Research graph
References from RNA-seq data analysis of stimulated hepatocellular carcinoma cells treated with epigallocatechin gallate and fisetin reveals target genes and action mechanisms. Local targets link to admitted publications; unresolved targets remain external evidence.
Hepatocellular carcinoma
10.1016/s0140-6736(11)61347-0 · 2012 · External reference
Inflammation and liver cancer: new molecular links
10.1111/j.1749-6632.2009.03704.x · 2009 · External reference
10.1056/nejmra1001683
10.1056/nejmra1001683 · External reference
10.1111/hepr.12310
10.1111/hepr.12310 · External reference
10.1146/annurev-med-090514-013832
10.1146/annurev-med-090514-013832 · External reference
Nonalcoholic fatty liver disease and hepatocellular carcinoma
10.1155/2014/106247 · 2014 · External reference
10.1002/hep.22580
10.1002/hep.22580 · External reference
10.1007/s00204-012-0931-2
10.1007/s00204-012-0931-2 · External reference
10.1056/nejmoa0708857
10.1056/nejmoa0708857 · External reference
10.1208/ps050325
10.1208/ps050325 · External reference
10.1007/s10555-010-9235-2
10.1007/s10555-010-9235-2 · External reference
New concepts in nutraceuticals as alternative for pharmaceuticals
2014 · External reference
10.1038/nrc3017
10.1038/nrc3017 · External reference
Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
10.18632/oncotarget.6237 · 2015 · External reference
Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy
10.1016/j.clnu.2013.03.008 · 2013 · External reference
10.1080/01635581.2012.630551
10.1080/01635581.2012.630551 · External reference
Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer
10.1080/01635581.2013.767367 · 2013 · External reference
10.1016/j.semcancer.2016.04.002
10.1016/j.semcancer.2016.04.002 · External reference
10.1016/j.semcancer.2016.03.005
10.1016/j.semcancer.2016.03.005 · External reference
Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals
10.1016/j.canlet.2016.03.042 · 2017 · External reference
: Network-based analysis of nutraceuticals in human hepatocellular carcinomas reveals mechanisms of chemopreventive action
2015 · External reference
Molecular targets of epigallocatechin-gallate (EGCG): a special focus on signal transduction and cancer
2018 · External reference
10.1016/j.semcancer.2016.04.003
10.1016/j.semcancer.2016.04.003 · External reference
The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways
10.1371/journal.pone.0169335 · 2017 · External reference
Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells
10.3390/cancers3010789 · 2011 · External reference
Unresolved reference
External reference
10.1093/bioinformatics/btu170
10.1093/bioinformatics/btu170 · External reference
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
2013 · External reference
10.1093/bioinformatics/btu638
10.1093/bioinformatics/btu638 · External reference
10.1186/s13059-014-0550-8
10.1186/s13059-014-0550-8 · External reference
A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival
10.1186/1755-8794-2-68 · 2009 · External reference
10.1093/nar/gkz446
10.1093/nar/gkz446 · External reference
Analyzing and vizualizing genomic complexity for the derivation of the emergent molecular networks
2016 · External reference
Dual IRE1 RNase functions dictate glioblastoma development
10.15252/emmm.201707929 · 2018 · External reference
10.1006/meth.2001.1262
10.1006/meth.2001.1262 · External reference
10.1016/j.biochi.2007.08.008
10.1016/j.biochi.2007.08.008 · External reference
10.1016/j.cell.2010.03.015
10.1016/j.cell.2010.03.015 · External reference
Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance
10.1007/s13277-014-2430-y · 2014 · External reference
10.1038/ncomms14206
10.1038/ncomms14206 · External reference
From pharmaceuticals to nutraceuticals: bridging disease prevention and management
10.1080/17512433.2019.1552135 · 2019 · External reference
10.1134/s0006297917080016
10.1134/s0006297917080016 · External reference
Targeting transcription factors for cancer treatment
2018 · External reference
10.1083/jcb.201102147
10.1083/jcb.201102147 · External reference
Promoter hypermethylation mediates the down-regulated expression of ADAMTS9 and associated with the prognosis in hepatocellular carcinoma
2016 · External reference
ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer
10.1038/onc.2012.359 · 2013 · External reference
10.1126/science.1067100
10.1126/science.1067100 · External reference
Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth
10.3748/wjg.v18.i47.7070 · 2012 · External reference
10.1158/0008-5472.can-17-3844
10.1158/0008-5472.can-17-3844 · External reference
Expression and prognostic value of VEGFR-2, PDGFR-beta, and c-Met in advanced hepatocellular carcinoma
10.1186/1756-9966-32-16 · 2013 · External reference
10.1002/ijc.25469
10.1002/ijc.25469 · External reference
10.1186/gb-2006-7-5-216
10.1186/gb-2006-7-5-216 · External reference
10.1007/s10735-013-9529-0
10.1007/s10735-013-9529-0 · External reference
HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma
10.1016/j.yexcr.2014.11.018 · 2015 · External reference
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets
10.1016/j.bbamem.2014.12.012 · 2015 · External reference
IkappaB kinases: key regulators of the NF-kappaB pathway
10.1016/j.tibs.2003.12.003 · 2004 · External reference
Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis
10.1186/1471-2407-9-100 · 2009 · External reference
10.1093/carcin/bgv045
10.1093/carcin/bgv045 · External reference
Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo
10.1186/1471-2407-10-276 · 2010 · External reference
