Research graph
References from Bivalent Ligands for Protein Degradation in Drug Discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1016/j.molcel.2015.04.028
10.1016/j.molcel.2015.04.028 · External reference
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10.1038/nrd.2016.211 · External reference
Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States
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10.1016/j.pharmthera.2017.02.027
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Proteolysis Targeting Chimera (PROTAC): a paradigm-shifting approach in small molecule drug discovery
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PROTACs: an emerging targeting technique for protein degradation in drug discovery
10.1002/bies.201700247 · 2018 · External reference
10.1021/acs.jmedchem.7b01272
10.1021/acs.jmedchem.7b01272 · External reference
Unresolved reference
2001 · External reference
10.1126/science.2876518
10.1126/science.2876518 · External reference
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10.1038/349132a0 · External reference
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
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10.1126/science.7694365 · External reference
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10.1016/j.bmcl.2005.04.008
10.1016/j.bmcl.2005.04.008 · External reference
Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention
10.1124/mol.107.040840 · 2008 · External reference
10.1016/j.bmcl.2008.07.114
10.1016/j.bmcl.2008.07.114 · External reference
10.1016/j.bmc.2011.09.041
10.1016/j.bmc.2011.09.041 · External reference
Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins
10.1021/ja100691p · 2010 · External reference
10.1016/j.febslet.2011.03.019
10.1016/j.febslet.2011.03.019 · External reference
Unresolved reference
2018 · External reference
Unresolved reference
2018 · External reference
Unresolved reference
2018 · External reference
10.1038/s41589-018-0021-8
10.1038/s41589-018-0021-8 · External reference
Unresolved reference
2016 · External reference
10.1021/jm5011258
10.1021/jm5011258 · External reference
10.1126/science.aam7340
10.1126/science.aam7340 · External reference
10.1021/acs.biochem.8b00391
10.1021/acs.biochem.8b00391 · External reference
10.1021/acschembio.5b00216
10.1021/acschembio.5b00216 · External reference
10.1016/j.bmcl.2018.05.057
10.1016/j.bmcl.2018.05.057 · External reference
Three consecutive false negative pregnancy tests in a twin pregnancy: a case report
2006 · External reference
Delineating the role of cooperativity in the design of potent PROTACs for BTK
10.1073/pnas.1803662115 · 2018 · External reference
10.1371/journal.pcbi.1000975
10.1371/journal.pcbi.1000975 · External reference
Cooperative binding mitigates the high-dose hook effect
2017 · External reference
10.1016/j.bbrc.2018.09.169
10.1016/j.bbrc.2018.09.169 · External reference
Unresolved reference
External reference
Unresolved reference
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10.1021/acs.jmedchem.6b01781
10.1021/acs.jmedchem.6b01781 · External reference
10.1002/anie.201507634
10.1002/anie.201507634 · External reference
10.1042/bj20141450
10.1042/bj20141450 · External reference
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
10.1016/j.bbamcr.2011.10.008 · 2012 · External reference
10.1038/nm.1754
10.1038/nm.1754 · External reference
10.1002/anie.201307761
10.1002/anie.201307761 · External reference
10.1002/anie.201507978
10.1002/anie.201507978 · External reference
10.1042/bcj20160762
10.1042/bcj20160762 · External reference
Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
10.1038/onc.2008.320 · 2008 · External reference
10.1002/cbic.201000222
10.1002/cbic.201000222 · External reference
10.1073/pnas.1217206110
10.1073/pnas.1217206110 · External reference
10.1016/j.bcp.2016.07.017
10.1016/j.bcp.2016.07.017 · External reference
Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles
10.1186/s13619-015-0015-x · 2015 · External reference
10.1016/j.bcp.2015.12.006
10.1016/j.bcp.2015.12.006 · External reference
Inside HDACs with more selective HDAC inhibitors
10.1016/j.ejmech.2016.05.047 · 2016 · External reference
Targeting Brd4 for cancer therapy: inhibitors and degraders
10.1039/c8md00198g · 2018 · External reference
10.1002/tcr.201800074
10.1002/tcr.201800074 · External reference
10.1038/nchembio.2115
10.1038/nchembio.2115 · External reference
LP99: Discovery and Synthesis of the first Selective BRD7/9 Bromodomain Inhibitor
10.1002/anie.201501394 · 2015 · External reference
10.1021/acs.jmedchem.5b01865
10.1021/acs.jmedchem.5b01865 · External reference
10.1002/anie.201611281
10.1002/anie.201611281 · External reference
The human Sir2 ortholog, SIRT2, is an NAD+−dependent tubulin deacetylase
10.1016/s1097-2765(03)00038-8 · 2003 · External reference
10.1002/emmm.201302451
10.1002/emmm.201302451 · External reference
10.1016/j.ccr.2011.09.004
10.1016/j.ccr.2011.09.004 · External reference
10.1021/acs.jmedchem.6b01872
10.1021/acs.jmedchem.6b01872 · External reference
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
10.1038/ng.2007.15 · 2007 · External reference
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
