Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from An Energetically Favorable Ligand Entrance Gate of a Multidrug Transporter Revealed by Partial Nudged Elastic Band Simulations. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nature05630
10.1038/nature05630 · External reference
P-glycoproteins: mediators of multidrug resistance
10.1006/scel.1993.1008 · 1993 · External reference
10.1126/science.6137059
10.1126/science.6137059 · External reference
10.1016/j.drup.2014.11.002
10.1016/j.drup.2014.11.002 · External reference
10.1016/0005-2736(76)90160-7
10.1016/0005-2736(76)90160-7 · External reference
10.1074/jbc.m308559200
10.1074/jbc.m308559200 · External reference
Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs
10.1021/bi0511179 · 2005 · External reference
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
10.1073/pnas.94.20.10594 · 1997 · External reference
10.1074/jbc.m310448200
10.1074/jbc.m310448200 · External reference
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site
10.1046/j.1432-1327.1999.00098.x · 1999 · External reference
10.1124/mol.58.3.624
10.1124/mol.58.3.624 · External reference
10.1111/j.1432-1033.1997.00130.x
10.1111/j.1432-1033.1997.00130.x · External reference
Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate
10.1074/jbc.272.51.31945 · 1997 · External reference
Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane
10.1074/jbc.274.50.35388 · 1999 · External reference
Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane
10.1074/jbc.m007741200 · 2000 · External reference
10.1074/jbc.m100407200
10.1074/jbc.m100407200 · External reference
Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site
10.1074/jbc.c300154200 · 2003 · External reference
10.1042/bj20060715
10.1042/bj20060715 · External reference
10.1042/bj20060012
10.1042/bj20060012 · External reference
Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein
10.1074/jbc.m208433200 · 2002 · External reference
The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface
10.1074/jbc.274.35.24759 · 1999 · External reference
Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding
10.1074/jbc.c300073200 · 2003 · External reference
10.1007/s00232-005-0792-1
10.1007/s00232-005-0792-1 · External reference
10.1126/science.1168750
10.1126/science.1168750 · External reference
10.1002/pro.2387
10.1002/pro.2387 · External reference
10.1073/pnas.1309275110
10.1073/pnas.1309275110 · External reference
10.1107/s1399004715000978
10.1107/s1399004715000978 · External reference
10.1126/sciadv.1600001
10.1126/sciadv.1600001 · External reference
10.1016/j.ijpharm.2016.02.022
10.1016/j.ijpharm.2016.02.022 · External reference
10.1007/s10822-013-9697-8
10.1007/s10822-013-9697-8 · External reference
The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter
10.1021/bi990064q · 1999 · External reference
10.1016/0968-0004(92)90419-a
10.1016/0968-0004(92)90419-a · External reference
Biochemistry of multidrug resistance mediated by the multidrug transporter
10.1146/annurev.bi.62.070193.002125 · 1993 · External reference
Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein
10.1046/j.1432-1327.1998.2540181.x · 1998 · External reference
10.1111/j.1432-1033.1997.00122.x
10.1111/j.1432-1033.1997.00122.x · External reference
10.1038/nature11448
10.1038/nature11448 · External reference
10.1021/acs.biochem.5b00649
10.1021/acs.biochem.5b00649 · External reference
A partial nudged elastic band implementation for use with large or explicitly solvated systems
10.1002/qua.22405 · 2009 · External reference
Unresolved reference
2012 · External reference
Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"?
10.1016/j.bbrc.2005.01.134 · 2005 · External reference
10.1002/cmdc.201300233
10.1002/cmdc.201300233 · External reference
10.1039/c0cc03075a
10.1039/c0cc03075a · External reference
10.1021/jm201705f
10.1021/jm201705f · External reference
10.1016/j.jmgm.2013.09.001
10.1016/j.jmgm.2013.09.001 · External reference
10.1073/pnas.1303888110
10.1073/pnas.1303888110 · External reference
10.1016/j.bcp.2016.08.013
10.1016/j.bcp.2016.08.013 · External reference
10.1038/nature21414
10.1038/nature21414 · External reference
10.1002/prot.24324
10.1002/prot.24324 · External reference
10.1073/pnas.1321562111
10.1073/pnas.1321562111 · External reference
10.1016/j.tibs.2009.10.007
10.1016/j.tibs.2009.10.007 · External reference
Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein
10.1021/bi00251a013 · 1994 · External reference
10.1124/mol.51.6.922
10.1124/mol.51.6.922 · External reference
10.1021/acs.jctc.5b00652
10.1021/acs.jctc.5b00652 · External reference
10.1124/mol.110.067611
10.1124/mol.110.067611 · External reference
