Research graph
References from G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/0014-4827(61)90192-6
10.1016/0014-4827(61)90192-6 · External reference
10.1038/nm.4000
10.1038/nm.4000 · External reference
10.1128/mcb.00510-12
10.1128/mcb.00510-12 · External reference
10.1038/nrm3823
10.1038/nrm3823 · External reference
The role of inflammation in age-related disease
10.18632/aging.100531 · 2013 · External reference
10.1016/j.cell.2013.05.039
10.1016/j.cell.2013.05.039 · External reference
10.1016/j.arr.2014.09.002
10.1016/j.arr.2014.09.002 · External reference
10.1126/science.1173635
10.1126/science.1173635 · External reference
Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography
10.1073/pnas.69.10.2828 · 1972 · External reference
10.1038/nrd.2017.178
10.1038/nrd.2017.178 · External reference
10.1016/j.ymeth.2015.05.013
10.1016/j.ymeth.2015.05.013 · External reference
10.1124/mol.114.095224
10.1124/mol.114.095224 · External reference
10.1126/science.283.5402.655
10.1126/science.283.5402.655 · External reference
beta-Arrestin based receptor signaling paradigms: potential therapeutic targets for complex age-related disorders
10.3389/fphar.2018.01369 · 2018 · External reference
Cancer and aging - the inflammatory connection
10.14336/ad.2016.1230 · 2017 · External reference
Cancer statistics, 2015
2015 · External reference
Type 2 diabetes and the aging pancreatic beta cell
10.18632/aging.100350 · 2011 · External reference
Subjective age and risk of incident dementia: evidence from the National Health and aging trends survey
10.1016/j.jpsychires.2018.02.008 · 2018 · External reference
10.1161/circresaha.111.246876
10.1161/circresaha.111.246876 · External reference
Cardiac aging and heart disease in humans
10.1007/s12551-017-0255-9 · 2017 · External reference
10.1038/nrg1272
10.1038/nrg1272 · External reference
10.1016/j.arr.2018.02.002
10.1016/j.arr.2018.02.002 · External reference
Exploring biomedical ontology mappings with graph theory methods
10.7717/peerj.2990 · 2017 · External reference
Analysis of topological parameters of complex disease genes reveals the importance of location in a biomolecular network
2019 · External reference
10.1038/ng1530
10.1038/ng1530 · External reference
10.1038/35019019
10.1038/35019019 · External reference
10.1038/35075138
10.1038/35075138 · External reference
10.1371/journal.pone.0014352
10.1371/journal.pone.0014352 · External reference
10.1371/journal.pone.0036975
10.1371/journal.pone.0036975 · External reference
GIT2 acts as a systems-level coordinator of neurometabolic activity and pathophysiological aging
2015 · External reference
10.18632/aging.101185
10.18632/aging.101185 · External reference
10.1128/mcb.01432-14
10.1128/mcb.01432-14 · External reference
The synergistic GIT2-RXFP3 system in the brain and its importance in age-related disorders
2016 · External reference
The RXFP3-GIT2 signaling system represents a potential multidimensional therapeutic target in age-related disorders
2018 · External reference
10.1083/jcb.201708092
10.1083/jcb.201708092 · External reference
Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system
10.1007/s11357-014-9631-6 · 2014 · External reference
10.1038/nature13193
10.1038/nature13193 · External reference
Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
10.1007/s10522-019-09796-4 · 2019 · External reference
Senescence promotes in vivo reprogramming through p16(INK)(4a) and IL-6
10.1111/acel.12711 · 2018 · External reference
Mitochondrial-derived peptides exacerbate senescence
10.1089/rej.2018.2114 · 2018 · External reference
10.1111/acel.12344
10.1111/acel.12344 · External reference
10.1111/jgs.14969
10.1111/jgs.14969 · External reference
Identification of HSP90 inhibitors as a novel class of senolytics
10.1038/s41467-017-00314-z · 2017 · External reference
10.1038/nm.4010
10.1038/nm.4010 · External reference
10.1038/s41467-018-07825-3
10.1038/s41467-018-07825-3 · External reference
G Protein-coupled receptor systems as crucial regulators of dna damage response processes
10.3390/ijms19102919 · 2018 · External reference
G protein-coupled receptors (GPCRs) in Alzheimer's disease: a focus on BACE1 related GPCRs
10.3389/fnagi.2016.00058 · 2016 · External reference
10.1172/jci64098
10.1172/jci64098 · External reference
10.1080/15384101.2014.1000134
10.1080/15384101.2014.1000134 · External reference
Cellular senescence, ageing and disease
10.1007/s11357-008-9075-y · 2009 · External reference
Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals
10.1186/1747-1028-5-1 · 2010 · External reference
10.1126/science.1122446
10.1126/science.1122446 · External reference
10.1111/j.1474-9726.2012.00837.x
10.1111/j.1474-9726.2012.00837.x · External reference
Cellular senescence: a link between cancer and age-related degenerative disease?
