Research graph
References from Triazolo[4,5 -d ]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/16729
10.1038/16729 · External reference
10.1091/mbc.10.11.3787
10.1091/mbc.10.11.3787 · External reference
10.1016/0092-8674(93)90648-a
10.1016/0092-8674(93)90648-a · External reference
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
10.1016/0092-8674(93)90521-q · 1993 · External reference
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
10.1073/pnas.86.12.4579 · 1989 · External reference
10.1016/0092-8674(92)90193-g
10.1016/0092-8674(92)90193-g · External reference
10.1016/s0960-9822(02)01037-0
10.1016/s0960-9822(02)01037-0 · External reference
The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2
10.1074/jbc.m109.008821 · 2009 · External reference
10.1016/s1097-2765(00)00108-8
10.1016/s1097-2765(00)00108-8 · External reference
10.1016/s1097-2765(03)00105-9
10.1016/s1097-2765(03)00105-9 · External reference
10.1042/bst0340007
10.1042/bst0340007 · External reference
10.1371/journal.pone.0126795
10.1371/journal.pone.0126795 · External reference
10.1083/jcb.153.5.1011
10.1083/jcb.153.5.1011 · External reference
10.1101/gad.1250704
10.1101/gad.1250704 · External reference
10.1182/blood-2003-06-1859
10.1182/blood-2003-06-1859 · External reference
10.1038/sj.emboj.7600777
10.1038/sj.emboj.7600777 · External reference
10.1038/emboj.2010.81
10.1038/emboj.2010.81 · External reference
10.1038/leu.2010.264
10.1038/leu.2010.264 · External reference
10.1038/sj.onc.1203632
10.1038/sj.onc.1203632 · External reference
Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation
10.1593/neo.91354 · 2010 · External reference
10.1091/mbc.e05-03-0268
10.1091/mbc.e05-03-0268 · External reference
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability
10.1074/jbc.m114.566927 · 2014 · External reference
Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma
10.1038/srep11781 · 2015 · External reference
Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway
10.1593/neo.13262 · 2013 · External reference
10.1080/13543776.2017.1254194
10.1080/13543776.2017.1254194 · External reference
Pegaspargase: a review of clinical studies
10.1016/s0169-409x(03)00110-8 · 2003 · External reference
10.1038/bcj.2017.53
10.1038/bcj.2017.53 · External reference
10.3945/jn.110.129197
10.3945/jn.110.129197 · External reference
10.1016/j.bbrc.2016.12.062
10.1016/j.bbrc.2016.12.062 · External reference
10.1021/ml400228e
10.1021/ml400228e · External reference
10.1016/s0006-291x(03)01318-4
10.1016/s0006-291x(03)01318-4 · External reference
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase
10.1016/j.bmcl.2009.10.033 · 2009 · External reference
Unresolved reference
2013 · External reference
10.1073/pnas.1805523115
10.1073/pnas.1805523115 · External reference
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster
10.1093/genetics/143.2.929 · 1996 · External reference
10.1083/jcb.201511073
10.1083/jcb.201511073 · External reference
10.1021/jm5017494
10.1021/jm5017494 · External reference
10.1006/jmbi.1997.1287
10.1006/jmbi.1997.1287 · External reference
10.1093/nar/gkw1074
10.1093/nar/gkw1074 · External reference
10.1007/s10822-012-9547-0
10.1007/s10822-012-9547-0 · External reference
10.1126/science.1241159
10.1126/science.1241159 · External reference
10.1200/jco.2009.23.4732
10.1200/jco.2009.23.4732 · External reference
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage
10.1158/0008-5472.can-07-0804 · 2007 · External reference
10.1523/jneurosci.16-15-04543.1996
10.1523/jneurosci.16-15-04543.1996 · External reference
Tetrandrine down-regulates ERK/NF-kappaB signaling and inhibits activation of mesangial cells
10.1016/j.tiv.2011.09.024 · 2011 · External reference
Unresolved reference
2014 · External reference
HDAC pharmacological inhibition promotes cell death through the eIF2alpha kinases PKR and GCN2
10.18632/aging.100216 · 2010 · External reference
10.1006/meth.2001.1262
10.1006/meth.2001.1262 · External reference
Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5)
10.1186/1742-4682-10-56 · 2013 · External reference
10.1002/prot.340230314
10.1002/prot.340230314 · External reference
10.1006/jmbi.1994.1052
10.1006/jmbi.1994.1052 · External reference
Predictions of protein flexibility: first-order measures
10.1002/prot.20151 · 2004 · External reference
10.1093/jnci/81.14.1088
10.1093/jnci/81.14.1088 · External reference
Unresolved reference
2006 · External reference
Analysis of food and drug administration-approved anticancer agents in the NCI60 panel of human tumor cell lines
10.1158/1535-7163.mct-10-0106 · 2010 · External reference
10.1002/ddr.430340203
10.1002/ddr.430340203 · External reference
10.1593/neo.07112
10.1593/neo.07112 · External reference