Research graph
References from Stapled Peptides Inhibitors: A New Window for Target Drug Discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1111/cbdd.12055
10.1111/cbdd.12055 · External reference
10.1016/j.canlet.2013.07.029
10.1016/j.canlet.2013.07.029 · External reference
10.1016/j.drudis.2007.07.011
10.1016/j.drudis.2007.07.011 · External reference
Characterization of protein-protein interfaces
10.1007/s10930-007-9108-x · 2008 · External reference
Unresolved reference
2012 · External reference
10.1016/j.drudis.2010.05.015
10.1016/j.drudis.2010.05.015 · External reference
10.1016/j.tips.2013.04.007
10.1016/j.tips.2013.04.007 · External reference
10.1017/erm.2012.10
10.1017/erm.2012.10 · External reference
10.4155/fmc.14.50
10.4155/fmc.14.50 · External reference
10.1146/annurev.biophys.36.040306.132550
10.1146/annurev.biophys.36.040306.132550 · External reference
10.1016/j.crci.2015.12.004
10.1016/j.crci.2015.12.004 · External reference
Further insights into the effects of pre-organizing the BimBH3 Helix
10.1021/cb400638p · 2014 · External reference
10.1038/nsmb.2922
10.1038/nsmb.2922 · External reference
10.1039/c4cs00246f
10.1039/c4cs00246f · External reference
Serum stability of peptides
10.1007/978-1-59745-419-3_10 · 2008 · External reference
10.1016/j.ejmech.2015.01.014
10.1016/j.ejmech.2015.01.014 · External reference
10.1016/j.tips.2012.03.006
10.1016/j.tips.2012.03.006 · External reference
10.1016/j.bmc.2017.06.052
10.1016/j.bmc.2017.06.052 · External reference
10.1021/ja000563a
10.1021/ja000563a · External reference
Unresolved reference
2005 · External reference
10.1021/ar800064f
10.1021/ar800064f · External reference
10.1073/pnas.1002498107
10.1073/pnas.1002498107 · External reference
10.1038/nprot.2011.324
10.1038/nprot.2011.324 · External reference
Highly efficient synthesis of covalently cross-linked peptide helices by ring-closing metathesis
10.1002/(sici)1521-3773(19981217)37:23<3281::aid-anie3281>3.0.co;2-v · 1998 · External reference
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
10.1126/science.1099191 · 2004 · External reference
10.4155/fmc.12.76
10.4155/fmc.12.76 · External reference
Cancer immunotherapy: present status, future perspective, and a new paradigm of peptide immunotherapeutics
2013 · External reference
Synthetic therapeutic peptides: science and market
10.1016/j.drudis.2009.10.009 · 2010 · External reference
10.1021/ja0693587
10.1021/ja0693587 · External reference
10.1073/pnas.1002713107
10.1073/pnas.1002713107 · External reference
10.1002/9780470559277.ch110042
10.1002/9780470559277.ch110042 · External reference
10.1021/jm4011675
10.1021/jm4011675 · External reference
A thiol – Ene coupling approach to native peptide stapling and macrocyclization ** Angewandte
10.1002/anie.201503975 · 2015 · External reference
Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-x L
10.1002/cbic.200800502 · 2008 · External reference
Stapled α−helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
10.1073/pnas.1303002110 · 2013 · External reference
Unresolved reference
2014 · External reference
10.1111/j.1399-3011.1988.tb01375.x
10.1111/j.1399-3011.1988.tb01375.x · External reference
10.1021/bi00838a031
10.1021/bi00838a031 · External reference
10.1021/ja0456003
10.1021/ja0456003 · External reference
10.1021/jm200839a
10.1021/jm200839a · External reference
10.1039/b613014n
10.1039/b613014n · External reference
Cui catalyzed azide-alkyne intramolecular i-to-(i+4) side-chain-to-SideChain cyclization promotes the formation of Helix-like secondary structures
10.1002/ejoc.200901157 · 2010 · External reference
10.1021/jm201125d
10.1021/jm201125d · External reference
10.1016/j.bmcl.2011.01.004
10.1016/j.bmcl.2011.01.004 · External reference
General approach to the synthesis of short .alpha.-helical peptides
10.1021/ja00024a067 · 1991 · External reference
Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links
10.1039/c1cc12010g · 2011 · External reference
10.1021/ja9611654
10.1021/ja9611654 · External reference
10.1021/ja400119t
