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References from Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa. Local targets link to admitted publications; unresolved targets remain external evidence.
The antibiotic resistance crisis: part 1: causes and threats
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Unresolved reference
External reference
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Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease
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10.1016/s1473-3099(06)70580-1
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Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus
10.1016/s1473-3099(14)70850-3 · 2015 · External reference
10.1101/cshperspect.a025288
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10.1128/iai.05226-11
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Heteroresistance to colistin in multidrug-resistant acinetobacter baumannii
10.1128/aac.00103-06 · 2006 · External reference
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10.1093/jac/dks084 · 2012 · External reference
Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use
10.1002/phar.1537 · 2015 · External reference
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Antibiotic–non-antibiotic combinations for combating extremely drug-resistant Gram-negative ‘superbugs’
10.1042/ebc20160058 · 2017 · External reference
10.1089/mdr.2016.0196
10.1089/mdr.2016.0196 · External reference
An “unlikely” pair: the antimicrobial synergy of polymyxin B in combination with the cystic fibrosis transmembrane conductance regulator drugs KALYDECO and ORKAMBI
10.1021/acsinfecdis.6b00035 · 2016 · External reference
Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B
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Global analysis of the Staphylococcus aureus response to mupirocin
10.1128/aac.05363-11 · 2012 · External reference
Metabolite concentration as a criterion for antibacterial discovery
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Mapping the trimethoprim-induced secondary metabolome of Burkholderia thailandensis
10.1021/acschembio.6b00447 · 2016 · External reference
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Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against acinetobacter baumannii
2017 · External reference
Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control
10.1038/sdata.2014.12 · 2014 · External reference
Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against acinetobacter baumannii
10.1038/srep45527 · 2017 · External reference
Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa
2018 · External reference
The biosynthesis of nicotinamide adenine dinucleotides in bacteria
10.1016/s0083-6729(01)61003-3 · 2001 · External reference
10.1093/jac/dku567
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Pharmacokinetics of selective estrogen receptor modulators
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Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo
10.1128/mbio.00765-13 · 2014 · External reference
Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and leishmania chagasi infections
10.1093/jac/dkn509 · 2008 · External reference
10.1128/aac.01564-08
10.1128/aac.01564-08 · External reference
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection
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10.1016/s0301-2115(98)00278-4
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Clinical pharmacokinetics of toremifene
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Fatty acid composition of bacterial membrane and wall lipids. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid
1966 · External reference
Control of membrane lipid fluidity by molecular thermosensors
10.1128/jb.186.20.6681-6688.2004 · 2004 · External reference
Tamoxifen and related compounds decrease membrane fluidity in liposomes: mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?
10.1016/0014-5793(93)80918-k · 1993 · External reference
The anticancer drug tamoxifen induces changes in the physical properties of model and native membranes
10.1016/0005-2736(93)90080-j · 1993 · External reference
10.1038/nrmicro1839
10.1038/nrmicro1839 · External reference
Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: chemical synthesis and functional studies
10.2183/pjab.86.322 · 2010 · External reference
Metabolism and function of the membrane phospholipids of Escherichia coli
10.1016/0304-4157(72)90018-4 · 1972 · External reference
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of Lipid A
10.1128/aac.00256-11 · 2011 · External reference
Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli
10.1073/pnas.1521168113 · 2016 · External reference
10.3389/fmicb.2014.00643
10.3389/fmicb.2014.00643 · External reference
Bacterial lipopolysaccharides: a remarkable family of bioactive macroamphiphiles
1996 · External reference
Murein synthesis
1996 · External reference
Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli
10.1128/jb.181.1.47-54.1999 · 1999 · External reference
Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis
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Biosynthesis of 6-deoxyhexose glycans in bacteria
10.1093/glycob/cwh040 · 2004 · External reference
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10.1128/aac.03104-14 · External reference
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Bacterial cell wall assembly: still an attractive antibacterial target
10.1016/j.tibtech.2010.12.006 · 2011 · External reference
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10.3390/antibiotics6040024
10.3390/antibiotics6040024 · External reference
Risk factors associated with the isolation of colistin-resistant gram-negative bacteria: a matched case-control study
10.1097/ccm.0b013e3181652fae · 2008 · External reference
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10.1128/jb.178.11.3339-3341.1996 · External reference
Probing the active site of the sugar isomerase domain from E. coli arabinose-5-phosphate isomerase via X-ray crystallography
10.1002/pro.525 · 2010 · External reference
10.1016/j.chembiol.2014.08.020
10.1016/j.chembiol.2014.08.020 · External reference
The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase homology modeling, cofactor docking, and molecular dynamics simulation studies
10.1074/jbc.m311876200 · 2004 · External reference
10.1128/iai.01226-07
10.1128/iai.01226-07 · External reference
Energetics of pathogenic bacteria and opportunities for drug development
2014 · External reference
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis an essential role for nad in nonreplicating bacilli
10.1074/jbc.m800694200 · 2008 · External reference
Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria
10.1128/mbio.00747-13 · 2014 · External reference
