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References from Neuropeptides in gut-brain axis and their influence on host immunity and stress. Local targets link to admitted publications; unresolved targets remain external evidence.
The gut microbiome and obesity
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Gut microbiota, the immune system, and diet influence the neonatal gut–brain axis
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10.1016/j.tins.2013.01.005
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10.1016/j.clinthera.2015.04.002
10.1016/j.clinthera.2015.04.002 · External reference
10.1038/26239
10.1038/26239 · External reference
Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury
10.1177/0148607111413772 · 2011 · External reference
Calcium imaging of nerve-mast cell signaling in the human intestine
10.3389/fphys.2017.00971 · 2017 · External reference
The three minds of the body
2011 · External reference
Principles and clinical implications of the brain–gut–enteric microbiota axis
10.1038/nrgastro.2009.35 · 2009 · External reference
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
2015 · External reference
Ontogeny of immunoreactive CCK, VIP and secretin in rat brain and gut
10.1016/0006-291x(83)91701-1 · 1983 · External reference
Brain-gut interactions: brain stem neuronal response to local gastric effects of substance P
1987 · External reference
The role of neuropeptides in the control of regional immunity
10.1016/j.clindermatol.2014.04.011 · 2014 · External reference
The intriguing role of neuropeptides at the ocular surface
10.1016/j.jtos.2016.10.003 · 2017 · External reference
Sensory neuron regulation of gastrointestinal inflammation and bacterial host defense HHS Public Access
10.1111/joim.12591 · 2017 · External reference
Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni
10.1016/j.bbi.2004.09.002 · 2005 · External reference
10.1053/j.gastro.2011.04.052
10.1053/j.gastro.2011.04.052 · External reference
10.1113/jphysiol.2004.063388
10.1113/jphysiol.2004.063388 · External reference
10.1016/j.ynstr.2017.03.001
10.1016/j.ynstr.2017.03.001 · External reference
Microbiota and host determinants of behavioural phenotype in maternally separated mice
10.1038/ncomms8735 · 2015 · External reference
Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood
10.1016/j.psyneuen.2015.06.002 · 2015 · External reference
Effect of maternal probiotic intervention on HPA Axis, immunity and gut microbiota in a rat model of irritable bowel syndrome
10.1371/journal.pone.0046051 · 2012 · External reference
Chronic early-life stress in rat pups alters basal corticosterone, intestinal permeability, and fecal microbiota at weaning: influence of sex
10.5056/jnm16105 · 2017 · External reference
10.3892/etm.2016.3368
10.3892/etm.2016.3368 · External reference
Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression
10.18632/oncotarget.4911 · 2015 · External reference
10.1016/0024-3205(87)90405-x
10.1016/0024-3205(87)90405-x · External reference
Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites
10.1016/j.jneuroim.2008.05.014 · 2008 · External reference
10.18632/oncotarget.17754
10.18632/oncotarget.17754 · External reference
10.5056/jnm15146
10.5056/jnm15146 · External reference
10.1186/rr49 · 2001 · Admitted local publication
10.4049/jimmunol.156.5.1810
10.4049/jimmunol.156.5.1810 · External reference
The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs
10.1038/nm1202-801 · 2002 · External reference
Distinct distribution of CGRP-, enkephalin-, galanin-, neuromedin U-, neuropeptide Y-, somatostatin-, substance P-, VIP- and serotonin-containing neurons in the two submucosal ganglionic neural networks of the porcine small intestine
10.1007/bf00318639 · 1990 · External reference
Direct and indirect antimicrobial activities of neuropeptides and their therapeutic potential
10.2174/138920312804871139 · 2012 · External reference
10.1038/nri1180
10.1038/nri1180 · External reference
10.1038/415389a
10.1038/415389a · External reference
Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects
10.1016/0167-0115(86)90071-6 · 1986 · External reference
10.1152/physrev.00034.2013
10.1152/physrev.00034.2013 · External reference
Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis
10.3389/fnins.2014.00023 · 2014 · External reference
10.1016/s1567-5769(03)00201-7
10.1016/s1567-5769(03)00201-7 · External reference
