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References from Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model. Local targets link to admitted publications; unresolved targets remain external evidence.
Type 1 diabetes mellitus
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Unresolved reference
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Teenage girls with type 1 diabetes have poorer metabolic control than boys and face more complications in early adulthood
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Diabetic encephalopathy: a concept in need of a definition
10.1007/s00125-006-0221-8 · 2006 · External reference
Clinically significant cognitive impairment in older adults with type 1 diabetes
10.1016/j.jdiacomp.2018.04.003 · 2019 · External reference
Cognitive dysfunction in type 1 diabetes mellitus
10.1210/jc.2018-01315 · 2019 · External reference
Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume
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10.2337/db11-1358 · External reference
10.1016/j.ajpath.2013.11.021
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10.1074/jbc.m112.440784 · External reference
Nrf2-mediated neuroprotection against recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes
10.2337/db15-1653 · 2016 · External reference
Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction
10.1007/s10787-019-00665-7 · 2020 · External reference
10.1016/j.bbadis.2019.165541
10.1016/j.bbadis.2019.165541 · External reference
Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury
10.1097/01.wcb.0000143700.15489.b2 · 2004 · External reference
Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus
10.1007/s00234-005-1387-3 · 2005 · External reference
NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction
10.1007/s11011-016-9949-0 · 2017 · External reference
Cognitive decline in type 2 diabetic db/db mice may be associated with brain region-specific metabolic disorders
10.1016/j.bbadis.2016.11.003 · 2017 · External reference
The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease
10.1016/j.bbadis.2017.10.028 · 2018 · External reference
Streptozotocin-induced diabetic models in mice and rats
10.1002/0471141755.ph0547s70 · 2015 · External reference
Unresolved reference
2019 · External reference
icoshift: A versatile tool for the rapid alignment of 1D NMR spectra
10.1016/j.jmr.2009.11.012 · 2010 · External reference
10.1093/nar/gkx1089
10.1093/nar/gkx1089 · External reference
KEGG Atlas mapping for global analysis of metabolic pathways
10.1093/nar/gkn282 · 2008 · External reference
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10.1007/s00125-007-0886-7 · External reference
10.1172/jci44564
10.1172/jci44564 · External reference
Estrogen deficiency aggravates insulin resistance and induces β-cell loss and diabetes in female New Zealand obese mice
10.1055/s-0032-1331700 · 2013 · External reference
Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1
10.2337/db18-0638 · 2019 · External reference
10.1016/j.physbeh.2017.08.016
10.1016/j.physbeh.2017.08.016 · External reference
The effect of sex and gender on diabetic complications
10.2174/1573399812666160517115756 · 2017 · External reference
10.1016/j.cmet.2011.08.016
10.1016/j.cmet.2011.08.016 · External reference
Sex-specific metabolic changes in peripheral organs of diabetic mice
2020 · External reference
10.1126/science.7824953
10.1126/science.7824953 · External reference
10.1016/s0022-510x(02)00112-0
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10.1111/j.1552-6569.2010.00543.x
10.1111/j.1552-6569.2010.00543.x · External reference
Unresolved reference
2019 · External reference
10.1186/s13024-019-0305-9
10.1186/s13024-019-0305-9 · External reference
Gender differences in the gene expression profiles of glucose transporter GLUT class I and SGLT in mouse tissues
10.31083/ph.2014.4647 · 2014 · External reference
Metabolomic analysis identifies lactate as an important pathogenic factor in diabetes-associated cognitive decline rats
10.1074/mcp.ra118.000690 · 2018 · External reference
Age and sex-related changes in rat brain mitochondrial function
10.1159/000327945 · 2011 · External reference
Role of sex hormones on brain mitochondrial function, with special reference to aging and neurodegenerative diseases
10.3389/fnagi.2017.00406 · 2017 · External reference
10.1523/jneurosci.0415-11.2011
10.1523/jneurosci.0415-11.2011 · External reference
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease
10.1136/jnnp-2014-308577 · 2015 · External reference
Cerebral lactic acidosis correlates with neurological impairment in MELAS
10.1212/01.wnl.0000120557.83907.a8 · 2004 · External reference
