Research graph
References from Combining structure and genomics to understand antimicrobial resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
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10.1038/ja.2013.49
10.1038/ja.2013.49 · External reference
Unresolved reference
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Global burden of tuberculosis: where we are and what to do
10.1016/s1473-3099(18)30654-6 · 2018 · External reference
Unresolved reference
External reference
10.1093/jac/dkx506
10.1093/jac/dkx506 · External reference
10.1146/annurev.pharmtox.45.120403.100120
10.1146/annurev.pharmtox.45.120403.100120 · External reference
10.1111/1469-0691.12253
10.1111/1469-0691.12253 · External reference
tuberculosis persistence, latency, and drug tolerance
10.1016/j.tube.2003.08.003 · 2004 · External reference
10.1111/j.1574-6976.2012.00331.x
10.1111/j.1574-6976.2012.00331.x · External reference
10.1038/s41588-017-0029-0
10.1038/s41588-017-0029-0 · External reference
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
2019 · External reference
Antimicrobial resistance mechanisms and potential synthetic treatments
10.4155/fsoa-2017-0109 · 2018 · External reference
An overview of the antimicrobial resistance mechanisms of bacteria
10.3934/microbiol.2018.3.482 · 2018 · External reference
10.1128/microbiolspec.vmbf-0016-2015
10.1128/microbiolspec.vmbf-0016-2015 · External reference
10.1038/nature13377
10.1038/nature13377 · External reference
Self-resistance mechanisms of actinomycetes producing lipid II-targeting antibiotics
10.1016/j.ijmm.2014.12.015 · 2015 · External reference
10.1038/nrmicro.2017.42
10.1038/nrmicro.2017.42 · External reference
10.3389/fmicb.2011.00203
10.3389/fmicb.2011.00203 · External reference
10.1177/0300985813511131
10.1177/0300985813511131 · External reference
What antimicrobial resistance has taught us about horizontal gene transfer
10.1007/978-1-60327-853-9_23 · 2009 · External reference
Efflux pump as alternate mechanism for drug resistance in Mycobacterium tuberculosis
10.1016/j.ijtb.2018.07.008 · 2019 · External reference
Single nucleotide polymorphisms in efflux pumps genes in extensively drug resistant Mycobacterium tuberculosis isolates from Pakistan
10.1016/j.tube.2017.07.012 · 2017 · External reference
Mechanisms of Antifungal Drug Resistance
10.1101/cshperspect.a019752 · 2014 · External reference
Antifungal resistance: current trends and future strategies to combat
10.2147/idr.s124918 · 2017 · External reference
Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside
10.2217/fmb-2018-0059 · 2018 · External reference
Antiviral drug resistance as an adaptive process
10.1093/ve/vew014 · 2016 · External reference
Antiviral drug resistance: mechanisms and clinical implications
10.1016/j.idc.2010.01.001 · 2010 · External reference
10.1016/j.jgar.2019.01.023
10.1016/j.jgar.2019.01.023 · External reference
10.1016/s1875-5364(19)30038-x
10.1016/s1875-5364(19)30038-x · External reference
10.1111/1574-6976.12032
10.1111/1574-6976.12032 · External reference
10.1111/j.1469-0691.2006.01492.x
10.1111/j.1469-0691.2006.01492.x · External reference
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment
2017 · External reference
10.1016/j.meegid.2016.08.031
10.1016/j.meegid.2016.08.031 · External reference
Detection and analysis of resistance mutations of hepatitis B virus
2015 · External reference
Genetic variation of hepatitis B virus and its significance for pathogenesis
10.3748/wjg.v22.i1.126 · 2016 · External reference
Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms
10.1128/aac.00241-18 · 2018 · External reference
10.1038/nrmicro.2017.28
10.1038/nrmicro.2017.28 · External reference
10.1111/nyas.13257
10.1111/nyas.13257 · External reference
10.1186/s13073-015-0164-0
10.1186/s13073-015-0164-0 · External reference
ARIBA: rapid antimicrobial resistance genotyping directly from sequencing reads
10.1099/mgen.0.000131 · 2017 · External reference
Antimicrobial resistance genetic factor identification from whole-genome sequence data using deep feature selection
10.1186/s12859-019-3054-4 · 2019 · External reference
10.1101/gr.218727.116
10.1101/gr.218727.116 · External reference
Classification of Mycobacterium tuberculosis DR, MDR, XDR Isolates and Identification of Signature MutationPattern of Drug Resistance
10.6026/97320630015261 · 2019 · External reference
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines
10.1038/s41598-019-45566-5 · 2019 · External reference
Whole-genome sequencing and single nucleotide polymorphisms in multidrug-resistant clinical isolates of Mycobacterium tuberculosis from the Philippines
10.1016/j.jgar.2018.08.009 · 2018 · External reference
Next generation sequencing reveals the antibiotic resistant variants in the genome of Pseudomonas aeruginosa
10.1371/journal.pone.0182524 · 2017 · External reference
10.1016/j.ajhg.2018.10.001
10.1016/j.ajhg.2018.10.001 · External reference
