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References from Computational biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity. Local targets link to admitted publications; unresolved targets remain external evidence.
SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
10.1016/j.cell.2020.02.052 · 2020 · External reference
Structural basis of receptor recognition by SARS-CoV-2
2020 · External reference
Structural and functional basis of SARS-CoV-2 entry by using human ACE2
2020 · External reference
COVID-19 drug discovery using intensive approaches
10.3390/ijms21082839 · 2020 · External reference
10.1038/nm1267
10.1038/nm1267 · External reference
Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
2020 · External reference
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 · External reference
Site-specific analysis of the SARS-CoV-2 glycan shield
2020 · External reference
Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions
2020 · External reference
10.3390/v12050497
10.3390/v12050497 · External reference
10.1021/acs.jpclett.0c01148
10.1021/acs.jpclett.0c01148 · External reference
10.1021/acs.jpclett.0c01064
10.1021/acs.jpclett.0c01064 · External reference
10.1101/2020.06.17.157982
10.1101/2020.06.17.157982 · External reference
Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS
10.1128/jvi.00127-20 · 2020 · External reference
SARS-CoV-2 spike protein predicted to form stable complexes with host receptor protein orthologues from mammals, but not fish, birds or reptiles
2020 · External reference
10.1371/journal.ppat.1007236
10.1371/journal.ppat.1007236 · External reference
Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease
10.1155/2012/256294 · 2012 · External reference
Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an Angiotensin II type I receptor-dependent mechanism
10.1161/hypertensionaha.114.03743 · 2014 · External reference
Unresolved reference
External reference
10.1126/science.abb2762
10.1126/science.abb2762 · External reference
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
2020 · External reference
PRODIGY: A web server for predicting the binding affinity of protein-protein complexes
2016 · External reference
10.1002/jcc.23796
10.1002/jcc.23796 · External reference
IPRO+/−: Computational protein design tool allowing for insertions and deletions
2020 · External reference
10.1101/2020.03.30.015347
10.1101/2020.03.30.015347 · External reference
Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV
2020 · External reference
10.1016/b978-012374410-4.00780-9
10.1016/b978-012374410-4.00780-9 · External reference
Coronavirus can infect cats - dogs, not so much
2020 · External reference
Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2
10.1016/j.micinf.2020.03.003 · 2020 · External reference
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
2020 · External reference
Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
2020 · External reference
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia
2005 · External reference
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
10.1038/s41368-020-0074-x · 2020 · External reference
ACE2 expression is increased in the lungs of patients with comorbidities associated with severe COVID-19
2020 · External reference
Journal pre-proof making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear
10.1016/j.cell.2020.06.040 · 2020 · External reference
The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
2020 · External reference
Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus
10.1016/j.cell.2020.06.043 · 2020 · External reference
I-TASSER server: New development for protein structure and function predictions
2015 · External reference
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
2004 · External reference
Integrating statistical pair potentials into protein complex prediction
10.1002/prot.21502 · 2007 · External reference
10.1093/bioinformatics/btq007
10.1093/bioinformatics/btq007 · External reference
10.3390/antib7030023
10.3390/antib7030023 · External reference
Replica Monte Carlo simulation of spin-glasses
10.1103/physrevlett.57.2607 · 1986 · External reference
SPICKER: A clustering approach to identify near-native protein folds
10.1002/jcc.20011 · 2004 · External reference
Atomic-level protein structure refinement using fragment-guided molecular dynamics conformation sampling
2011 · External reference
10.1021/acs.jctc.7b00125
10.1021/acs.jctc.7b00125 · External reference
A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
10.1002/pro.2187 · 2013 · External reference
10.1007/s10822-013-9644-8
10.1007/s10822-013-9644-8 · External reference
10.1021/jp003919d
10.1021/jp003919d · External reference
10.1109/sc.2006.54
10.1109/sc.2006.54 · External reference
10.1093/nar/gkr703
10.1093/nar/gkr703 · External reference
