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References from Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1). Local targets link to admitted publications; unresolved targets remain external evidence.
The trajectory of dementia in the UK - Making a difference
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Unresolved reference
External reference
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2010 · External reference
Intracellular dynamics of synucleins: “Here, There and Everywhere”
2015 · External reference
Proteostasis impairment in protein-misfolding and -aggregation diseases
2014 · External reference
Synaptojanin 1 Mutation in Parkinson’s disease brings further insight into the neuropathological mechanisms
2014 · External reference
α-synuclein locus duplication as a cause of familial Parkinson’s disease
10.1016/s0140-6736(04)17103-1 · 2004 · External reference
α-Synuclein Locus Triplication Causes Parkinson’s disease
10.1126/science.1090278 · 2003 · External reference
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson’s disease
10.1038/ng0298-106 · 1998 · External reference
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast?
2010 · External reference
Genome-scale networks link neurodegenerative disease genes to α-synuclein through specific molecular pathways
2017 · External reference
Neuropathology of synuclein aggregates
2000 · External reference
Yeast genes that enhance the toxicity of a mutant Huntingtin fragment or α-synuclein
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Genomic, proteomic, and metabolomic data integration strategies
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Unresolved reference
External reference
Mutational analysis of SYNJ1 gene (PARK20) in Parkinson’s disease in a Taiwanese population
2015 · External reference
Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer’s disease
10.1523/jneurosci.2034-12.2012 · 2012 · External reference
PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family
10.1007/s10048-014-0406-0 · 2014 · External reference
Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset parkinsonism
2013 · External reference
Excess synaptojanin 1 contributes to place cell dysfunction and memory deficits in the aging hippocampus in three types of Alzheimer’s disease
10.1016/j.celrep.2018.05.011 · 2018 · External reference
PIPs in neurological diseases
2015 · External reference
The SAC 1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals
10.15252/embj.201695773 · 2017 · External reference
Recycling and EH domain proteins at the synapse
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The sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive parkinsonism with generalized seizures
10.1002/humu.22372 · 2013 · External reference
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Cations in motion: QM/MM studies of the dynamic and electrostatic roles of H+ and Mg2+ ions in enzyme reactions
2020 · External reference
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe synaptojanin and SHIP2
10.1074/jbc.m406416200 · 2004 · External reference
Calcium inhibition of ribonuclease H1 two-metal ion catalysis
10.1021/ja411408x · 2014 · External reference
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape 1: implications for the catalytic mechanism
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YeastMine-An integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit
10.1093/database/bar062 · 2012 · External reference
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10.1093/database/bat018 · 2013 · External reference
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2014 · External reference
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2004 · External reference
Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase
10.1016/s0092-8674(01)00326-9 · 2001 · External reference
Scalable molecular dynamics with NAMD
10.1002/jcc.20289 · 2005 · External reference
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
2013 · External reference
Particle mesh Ewald: an N·log(N) method for Ewald sums in large systems
10.1063/1.464397 · 1993 · External reference
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2008 · External reference
CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field
2016 · External reference
OPM: orientations of proteins in membranes database
2006 · External reference
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search
10.1093/nar/gkw1012 · 2017 · External reference
Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78)
10.1093/brain/aww307 · 2017 · External reference
Structure and expression of the Saccharomyces cerevisiae CRY1 gene: a highly conserved ribosomal protein gene
1987 · External reference
Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly
10.1083/jcb.111.6.2261 · 1990 · External reference
Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale
10.1093/nar/gkf693 · 2002 · External reference
The carboxy-terminal extension of yeast ribosomal protein S14 is necessary for maturation of 43S preribosomes
10.1016/s1097-2765(04)00215-1 · 2004 · External reference
Molecular genetic analysis of Rts1p, a B’ regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A
10.1128/mcb.17.6.3242 · 1997 · External reference
Phosphorylation-dependent regulation of septin dynamics during the cell cycle
10.1016/s1534-5807(03)00061-3 · 2003 · External reference
STITCH: interaction networks of chemicals and proteins
2008 · External reference
Autophagy in the presynaptic compartment in health and disease
2017 · External reference
Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases
10.1007/s11011-018-0214-6 · 2018 · External reference
Presenilin mutations linked to familial Alzheimer’s disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism
10.1073/pnas.0604954103 · 2006 · External reference
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
10.1016/j.str.2014.01.013 · 2014 · External reference
ClustalW and ClustalX
2003 · External reference
MUSCLE: Multiple sequence alignment with high accuracy and high throughput
10.1093/nar/gkh340 · 2004 · External reference
ESPript: Analysis of multiple sequence alignments in PostScript
1999 · External reference
A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery
2012 · External reference
Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases
2000 · External reference
The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis
10.1074/jbc.m006244200 · 2000 · External reference
Structure and function of type II restriction endonucleases
10.1093/nar/29.18.3705 · 2001 · External reference
A “moving metal mechanism” for substrate cleavage by the DNA repair endonuclease APE-1
2007 · External reference
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10.5860/choice.196525 · External reference
Spreading of pathology in neurodegenerative diseases: a focus on human studies
10.1038/nrn3887 · 2015 · External reference
The genetic background of Parkinson’s disease: current progress and future prospects
10.1111/ane.12563 · 2016 · External reference