas ruminantium β-xylosidase by experimental and computational methods
10.1016/j.ijbiomac.2016.10.104 · 2017 · External reference
Enhancement of the thermal stability of pyroglutamyl peptidase I by introduction of an intersubunit disulfide bond
10.1016/s0167-4838(01)00185-6 · 2001 · External reference
Stabilization of phage T4 Iysozyme by engineered disulfide bonds (thermostability/lysozyme/protein structure)
1989 · External reference
10.1016/j.febslet.2013.11.024
10.1016/j.febslet.2013.11.024 · External reference
10.1093/protein/gzt061
10.1093/protein/gzt061 · External reference
Disulfide by Design™: a computational method for the rational design of disulfide bonds in proteins
10.1093/bioinformatics/btg231 · 2003 · External reference
Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins
10.1186/1471-2105-14-346 · 2013 · External reference
Engineering de novo disulfide bond in bacterial α-type carbonic anhydrase for thermostable carbon sequestration
10.1038/srep29322 · 2016 · External reference
10.1006/jmbi.1998.2342
10.1006/jmbi.1998.2342 · External reference
10.1016/b978-0-12-381270-4.00019-6
10.1016/b978-0-12-381270-4.00019-6 · External reference
10.1074/jbc.272.30.18686
10.1074/jbc.272.30.18686 · External reference
10.1073/pnas.1115172109
10.1073/pnas.1115172109 · External reference
Unresolved reference
2014 · External reference
10.1006/jmbi.2001.5326
10.1006/jmbi.2001.5326 · External reference
Sequence statistics reliably predict stabilizing mutations in a protein domain
10.1006/jmbi.1994.1434 · 1994 · External reference
10.1110/ps.8.10.2186
10.1110/ps.8.10.2186 · External reference
10.1128/aem.07985-11
10.1128/aem.07985-11 · External reference
10.1093/protein/gzs058
10.1093/protein/gzs058 · External reference
10.1016/j.jbiotec.2015.02.035
10.1016/j.jbiotec.2015.02.035 · External reference
CUPSAT: prediction of protein stability upon point mutations
10.1093/nar/gkl190 · 2006 · External reference
10.1039/c6ra16992a
10.1039/c6ra16992a · External reference
Engineering proteins for thermostability with iRDP web server
10.1371/journal.pone.0139486 · 2015 · External reference
A multiscale approach to predicting affinity changes in protein-protein interfaces
10.1002/prot.24634 · 2014 · External reference
ProTherm, version 4.0: thermodynamic database for proteins and mutants
10.1093/nar/gkh082 · 2004 · External reference
Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations
10.1038/s41598-017-04950-9 · 2017 · External reference
10.1093/nar/gkt450
10.1093/nar/gkt450 · External reference
ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability
10.1093/nar/gkv343 · 2015 · External reference
10.1002/anie.200602795
10.1002/anie.200602795 · External reference
Improvement of the thermostability of a β-amino acid converting ω-transaminase using FoldX
2017 · External reference
10.1016/s0022-2836(02)00442-4
10.1016/s0022-2836(02)00442-4 · External reference
10.1093/nar/gki387
10.1093/nar/gki387 · External reference
In-silico driven engineering of enantioselectivity of a penicillin G acylase towards active pharmaceutical ingredients
10.1016/j.molcatb.2016.11.014 · 2016 · External reference
Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
10.1371/journal.pgen.1006739 · 2017 · External reference
Increasing stability of antibody via antibody engineering: stability engineering on an anti-hVEGF
10.1002/prot.24626 · 2014 · External reference
FireProt: energy- and evolution-based computational design of thermostable multiple-point mutants
10.1371/journal.pcbi.1004556 · 2015 · External reference
Stability of domain structures in multi-domain proteins
10.1038/srep00040 · 2011 · External reference
10.1080/07391102.2012.743438
10.1080/07391102.2012.743438 · External reference
Directed laccase evolution for improved ionic liquid resistance
10.1039/c3gc36899h · 2013 · External reference
Structure-based DNA-binding prediction and design
10.1007/978-1-60761-753-2_4 · 2010 · External reference
Engineering catalytic efficiency of thermophilic lipase from Geobacillus zalihae by hydrophobic residue mutation near the catalytic pocket
10.4236/abb.2012.32024 · 2012 · External reference
Manipulation of the conformation and enzymatic properties of T1 lipase by site-directed mutagenesis of the protein core
10.1007/s12010-012-9728-2 · 2012 · External reference
10.1038/nbt1012
10.1038/nbt1012 · External reference
Computational tools help improve protein stability but with a solubility tradeoff
10.1074/jbc.m117.784165 · 2017 · External reference