10.1021/ja400119t · External reference
Synthesis of constrained helical peptides by thioether ligation: application to analogs of gp41
10.1039/b419015g · 2005 · External reference
10.1128/jvi.80.4.1680-1687.2006
10.1128/jvi.80.4.1680-1687.2006 · External reference
Unresolved reference
External reference
IKKγ-mimetic peptides block the resistance to apoptosis associated with Kaposi's sarcoma-associated herpesvirus infection
10.1128/jvi.01170-17 · 2017 · External reference
10.1021/acschembio.6b00727
10.1021/acschembio.6b00727 · External reference
Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot
10.1074/jbc.c110.105825 · 2010 · External reference
10.1021/jacs.6b10234
10.1021/jacs.6b10234 · External reference
Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7
10.1038/srep27060 · 2016 · External reference
10.1093/protein/gzx029
10.1093/protein/gzx029 · External reference
Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces
10.1038/srep03451 · 2013 · External reference
Structure-enabled discovery of a stapled peptide inhibitor to target the oncogenic transcriptional repressor TLE1
10.1002/chem.201700747 · 2017 · External reference
10.1016/j.cell.2005.08.029
10.1016/j.cell.2005.08.029 · External reference
Structure of the MSM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
10.1126/science.274.5289.948 · 1996 · External reference
10.1021/ja2090367
10.1021/ja2090367 · External reference
10.1371/journal.pone.0104914
10.1371/journal.pone.0104914 · External reference
10.1002/anie.201508416
10.1002/anie.201508416 · External reference
10.1021/acs.jpclett.6b01525
10.1021/acs.jpclett.6b01525 · External reference
10.1371/journal.pone.0189379
10.1371/journal.pone.0189379 · External reference
Unresolved reference
External reference
10.1038/nchembio.391
10.1038/nchembio.391 · External reference
10.1039/c5sc04048e
10.1039/c5sc04048e · External reference
Iterative optimization yields mcl-1–targeting stapled peptides with selective cytotoxicity to mcl-1–dependent cancer cells
2018 · External reference
10.1016/j.str.2017.11.016
10.1016/j.str.2017.11.016 · External reference
10.1021/ja202946k
10.1021/ja202946k · External reference
Stapled peptides with γ-methylated hydrocarbon chains for the estrogen receptor/coactivator interaction
10.1002/anie.201510557 · 2016 · External reference
10.1039/c8ob00790j
10.1039/c8ob00790j · External reference
10.1021/jm401730y
10.1021/jm401730y · External reference
10.1073/pnas.1208396109
10.1073/pnas.1208396109 · External reference
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex
10.1126/science.1209307 · 2011 · External reference
10.1021/acschemneuro.6b00454
10.1021/acschemneuro.6b00454 · External reference
10.1021/jacs.7b08972
10.1021/jacs.7b08972 · External reference
10.1002/anie.201705611
10.1002/anie.201705611 · External reference
10.1002/chem.201300506
10.1002/chem.201300506 · External reference
Lybatides from Lycium barbarum contain an unusual cystine-stapled helical peptide scaffold
2017 · External reference
Structure at 2.5-Å resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor
10.1021/bi00220a023 · 1991 · External reference
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor
10.1073/pnas.87.22.8805 · 1990 · External reference
10.1074/jbc.c800048200
10.1074/jbc.c800048200 · External reference
10.1002/cbic.200700251
10.1002/cbic.200700251 · External reference
Solution structure and thermodynamic investigation of the HIV-1 frameshift inducing element
10.1016/j.jmb.2005.03.038 · 2005 · External reference
Solution structure of the HIV-1 frameshift inducing stem-loop RNA
10.1093/nar/gkg654 · 2003 · External reference
10.1111/febs.13129
10.1111/febs.13129 · External reference
Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction
10.1021/cb500271c · 2014 · External reference
Crystal structures of Beta- and Gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry
10.1128/jvi.02023-13 · 2014 · External reference
Actin by stapling filaments with nonglobular protein arms
10.1126/science.1088433 · 2003 · External reference
