Research graph
References from Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
10.1128/jb.00762-09
10.1128/jb.00762-09 · External reference
Unresolved reference
External reference
Structural implications of mutations conferring rifampin resistance in Mycobacterium leprae
10.1038/s41598-018-23423-1 · 2018 · External reference
Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis
10.1128/aac.05831-11 · 2012 · External reference
In silico functional dissection of saturation mutagenesis: interpreting the relationship between phenotypes and changes in protein stability, interactions and activity
10.1038/srep19848 · 2016 · External reference
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
10.1038/s41598-018-33370-6 · 2018 · External reference
Analysis of a novel pncA mutation for susceptibility to pyrazinamide therapy
10.1164/rccm.201712-2572le · 2018 · External reference
Multiple mutations in the rpoB gene of Mycobacterium leprae strains from leprosy patients in Thailand
2000 · External reference
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15
10.1016/j.cmi.2018.02.022 · 2018 · External reference
Drug-resistant leprosy: monitoring and current status
10.47276/lr.83.3.269 · 2012 · External reference
Tuberculosis drug resistance mutation database
10.1371/journal.pmed.1000002 · 2009 · External reference
Novel mutation detection IN rpoB OF rifampicin-resistant Mycobacterium tuberculosis using pyrosequencing
2014 · External reference
Novel rapid PCR for the detection of Ile491Phe rpoB mutation of Mycobacterium tuberculosis, a rifampicin-resistance-conferring mutation undetected by commercial assays
10.1016/j.cmi.2016.12.009 · 2017 · External reference
Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis
10.1186/s12879-018-3638-z · 2019 · External reference
10.1074/jbc.m116.716704
10.1074/jbc.m116.716704 · External reference
A diagnostic algorithm to investigate pyrazinamide and ethambutol resistance in rifampin-resistant Mycobacterium tuberculosis isolates in a low-incidence setting
10.1128/aac.01798-18 · 2019 · External reference
SDM: a server for predicting effects of mutations on protein stability
10.1093/nar/gkx439 · 2017 · External reference
10.1093/nar/gki387
10.1093/nar/gki387 · External reference
ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability
10.1093/nar/gkv343 · 2015 · External reference
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
10.1093/nar/gky300 · 2018 · External reference
Identifying interactions that determine fragment binding at protein hotspots
10.1021/acs.jmedchem.5b01980 · 2016 · External reference
10.1006/jmbi.1993.1626
10.1006/jmbi.1993.1626 · External reference
10.1093/nar/gkh398
10.1093/nar/gkh398 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities
10.1093/bioinformatics/btm073 · 2007 · External reference
10.1093/nar/gki524
10.1093/nar/gki524 · External reference
10.1093/bioinformatics/btt691
10.1093/bioinformatics/btt691 · External reference
mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions
2017 · External reference
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
10.1038/srep29575 · 2016 · External reference
MAESTRO – multi agent stability prediction upon point mutations
10.1186/s12859-015-0548-6 · 2015 · External reference
CUPSAT: prediction of protein stability upon point mutations
10.1093/nar/gkl190 · 2006 · External reference
I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure
10.1093/nar/gki375 · 2005 · External reference
10.1371/journal.pone.0046688
10.1371/journal.pone.0046688 · External reference
10.1093/nar/gkw408
10.1093/nar/gkw408 · External reference
10.1016/j.jmb.2016.12.004
10.1016/j.jmb.2016.12.004 · External reference
Mutation of exposed hydrophobic amino acids to arginine to increase protein stability
10.1186/1471-2091-5-9 · 2004 · External reference
Topology of RNA–protein nucleobase–amino acid π–π interactions and comparison to analogous DNA–protein π–π contacts
10.1261/rna.054924.115 · 2016 · External reference
10.1093/jn/137.6.1504s
10.1093/jn/137.6.1504s · External reference
10.1073/pnas.96.17.9459
10.1073/pnas.96.17.9459 · External reference
Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis
10.1128/jcm.00691-14 · 2014 · External reference
Role of disputed mutations in the rpoB gene in interpretation of automated liquid mgit culture results for rifampin susceptibility testing of Mycobacterium tuberculosis
10.1128/jcm.01599-17 · 2018 · External reference
The “proportional bactericidal test”: a method for assessing bactericidal activity in drugs against Mycobacterium leprae in mice
1978 · External reference
10.1038/ng.1038
10.1038/ng.1038 · External reference
10.1093/bioinformatics/bty340
10.1093/bioinformatics/bty340 · External reference
Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition
2017 · External reference
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
2018 · External reference
10.1002/cbic.201100051
10.1002/cbic.201100051 · External reference
