Research graph
References from Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Unresolved reference
2017 · External reference
10.1086/595011
10.1086/595011 · External reference
Unresolved reference
2008 · External reference
10.1016/j.tim.2011.04.005
10.1016/j.tim.2011.04.005 · External reference
10.1016/s1473-3099(06)70580-1
10.1016/s1473-3099(06)70580-1 · External reference
Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus
10.1016/s1473-3099(14)70850-3 · 2015 · External reference
Structure− activity relationships of polymyxin antibiotics
10.1021/jm900999h · 2009 · External reference
The chemistry of the polymyxin antibiotics
10.1007/bf01901127 · 1966 · External reference
Gram-negative outer and inner membrane models: insertion of cyclic cationic lipopeptides
10.1021/jp064757+ · 2007 · External reference
10.1101/cshperspect.a025288
10.1101/cshperspect.a025288 · External reference
Pharmacology of polymyxins: new insights into an ‘old’class of antibiotics
10.2217/fmb.13.39 · 2013 · External reference
10.1128/aac.00079-11
10.1128/aac.00079-11 · External reference
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A
10.1128/aac.00256-11 · 2011 · External reference
Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production
10.1128/aac.00834-10 · 2010 · External reference
Phenothiazine: the parent molecule
10.2174/138945006778226552 · 2006 · External reference
Unresolved reference
External reference
Die Chemie der Insektizide, ihre Entwicklung und ihr heutiger Stand
10.1007/bf02158514 · 1954 · External reference
10.1016/j.drudis.2011.01.001
10.1016/j.drudis.2011.01.001 · External reference
Studies on phenothiazine VIII. Antiseptic value of phenothiazine in urinary tract infections
10.1016/s0022-3565(25)08193-5 · 1939 · External reference
The potential management of resistant infections with non-antibiotics
10.1093/jac/40.3.319 · 1997 · External reference
The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria
10.1111/j.1699-0463.1986.tb03073.x · 1986 · External reference
The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus
10.1016/s0924-8579(03)00205-x · 2003 · External reference
10.1371/journal.pone.0189950
10.1371/journal.pone.0189950 · External reference
Reversal of resistance in microorganisms by help of non-antibiotics
10.1093/jac/dkm071 · 2007 · External reference
Chlorpromazine in nonpsychotic patients with pulmonary tuberculosis
1960 · External reference
10.1089/mdr.2016.0196
10.1089/mdr.2016.0196 · External reference
An “Unlikely” Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI
10.1021/acsinfecdis.6b00035 · 2016 · External reference
Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
10.3389/fphar.2018.00359 · 2018 · External reference
Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens
10.3389/fmicb.2018.00721 · 2018 · External reference
Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'
10.1042/ebc20160058 · 2017 · External reference
In vitro synergistic effects of chlorpromazine and sertraline in combination with amphotericin B against Cryptococcus neoformans var. grubii
10.1007/s12223-016-0449-8 · 2016 · External reference
Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae
2019 · External reference
10.1016/j.csbj.2018.11.001 · Admitted local publication
10.1038/ja.2015.127
10.1038/ja.2015.127 · External reference
Polycations sensitize enteric bacteria to antibiotics
10.1128/aac.24.1.107 · 1983 · External reference
Unresolved reference
2015 · External reference
The pharmacokinetics and effects of prochlorperazine in elderly female volunteers
10.1093/ageing/21.1.27 · 1992 · External reference
10.1021/acsinfecdis.5b00097 · Admitted local publication
10.1074/jbc.r116.734780
10.1074/jbc.r116.734780 · External reference
10.3390/ijms17030363
10.3390/ijms17030363 · External reference
10.1016/s0076-6879(09)04617-5
10.1016/s0076-6879(09)04617-5 · External reference
Antifungal activity of nonantifungal drugs
10.1007/s10096-003-0947-x · 2003 · External reference
Preliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteers
10.1111/j.1365-2125.1987.tb03021.x · 1987 · External reference
Unresolved reference
2011 · External reference
Improving the role of intraventricular antimicrobial agents in the management of meningitis
10.1097/wco.0b013e32832c1396 · 2009 · External reference
Intracerebroventricular administration of drugs. Pharmacotherapy: The Journal of Human Pharmacology and Drug
2009 · External reference
Efficacy and safety of intrathecal meropenem and vancomycin in the treatment of postoperative intracranial infection in patients with severe traumatic brain injury
2019 · External reference
Efficacy of intravenous plus intrathecal/intracerebral ventricle injection of polymyxin B for post-neurosurgical intracranial infections due to MDR/XDR Acinectobacter baumannii: a retrospective cohort study
10.1186/s13756-018-0305-5 · 2018 · External reference
Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two ‘old’antibiotics—polymyxin B and chloramphenicol
10.1093/jac/dkv135 · 2015 · External reference
Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine
10.1021/pr070183p · 2007 · External reference