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
10.1007/s00125-011-2261-y · 2011 · External reference
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania
10.1371/journal.pgen.1007172 · 2018 · External reference
10.1371/journal.ppat.1007453
10.1371/journal.ppat.1007453 · External reference
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions
2019 · External reference
Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance
10.1186/s12864-019-5615-3 · 2019 · External reference
10.1371/journal.ppat.1007478
10.1371/journal.ppat.1007478 · External reference
Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance
10.3390/ijms21041363 · 2020 · External reference
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
10.1038/s41467-018-06634-y · 2018 · External reference
Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data
10.1371/journal.pcbi.1006258 · 2018 · External reference
A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action
2019 · External reference
Antimicrobial Resistance Prediction in PATRIC and RAST
10.1038/srep27930 · 2016 · External reference
PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens
10.1093/jac/dkx217 · 2017 · External reference
Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data
10.3389/fgene.2019.00922 · 2019 · External reference
10.1016/j.tube.2015.11.009
10.1016/j.tube.2015.11.009 · External reference
10.1038/s41576-019-0127-1
10.1038/s41576-019-0127-1 · External reference
10.1016/j.ajhg.2018.04.002
10.1016/j.ajhg.2018.04.002 · External reference
10.1038/nrg1672
10.1038/nrg1672 · External reference
10.7554/elife.00631
10.7554/elife.00631 · External reference
10.1098/rsif.2014.0419
10.1098/rsif.2014.0419 · External reference
Evolution favors protein mutational robustness in sufficiently large populations
10.1186/1741-7007-5-29 · 2007 · External reference
10.1016/j.jmb.2007.03.069
10.1016/j.jmb.2007.03.069 · External reference
A relationship between protein stability and protein function
10.1073/pnas.92.2.452 · 1995 · External reference
Novel missense mutations in gidB gene associated with streptomycin resistance in Mycobacterium tuberculosis: insights from molecular dynamics
10.1080/07391102.2017.1417913 · 2019 · External reference
10.1016/j.jmb.2009.11.005
10.1016/j.jmb.2009.11.005 · External reference
10.1371/journal.pone.0097202
10.1371/journal.pone.0097202 · External reference
10.1021/cb2001846
10.1021/cb2001846 · External reference
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
10.1111/j.1742-4658.2007.06241.x · 2008 · External reference
Evaluation of gidB alterations responsible for streptomycin resistance in Mycobacterium tuberculosis
10.1093/jac/dku273 · 2014 · External reference
Pandemic Influenza Virus
2009 · External reference
Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13
10.1038/s41598-019-47034-6 · 2019 · External reference
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
10.1186/s12916-016-0575-9 · 2016 · External reference
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
10.1038/s41598-018-33370-6 · 2018 · External reference
10.1371/journal.pone.0217169
10.1371/journal.pone.0217169 · External reference
Structure guided prediction of Pyrazinamide resistance mutations in pncA
10.1038/s41598-020-58635-x · 2020 · External reference
10.1186/1471-2164-14-s3-s7
10.1186/1471-2164-14-s3-s7 · External reference
10.1534/genetics.116.190033
10.1534/genetics.116.190033 · External reference
10.1016/j.csbj.2020.07.011 · Admitted local publication
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
10.1038/srep04765 · 2014 · External reference
10.1371/journal.pntd.0005177
10.1371/journal.pntd.0005177 · External reference
mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
10.1038/srep29575 · 2016 · External reference
In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity
2016 · External reference
10.1080/17460441.2017.1322579
10.1080/17460441.2017.1322579 · External reference
Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection
10.1099/mgen.0.000165 · 2018 · External reference
10.1038/s41588-018-0117-9
10.1038/s41588-018-0117-9 · External reference
Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy
10.1164/rccm.201712-2572le · 2018 · External reference
Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae
2018 · External reference
10.1016/j.csbj.2020.01.002 · Admitted local publication
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis
10.1021/acsinfecdis.6b00103 · 2017 · External reference
10.1021/acsinfecdis.6b00102
10.1021/acsinfecdis.6b00102 · External reference
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
10.1021/acs.jmedchem.7b01622 · 2018 · External reference
Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH
10.1016/j.ejmech.2019.04.027 · 2019 · External reference
10.1038/nprot.2009.86
10.1038/nprot.2009.86 · External reference
10.1093/nar/gkz457
10.1093/nar/gkz457 · External reference
DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
10.1093/nar/gku411 · 2014 · External reference
10.1093/nar/gkx1098
10.1093/nar/gkx1098 · External reference
10.1371/journal.pone.0046688
10.1371/journal.pone.0046688 · External reference
Better prediction of functional effects for sequence variants
10.1186/1471-2164-16-s8-s1 · 2015 · External reference
10.1093/nar/gkw408
10.1093/nar/gkw408 · External reference
10.1101/2020.05.29.124610
10.1101/2020.05.29.124610 · External reference
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
10.1038/s41467-019-10280-3 · 2019 · External reference
10.1073/pnas.1707304114
10.1073/pnas.1707304114 · External reference
10.1101/gr.3804205
10.1101/gr.3804205 · External reference
10.1101/gr.097121.109
10.1101/gr.097121.109 · External reference
10.1016/j.sbi.2009.08.003
10.1016/j.sbi.2009.08.003 · External reference
10.1093/nar/gki387
10.1093/nar/gki387 · External reference
Role of conformational sampling in computing mutation-induced changes in protein structure and stability
10.1002/prot.22921 · 2011 · External reference
PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality
10.1186/1471-2105-12-151 · 2011 · External reference
I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure
10.1093/nar/gki375 · 2005 · External reference
10.1093/bioinformatics/btw361
10.1093/bioinformatics/btw361 · External reference
DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
10.1093/nar/gky300 · 2018 · External reference
10.1093/nar/gkz383
10.1093/nar/gkz383 · External reference
10.1093/nar/gkx236
10.1093/nar/gkx236 · External reference
Cutoff Scanning Matrix (CSM): structural classification and function prediction by protein inter-residue distance patterns
10.1186/1471-2164-12-s4-s12 · 2011 · External reference
10.1093/bioinformatics/btt691
10.1093/bioinformatics/btt691 · External reference
Computational tools help improve protein stability but with a solubility tradeoff
10.1074/jbc.m117.784165 · 2017 · External reference
10.1093/bioinformatics/btw031
10.1093/bioinformatics/btw031 · External reference
HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new target site for drugs
10.1110/ps.03468904 · 2004 · External reference
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
2020 · External reference
Molecular simulations of fluconazole-mediated inhibition of sterol biosynthesis
2020 · External reference
Mutations in catalase-peroxidase KatG from isoniazid resistant Mycobacterium tuberculosis clinical isolates: insights from molecular dynamics simulations
10.1007/s00894-017-3290-3 · 2017 · External reference
10.1016/j.csbj.2020.05.009 · Admitted local publication
Computational analysis of the molecular mechanism of RamR mutations contributing to antimicrobial resistance in salmonella enterica
2017 · External reference
10.1038/s41598-019-48940-5
10.1038/s41598-019-48940-5 · External reference
10.1039/c7sc03336b
10.1039/c7sc03336b · External reference
Insight into the antimicrobial mechanism of action of β2,2-amino acid derivatives from molecular dynamics simulation: Dancing the can-can at the membrane surface
10.1016/j.bbamem.2019.07.016 · 2019 · External reference
Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses
10.1371/journal.pone.0160172 · 2016 · External reference
10.1111/mmi.12520
10.1111/mmi.12520 · External reference
Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis
10.3389/fmicb.2018.02895 · 2018 · External reference
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
10.1038/ng.1038 · 2011 · External reference
10.1101/518142
10.1101/518142 · External reference
Influenza virus neuraminidase: Structure, antibodies, and inhibitors
10.1002/pro.5560031007 · 1994 · External reference
Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens
10.1093/nar/gkx1015 · 2018 · External reference
INPS-MD: a web server to predict stability of protein variants from sequence and structure
10.1093/bioinformatics/btw192 · 2016 · External reference
DeepDDG: Predicting the Stability Change of Protein Point Mutations Using Neural Networks
10.1021/acs.jcim.8b00697 · 2019 · External reference
10.1021/jm040031v
10.1021/jm040031v · External reference
In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery
10.3389/fchem.2020.00093 · 2020 · External reference
10.1038/nrd.2016.109
10.1038/nrd.2016.109 · External reference
10.1021/acs.jmedchem.0c00007
10.1021/acs.jmedchem.0c00007 · External reference
Fragment-based screening with natural products for novel anti-parasitic disease drug discovery
10.1080/17460441.2019.1653849 · 2019 · External reference
10.1111/cbdd.13030
10.1111/cbdd.13030 · External reference
10.1093/bioinformatics/btw222
10.1093/bioinformatics/btw222 · External reference
MAESTROweb: a web server for structure-based protein stability prediction
10.1093/bioinformatics/btv769 · 2016 · External reference
10.1021/acs.jpcb.7b11367
10.1021/acs.jpcb.7b11367 · External reference