Research graph
References from Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS 2 technology and systems pharmacology. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3322/caac.21492
10.3322/caac.21492 · External reference
The use of complementary and alternative medicine by cancer patients
2007 · External reference
Effects of traditional Chinese medicine in treatment of breast cancer patients after mastectomy: A meta-analysis
10.1007/s12013-014-0348-z · 2015 · External reference
Main progress on studies of pharmacological activities and clinical applications of Guizhi Fuling capsule
2015 · External reference
Effect of Guizhi Fuling capsule and its ingredients on human breast cancer cells proliferation
2018 · External reference
The effect of Guizhifuling Decoction on related protein of the mitochondrial pathway of apoptosis of breast cancer cell lines and cell cycle
2015 · External reference
10.1093/bib/bbt035
10.1093/bib/bbt035 · External reference
A new strategy to uncover the anticancer mechanism of chinese compound formula by integrating systems pharmacology and bioinformatics
10.1155/2018/6707850 · 2018 · External reference
10.1007/s13238-018-0533-8
10.1007/s13238-018-0533-8 · External reference
10.1073/pnas.1200305109
10.1073/pnas.1200305109 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
10.1186/1758-2946-6-13 · 2014 · External reference
10.1093/nar/gkv951
10.1093/nar/gkv951 · External reference
10.3390/ijms13066964
10.3390/ijms13066964 · External reference
Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease
10.1016/j.jep.2012.09.051 · 2013 · External reference
10.1371/journal.pone.0037608
10.1371/journal.pone.0037608 · External reference
10.1093/nar/gkv1277
10.1093/nar/gkv1277 · External reference
10.1093/nar/gkv1230
10.1093/nar/gkv1230 · External reference
UniProt: The universal protein knowledgebase
2017 · External reference
10.1002/(sici)1098-1004(200001)15:1<57::aid-humu12>3.0.co;2-g
10.1002/(sici)1098-1004(200001)15:1<57::aid-humu12>3.0.co;2-g · External reference
10.1093/nar/gkx1037
10.1093/nar/gkx1037 · External reference
10.1101/gr.1239303
10.1101/gr.1239303 · External reference
10.1038/nprot.2008.211
10.1038/nprot.2008.211 · External reference
Unresolved reference
External reference
The cBio Cancer Genomics Portal: An open platform for exploring multidimensional cancer genomics data
10.1158/2159-8290.cd-12-0095 · 2012 · External reference
RASL-seq for massively parallel and quantitative analysis of gene expression
2012 · External reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
Differential analysis of count data – the DESeq2 package
2014 · External reference
Unresolved reference
External reference
ggplot2: elegant graphics for data analysis
10.1111/j.1467-985x.2010.00676_9.x · 2011 · External reference
10.1093/nar/gky1131
10.1093/nar/gky1131 · External reference
10.1007/s10549-009-0674-9
10.1007/s10549-009-0674-9 · External reference
10.1107/s0907444902003451
10.1107/s0907444902003451 · External reference
Unresolved reference
External reference
10.1021/jm051256o
10.1021/jm051256o · External reference
10.1002/jcc.20291
10.1002/jcc.20291 · External reference
Unresolved reference
External reference
10.1016/j.bbagen.2016.06.009
10.1016/j.bbagen.2016.06.009 · External reference
Mitotic and apoptotic activity in colorectal neoplasia
10.1186/s12876-018-0786-y · 2018 · External reference
10.1016/j.molmed.2017.03.004
10.1016/j.molmed.2017.03.004 · External reference
MicroRNA (miRNA) in cancer
10.1186/s12935-015-0185-1 · 2015 · External reference
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
10.1111/j.1582-4934.2010.01236.x · 2011 · External reference
Antithetic roles of proteoglycans in cancer
10.1007/s00018-011-0816-1 · 2012 · External reference
Unique dependence on Sos1 in KrasG12D-induced leukemogenesis
10.1182/blood-2018-09-874107 · 2018 · External reference
Molecular dynamics simulations and drug discovery
10.1186/1741-7007-9-71 · 2011 · External reference
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation article
10.1038/s41419-018-0267-9 · 2018 · External reference
Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
10.2147/dddt.s181939 · 2018 · External reference
Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma
10.1016/j.bbrc.2018.05.143 · 2018 · External reference
Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway
10.1016/j.biopha.2017.03.091 · 2017 · External reference
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway
10.1016/j.jep.2017.05.028 · 2017 · External reference
Guizhi Fuling Wan, a traditional Chinese herbal formula, sensitizes cisplatin-resistant human ovarian cancer cells through inactivation of the PI3K/AKT/mTOR Pathway
10.1155/2016/4651949 · 2016 · External reference
Breast cancer invasion and metastasis by mPRα through the PI3K/Akt signaling pathway
10.1007/s12253-015-0023-8 · 2016 · External reference
Casticin inhibits breast cancer cell migration and invasion by downregulation of PI3K/Akt signaling pathway
2018 · External reference
Effects of endoplasmic reticulum stress on the autophagy, apoptosis, and chemotherapy resistance of human breast cancer cells by regulating the PI3K/AKT/mTOR signaling pathway
2017 · External reference
Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase
10.1016/j.pharep.2017.04.008 · 2017 · External reference
MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway
10.1038/srep41942 · 2017 · External reference
DEK promoted EMT and angiogenesis through regulating PI3K/ AKT/mTOR pathway in triple-negative breast cancer
10.18632/oncotarget.21864 · 2017 · External reference
The PIK3CA gene is mutated with high frequency in human breast cancers
10.4161/cbt.3.8.994 · 2004 · External reference
10.3892/or.2017.5798
10.3892/or.2017.5798 · External reference
miR-3188 regulates cell proliferation, apoptosis, and migration in breast cancer by targeting TUSC5 and regulating the p38 MAPK signaling pathway
10.3727/096504017x14953948675421 · 2018 · External reference
Dalbergia odorifera extract promotes angiogenesis through upregulation of VEGFRs and PI3K/MAPK signaling pathways
10.1016/j.jep.2017.04.006 · 2017 · External reference
Prognostic and predictive value of EGFR and EGFR-ligands in blood of breast cancer patients: A systematic review
10.1515/cclm-2017-0592 · 2018 · External reference
10.7314/apjcp.2016.17.2.445
10.7314/apjcp.2016.17.2.445 · External reference
Molecular characterization of apocrine salivary duct carcinoma
10.1097/pas.0000000000000410 · 2015 · External reference
HRAS mutations in epithelial-myoepithelial carcinoma
10.1007/s12105-013-0506-4 · 2014 · External reference
Expressions of Ras and Sos1 in epithelial ovarian cancer tissues and their clinical significance
2016 · External reference
10.1158/1541-7786.mcr-18-0316
10.1158/1541-7786.mcr-18-0316 · External reference
MicroRNA 628 suppresses migration and invasion of breast cancer stem cells through targeting SOS1
10.2147/ott.s164575 · 2018 · External reference
Expression of long non-coding RNA linc-ITGB1 in breast cancer and its influence on prognosis and survival
2017 · External reference
FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth
10.1186/s13058-015-0551-x · 2015 · External reference
10.18632/oncotarget.18983
10.18632/oncotarget.18983 · External reference