2011 · External reference
10.1093/nar/gkm756
10.1093/nar/gkm756 · External reference
10.1016/j.it.2015.10.008
10.1016/j.it.2015.10.008 · External reference
10.1016/j.cell.2017.05.015
10.1016/j.cell.2017.05.015 · External reference
10.1002/jcp.26956
10.1002/jcp.26956 · External reference
10.1111/cas.13184
10.1111/cas.13184 · External reference
10.1007/978-1-62703-239-1_3
10.1007/978-1-62703-239-1_3 · External reference
10.1126/scisignal.2000053
10.1126/scisignal.2000053 · External reference
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
10.1128/mcb.25.7.2660-2672.2005 · 2005 · External reference
Role of p16(INK4A) in replicative senescence and DNA damage-induced premature senescence in p53-deficient human cells
10.1155/2012/951574 · 2012 · External reference
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
10.1038/s41467-018-04010-4 · 2018 · External reference
Whole chromosome instability induces senescence and promotes SASP
10.1038/srep35218 · 2016 · External reference
10.5483/bmbrep.2015.48.10.122
10.5483/bmbrep.2015.48.10.122 · External reference
10.4161/psb.4.10.9530
10.4161/psb.4.10.9530 · External reference
The two-state model of receptor activation
10.1016/s0165-6147(00)88989-0 · 1995 · External reference
10.1124/pr.109.002436
10.1124/pr.109.002436 · External reference
10.1124/jpet.105.083121
10.1124/jpet.105.083121 · External reference
10.1016/j.tips.2011.05.002
10.1016/j.tips.2011.05.002 · External reference
Desensitization of G protein-coupled receptors
1996 · External reference
10.1126/science.271.5247.363
10.1126/science.271.5247.363 · External reference
10.1038/383447a0
10.1038/383447a0 · External reference
10.1074/jbc.271.31.18302
10.1074/jbc.271.31.18302 · External reference
10.1016/s0021-9258(18)54155-7
10.1016/s0021-9258(18)54155-7 · External reference
10.1016/0165-6147(93)90048-o
10.1016/0165-6147(93)90048-o · External reference
10.1124/mol.116.105940
10.1124/mol.116.105940 · External reference
Functional signaling biases in G protein-coupled receptors: game theory and receptor dynamics
10.2174/138955712800959071 · 2012 · External reference
10.1111/j.1476-5381.2011.01552.x
10.1111/j.1476-5381.2011.01552.x · External reference
10.1146/annurev.pharmtox.42.091401.113012
10.1146/annurev.pharmtox.42.091401.113012 · External reference
The role of conformational ensembles of seven transmembrane receptors in functional selectivity
10.1016/j.coph.2010.09.004 · 2010 · External reference
10.1016/j.neuropharm.2019.01.018
10.1016/j.neuropharm.2019.01.018 · External reference
10.1146/annurev.pharmtox.010909.105705
10.1146/annurev.pharmtox.010909.105705 · External reference
10.1254/jphs.11r10cp
10.1254/jphs.11r10cp · External reference
10.1016/j.tips.2007.06.006
10.1016/j.tips.2007.06.006 · External reference
10.4062/biomolther.2016.165
10.4062/biomolther.2016.165 · External reference
10.1016/j.cellsig.2017.05.002
10.1016/j.cellsig.2017.05.002 · External reference
10.1016/j.ceb.2013.10.003
10.1016/j.ceb.2013.10.003 · External reference
GPCR signaling from intracellular membranes - a novel concept