10.1007/s11427-011-4159-9
10.1007/s11427-011-4159-9 · External reference
10.1038/nbt1317
10.1038/nbt1317 · External reference
Predicting changes in protein thermostability brought about by single- or multi-site mutations
10.1186/1471-2105-11-370 · 2010 · External reference
A robust cosolvent-compatible halohydrin dehalogenase by computational library design
2016 · External reference
Optimization algorithms for functional deimmunization of therapeutic proteins
10.1186/1471-2105-11-180 · 2010 · External reference
10.1093/nar/gkw374
10.1093/nar/gkw374 · External reference
10.1002/humu.21242
10.1002/humu.21242 · External reference
10.1002/bit.26012
10.1002/bit.26012 · External reference
The conserved lid tryptophan, w211, potentiates thermostability and thermoactivity in bacterial thermoalkalophilic lipases
10.1371/journal.pone.0085186 · 2013 · External reference
10.1002/cbic.201402128
10.1002/cbic.201402128 · External reference
10.1016/j.bbrc.2016.12.131
10.1016/j.bbrc.2016.12.131 · External reference
10.1021/ci300398z
10.1021/ci300398z · External reference
Enzymatic properties and mutational studies of chalcone synthase from Physcomitrella patens
10.3390/ijms13089673 · 2012 · External reference
Engineering Streptomyces coelicolor carbonyl reductase for efficient atorvastatin precursor synthesis
2017 · External reference
10.1021/acscatal.6b01062
10.1021/acscatal.6b01062 · External reference
10.1002/biot.200600029
10.1002/biot.200600029 · External reference
Stabilizing proteins from sequence statistics: the interplay of conservation and correlation in triosephosphate isomerase stability
10.1016/j.jmb.2012.04.025 · 2012 · External reference
10.1371/journal.pcbi.1000052
10.1371/journal.pcbi.1000052 · External reference
The role of salt bridges on the temperature adaptation of aqualysin I, a thermostable subtilisin-like proteinase
1844 · External reference
Computer-assisted engineering of hyperstable fibroblast growth factor 2
2016 · External reference
Engineering a more thermostable blue light photo receptor Bacillus subtilis YtvA LOV domain by a computer aided rational design method
10.1371/journal.pcbi.1003129 · 2013 · External reference
10.1093/protein/gzv004
10.1093/protein/gzv004 · External reference
10.1002/humu.23251
10.1002/humu.23251 · External reference
Unresolved reference
2013 · External reference
Probing impact of active site residue mutations on stability and activity of Neisseria polysaccharea amylosucrase
10.1002/pro.2375 · 2013 · External reference
Towards a “golden standard” for computing globin stability: stability and structure sensitivity of myoglobin mutants
1854 · External reference
10.1021/ct4002152
10.1021/ct4002152 · External reference
Computing stability effects of mutations in human superoxide dismutase 1
10.1021/jp4119138 · 2014 · External reference
10.1016/j.jmb.2007.03.069
10.1016/j.jmb.2007.03.069 · External reference
10.1086/521879
10.1086/521879 · External reference
10.1093/protein/gzp030
10.1093/protein/gzp030 · External reference
Unresolved reference
2015 · External reference
Predicting protein thermostability upon mutation using molecular dynamics timeseries data
2016 · External reference
10.1093/protein/gzq072
10.1093/protein/gzq072 · External reference
10.1146/annurev.biochem.72.121801.161647
10.1146/annurev.biochem.72.121801.161647 · External reference
Optimizing protein stability in vivo
10.1016/j.molcel.2009.11.022 · 2009 · External reference
Predicting free energy changes using structural ensembles
10.1038/nmeth0109-3 · 2009 · External reference
How protein stability and new functions trade off
10.1371/journal.pcbi.1000002 · 2008 · External reference
10.1016/j.jmb.2006.08.020
10.1016/j.jmb.2006.08.020 · External reference
10.1021/acs.jctc.7b00125
10.1021/acs.jctc.7b00125 · External reference
10.1093/nar/gkx285
10.1093/nar/gkx285 · External reference
10.1016/j.molcel.2016.06.012
10.1016/j.molcel.2016.06.012 · External reference
Correlating protein function and stability through the analysis of single amino acid substitutions
10.1186/1471-2105-10-s8-s8 · 2009 · External reference
Assessing predictors of changes in protein stability upon mutation using self-consistency
10.1371/journal.pone.0046084 · 2012 · External reference
10.1016/j.crci.2015.12.004
10.1016/j.crci.2015.12.004 · External reference
Population-specific design of de-immunized protein biotherapeutics
2017 · External reference
10.1007/s10545-016-9923-3
10.1007/s10545-016-9923-3 · External reference
Unresolved reference
2018 · External reference
