Research graph
References from Development of Fangjiomics for Systems Elucidation of Synergistic Mechanism Underlying Combination Therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1016/j.drudis.2012.01.003 · External reference
Combination therapy for multi-target manipulation of secondary brain injury mechanisms
10.2174/1570159x15666170828165711 · 2018 · External reference
VEGF inhibitor (Iressa) arrests histone deacetylase expression: single-cell cotransfection imaging cytometry for multi-target-multi-drug analysis
10.1002/jcp.22540 · 2011 · External reference
Killing cancer with platycodin D through multiple mechanisms
10.1111/jcmm.12749 · 2016 · External reference
Integrating individual functional moieties of CXCL10 and CXCL11 into a novel chimeric chemokine leads to synergistic antitumor effects: a strategy for chemokine-based multi-target-directed cancer therapy
10.1007/s00262-010-0901-6 · 2010 · External reference
Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies
10.18632/oncotarget.20094 · 2017 · External reference
Phase II study of the combination of cetuximab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
10.1093/annonc/mdr367 · 2012 · External reference
Addition of droperidol to prophylactic ondansetron and dexamethasone in children at high risk for postoperative vomiting. A randomized, controlled, double-blind study
10.1093/bja/aex099 · 2017 · External reference
Efficacy of the combination of Sofosbuvir, Velpatasvir, and the NS3/4A protease Inhibitor GS-9857 in treatment-naive or previously treated patients with hepatitis C virus genotype 1 or 3 infections
2016 · External reference
Synergy Maps: exploring compound combinations using network-based visualization
2015 · External reference
10.1038/onc.2008.49
10.1038/onc.2008.49 · External reference
10.1097/00004850-200607000-00005
10.1097/00004850-200607000-00005 · External reference
Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells
10.1186/s12967-016-0803-2 · 2016 · External reference
Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze
10.1016/j.neulet.2011.03.040 · 2011 · External reference
10.1073/pnas.0400063101
10.1073/pnas.0400063101 · External reference
AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia
10.1038/leu.2011.316 · 2012 · External reference
Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway
10.1016/j.bcp.2017.01.004 · 2017 · External reference
10.1158/1535-7163.mct-11-0873
10.1158/1535-7163.mct-11-0873 · External reference
Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
10.18632/oncotarget.15599 · 2017 · External reference
10.18632/oncotarget.6568
10.18632/oncotarget.6568 · External reference
VNP: interactive visual network pharmacology of diseases, targets, and drugs
2014 · External reference
10.1177/0091270010382913
10.1177/0091270010382913 · External reference
10.1038/aps.2014.125
10.1038/aps.2014.125 · External reference
Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor
10.1158/1078-0432.ccr-16-0529 · 2017 · External reference
Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin
10.3892/etm.2010.145 · 2010 · External reference
Fusion of core pathways reveals a horizontal synergistic mechanism underlying combination therapy
10.1016/j.ejphar.2011.05.046 · 2011 · External reference
Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii
10.1038/srep45527 · 2017 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
Infectious Disease. How to bolster the antifungal pipeline
10.1126/science.aaa6097 · 2015 · External reference
Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response
10.1038/srep40232 · 2017 · External reference
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia
10.18632/oncotarget.5715 · 2015 · External reference
10.1016/j.molmed.2017.11.001
10.1016/j.molmed.2017.11.001 · External reference
Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli
10.1038/ncomms13090 · 2016 · External reference
10.1073/pnas.0813142106
10.1073/pnas.0813142106 · External reference
Coordination of intrinsic, extrinsic, and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia
10.1182/blood-2005-06-2318 · 2006 · External reference
10.1038/nchembio.1085
10.1038/nchembio.1085 · External reference
Metabolomics coupled with proteomics advancing drug discovery toward more agile development of targeted combination therapies
10.1074/mcp.m112.021683 · 2013 · External reference
10.1158/1078-0432.ccr-16-1193
10.1158/1078-0432.ccr-16-1193 · External reference
Outcome-dependent global similarity analysis of imbalanced core signaling pathways in ischemic mouse hippocampus
10.2174/1871527311211080018 · 2012 · External reference
10.1371/journal.pcbi.1005985
10.1371/journal.pcbi.1005985 · External reference
10.3390/cells3020563
10.3390/cells3020563 · External reference
10.1186/1752-0509-5-s1-s10
10.1186/1752-0509-5-s1-s10 · External reference
Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer
10.1038/ncomms9481 · 2015 · External reference
10.1371/journal.pcbi.1004975
10.1371/journal.pcbi.1004975 · External reference
10.1093/bioinformatics/btr202
10.1093/bioinformatics/btr202 · External reference
Profound blockage of CXCR4 signaling at multiple points using the synergy between plerixafor, mirtazapine, and clotrimazole as a new glioblastoma treatment adjunct
2010 · External reference
Pooled efficacy analysis from a phase I-II study of biweekly irinotecan in combination with gemcitabine, 5-fluorouracil, leucovorin and cisplatin in patients with metastatic pancreatic cancer
10.1097/cad.0b013e3280121334 · 2007 · External reference
An integrative platform of TCM network pharmacology and its application on a herbal formula, Qing-Luo-Yin
2013 · External reference
Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia
10.2174/1871527315666160321111053 · 2016 · External reference
Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury
10.1111/cns.12205 · 2014 · External reference
10.1038/nrd2683
10.1038/nrd2683 · External reference
10.1039/c6mb00476h
10.1039/c6mb00476h · External reference
10.1016/j.tibtech.2015.12.013
10.1016/j.tibtech.2015.12.013 · External reference
Deep Learning based multi-omics integration robustly predicts survival in liver cancer
10.1158/1078-0432.ccr-17-0853 · 2018 · External reference
10.1016/j.metabol.2017.01.011
10.1016/j.metabol.2017.01.011 · External reference
