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References from Hallmarks of Aging in the Liver. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.cell.2013.05.039
10.1016/j.cell.2013.05.039 · External reference
Ageing as a risk factor for disease
10.1016/j.cub.2012.07.024 · 2012 · External reference
Energy metabolism in the liver
10.1002/j.2040-4603.2014.tb00548.x · 2011 · External reference
Aging and liver disease
10.1097/mog.0000000000000176 · 2015 · External reference
Metabolic syndrome, aging and involvement of oxidative stress
10.14336/ad.2014.0305 · 2015 · External reference
10.1016/j.mce.2016.12.022
10.1016/j.mce.2016.12.022 · External reference
Aging and liver regeneration
10.1016/j.tem.2009.01.005 · 2009 · External reference
10.1002/hep.22146
10.1002/hep.22146 · External reference
Reduced DNA synthesis in primary cultures of hepatocytes from old mice is restored by thymus grafts
1998 · External reference
Metabolism, genomics, and DNA repair in the mouse aging liver
10.1155/2011/859415 · 2011 · External reference
Reversal of hepatocyte senescence after continuous in vivo cell proliferation
10.1002/hep.27094 · 2014 · External reference
10.1002/cyto.a.20356
10.1002/cyto.a.20356 · External reference
10.1002/cyto.a.22102
10.1002/cyto.a.22102 · External reference
10.1038/s41586-018-0004-7
10.1038/s41586-018-0004-7 · External reference
10.1096/fj.01-0977com
10.1096/fj.01-0977com · External reference
Long-term dietary macronutrients and hepatic gene expression in aging mice
10.1093/gerona/glx186 · 2018 · External reference
Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication
10.1101/gad.1453606 · 2006 · External reference
Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration
10.3748/wjg.v20.i47.17851 · 2014 · External reference
10.1146/annurev-physiol-030212-183653
10.1146/annurev-physiol-030212-183653 · External reference
10.1111/j.1474-9726.2009.00481.x
10.1111/j.1474-9726.2009.00481.x · External reference
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
10.1016/j.jhep.2012.08.008 · 2013 · External reference
Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse
10.1016/0921-8734(90)90019-n · 1990 · External reference
Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential
10.1007/s00125-008-1034-8 · 2008 · External reference
Selective insulin resistance in hepatocyte senescence
10.1016/j.yexcr.2014.09.025 · 2015 · External reference
The senescent hepatocyte gene signature in chronic liver disease
10.1016/j.exger.2014.09.011 · 2014 · External reference
Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging
10.1152/ajpregu.00226.2004 · 2004 · External reference
10.1016/j.it.2015.02.009
10.1016/j.it.2015.02.009 · External reference
10.1038/ncomms15691
10.1038/ncomms15691 · External reference
10.1016/j.cmet.2015.04.004
10.1016/j.cmet.2015.04.004 · External reference
10.1073/pnas.1305462110
10.1073/pnas.1305462110 · External reference
10.1111/j.1532-5415.1972.tb00787.x
10.1111/j.1532-5415.1972.tb00787.x · External reference
10.1073/pnas.94.7.3064
10.1073/pnas.94.7.3064 · External reference
Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene
10.1093/nar/29.22.4541 · 2001 · External reference
10.1101/gad.2016211
10.1101/gad.2016211 · External reference
10.1053/j.gastro.2015.09.042
10.1053/j.gastro.2015.09.042 · External reference
10.1016/j.jhep.2013.03.037
10.1016/j.jhep.2013.03.037 · External reference
Isobe K-i. Autophagic activity in thymus and liver during aging
10.1007/s11357-011-9221-9 · 2012 · External reference
Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions
2001 · External reference
10.1006/excr.1997.3931
10.1006/excr.1997.3931 · External reference
10.1074/jbc.m002102200
10.1074/jbc.m002102200 · External reference
Autophagy and aging
10.1016/j.cell.2011.07.030 · 2011 · External reference
10.1111/acel.12310
10.1111/acel.12310 · External reference
10.1038/nm.1851
10.1038/nm.1851 · External reference
Autophagy following heat stress: the role of aging and protein nitration
10.4161/auto.6768 · 2008 · External reference
Liver aging and pseudocapillarization in a Werner syndrome mouse model
10.1093/gerona/glt169 · 2014 · External reference
Pseudocapillarization and associated energy limitation in the aged rat liver
10.1053/jhep.2001.22754 · 2001 · External reference
10.1002/hep.28988
10.1002/hep.28988 · External reference
10.1016/j.exger.2007.06.001
10.1016/j.exger.2007.06.001 · External reference
Aging-associated oxidative stress inhibits liver progenitor cell activation in mice
10.18632/aging.101232 · 2017 · External reference
10.1093/gerona/glq135
10.1093/gerona/glq135 · External reference
Hepatic sinusoidal pseudocapillarization with aging in the non-human primate