10.1039/c0cc04795c
10.1039/c0cc04795c · External reference
10.1016/j.bioorg.2018.07.013
10.1016/j.bioorg.2018.07.013 · External reference
Cullin3 - BTB interface:a novel target for stapled peptides
10.1371/journal.pone.0121149 · 2015 · External reference
10.1016/j.jmb.2007.08.033
10.1016/j.jmb.2007.08.033 · External reference
10.1110/ps.9.5.942
10.1110/ps.9.5.942 · External reference
Circular permutation of the Trp-cage: fold rescue upon addition of a hydrophobic staple
10.1039/c3ra43674h · 2013 · External reference
10.1021/cb3005148
10.1021/cb3005148 · External reference
Enhancing specific disruption of intracellular protein complexes by hydrocarbon stapled peptides using lipid based delivery
10.1038/s41598-017-01712-5 · 2017 · External reference
10.1038/nm.3048
10.1038/nm.3048 · External reference
10.1038/leu.2010.35
10.1038/leu.2010.35 · External reference
10.1111/bjh.12457
10.1111/bjh.12457 · External reference
10.1182/blood-2013-01-475855
10.1182/blood-2013-01-475855 · External reference
10.1182/blood.v99.6.1885
10.1182/blood.v99.6.1885 · External reference
10.1016/j.ccr.2006.10.006
10.1016/j.ccr.2006.10.006 · External reference
10.1158/1541-7786.mcr-08-0358
10.1158/1541-7786.mcr-08-0358 · External reference
10.1158/0008-5472.can-06-1788
10.1158/0008-5472.can-06-1788 · External reference
10.1152/physrev.00026.2006
10.1152/physrev.00026.2006 · External reference
Meta-analyses of adjuvant therapies for women with early breast cancer: the early breast Cancer Trialists' collaborative group overview
10.1093/annonc/mdl238 · 2006 · External reference
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
10.1016/s0140-6736(05)66544-0 · 2005 · External reference
10.1016/j.drudis.2016.06.012
10.1016/j.drudis.2016.06.012 · External reference
Computational modeling of stapled peptides toward a treatment strategy for CML and broader implications in the design of lengthy peptide therapeutics
10.1021/acs.jpcb.8b01014 · 2018 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
10.1021/ja00124a002
10.1021/ja00124a002 · External reference
10.1021/ct5010406
10.1021/ct5010406 · External reference
10.1038/nature03579
10.1038/nature03579 · External reference
Small-molecule inhibitors of the p53-MDM2 interaction
2011 · External reference
HSP90 as a new therapeutic target for cancer therapy: the story unfolds
10.1517/14712598.2.1.3 · 2002 · External reference
10.1158/1078-0432.ccr-11-1000
10.1158/1078-0432.ccr-11-1000 · External reference
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
10.1182/blood-2006-10-047951 · 2007 · External reference
10.1073/pnas.0709443104
10.1073/pnas.0709443104 · External reference
A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer
10.1016/j.lungcan.2011.05.005 · 2011 · External reference
10.1038/leu.2012.88
10.1038/leu.2012.88 · External reference
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
10.1126/science.1092472 · 2004 · External reference
10.1007/s002800050817
10.1007/s002800050817 · External reference
Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
2016 · External reference
10.1021/mp400680d
10.1021/mp400680d · External reference
Safety and efficacy of Oral octreotide in acromegaly: results of a multicenter phase III trial
10.1210/jc.2014-4113 · 2015 · External reference
10.1016/j.addr.2016.10.005
10.1016/j.addr.2016.10.005 · External reference
10.1111/bph.13834
10.1111/bph.13834 · External reference
10.1021/cb3005403
10.1021/cb3005403 · External reference
10.1038/nature08543
10.1038/nature08543 · External reference
Unresolved reference
2015 · External reference
Unresolved reference
2015 · External reference
The BRET technology and its application to screening assays
10.1002/biot.200700222 · 2008 · External reference
10.1038/nmeth947
10.1038/nmeth947 · External reference
10.1016/j.ccr.2010.10.024
10.1016/j.ccr.2010.10.024 · External reference
Visualization and targeted disruption of protein interactions in living cells
10.1038/ncomms3660 · 2013 · External reference
Unresolved reference
2014 · External reference