10.1002/bies.201700200 · 2017 · External reference
Exosome nanovesicles displaying G protein-coupled receptors for drug discovery
2007 · External reference
10.1194/jlr.r046458
10.1194/jlr.r046458 · External reference
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
10.1016/j.prostaglandins.2009.02.002 · 2010 · External reference
10.1111/bph.12678
10.1111/bph.12678 · External reference
The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities
10.1093/oxfordjournals.jbchem.a003163 · 2002 · External reference
10.1523/jneurosci.6151-09.2010
10.1523/jneurosci.6151-09.2010 · External reference
Promising pharmacological directions in the world of lysophosphatidic acid signaling
10.4062/biomolther.2014.109 · 2015 · External reference
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
10.1074/jbc.273.14.7906 · 1998 · External reference
10.1083/jcb.135.4.1071
10.1083/jcb.135.4.1071 · External reference
10.1146/annurev.pharmtox.41.1.507
10.1146/annurev.pharmtox.41.1.507 · External reference
10.1074/jbc.m302648200
10.1074/jbc.m302648200 · External reference
10.1074/jbc.m603670200
10.1074/jbc.m603670200 · External reference
10.1038/ng.84
10.1038/ng.84 · External reference
10.1242/dev.121723
10.1242/dev.121723 · External reference
Lipid phosphate phosphatases and signaling
10.1194/jlr.r800055-jlr200 · 2009 · External reference
Lysophosphatidic acid synthesis and release
10.1016/s0090-6980(01)00110-1 · 2001 · External reference
Ligand-directed signalling at beta-adrenoceptors
10.1111/j.1476-5381.2009.00602.x · 2010 · External reference
Premature aging/senescence in cancer cells facing therapy: good or bad?
10.1007/s10522-015-9593-9 · 2016 · External reference
10.1093/nar/gkz124
10.1093/nar/gkz124 · External reference
10.1016/j.gde.2019.02.001
10.1016/j.gde.2019.02.001 · External reference
Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D
10.1006/bbrc.1993.1651 · 1993 · External reference
Lysophospholipids activate ovarian and breast cancer cells
10.1042/bj3090933 · 1995 · External reference
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells
1999 · External reference
10.1038/nrc1143
10.1038/nrc1143 · External reference
Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation
10.1016/j.bbalip.2008.04.007 · 2008 · External reference
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling
10.1158/1541-7786.mcr-08-0066 · 2008 · External reference
An lysophosphatidic acid receptors 1 and 3 Axis governs cellular senescence of mesenchymal stromal cells and promotes growth and vascularization of multiple myeloma
10.1002/stem.2499 · 2017 · External reference
The aging risk and atherosclerosis: a fresh look at arterial homeostasis
10.3389/fgene.2017.00216 · 2017 · External reference
10.1097/mol.0000000000000327
10.1097/mol.0000000000000327 · External reference
10.1126/science.aaf6659
10.1126/science.aaf6659 · External reference
Cardiac cell senescence and redox Signaling
10.3389/fcvm.2017.00038 · 2017 · External reference
Adult cardiac stem cell aging: a reversible stochastic phenomenon?
