Research graph
References from Surface Binding Energy Landscapes Affect Phosphodiesterase Isoform-Specific Inhibitor Selectivity. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1111/j.1476-5381.2011.01729.x
10.1111/j.1476-5381.2011.01729.x · External reference
10.1007/s10741-008-9130-x
10.1007/s10741-008-9130-x · External reference
Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia
10.1523/jneurosci.1635-10.2010 · 2010 · External reference
10.1242/jcs.01096
10.1242/jcs.01096 · External reference
Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists
10.1007/s11934-003-0027-x · 2003 · External reference
10.1038/bjp.2008.307
10.1038/bjp.2008.307 · External reference
Evaluation of a new bipyridine inotropic agent–milrinone–in patients with severe congestive heart failure
10.1056/nejm198309293091302 · 1983 · External reference
Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function
10.1038/ijir.2008.4 · 2008 · External reference
Milrinone: basic and clinical pharmacology and acute and chronic management
10.1016/s0002-9629(15)41723-9 · 1996 · External reference
10.1021/acs.jmedchem.5b01813
10.1021/acs.jmedchem.5b01813 · External reference
X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity
10.1021/ja404449g · 2013 · External reference
10.1016/j.neuropharm.2004.07.040
10.1016/j.neuropharm.2004.07.040 · External reference
10.1124/mol.115.099671
10.1124/mol.115.099671 · External reference
10.1016/j.drudis.2013.02.007
10.1016/j.drudis.2013.02.007 · External reference
10.1021/ja202726y
10.1021/ja202726y · External reference
Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity
10.1021/bi049868i · 2004 · External reference
Discovery of triazines as potent, selective and orally active PDE4 inhibitors
10.1016/j.bmcl.2013.05.099 · 2013 · External reference
Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development
10.1074/jbc.m512527200 · 2006 · External reference
10.1073/pnas.0401120101
10.1073/pnas.0401120101 · External reference
10.1073/pnas.0700279104
10.1073/pnas.0700279104 · External reference
10.1006/jmbi.1993.1626
10.1006/jmbi.1993.1626 · External reference
10.1038/nmeth.3213
10.1038/nmeth.3213 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
10.1021/ct300400x
10.1021/ct300400x · External reference
10.1063/1.445869
10.1063/1.445869 · External reference
10.1002/jcc.21816
10.1002/jcc.21816 · External reference
10.1063/1.467468
10.1063/1.467468 · External reference
10.1002/jcc.20289
10.1002/jcc.20289 · External reference
10.1063/1.464397
10.1063/1.464397 · External reference
10.1063/1.470117
10.1063/1.470117 · External reference
10.1016/0021-9991(77)90098-5
10.1016/0021-9991(77)90098-5 · External reference
10.1063/1.448118
10.1063/1.448118 · External reference
10.1103/physreva.31.1695
10.1103/physreva.31.1695 · External reference
10.1063/1.447334
10.1063/1.447334 · External reference
10.1093/nar/gki524
10.1093/nar/gki524 · External reference
A semiempirical free energy force field with charge-based desolvation
10.1002/jcc.20634 · 2007 · External reference
10.1002/jcc.21256
10.1002/jcc.21256 · External reference
Unresolved reference
1976 · External reference
Unresolved reference
2015 · External reference
Unresolved reference
2017 · External reference
Unresolved reference
2017 · External reference
10.1016/j.str.2004.10.004
10.1016/j.str.2004.10.004 · External reference
10.1110/ps.8.6.1181
10.1110/ps.8.6.1181 · External reference
10.1038/nature06522
10.1038/nature06522 · External reference
10.1038/nrd2082
10.1038/nrd2082 · External reference
Design strategies to address kinetics of drug binding and residence time
10.1016/j.bmcl.2015.02.027 · 2015 · External reference
10.1073/pnas.44.2.98
10.1073/pnas.44.2.98 · External reference
Strategies for the discovery of target-specific or isoform-selective modulators
10.1021/acs.jmedchem.5b00229 · 2015 · External reference
10.1126/science.1095920
10.1126/science.1095920 · External reference
10.1021/jm2010332
10.1021/jm2010332 · External reference
10.1021/jacs.6b11467
10.1021/jacs.6b11467 · External reference
10.1016/j.drudis.2016.11.001
10.1016/j.drudis.2016.11.001 · External reference
