Research graph
References from Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/25519
10.1038/25519 · External reference
Out of control: accelerated aging in uremia
10.1093/ndt/gfs451 · 2013 · External reference
Premature aging in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences
2015 · External reference
Premature cardiovascular disease in chronic renal failure (CRF): a model for an advanced ageing process
10.1016/j.exger.2010.04.003 · 2010 · External reference
10.1038/nrneph.2014.185
10.1038/nrneph.2014.185 · External reference
10.1053/j.ajkd.2012.11.051
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Early vascular ageing (EVA): definitions and clinical applicability
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Mechanisms of vascular calcification in CKD - evidence for premature ageing?
10.1038/nrneph.2013.176 · 2013 · External reference
Mechanistic insights into vascular calcification in CKD
10.1681/asn.2011121191 · 2013 · External reference
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10.1007/s12079-017-0434-2 · External reference
10.1038/nrneph.2016.183
10.1038/nrneph.2016.183 · External reference
Cellular senescence in pretransplant renal biopsies predicts postoperative organ function
10.1111/j.1474-9726.2008.00447.x · 2009 · External reference
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
2014 · External reference
10.1038/nature03841
10.1038/nature03841 · External reference
10.1074/jbc.m409153200
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10.1038/nrm2233
10.1038/nrm2233 · External reference
10.1016/0014-4827(61)90192-6
10.1016/0014-4827(61)90192-6 · External reference
The limited in vitro lifetime of human diploid cell strains
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Youthful systemic milieu alleviates renal ischemia-reperfusion injury in elderly mice
10.1016/j.kint.2018.03.019 · 2018 · External reference
Young blood for old kidneys? More questions than answers so far
10.1016/j.kint.2018.04.015 · 2018 · External reference
Vitamin D and kidney disease
10.1016/j.bonr.2018.07.002 · 2018 · External reference
10.1111/acel.12344
10.1111/acel.12344 · External reference
Identification of HSP90 inhibitors as a novel class of senolytics
2017 · External reference
10.1111/acel.12445
10.1111/acel.12445 · External reference
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
2015 · External reference
10.1038/nature13193
10.1038/nature13193 · External reference
10.1038/366704a0
10.1038/366704a0 · External reference
10.1016/j.devcel.2014.11.012
10.1016/j.devcel.2014.11.012 · External reference
Upregulation of chicken p15INK4b at senescence and in the developing brain
10.1242/jcs.02989 · 2006 · External reference
10.1016/j.cell.2013.10.041
10.1016/j.cell.2013.10.041 · External reference
10.1097/hjh.0b013e3283399326
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Senescent intimal foam cells are deleterious at all stages of atherosclerosis
10.1126/science.aaf6659 · 2016 · External reference
10.1038/ncb1909
10.1038/ncb1909 · External reference
Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
10.1111/j.1600-6143.2005.00846.x · 2005 · External reference
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
10.1172/jci64098 · 2013 · External reference
10.1038/s41569-018-0064-2
10.1038/s41569-018-0064-2 · External reference
Inflammation and premature aging in advanced chronic kidney disease
10.1152/ajprenal.00256.2017 · 2017 · External reference
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
2012 · External reference
When cells get stressed: an integrative view of cellular senescence
10.1172/jci200420663 · 2004 · External reference
10.1046/j.1474-9728.2003.00048.x
10.1046/j.1474-9728.2003.00048.x · External reference
10.1038/nbt0702-682
10.1038/nbt0702-682 · External reference
10.1038/ncb1201-e277
10.1038/ncb1201-e277 · External reference
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
10.1126/science.277.5327.831 · 1997 · External reference
10.1093/emboj/cdg417
10.1093/emboj/cdg417 · External reference
10.1016/s1535-6108(02)00102-2
10.1016/s1535-6108(02)00102-2 · External reference
10.1016/s0092-8674(03)00401-x
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10.1016/s0959-437x(02)00013-8
10.1016/s0959-437x(02)00013-8 · External reference
What can progeroid syndromes tell us about human aging?
10.1126/science.1102587 · 2004 · External reference
Cellular senescence: putting the paradoxes in perspective
10.1016/j.gde.2010.10.005 · 2011 · External reference
10.1038/nm.2014
10.1038/nm.2014 · External reference
10.1083/jcb.201009094
10.1083/jcb.201009094 · External reference
10.1038/ncb2070
10.1038/ncb2070 · External reference
Cellular senescence controls fibrosis in wound healing
10.18632/aging.100201 · 2010 · External reference
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
10.1038/ncb1699 · 2008 · External reference
10.1016/j.ccr.2004.09.028
10.1016/j.ccr.2004.09.028 · External reference
Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells
10.1073/pnas.91.8.3329 · 1994 · External reference
10.1101/gad.17276711
10.1101/gad.17276711 · External reference
10.1046/j.1365-2443.2003.00620.x
10.1046/j.1365-2443.2003.00620.x · External reference
10.18632/aging.100520
10.18632/aging.100520 · External reference
10.1016/j.kint.2018.12.014
10.1016/j.kint.2018.12.014 · External reference
10.1111/jgs.14969
10.1111/jgs.14969 · External reference
Overviews of biological importance of quercetin: a bioactive flavonoid
10.4103/0973-7847.194044 · 2016 · External reference
10.1021/jm049486a
10.1021/jm049486a · External reference
Transplanted senescent cells induce an osteoarthritis-like condition in mice
2017 · External reference
Transgenic overexpression of tartrate-resistant acid phosphatase is associated with induction of osteoblast gene expression and increased cortical bone mineral content and density
10.1159/000330806 · 2012 · External reference
10.1016/j.ebiom.2017.04.013
10.1016/j.ebiom.2017.04.013 · External reference
Protective action of fish muscle extracts against cellular senescence induced by oxidative stress