10.1155/2019/5813147 · 2019 · External reference
Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions
10.1073/pnas.96.12.6931 · 1999 · External reference
Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate
10.1016/s1388-1981(02)00173-7 · 2002 · External reference
The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes
10.1006/jmcc.2001.1429 · 2001 · External reference
Influence of acetylsalicylate on plasma lysophosphatidic acid level in patients with ischemic cerebral vascular diseases
10.1179/174313208x300369 · 2008 · External reference
Lysophosphatidic acid signaling in obesity and insulin resistance
2018 · External reference
10.1016/j.bbalip.2012.08.001
10.1016/j.bbalip.2012.08.001 · External reference
10.1016/j.tem.2009.08.003
10.1016/j.tem.2009.08.003 · External reference
10.1371/journal.pone.0032185
10.1371/journal.pone.0032185 · External reference
10.1210/er.2003-0001
10.1210/er.2003-0001 · External reference
Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders
1995 · External reference
Signaling mechanisms of angiotensin II in regulating vascular senescence
10.1016/j.arr.2008.12.002 · 2009 · External reference
10.1161/circulationaha.106.626606
10.1161/circulationaha.106.626606 · External reference
Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence
10.1016/j.cardiores.2007.07.008 · 2007 · External reference
10.1016/j.regpep.2004.12.027
10.1016/j.regpep.2004.12.027 · External reference
Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways
10.1161/circresaha.107.158626 · 2008 · External reference
Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition
10.1161/hypertensionaha.107.105692 · 2008 · External reference
Angiotensin II type 2 receptor-interacting protein prevents vascular senescence
10.1016/j.jash.2012.01.006 · 2012 · External reference
10.1016/j.drudis.2010.11.016
10.1016/j.drudis.2010.11.016 · External reference
Targeting angiotensin II type I receptors to reduce the risk of stroke in patients with hypertension
10.1517/14728222.10.2.231 · 2006 · External reference
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain
10.1517/14728222.2014.957673 · 2015 · External reference
Molecular targeting therapy with angiotensin II receptor blocker for prostatic cancer
10.1007/s12156-007-0002-8 · 2007 · External reference
10.1124/pr.116.013367
10.1124/pr.116.013367 · External reference
10.1038/nature10368
10.1038/nature10368 · External reference
10.1074/jbc.m115.655829
10.1074/jbc.m115.655829 · External reference
The cellular senescence of leukemia-initiating cells from acute lymphoblastic leukemia is postponed by beta-Arrestin1 binding with P300-Sp1 to regulate hTERT transcription
10.1038/cddis.2017.164 · 2017 · External reference
10.1016/j.cell.2005.09.011
10.1016/j.cell.2005.09.011 · External reference
10.4331/wjbc.v9.i3.25
10.4331/wjbc.v9.i3.25 · External reference
Structural basis of arrestin-3 activation and signaling
10.1038/s41467-017-01218-8 · 2017 · External reference
10.1002/1873-3468.13057
10.1002/1873-3468.13057 · External reference
10.1016/s1359-6101(02)00007-2
10.1016/s1359-6101(02)00007-2 · External reference
GRK5 - a functional bridge between cardiovascular and neurodegenerative disorders
10.3389/fphar.2018.01484 · 2018 · External reference
10.1096/fasebj.9.2.7781920
10.1096/fasebj.9.2.7781920 · External reference
10.1073/pnas.0905778107
10.1073/pnas.0905778107 · External reference
10.1074/jbc.m111.298034
10.1074/jbc.m111.298034 · External reference
10.1002/jcp.22972
10.1002/jcp.22972 · External reference
Dual role of GRK5 in cancer development and progression
2016 · External reference
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling
10.1016/j.yexcr.2017.09.017 · 2017 · External reference
10.1074/jbc.275.29.22373
10.1074/jbc.275.29.22373 · External reference
10.1016/s0898-6568(04)00023-3
10.1016/s0898-6568(04)00023-3 · External reference
10.1021/cb300139y
10.1021/cb300139y · External reference
10.1371/journal.pone.0040504
10.1371/journal.pone.0040504 · External reference
Autofluorescence is a reliable in vitro marker of cellular senescence in human mesenchymal stromal cells
10.1038/s41598-019-38546-2 · 2019 · External reference