10.1016/j.exger.2003.07.002 · 2003 · External reference
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance
10.1111/acel.12481 · 2016 · External reference
Age-related changes in scavenger receptor–mediated endocytosis in rat liver sinusoidal endothelial cells
10.1093/gerona/glq108 · 2010 · External reference
10.5936/csbj.201308003 · Admitted local publication
Manipulating fenestrations in young and old liver sinusoidal endothelial cells
2018 · External reference
Metformin induced attenuation of age-related pseudocapillarization in mouse liver endothelium
2019 · External reference
Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury
10.1016/j.jhep.2018.10.015 · 2019 · External reference
Short-term treatment with hepatoselective NO donor V-PYRRO/NO improves blood flow in hepatic microcirculation in liver steatosis in mice
10.1016/j.pharep.2017.11.019 · 2018 · External reference
10.1016/j.jhep.2016.07.009
10.1016/j.jhep.2016.07.009 · External reference
10.1002/hep.27376
10.1002/hep.27376 · External reference
Effects of aging on liver microcirculatory function and sinusoidal phenotype
10.1111/acel.12829 · 2018 · External reference
Age-related changes in the hepatic microcirculation in mice
10.1016/j.exger.2007.04.008 · 2007 · External reference
Mechanisms of dysfunction in the aging vasculature and role in age-related disease
10.1161/circresaha.118.312563 · 2018 · External reference
10.1038/nrgastro.2017.38
10.1038/nrgastro.2017.38 · External reference
Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells
10.1111/joa.12448 · 2016 · External reference
The effects of old age on hepatic stellate cells
10.1155/2011/439835 · 2011 · External reference
10.1002/hep.25787
10.1002/hep.25787 · External reference
Basal activity of Kupffer cells increases with old age
10.1093/gerona/62.9.973 · 2007 · External reference
Macrophages in the aging liver and age-related liver disease
10.3389/fimmu.2018.02795 · 2018 · External reference
10.1002/hep.22224
10.1002/hep.22224 · External reference
Age-induced hepatic steatosis and inflammation of murine livers is influenced by MCP-1
10.1096/fasebj.2018.32.1_supplement.150.5 · 2018 · External reference
Monocyte chemoattractant protein (MCP)-1 is not required for Kupffer cell activation after partial hepatectomy
10.1096/fasebj.25.1_supplement.1117.12 · 2011 · External reference
10.1002/hep.24713
10.1002/hep.24713 · External reference
Unresolved reference
2013 · External reference
10.1186/1741-7015-9-98
10.1186/1741-7015-9-98 · External reference
10.1093/gerona/glu042
10.1093/gerona/glu042 · External reference
10.1002/hep.27131
10.1002/hep.27131 · External reference
Chronological aging standard curves of telomere length and mitochondrial DNA copy number in twelve tissues of C57BL/6 male mouse
10.3390/cells8030247 · 2019 · External reference
Telomere shortening with aging in human liver
10.1093/gerona/55.11.b533 · 2000 · External reference
Ageing and telomeres: a study into organ-and gender-specific telomere shortening
10.1093/nar/gkg208 · 2003 · External reference
10.1016/j.molcel.2016.05.013
10.1016/j.molcel.2016.05.013 · External reference
10.1038/nrm4048
10.1038/nrm4048 · External reference
Regulation of age-related decline by transcription factors and their crosstalk with the epigenome
10.2174/1389202919666180503125850 · 2018 · External reference
10.1111/j.1474-9726.2010.00577.x
10.1111/j.1474-9726.2010.00577.x · External reference
10.7554/elife.40675
10.7554/elife.40675 · External reference
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
2018 · External reference
Molecular aging of human liver: an epigenetic/transcriptomic signature
2018 · External reference
10.1186/s13059-017-1186-2
10.1186/s13059-017-1186-2 · External reference
10.1371/journal.pgen.1007766
10.1371/journal.pgen.1007766 · External reference
Comprehensive transcriptional landscape of aging mouse liver
10.1186/s12864-015-2061-8 · 2015 · External reference
10.1111/acel.12427
10.1111/acel.12427 · External reference
10.2337/db12-1296
10.2337/db12-1296 · External reference
rSjP40 suppresses hepatic stellate cell activation by promoting microRNA-155 expression and inhibiting STAT5 and FOXO3a expression
10.1111/jcmm.13819 · 2018 · External reference
10.1016/j.tem.2005.03.010
10.1016/j.tem.2005.03.010 · External reference
10.1126/science.1094637
10.1126/science.1094637 · External reference
10.1016/j.celrep.2014.09.048
10.1016/j.celrep.2014.09.048 · External reference
10.1016/j.exger.2014.03.002
10.1016/j.exger.2014.03.002 · External reference
10.1016/j.mce.2016.12.021
10.1016/j.mce.2016.12.021 · External reference
Downregulation of transcription factor, Sp1, during cellular senescence
