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References from Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
The global prevalence of dementia: a systematic review and metaanalysis
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Evidence for ordering of Alzheimer disease biomarkers
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10.1212/wnl.0000000000002923
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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
10.1212/wnl.0b013e3181c67808 · 2009 · External reference
10.1056/nejmoa1312889
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A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease
10.1186/s13195-017-0318-y · 2017 · External reference
10.1016/j.trci.2017.05.003
10.1016/j.trci.2017.05.003 · External reference
Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)
10.1186/s13195-018-0424-5 · 2018 · External reference
10.1056/nejmoa1210951
10.1056/nejmoa1210951 · External reference
Tau immunotherapies for Alzheimer’s disease
10.1080/13543784.2019.1619694 · 2019 · External reference
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Calcium Hypothesis of Alzheimer's disease and brain aging: a framework for integrating new evidence into a comprehensive theory of pathogenesis
10.1016/j.jalz.2016.12.006 · 2017 · External reference
Neuroinflammation and Alzheimer's disease: implications for microglial activation
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10.1016/s1474-4422(15)70016-5
10.1016/s1474-4422(15)70016-5 · External reference
Systemic inflammation and disease progression in Alzheimer disease
10.1212/wnl.0b013e3181d5df7f · 2010 · External reference
Protective effects of NSAIDs on the development of Alzheimer disease
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Risk of Alzheimer's disease and duration of NSAID use
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Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's disease anti-inflammatory prevention trial
10.1002/gps.2723 · 2012 · External reference
Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis
10.3233/jad-2010-100018 · 2010 · External reference
Systemic inflammation and disease progression in Alzheimer disease
10.1212/wnl.0b013e3181b6bb95 · 2009 · External reference
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
10.1186/1742-2094-9-151 · 2012 · External reference
Enhanced susceptibility of triple transgenic Alzheimer's disease (3xTg-AD) mice to acute infection
10.1186/s12974-017-0826-5 · 2017 · External reference
10.1038/nrmicro2876
10.1038/nrmicro2876 · External reference
Extensive unexplored human microbiome diversity revealed by Over 150,000 genomes from metagenomes spanning age, geography, and lifestyle
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10.1111/imr.12567
10.1111/imr.12567 · External reference
Intestinal barrier and gut microbiota: shaping our immune responses throughout life
10.1080/21688370.2017.1373208 · 2017 · External reference
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Role of microbiota and innate immunity in recurrent Clostridium difficile infection
10.1155/2014/462740 · 2014 · External reference
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10.1016/j.smim.2006.12.004
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10.1074/jbc.m113.523480
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10.1038/ni1411
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Broad expression of Toll-like receptors in the human central nervous system
10.1093/jnen/61.11.1013 · 2002 · External reference
10.1128/jvi.79.20.12893-12904.2005
10.1128/jvi.79.20.12893-12904.2005 · External reference
Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection
10.1177/154405910608500108 · 2006 · External reference
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
10.1016/0304-3940(87)90696-3 · 1987 · External reference
Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain
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10.1523/jneurosci.3158-09.2009
10.1523/jneurosci.3158-09.2009 · External reference
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10.1016/j.neurobiolaging.2007.08.018 · External reference
10.1159/000110455
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10.1016/j.pharmthera.2013.12.009
10.1016/j.pharmthera.2013.12.009 · External reference
Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease
10.4049/jimmunol.181.10.7254 · 2008 · External reference
The role of TLR2/JNK/NF-κB pathway in amyloid β peptide-induced inflammatory response in mouse NG108-15 neural cells
10.1016/j.intimp.2013.09.016 · 2013 · External reference
Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease
10.1016/j.bbi.2016.07.143 · 2016 · External reference
alpha-TLR2 antibody attenuates the Abeta-mediated inflammatory response in microglia through enhanced expression of SIGIRR
10.1016/j.bbi.2015.01.005 · 2015 · External reference
TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation
10.4049/jimmunol.1101121 · 2012 · External reference
10.1523/jneurosci.1146-08.2008
10.1523/jneurosci.1146-08.2008 · External reference
10.1074/jbc.m508125200
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Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
10.1186/1742-2094-5-23 · 2008 · External reference
TLR4 mutation reduces microglial activation, increases Abeta deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease
10.1186/1742-2094-8-92 · 2011 · External reference
Stimulation of TLR4 attenuates alzheimer's disease-related symptoms and pathology in tau-transgenic mice
10.4049/jimmunol.1600873 · 2016 · External reference
Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: implication of TLR4 signaling in disease progression
10.1016/j.bbrc.2016.09.073 · 2016 · External reference
Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer's disease in Han Chinese
2013 · External reference
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2
10.1002/embr.201337945 · 2014 · External reference
10.1016/j.neuroscience.2016.03.001
10.1016/j.neuroscience.2016.03.001 · External reference
Amyloid beta and Tau Alzheimer's disease related pathology is reduced by Toll-like receptor 9 stimulation