10.1146/annurev.pharmtox.40.1.235
10.1146/annurev.pharmtox.40.1.235 · External reference
A G-protein signaling network mediated by an RGS protein
10.1101/gad.13.14.1763 · 1999 · External reference
Introduction: G protein-coupled receptors and RGS proteins
10.1016/bs.pmbts.2015.03.002 · 2015 · External reference
10.1152/ajpheart.00764.2011
10.1152/ajpheart.00764.2011 · External reference
10.1016/j.neurobiolaging.2015.02.006
10.1016/j.neurobiolaging.2015.02.006 · External reference
10.1016/bs.pmbts.2015.01.005
10.1016/bs.pmbts.2015.01.005 · External reference
Regulator of G-protein signaling-10 negatively regulates NF-kappaB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats
10.1523/jneurosci.1002-11.2011 · 2011 · External reference
Textrous!: extracting semantic textual meaning from gene sets
10.1371/journal.pone.0062665 · 2013 · External reference
Stress kinase MKK7: savior of cell cycle arrest and cellular senescence
10.4161/cc.3.5.888 · 2004 · External reference
10.1016/j.yexcr.2014.11.001
10.1016/j.yexcr.2014.11.001 · External reference
10.18632/oncotarget.11229
10.18632/oncotarget.11229 · External reference
10.1074/jbc.m310784200
10.1074/jbc.m310784200 · External reference
10.1096/fj.201800548
10.1096/fj.201800548 · External reference
10.1016/j.cellsig.2015.03.026
10.1016/j.cellsig.2015.03.026 · External reference
Cellular senescence and protein degradation: breaking down cancer
10.4161/cc.29335 · 2014 · External reference
10.1038/s41388-018-0605-5
10.1038/s41388-018-0605-5 · External reference
10.1101/gad.304857.117
10.1101/gad.304857.117 · External reference
Ubiquitin-like modifications in the DNA damage response
2017 · External reference
10.1093/nar/gku443
10.1093/nar/gku443 · External reference
10.1016/s1097-2765(00)80283-x
10.1016/s1097-2765(00)80283-x · External reference
10.1074/jbc.m003042200
10.1074/jbc.m003042200 · External reference
10.1016/j.cellsig.2009.06.008
10.1016/j.cellsig.2009.06.008 · External reference
10.1016/j.cellsig.2010.05.007
10.1016/j.cellsig.2010.05.007 · External reference
Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1
10.4049/jimmunol.1400313 · 2014 · External reference
10.1016/j.tins.2008.07.005
10.1016/j.tins.2008.07.005 · External reference
10.1111/jcmm.14223
10.1111/jcmm.14223 · External reference
10.1074/jbc.m114.608703
10.1074/jbc.m114.608703 · External reference
The GTPase-activating protein GIT2 protects against colitis by negatively regulating toll-like receptor signaling
10.1073/pnas.1309218111 · 2014 · External reference
10.1016/s0021-9258(20)79672-9
10.1016/s0021-9258(20)79672-9 · External reference
10.1016/s0021-9258(18)53442-6
10.1016/s0021-9258(18)53442-6 · External reference
The cubic ternary complex receptor-occupancy model. III. Resurrecting efficacy
10.1006/jtbi.1996.0139 · 1996 · External reference
Allosteric theory: taking therapeutic advantage of the malleable nature of GPCRs
10.2174/157015907781695973 · 2007 · External reference
GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?
2004 · External reference
10.1016/j.tins.2007.11.007
10.1016/j.tins.2007.11.007 · External reference
10.1124/mol.115.099630
10.1124/mol.115.099630 · External reference
Challenges and opportunities in drug discovery of biased ligands
10.1007/978-1-4939-7465-8_14 · 2018 · External reference
Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
10.18632/aging.100971 · 2016 · External reference
10.1158/1541-7786.mcr-18-0017
10.1158/1541-7786.mcr-18-0017 · External reference
Age- and tissue-specific expression of senescence biomarkers in mice
10.3389/fgene.2018.00059 · 2018 · External reference
10.1210/me.2012-1091
10.1210/me.2012-1091 · External reference
Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells
10.1371/journal.pone.0204197 · 2019 · External reference
Manifold roles of beta-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
10.1126/scisignal.aat7650 · 2018 · External reference
Fifteen years of stable isotope Labeling by amino acids in cell culture (SILAC)
10.1007/978-1-4939-1142-4_1 · 2014 · External reference
10.1152/ajpcell.00339.2013
10.1152/ajpcell.00339.2013 · External reference
10.1073/pnas.1721033115
10.1073/pnas.1721033115 · External reference