Transient receptor potential vanilloid 1 expression and function in splenic dendritic cells: a potential role in immune homeostasis
10.1111/imm.12562 · 2016 · External reference
Acute and chronic phases of unilateral inflammation in rat’s ankle are associated with an increase in the proportion of calcitonin gene-related peptide-immunoreactive dorsal root ganglion cells
10.1111/j.1460-9568.1993.tb00481.x · 1993 · External reference
CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis
10.1038/s41598-018-36796-0 · 2019 · External reference
10.1016/j.coph.2008.12.007
10.1016/j.coph.2008.12.007 · External reference
The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria
10.1371/journal.ppat.1007279 · 2018 · External reference
10.1002/hep.25802
10.1002/hep.25802 · External reference
PACAP is an endogenous protective factor—insights from PACAP-deficient mice
10.1007/s12031-012-9762-0 · 2012 · External reference
PACAP in immunity and inflammation
10.1111/j.1749-6632.2003.tb03145.x · 2003 · External reference
Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans
10.1016/j.fsi.2018.11.056 · 2019 · External reference
Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide
10.1371/journal.pone.0207366 · 2018 · External reference
Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide
10.1016/j.jconrel.2012.08.021 · 2012 · External reference
Pituitary adenylate cyclase-activating peptide (PACAP): Assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential
10.1016/j.peptides.2005.11.010 · 2006 · External reference
Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: a new human antimicrobial peptide
10.1371/journal.pone.0207366 · 2018 · External reference
Enteroendocrine cell signalling via the vagus nerve
10.1016/j.coph.2013.09.007 · 2013 · External reference
10.1038/nature23874
10.1038/nature23874 · External reference
10.1007/s13311-017-0585-0
10.1007/s13311-017-0585-0 · External reference
Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice
10.1016/j.biopsych.2016.12.031 · 2017 · External reference
10.1073/pnas.1010529108
10.1073/pnas.1010529108 · External reference
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
10.1038/mp.2016.46 · 2016 · External reference
Peptide therapeutics for CNS indications
10.1016/j.bcp.2011.10.014 · 2012 · External reference
The gut–brain axis in the neuropsychological disease model of obesity: a classical movie revised by the emerging director microbiome
10.3390/nu11010156 · 2019 · External reference
Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn’s disease
10.1111/j.1572-0241.2002.05842.x · 2002 · External reference
Health-related quality of life and psychological distress in a population-based sample of Swedish patients with inflammatory bowel disease
10.1080/003655202317316097 · 2002 · External reference
The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders
10.1111/j.1572-0241.2008.01980.x · 2008 · External reference
Stress coping, distress and health perceptions in inflammatory bowel disease and community controls
10.1038/ajg.2009.529 · 2009 · External reference
Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction
10.1136/gut.33.6.825 · 1992 · External reference
10.1016/j.physbeh.2016.11.014
10.1016/j.physbeh.2016.11.014 · External reference
10.1258/ebm.2010.009331
10.1258/ebm.2010.009331 · External reference
Neuropeptides and the microbiota-gut-brain axis
10.1007/978-1-4939-0897-4_9 · 2014 · External reference
Neuroendocrine dysregulation in irritable bowel syndrome patients: a pilot study
10.5056/jnm16155 · 2017 · External reference
Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice
10.3389/fnbeh.2014.00386 · 2014 · External reference
Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice
10.1038/srep09970 · 2015 · External reference
Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)
10.1186/s12906-015-0863-5 · 2015 · External reference
Traumatic stress-induced persistent changes in DNA methylation regulate neuropeptide Y expression in rat jejunum
10.1111/nmo.13074 · 2017 · External reference
10.1111/apha.12445
10.1111/apha.12445 · External reference
10.1016/j.npep.2015.09.008
10.1016/j.npep.2015.09.008 · External reference
The potential role of thyrotropin-releasing hormone in colonic dysmotility induced by water avoidance stress in rats
10.1016/j.npep.2018.05.005 · 2018 · External reference
10.1136/gutjnl-2016-311456
10.1136/gutjnl-2016-311456 · External reference
Acute restraint stress induces cholecystokinin release via enteric apelin