10.1016/j.bbrc.2006.11.118 · 2007 · External reference
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
10.1016/j.mad.2010.12.004 · 2011 · External reference
10.5936/csbj.201303010 · Admitted local publication
10.1111/acel.12317
10.1111/acel.12317 · External reference
10.1016/j.semcdb.2017.06.012
10.1016/j.semcdb.2017.06.012 · External reference
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
10.1111/acel.12777 · 2018 · External reference
Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver
10.1016/j.mad.2014.09.003 · 2014 · External reference
10.1016/s0047-6374(02)00096-9
10.1016/s0047-6374(02)00096-9 · External reference
Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice
10.1152/ajpgi.00418.2015 · 2016 · External reference
The essential functions of endoplasmic reticulum chaperones in hepatic lipid metabolism
10.1016/j.dld.2016.03.016 · 2016 · External reference
10.1016/j.cell.2013.06.016
10.1016/j.cell.2013.06.016 · External reference
Biochemical genetic pathways that modulate aging in multiple species
10.1101/cshperspect.a025114 · 2015 · External reference
10.1126/science.1172539
10.1126/science.1172539 · External reference
Insulin, IGF-1 and longevity
2010 · External reference
10.1073/pnas.1002696107
10.1073/pnas.1002696107 · External reference
10.1146/annurev.pathol.4.110807.092250
10.1146/annurev.pathol.4.110807.092250 · External reference
10.1016/j.addr.2018.09.006
10.1016/j.addr.2018.09.006 · External reference
10.5936/csbj.201303020 · Admitted local publication
10.1016/j.cmet.2007.01.008
10.1016/j.cmet.2007.01.008 · External reference
Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver
10.1093/gerona/60.1.21 · 2005 · External reference
10.1016/j.tem.2009.11.005
10.1016/j.tem.2009.11.005 · External reference
10.1016/j.tips.2013.12.004
10.1016/j.tips.2013.12.004 · External reference
10.1002/hep.24471
10.1002/hep.24471 · External reference
10.1074/jbc.m109.045260
10.1074/jbc.m109.045260 · External reference
10.1371/journal.pone.0183541
10.1371/journal.pone.0183541 · External reference
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression
10.1016/j.jhep.2016.11.004 · 2017 · External reference
Resveratrol induces apoptosis through modulation of the Akt/FoxO3a/Bim pathway in HepG2 cells
10.3892/mmr.2015.4695 · 2016 · External reference
Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
2017 · External reference
Circadian reprogramming in the liver identifies metabolic pathways of aging
10.1016/j.cell.2017.07.042 · 2017 · External reference
10.1038/nature08221
10.1038/nature08221 · External reference
10.1111/acel.12425
10.1111/acel.12425 · External reference
10.4161/15384101.2014.949150
10.4161/15384101.2014.949150 · External reference
The metabolic footprint of aging in mice
10.1038/srep00134 · 2011 · External reference
10.1016/j.freeradbiomed.2016.11.035
10.1016/j.freeradbiomed.2016.11.035 · External reference
10.1371/journal.pone.0032117
10.1371/journal.pone.0032117 · External reference
Feedback between p21 and reactive oxygen production is necessary for cell senescence
10.1038/msb.2010.5 · 2010 · External reference
Unresolved reference
2018 · External reference
Identification of miR-31-5p, miR-141-3p, miR-200c-3p, and GLT1 as human liver aging markers sensitive to donor–recipient age-mismatch in transplants
10.1111/acel.12549 · 2017 · External reference
10.1371/journal.pone.0072904
10.1371/journal.pone.0072904 · External reference
Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts
10.1016/j.trim.2014.06.008 · 2014 · External reference
Liver damage and senescence increases in patients developing hepatocellular carcinoma
10.1111/jgh.13717 · 2017 · External reference
10.1053/hupa.2001.22747
10.1053/hupa.2001.22747 · External reference
10.1038/s41419-018-0622-x
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10.3390/ijms17030383 · External reference
10.1016/j.cels.2015.08.012
10.1016/j.cels.2015.08.012 · External reference
Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
10.1038/ncomms7790 · 2015 · External reference
Age-and tissue-specific expression of senescence biomarkers in mice
10.3389/fgene.2018.00059 · 2018 · External reference
10.1016/j.jhep.2016.05.030
10.1016/j.jhep.2016.05.030 · External reference
The peculiar aging of human liver: a geroscience perspective within transplant context
10.1016/j.arr.2019.02.002 · 2019 · External reference
Cooperation of liver cells in health and disease
2001 · External reference
10.1186/gb-2013-14-10-r115
10.1186/gb-2013-14-10-r115 · External reference
10.1073/pnas.1412759111
10.1073/pnas.1412759111 · External reference
Unresolved reference
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