2014 · External reference
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10.1126/science.aad0135 · External reference
Fecal incontinence in elderly patients: common, treatable, yet often undiagnosed
10.3949/ccjm.70.5.441 · 2003 · External reference
Aging of the mammalian gastrointestinal tract: a complex organ system
10.1007/s11357-013-9603-2 · 2014 · External reference
Age-induced nerve cell loss in the myenteric plexus of the small intestine in man
1993 · External reference
10.1136/gutjnl-2016-312940
10.1136/gutjnl-2016-312940 · External reference
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10.1016/j.chom.2016.10.014
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10.1136/gutjnl-2012-303249
10.1136/gutjnl-2012-303249 · External reference
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10.1038/nri.2017.77
10.1038/nri.2017.77 · External reference
10.1038/nrmicro2245
10.1038/nrmicro2245 · External reference
Antibiotics birth mode, and diet shape microbiome maturation during early life
10.1126/scitranslmed.aad7121 · 2016 · External reference
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability
10.1126/scitranslmed.aad0917 · 2016 · External reference
10.1053/j.gastro.2016.07.044
10.1053/j.gastro.2016.07.044 · External reference
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10.1038/ismej.2015.88
10.1038/ismej.2015.88 · External reference
10.1080/21688370.2017.1373897
10.1080/21688370.2017.1373897 · External reference
Age-associated changes in the blood-brain barrier: comparative studies in human and mouse
10.1111/nan.12408 · 2018 · External reference
10.1016/j.neuron.2010.09.043
10.1016/j.neuron.2010.09.043 · External reference
10.1002/ana.410010502
10.1002/ana.410010502 · External reference
Impact of gut microbiota on neurological diseases: diet composition and novel treatments
2018 · External reference
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10.1073/pnas.1102999108 · External reference
10.1007/s00401-014-1343-6
10.1007/s00401-014-1343-6 · External reference
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
10.1038/ncomms15062 · 2017 · External reference
10.1126/scitranslmed.3009759
10.1126/scitranslmed.3009759 · External reference
The gut microbiota influences blood-brain barrier permeability in mice
10.1126/scitranslmed.3009759 · 2014 · External reference
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10.3233/jad-150859
10.3233/jad-150859 · External reference
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10.1002/ana.410300509 · External reference
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1993 · External reference
Overexpression of mutant amyloid-beta protein precursor and presenilin 1 modulates enteric nervous system
10.3233/jad-142259 · 2015 · External reference
Impaired IL-17 production in gut-residing immune cells of 5xFAD mice with Alzheimer's disease pathology
10.3233/jad-170538 · 2018 · External reference
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Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan
10.1111/lam.12882 · 2018 · External reference
10.3233/jad-180176
10.3233/jad-180176 · External reference
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
2019 · External reference
10.1016/j.neurobiolaging.2016.08.019
10.1016/j.neurobiolaging.2016.08.019 · External reference
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease
10.1038/srep30028 · 2016 · External reference
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(ΔE9) murine model of Alzheimer's disease
10.1038/s41598-017-11047-w · 2017 · External reference
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10.1016/j.mib.2012.12.001
10.1016/j.mib.2012.12.001 · External reference
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Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines
10.1073/pnas.052709699 · 2002 · External reference
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10.1212/wnl.0000000000003391 · External reference
Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus
10.3389/fcimb.2017.00318 · 2017 · External reference
LPS-induced neuroinflammatory effects do not recover with time
10.1097/00001756-200006050-00032 · 2000 · External reference
Prolonged elevation in hippocampal Abeta and cognitive deficits following repeated endotoxin exposure in the mouse
10.1016/j.bbr.2012.01.010 · 2012 · External reference
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10.1096/fj.03-0364fje · External reference
Can a bacterial endotoxin be a key factor in the kinetics of amyloid fibril formation?
10.3233/jad-131394 · 2014 · External reference
Alzheimer's disease-associated beta-amyloid is rapidly seeded by herpesviridae to protect against brain infection
10.1016/j.neuron.2018.06.030 · 2018 · External reference
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Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection
10.1186/s12974-017-0826-5 · 2017 · External reference
10.1016/j.phrs.2017.12.009
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Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
2019 · External reference
Bacterial teichoic acids reverse predominant IL-12 production induced by certain <em>Lactobacillus</em> strains into predominant IL-10 production via TLR2-dependent ERK activation in macrophages
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Lactobacilli-fermented cow's milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
10.1017/s0022029917000620 · 2017 · External reference
Anti-Alzheimer properties of probiotic, MTCC 1325 in Alzheimer's disease induced albino rats
2017 · External reference
Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease
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Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: a randomized, double-blind and controlled trial
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Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: a randomized, double-blind, controlled trial
2018 · External reference
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The claudin-like protein HPO-30 is required to maintain LAChRs at the C. elegans neuromuscular junction
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