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References from Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke. Local targets link to admitted publications; unresolved targets remain external evidence.
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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
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Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol
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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment
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The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury
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4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
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Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice
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Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells
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Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study
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An 8-month systems toxicology inhalation/cessation study in apoe-/- mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes
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Effects of cigarette smoke, cessation, and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/- mice-an integrative systems toxicology analysis
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A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
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A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
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A network-based approach to quantifying the impact of biologically active substances
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A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes
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10.1016/j.csbj.2014.08.004 · Admitted local publication
Statistical inference from multiple iTRAQ experiments without using common reference standards
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An algorithm for fast preranked gene set enrichment analysis using cumulative statistic calculation
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Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure
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Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice
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The Apoe-/- Mouse PhysioLab® platform: A validated physiologically-based mathematical model of atherosclerotic plaque progression in the Apoe-/- mouse
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Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation
10.1016/j.atherosclerosis.2013.03.036 · 2013 · External reference
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
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Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD
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Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/- mice that are progressively deactivated upon cessation
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Variable selection for generalized canonical correlation analysis
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A network-based approach to quantifying the impact of biologically active substances
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