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References from Recent progress in structural studies on TMEM16A channel. Local targets link to admitted publications; unresolved targets remain external evidence.
A transient calcium-dependent chloride current in the immature Xenopus oocyte
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A calcium-dependent transient outward current in Xenopus laevis oocytes
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Anoctamins are a family of Ca2+-activated Cl-channels
2012 · External reference
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10.1038/ncomms3367
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10.1073/pnas.1312014110 · External reference
10.1073/pnas.1102147108
10.1073/pnas.1102147108 · External reference
Molecular basis of PIP2-dependent regulation of the Ca(2+)-activated chloride channel TMEM16A
10.1038/s41467-019-11784-8 · 2019 · External reference
10.1073/pnas.1904012116
10.1073/pnas.1904012116 · External reference
Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)
10.1016/j.bbalip.2017.12.009 · 2018 · External reference
Activation of Ca(2+)-dependent Cl-currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen
10.1113/jphysiol.1995.sp020518 · 1995 · External reference
Characteristics and physiological role of the Ca(2+)-activated Cl-conductance in smooth muscle
10.1152/ajpcell.1996.271.2.c435 · 1996 · External reference
Calcium-activated chloride channels in bovine pulmonary artery endothelial cells
10.1113/jphysiol.1997.sp021865 · 1997 · External reference
Intracellular calcium activates a chloride current in canine ventricular myocytes
1994 · External reference
Regulation of TMEM16A chloride channel properties by alternative splicing
10.1074/jbc.m109.046607 · 2009 · External reference
10.1146/annurev.physiol.67.032003.154341
10.1146/annurev.physiol.67.032003.154341 · External reference
10.1124/pr.111.005009
10.1124/pr.111.005009 · External reference
10.1152/physrev.00039.2011
10.1152/physrev.00039.2011 · External reference
10.1038/nrd2780
10.1038/nrd2780 · External reference
CFTR chloride channel drug discovery – inhibitors as antidiarrheals and activators for therapy of cystic fibrosis
10.2174/138161206777585148 · 2006 · External reference
10.1016/j.biocel.2014.03.022
10.1016/j.biocel.2014.03.022 · External reference
Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca(2+) transients and slow waves in adult mouse small intestine
10.1152/ajpgi.00363.2016 · 2017 · External reference
Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal
10.1113/jphysiol.2014.277152 · 2014 · External reference
10.1186/1744-8069-10-5
10.1186/1744-8069-10-5 · External reference
TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
10.1038/srep16657 · 2015 · External reference
10.18632/oncotarget.3412
10.18632/oncotarget.3412 · External reference
10.1097/pas.0b013e3181238cec
10.1097/pas.0b013e3181238cec · External reference
10.1371/journal.pone.0115443
10.1371/journal.pone.0115443 · External reference
10.1371/journal.pone.0136584
10.1371/journal.pone.0136584 · External reference
10.1002/ijc.31887
10.1002/ijc.31887 · External reference
Prediction of novel anoctamin1 (ANO1) inhibitors using 3D-QSAR pharmacophore modeling and molecular docking
2018 · External reference
Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
2017 · External reference
10.1038/nature25024
10.1038/nature25024 · External reference
10.1038/nature24652
10.1038/nature24652 · External reference
10.1016/j.bbamem.2013.08.010
10.1016/j.bbamem.2013.08.010 · External reference
10.1074/jbc.m109.046607
10.1074/jbc.m109.046607 · External reference
10.1152/ajprenal.00123.2003
10.1152/ajprenal.00123.2003 · External reference
Characterization of Ca2+-activated Cl- currents in mouse kidney inner medullary collecting duct cells
10.1152/ajprenal.00034.2003 · 2003 · External reference
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
2014 · External reference
10.1007/s10822-015-9876-x
10.1007/s10822-015-9876-x · External reference
10.1161/circresaha.112.264440
10.1161/circresaha.112.264440 · External reference
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K
10.1038/s41467-019-11753-1 · 2019 · External reference
Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions
2017 · External reference
10.1007/s10822-013-9668-0
10.1007/s10822-013-9668-0 · External reference
Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase
10.7554/elife.43229 · 2019 · External reference
10.1016/j.celrep.2019.06.023
10.1016/j.celrep.2019.06.023 · External reference
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
10.7554/elife.44364 · 2019 · External reference
10.1073/pnas.1502291112
10.1073/pnas.1502291112 · External reference
10.1146/annurev.biophys.31.082901.134259
10.1146/annurev.biophys.31.082901.134259 · External reference
10.1146/annurev-physiol-021113-170358
10.1146/annurev-physiol-021113-170358 · External reference
Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)
2017 · External reference
10.1111/bph.13913
10.1111/bph.13913 · External reference
10.1146/annurev.biophys.37.032807.125859
10.1146/annurev.biophys.37.032807.125859 · External reference
10.1016/j.neuron.2018.01.048
10.1016/j.neuron.2018.01.048 · External reference
Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
2018 · External reference
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F
10.7554/elife.44365 · 2019 · External reference
10.1002/jcp.27865
10.1002/jcp.27865 · External reference
10.1016/j.phrs.2019.104323
10.1016/j.phrs.2019.104323 · External reference
10.1007/s00232-017-9975-9
10.1007/s00232-017-9975-9 · External reference
10.1007/s00424-017-1934-x
10.1007/s00424-017-1934-x · External reference
10.1073/pnas.1214596109
10.1073/pnas.1214596109 · External reference
Blockade of anoctamin-1 in injured and uninjured nerves reduces neuropathic pain
10.1016/j.brainres.2018.06.001 · 2018 · External reference
10.1002/jcp.27529
10.1002/jcp.27529 · External reference
10.1016/j.bpj.2019.11.015
10.1016/j.bpj.2019.11.015 · External reference
10.1038/nbt0102-87
10.1038/nbt0102-87 · External reference
10.1124/pr.112.007336
10.1124/pr.112.007336 · External reference
Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach
10.2174/157340911793743547 · 2011 · External reference
