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References from The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa. Local targets link to admitted publications; unresolved targets remain external evidence.
Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets
10.1111/odi.12275 · 2015 · External reference
Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets
10.1111/odi.12275 · 2015 · External reference
10.1007/s11427-014-4665-7
10.1007/s11427-014-4665-7 · External reference
Unresolved reference
2014 · External reference
10.1007/s10585-012-9464-6
10.1007/s10585-012-9464-6 · External reference
10.1038/emboj.2009.284
10.1038/emboj.2009.284 · External reference
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca2+ homeostasis in melanoma cells
10.1007/s00018-009-0214-0 · 2010 · External reference
PDE6 isoforms are expressed in native endothelium but not in cultured cell lines
10.1096/fasebj.30.1_supplement.727.8 · 2016 · External reference
Evidence that NO/cGMP/PKG signalling cascade mediates endothelium dependent inhibition of IP 3 R mediated Ca 2+ oscillations in myocytes and pericytes of ureteric microvascular network in situ
10.1016/j.ceca.2015.08.006 · 2015 · External reference
An iterative structure-assisted approach to sequence alignment and comparative modeling
10.1002/(sici)1097-0134(1999)37:3+<55::aid-prot8>3.0.co;2-b · 1999 · External reference
10.1107/s0907444909042073
10.1107/s0907444909042073 · External reference
High-resolution homozygosity mapping is a powerful tool to detect novel mutations causative of autosomal recessive RP in the Dutch population
10.1167/iovs.10-6185 · 2011 · External reference
International network of cancer genome projects
10.1038/nature08987 · 2010 · External reference
10.1210/mend.14.9.0534
10.1210/mend.14.9.0534 · External reference
10.1146/annurev.biochem.76.060305.150444
10.1146/annurev.biochem.76.060305.150444 · External reference
Unresolved reference
2012 · External reference
Unresolved reference
2002 · External reference
Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells
10.1186/2193-1801-2-680 · 2013 · External reference
Frequency of mutations in the gene encoding the α subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis Pigmentosa
1999 · External reference
10.1067/mai.2001.119555
10.1067/mai.2001.119555 · External reference
Unresolved reference
2008 · External reference
OASIS: web-based platform for exploring cancer multi-omics data
10.1038/nmeth.3692 · 2015 · External reference
10.2174/138920211795860107
10.2174/138920211795860107 · External reference
10.1016/j.cub.2004.11.024
10.1016/j.cub.2004.11.024 · External reference
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
10.1093/nar/gku1075 · 2014 · External reference
10.1152/physrev.00030.2010
10.1152/physrev.00030.2010 · External reference
10.1124/pr.110.002907
10.1124/pr.110.002907 · External reference
10.1038/ng0594-64
10.1038/ng0594-64 · External reference
10.1016/j.jmb.2010.06.044
10.1016/j.jmb.2010.06.044 · External reference
The history and role of naturally occurring mouse models with Pde6b mutations
2013 · External reference
10.1006/dbio.1997.8552
10.1006/dbio.1997.8552 · External reference
Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations
10.1038/cddiscovery.2016.40 · 2016 · External reference
Splice-site mutations identified in PDE6A responsible for retinitis pigmentosa in consanguineous Pakistani families
2015 · External reference
10.1038/ng.2359
10.1038/ng.2359 · External reference
10.1002/iub.1111
10.1002/iub.1111 · External reference
10.1074/jbc.m603603200
10.1074/jbc.m603603200 · External reference
Homozygosity mapping and targeted sanger sequencing reveal genetic defects underlying inherited retinal disease in families from Pakistan
10.1371/journal.pone.0119806 · 2015 · External reference
10.1074/jbc.m802891200
10.1074/jbc.m802891200 · External reference
Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
10.1073/pnas.1108121108 · 2011 · External reference
JOY: protein sequence-structure representation and analysis
1998 · External reference
10.1046/j.1471-4159.2001.00407.x
10.1046/j.1471-4159.2001.00407.x · External reference
10.1038/nature11252
10.1038/nature11252 · External reference
10.1073/pnas.0907635106
10.1073/pnas.0907635106 · External reference
SDM: a server for predicting effects of mutations on protein stability
10.1093/nar/gkx439 · 2017 · External reference
Unresolved reference
2005 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
mCSM: Predicting the effects of mutations in proteins using graph-based signatures
10.1093/bioinformatics/btt691 · 2013 · External reference
10.1093/nar/gku411
10.1093/nar/gku411 · External reference
Mutations in the gene encoding the alpha-subunit of rod phosphodiesterase in consanguineous Pakistani families
2006 · External reference
Evaluation of comparative protein modeling by modeller
10.1002/prot.340230306 · 1995 · External reference
10.1126/science.1175668
10.1126/science.1175668 · External reference
10.1110/ps.062416606
10.1110/ps.062416606 · External reference
FUGUE: Sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties1
10.1006/jmbi.2001.4762 · 2001 · External reference
Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities
10.1093/bioinformatics/btm073 · 2007 · External reference
10.1093/hmg/ddv275
10.1093/hmg/ddv275 · External reference
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic β-cells
10.1111/j.1600-079x.2008.00593.x · 2008 · External reference
10.1006/jmbi.2001.4813
10.1006/jmbi.2001.4813 · External reference
10.1093/nar/22.22.4673
10.1093/nar/22.22.4673 · External reference
10.1016/j.cellsig.2017.05.012
10.1016/j.cellsig.2017.05.012 · External reference
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
10.1158/2159-8290.cd-13-0617 · 2013 · External reference
10.1074/jbc.m110.141614
10.1074/jbc.m110.141614 · External reference
10.1073/pnas.0602795103
10.1073/pnas.0602795103 · External reference
Unresolved reference
2019 · External reference
10.1016/j.molcel.2004.07.005
10.1016/j.molcel.2004.07.005 · External reference
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors
10.1021/bi7010702 · 2007 · External reference