10.1002/j.1460-2075.1996.tb01060.x · 1996 · External reference
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
10.1186/s13072-015-0026-4 · 2015 · External reference
Structure-guided design of IACS-9571, a selective high-affinity dual TRIM24-BRPF1 bromodomain inhibitor
10.1021/acs.jmedchem.5b00405 · 2016 · External reference
10.1038/nrd4360
10.1038/nrd4360 · External reference
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor
10.1158/1078-0432.ccr-08-0642 · 2008 · External reference
Overexpression of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells
10.3892/or.2012.1898 · 2012 · External reference
10.1021/acschembio.8b00705
10.1021/acschembio.8b00705 · External reference
Discovery of pyrazolo[1,5-a]pyrimidine B-cell lymphoma 6 (BCL6) binders and optimization to high affinity macrocyclic inhibitors
10.1021/acs.jmedchem.7b00359 · 2017 · External reference
Development of a novel B-Cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
10.1021/acschembio.8b00698 · 2018 · External reference
10.1016/j.chembiol.2015.05.009
10.1016/j.chembiol.2015.05.009 · External reference
10.1073/pnas.1521738113
10.1073/pnas.1521738113 · External reference
10.1021/acscentsci.6b00280
10.1021/acscentsci.6b00280 · External reference
10.1021/acs.jmedchem.6b01816
10.1021/acs.jmedchem.6b01816 · External reference
10.1038/s41589-018-0055-y
10.1038/s41589-018-0055-y · External reference
10.1021/acs.jmedchem.8b00506
10.1021/acs.jmedchem.8b00506 · External reference
10.1038/nrd.2017.178
10.1038/nrd.2017.178 · External reference
10.1038/nrc2559
10.1038/nrc2559 · External reference
Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic strategies
10.1158/1078-0432.ccr-13-1610 · 2014 · External reference
10.1016/j.chembiol.2017.10.005
10.1016/j.chembiol.2017.10.005 · External reference
10.1016/j.chembiol.2017.10.011
10.1016/j.chembiol.2017.10.011 · External reference
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
10.15252/embj.201899372 · 2018 · External reference
ERK1 and ERK2 map kinases: specific roles or functional redundancy?
10.3389/fcell.2016.00053 · 2016 · External reference
10.1039/c7cc03879h
10.1039/c7cc03879h · External reference
10.1038/nchembio.2538
10.1038/nchembio.2538 · External reference
10.1016/j.bioorg.2018.08.028
10.1016/j.bioorg.2018.08.028 · External reference
10.1016/j.chembiol.2017.09.009
10.1016/j.chembiol.2017.09.009 · External reference
10.1021/acs.jmedchem.7b00635
10.1021/acs.jmedchem.7b00635 · External reference
10.1016/j.ejmech.2018.03.066
10.1016/j.ejmech.2018.03.066 · External reference
10.1016/j.ejmech.2018.03.071
10.1016/j.ejmech.2018.03.071 · External reference
10.1021/acs.jmedchem.7b01655
10.1021/acs.jmedchem.7b01655 · External reference
Development of highly potent and selective steroidal inhibitors and degraders of CDK8
10.1021/acsmedchemlett.8b00011 · 2018 · External reference
10.1038/s41422-018-0055-1
10.1038/s41422-018-0055-1 · External reference
10.1242/jcs.00074
10.1242/jcs.00074 · External reference
10.1042/bj20080309
10.1042/bj20080309 · External reference
10.1016/j.bioorg.2018.09.005
10.1016/j.bioorg.2018.09.005 · External reference
10.1073/pnas.0609412103
10.1073/pnas.0609412103 · External reference
10.1038/nrd1551
10.1038/nrd1551 · External reference
10.1093/emboj/cdf406
10.1093/emboj/cdf406 · External reference
10.1002/pros.20568
10.1002/pros.20568 · External reference
10.1021/acs.jcim.8b00283
10.1021/acs.jcim.8b00283 · External reference
10.1002/anie.201503720
10.1002/anie.201503720 · External reference
10.1038/s42003-018-0105-8
10.1038/s42003-018-0105-8 · External reference
10.1016/j.cell.2006.07.025
10.1016/j.cell.2006.07.025 · External reference
10.1038/nrd2056
10.1038/nrd2056 · External reference
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
10.1038/s41467-017-00954-1 · 2017 · External reference
10.1021/acschembio.8b00693
10.1021/acschembio.8b00693 · External reference
On dihydroorotate dehydrogenases and their inhibitors and uses
10.1021/jm301848w · 2013 · External reference
Evaluation of WO2013076170: the use of a dihydroorotate dehydrogenase inhibitor for the treatment of psoriasis
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Design, synthesis, and characterization of brequinar conjugates as probes to study DHODH inhibition
10.1002/chem.201702999 · 2017 · External reference
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10.3390/ijms19041160 · External reference
Progression of Alzheimer's disease, tau propagation, and its modifiable risk factors
2018 · External reference
10.1016/j.ejmech.2018.01.063
10.1016/j.ejmech.2018.01.063 · External reference
10.1021/acs.chemrev.5b00205
10.1021/acs.chemrev.5b00205 · External reference
Unresolved reference
External reference
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10.1038/s41375-018-0044-x · External reference
10.1016/j.molcel.2014.05.016
10.1016/j.molcel.2014.05.016 · External reference
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10.1002/cmdc.201300434 · External reference
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10.1021/acs.jmedchem.5b01708
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10.1021/acs.jmedchem.6b01912
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