10.1177/153537020623100503
10.1177/153537020623100503 · External reference
Effect of choline-containing phospholipids on brain cholinergic transporters in the rat
10.1016/j.jns.2010.11.028 · 2011 · External reference
Effects of gender and region on proton MRS of normal human brain
10.1016/s0730-725x(98)00186-6 · 1999 · External reference
10.1016/j.pbb.2017.05.011
10.1016/j.pbb.2017.05.011 · External reference
Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation
10.1111/acel.13037 · 2019 · External reference
Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype
10.3945/jn.109.116673 · 2010 · External reference
10.1111/j.1471-4159.2006.03913.x
10.1111/j.1471-4159.2006.03913.x · External reference
10.1016/s0165-0173(02)00268-0
10.1016/s0165-0173(02)00268-0 · External reference
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain
10.1002/jmri.24123 · 2013 · External reference
10.1007/s10545-018-0201-4
10.1007/s10545-018-0201-4 · External reference
10.1016/j.neuropharm.2011.03.015
10.1016/j.neuropharm.2011.03.015 · External reference
Sex-dimorphic estrogen receptor regulation of ventromedial hypothalamic nucleus glucoregulatory neuron adrenergic receptor expression in hypoglycemic male and female rats
10.1016/j.brainres.2019.146311 · 2019 · External reference
Linking the gut microbiota to a brain neurotransmitter
10.1016/j.tins.2018.04.001 · 2018 · External reference
10.1007/bf00971582
10.1007/bf00971582 · External reference
Taurine homeostasis and volume control
10.1007/978-3-319-55769-4_3 · 2017 · External reference
Evidence for sexual difference in astrocytes of adult rat hippocampus
10.1016/s0304-3940(02)01484-2 · 2003 · External reference
10.1016/s0006-8993(02)03475-3
10.1016/s0006-8993(02)03475-3 · External reference
Astrocytic and microglial response in experimentally induced diabetic rat brain
10.1007/s11011-014-9562-z · 2014 · External reference
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10.1002/hipo.450040319 · External reference
Anterior insular cortex is a bottleneck of cognitive control
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Effects of entorhinal cortex lesions on sensory integration and spatial learning
10.1097/00006199-200103000-00003 · 2001 · External reference
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10.3389/fnins.2015.00037 · External reference
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10.1155/2015/949085 · External reference
Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism
10.1155/2015/567945 · 2015 · External reference
Effects of diabetes and ovariectomy on rat hippocampus (a biochemical and stereological study)
10.3109/09513590.2011.593662 · 2012 · External reference
The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes
10.2337/dc12-1986 · 2013 · External reference
10.1016/j.cyto.2017.07.013
10.1016/j.cyto.2017.07.013 · External reference
Associations between circulating inflammatory markers, diabetes type and complications in youth
10.1111/pedi.12913 · 2019 · External reference
Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans
10.2967/jnumed.111.097014 · 2012 · External reference
10.1016/j.freeradbiomed.2016.04.200
10.1016/j.freeradbiomed.2016.04.200 · External reference
Acute inflammation alters brain energy metabolism in mice and humans: role in suppressed spontaneous activity, impaired cognition, and delirium
10.1523/jneurosci.2876-19.2020 · 2020 · External reference
10.1038/tp.2016.200
10.1038/tp.2016.200 · External reference
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10.1007/978-3-211-98811-4_32 · 2010 · External reference
10.1007/s007020050130 · 1998 · Admitted local publication
Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat
10.3233/jad-2006-9305 · 2006 · External reference
Intracerebroventricular streptozotocin induces behavioral impairments and increases short–term C3 gene expression in the hippocampus of Wistar rats
10.21307/ane-2020-015 · 2020 · External reference
Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: A therapeutic intervention for treatment of sporadic Alzheimer’s disease (sAD)-like pathology
10.1007/s12035-015-9384-y · 2016 · External reference
Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment
10.1016/s0024-3205(00)01005-5 · 2001 · External reference
Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats
10.1016/j.neuint.2017.11.012 · 2018 · External reference
Hippocampal changes in STZ-model of Alzheimer’s disease are dependent on sex
10.1016/j.bbr.2016.08.057 · 2017 · External reference
Sex differences in the cognitive and hippocampal effects of streptozotocin in an animal model of sporadic AD
10.3389/fnagi.2017.00347 · 2017 · External reference