10.18097/pbmc20176304351 · 2017 · External reference
10.1038/ncomms14532
10.1038/ncomms14532 · External reference
Senolytic cocktail Dasatinib+quercetin (D+Q) does not enhance the efficacy of senescence-inducing chemotherapy in liver cancer
10.3389/fonc.2018.00459 · 2018 · External reference
10.1038/nm.4000
10.1038/nm.4000 · External reference
Understanding the role of the cytoprotective transcription factor NRF2 - Lessons from evolution, the animal kingdom and rare progeroid syndromes
2019 · External reference
Bone and mineral disorders in chronic kidney disease: implications for cardiovascular health and ageing in the general population
10.1016/s2213-8587(17)30310-8 · 2018 · External reference
10.1016/j.arr.2008.07.002
10.1016/j.arr.2008.07.002 · External reference
10.1016/j.mad.2006.11.016
10.1016/j.mad.2006.11.016 · External reference
10.1016/j.mad.2006.11.015
10.1016/j.mad.2006.11.015 · External reference
Telomere attrition is associated with inflammation, low fetuin-a levels and high mortality in prevalent haemodialysis patients
10.1111/j.1365-2796.2007.01890.x · 2008 · External reference
Persistent inflammation as a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal
10.2215/cjn.02720409 · 2009 · External reference
Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model
10.1007/s00223-014-9929-5 · 2015 · External reference
10.1371/journal.pone.0092115
10.1371/journal.pone.0092115 · External reference
10.1152/ajprenal.00527.2012
10.1152/ajprenal.00527.2012 · External reference
10.18632/aging.101173
10.18632/aging.101173 · External reference
10.1053/j.ajkd.2010.12.027
10.1053/j.ajkd.2010.12.027 · External reference
Circulating klotho levels: clinical relevance and relationship with tissue klotho expression
10.1038/ki.2012.370 · 2013 · External reference
Suppression of aging in mice by the hormone Klotho
10.1126/science.1112766 · 2005 · External reference
The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells
10.1111/jcmm.12996 · 2017 · External reference
10.1161/hypertensionaha.116.07709
10.1161/hypertensionaha.116.07709 · External reference
Unresolved reference
2018 · External reference
Evaluation of the coronary circulation and calcification in children on regular hemodialysis
10.1007/s00467-017-3678-4 · 2017 · External reference
Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis
10.1161/circulationaha.108.783738 · 2008 · External reference
The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease
10.1002/jbmr.539 · 2012 · External reference
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease
10.1038/ki.2012.477 · 2013 · External reference
10.1161/circresaha.110.234914
10.1161/circresaha.110.234914 · External reference
Oxidative stress in uremia: nature, mechanisms, and potential consequences
10.1016/j.semnephrol.2004.06.026 · 2004 · External reference
Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia
2019 · External reference
Fetuin-A-containing calciprotein particles in mineral trafficking and vascular disease
10.1093/ndt/gfw048 · 2016 · External reference
Association of plasma fetuin-a levels with peripheral arterial disease and lower extremity arterial calcification in subjects with type 2 diabetes mellitus
10.1016/j.jdiacomp.2016.11.006 · 2017 · External reference
Chronic kidney disease circulating Calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-rich protein)
10.1161/atvbaha.117.310578 · 2018 · External reference
10.1016/j.yexcr.2016.06.007
10.1016/j.yexcr.2016.06.007 · External reference
Runx2 expression in smooth muscle cells is required for arterial medial calcification in mice
10.1016/j.ajpath.2015.03.020 · 2015 · External reference
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification
10.1161/circresaha.112.267237 · 2012 · External reference
Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia
2019 · External reference
Zinc inhibits phosphate-induced vascular calcification through TNFAIP3-mediated suppression of NF-kappaB
10.1681/asn.2017050492 · 2018 · External reference
SOX9 and myocardin counteract each other in regulating vascular smooth muscle cell differentiation
10.1016/j.bbrc.2012.04.149 · 2012 · External reference
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling
10.1172/jci96477 · 2018 · External reference
The emerging role of phosphate in vascular calcification
10.1038/ki.2008.644 · 2009 · External reference
Indoxyl sulfate and p-Cresyl sulfate promote vascular calcification and associate with glucose intolerance
10.1681/asn.2018060609 · 2019 · External reference
10.1038/nrm3546
10.1038/nrm3546 · External reference
Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification
10.1111/j.1365-2796.2006.01692.x · 2006 · External reference
10.1161/circulationaha.109.902056
10.1161/circulationaha.109.902056 · External reference
Prelamin a accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells
2013 · External reference
Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells
10.1161/atvbaha.111.236349 · 2012 · External reference
10.1073/pnas.0511133103
10.1073/pnas.0511133103 · External reference
10.1152/ajpcell.00329.2011
10.1152/ajpcell.00329.2011 · External reference
10.1038/nrneph.2017.169
10.1038/nrneph.2017.169 · External reference
10.3390/diseases7010021
10.3390/diseases7010021 · External reference
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
10.1038/35092584 · 2001 · External reference
Adult-onset, short-term dietary restriction reduces cell senescence in mice
10.18632/aging.100196 · 2010 · External reference
Therapeutic approaches to aging-reply
10.1001/jama.2018.20554 · 2019 · External reference
10.1111/acel.12458
10.1111/acel.12458 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
10.1016/j.ebiom.2018.12.052
10.1016/j.ebiom.2018.12.052 · External reference
Inhibition of interleukin-1β by Canakinumab and cardiovascular outcomes in patients with chronic kidney disease
10.1016/j.jacc.2018.03.490 · 2018 · External reference
10.1158/2159-8290.cd-16-0217
10.1158/2159-8290.cd-16-0217 · External reference
