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References from Role of lipid transporters in fungal physiology and pathogenicity. Local targets link to admitted publications; unresolved targets remain external evidence.
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Cryo-EM structures capturing the entire transport cycle of the P4-ATPase flippase
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Phylogenetic analysis of fungal ABC transporters
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10.1091/mbc.e02-08-0501
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Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast
10.1016/j.bbrc.2006.03.095 · 2006 · External reference
Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway
10.1091/mbc.e06-05-0461 · 2007 · External reference
10.1074/jbc.m115.686253
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Uptake and utilization of lyso-phosphatidylethanolamine by Saccharomyces cerevisiae
10.1074/jbc.m608851200 · 2006 · External reference
Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation
10.1074/jbc.m706718200 · 2007 · External reference
10.1074/jbc.m113.476911
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Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans
10.1172/jci27890 · 2006 · External reference
Synthesis and biological properties of fungal glucosylceramide
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Changes in glucosylceramide structure affect virulence and membrane biophysical properties of Cryptococcus neoformans
10.1016/j.bbamem.2017.08.017 · 2017 · External reference
ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p
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10.1091/mbc.e05-06-0515
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Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1
10.1111/j.1600-0854.2011.01228.x · 2011 · External reference
10.1016/s0960-9822(02)01148-x
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Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection
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Cu(2+) binds to phosphatidylethanolamine and increases oxidation in lipid membranes
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10.1042/bcj20160024
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Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence
10.1046/j.1365-2958.2002.02769.x · 2002 · External reference
Vacuolar sequestration of azoles, a novel strategy of azole antifungal resistance conserved across pathogenic and nonpathogenic yeast
10.1128/aac.01347-18 · 2019 · External reference
Antibiotic resistance threats in the United States: stepping back from the brink
2014 · External reference
10.1371/journal.ppat.1006205
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The lipid flippase subunit Cdc50 is required for antifungal drug resistance, endocytosis, hyphal development and virulence in Candida albicans
2019 · External reference
The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum
10.1093/jac/dkm321 · 2007 · External reference
The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation
10.1111/mmi.12189 · 2013 · External reference
The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity
10.1074/jbc.m111.244525 · 2011 · External reference
Sterol uptake and sterol biosynthesis act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress
2018 · External reference
Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism
10.1128/ec.3.6.1391-1397.2004 · 2004 · External reference
Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes
10.1128/aac.49.5.1745-1752.2005 · 2005 · External reference
Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice
10.1128/aac.44.9.2411-2418.2000 · 2000 · External reference
Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae
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Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension
10.1128/aac.48.7.2483-2489.2004 · 2004 · External reference
Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains
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10.1093/ofid/ofy213
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10.1111/mmi.13019
10.1111/mmi.13019 · External reference
Phospholipid flippases DnfA and DnfB exhibit differential dynamics within the A. nidulans Spitzenkorper
10.1016/j.fgb.2016.12.007 · 2017 · External reference
10.1080/00275514.2018.1543927
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PDE1 encodes a P-type ATPase involved in appressorium-mediated plant infection by the rice blast fungus Magnaporthe grisea
10.1105/tpc.13.9.1987 · 2001 · External reference
A P-type ATPase required for rice blast disease and induction of host resistance
10.1038/nature04567 · 2006 · External reference
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10.1038/nrneurol.2016.167
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A putative P-type ATPase, Apt1, is involved in stress tolerance and virulence in Cryptococcus neoformans
10.1128/ec.00289-09 · 2010 · External reference
10.1128/ec.00273-13
10.1128/ec.00273-13 · External reference
The capsule of the fungal pathogen Cryptococcus neoformans
10.1016/s0065-2164(09)01204-0 · 2009 · External reference
10.1091/mbc.e06-08-0701
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Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport
10.1128/ec.00318-06 · 2007 · External reference
Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence
10.1128/ec.00370-07 · 2008 · External reference
10.1016/j.bbamcr.2017.12.007
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Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans
10.1101/gad.856001 · 2001 · External reference
Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside are required for host protection in an animal vaccination model
2019 · External reference
A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans
2017 · External reference
Lipid flippase subunit Cdc50 mediates drug resistance and virulence in Cryptococcus neoformans
10.1128/mbio.00478-16 · 2016 · External reference
Identifying a novel connection between the fungal plasma membrane and pH-sensing
10.1111/mmi.13998 · 2018 · External reference
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
10.1128/mbio.00522-12 · 2013 · External reference
Ca2+−dependent phospholipid scrambling by a reconstituted TMEM16 ion channel
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Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase
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10.1016/j.bbalip.2015.12.020
10.1016/j.bbalip.2015.12.020 · External reference
10.1146/annurev-physiol-022516-034031
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10.1016/j.fgb.2018.02.003
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The anti-helminthic compound mebendazole has multiple antifungal effects against Cryptococcus neoformans
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A novel protocol for the isolation of fungal extracellular vesicles reveals the participation of a putative scramblase in polysaccharide export and capsule construction in Cryptococcus gattii
2019 · External reference
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Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses
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First hospital outbreak of the globally emerging Candida auris in a European hospital
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Investigating fungal outbreaks in the 21st century
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Candida auris: a review of the literature
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10.1128/aac.00732-16
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Distinct roles of the 7-transmembrane receptor protein Rta3 in regulating the asymmetric distribution of phosphatidylcholine across the plasma membrane and biofilm formation in Candida albicans
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Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans
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Structure/activity study of tris(2-aminoethyl)amine-derived translocases for phosphatidylcholine
10.1021/jo016416s · 2002 · External reference
Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase
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A synthetic enzyme built from DNA flips 10(7) lipids per second in biological membranes
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Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases
10.1073/pnas.1115725109 · 2012 · External reference
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10.1080/21592799.2016.1228791 · External reference
Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast
10.1074/jbc.m112.416263 · 2013 · External reference
10.1074/jbc.m802379200
10.1074/jbc.m802379200 · External reference
In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network
10.1089/mdr.1998.4.143 · 1998 · External reference
SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process
10.1042/bj20040297 · 2004 · External reference
The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study
10.1016/j.bbrc.2010.11.099 · 2011 · External reference
Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p
10.1371/journal.pone.0184236 · 2017 · External reference
Functional characterization of Candida albicans ABC transporter Cdr1p
10.1128/ec.2.6.1361-1375.2003 · 2003 · External reference
Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system
10.1021/bi700453e · 2007 · External reference
10.1128/aac.00926-08
10.1128/aac.00926-08 · External reference
Serum albumin promotes ATP-binding cassette transporter-dependent sterol uptake in yeast
10.1111/1567-1364.12219 · 2014 · External reference