10.1016/j.npep.2018.11.007 · 2019 · External reference
10.1126/science.6267699
10.1126/science.6267699 · External reference
10.1080/10253890.2017.1322575
10.1080/10253890.2017.1322575 · External reference
Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
10.1136/gutjnl-2013-305690 · 2014 · External reference
10.1371/journal.pone.0157347
10.1371/journal.pone.0157347 · External reference
10.1371/journal.pone.0199698
10.1371/journal.pone.0199698 · External reference
Microbiota modulate anxiety-like behavior and endocrine abnormalities in hypothalamic-pituitary-adrenal axis
10.3389/fcimb.2017.00489 · 2017 · External reference
10.1016/j.neuroscience.2015.09.033
10.1016/j.neuroscience.2015.09.033 · External reference
Changes in intestinal motility and gut microbiota composition in a rat stress model
10.1159/000452364 · 2017 · External reference
Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum
10.1186/s13104-015-1800-x · 2015 · External reference
Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats
10.1111/nmo.12462 · 2015 · External reference
A novel reproductive peptide, phoenixin
10.1111/j.1365-2826.2012.02381.x · 2013 · External reference
10.1152/ajpregu.00191.2016
10.1152/ajpregu.00191.2016 · External reference
Phoenixin activates immortalized gnrh and kisspeptin neurons through the novel receptor GPR173
10.1210/me.2016-1039 · 2016 · External reference
Novel regulator of vasopressin secretion: phoenixin
10.1152/ajpregu.00426.2017 · 2018 · External reference
Phoenixin expression is regulated by the fatty acids palmitate, docosahexaenoic acid and oleate, and the endocrine disrupting chemical bisphenol a in immortalized hypothalamic neurons
10.3389/fnins.2018.00838 · 2018 · External reference
The Gn RH analogues affect novel neuropeptide SMIM 20/phoenixin and GPR 173 receptor expressions in the female rat hypothalamic–pituitary–gonadal (HPG) axis
10.1111/1440-1681.13061 · 2019 · External reference
Regulation of Gpr173 expression, a putative phoenixin receptor, by saturated fatty acid palmitate and endocrine-disrupting chemical bisphenol A through a p38-mediated mechanism in immortalized hypothalamic neurons
10.1016/j.mce.2019.01.026 · 2019 · External reference
Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome
10.1016/j.cca.2017.06.013 · 2017 · External reference
10.1016/j.neuroscience.2013.07.057
10.1016/j.neuroscience.2013.07.057 · External reference
The novel neuropeptide phoenixin is highly co-expressed with nesfatin-1 in the rat hypothalamus, an immunohistochemical study
10.1016/j.neulet.2015.02.060 · 2015 · External reference
Central and peripheral expression sites of phoenixin-14 immunoreactivity in rats
10.1016/j.bbrc.2017.09.048 · 2017 · External reference
Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats
10.1016/j.peptides.2017.08.004 · 2017 · External reference
10.1016/j.brainres.2019.03.034
10.1016/j.brainres.2019.03.034 · External reference
10.1016/j.neuroscience.2015.09.055
10.1016/j.neuroscience.2015.09.055 · External reference
Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection
10.1007/s00018-017-2661-3 · 2018 · External reference
Effects of Phoenixin-14 on anxiolytic-like behavior in mice
10.1016/j.bbr.2015.02.011 · 2015 · External reference
Phoenixin is negatively associated with anxiety in obese men
10.1016/j.peptides.2016.12.011 · 2017 · External reference
The role of phoenixin in behavior and food intake
10.1016/j.peptides.2019.04.002 · 2019 · External reference
Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice
10.1016/j.brainres.2015.10.030 · 2015 · External reference
Does plasma phoenixin level associate with cognition? Comparison between subjective memory complaint, mild cognitive impairment, and mild Alzheimer’s disease
10.1017/s1041610217000825 · 2017 · External reference
Antimicrobial activity of substance P and neuropeptide Y against laboratory strains of bacteria and oral microorganisms
10.1016/j.jneuroim.2006.05.011 · 2006 · External reference
10.1074/jbc.m114.560573
10.1074/jbc.m114.560573 · External reference
Antimicrobial effects of α-MSH peptides
10.1002/jlb.67.2.233 · 2000 · External reference
10.1016/s0167-0115(03)00033-8
10.1016/s0167-0115(03)00033-8 · External reference
Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids. Importance of enkelytin, the antibacterial PEAP209-237 secreted by stimulated chromaffin cells
10.1074/jbc.273.45.29847 · 1998 · External reference
