Research graph
References from The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nrm911
10.1038/nrm911 · External reference
10.1098/rsob.170213
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10.1146/annurev-micro-020518-120235
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10.1016/j.pt.2020.01.009
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10.1371/journal.ppat.1000008
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10.1371/journal.ppat.1000746 · External reference
10.1371/journal.pbio.3000264
10.1371/journal.pbio.3000264 · External reference
Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites
10.1038/srep34479 · 2016 · External reference
Protein kinase A is essential for invasion of Plasmodium falciparum into human erythrocytes
2019 · External reference
10.1016/j.chom.2018.10.015
10.1016/j.chom.2018.10.015 · External reference
10.15252/embj.201796794
10.15252/embj.201796794 · External reference
10.1016/j.ijpara.2005.08.014
10.1016/j.ijpara.2005.08.014 · External reference
10.1074/jbc.m113.465583
10.1074/jbc.m113.465583 · External reference
Cyclic nucleotide signaling in Toxoplasma gondii bradyzoite differentiation
10.1128/iai.69.1.148-153.2001 · 2001 · External reference
Toxoplasma gondii cyclic AMP-dependent protein kinase subunit 3 Is involved in the switch from tachyzoite to bradyzoite development
10.1128/mbio.00755-16 · 2016 · External reference
10.1371/journal.pbio.2005642
10.1371/journal.pbio.2005642 · External reference
Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite
10.1038/ncomms10519 · 2016 · External reference
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite
2009 · External reference
10.1111/j.1365-2958.2008.06267.x
10.1111/j.1365-2958.2008.06267.x · External reference
10.1016/j.cub.2018.06.069
10.1016/j.cub.2018.06.069 · External reference
10.1371/journal.ppat.1004815
10.1371/journal.ppat.1004815 · External reference
10.1038/s41564-018-0339-8
10.1038/s41564-018-0339-8 · External reference
10.26508/lsa.201900402
10.26508/lsa.201900402 · External reference
10.1074/jbc.ra118.005491
10.1074/jbc.ra118.005491 · External reference
10.1046/j.1365-2958.2002.02948.x
10.1046/j.1365-2958.2002.02948.x · External reference
10.1128/ec.1.3.317-328.2002
10.1128/ec.1.3.317-328.2002 · External reference
10.1016/s0166-6851(01)00451-0
10.1016/s0166-6851(01)00451-0 · External reference
Purification and molecular characterization of cGMP-dependent protein kinase from apicomplexan parasites: a novel chemotherapeutic target
10.1074/jbc.m108393200 · 2002 · External reference
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
10.1038/s41467-017-00572-x · 2017 · External reference
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function
10.26508/lsa.201900626 · 2020 · External reference
10.1128/ec.00186-09
10.1128/ec.00186-09 · External reference
Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii
10.1128/mbio.00375-17 · 2017 · External reference
10.1371/journal.pbio.3000154
10.1371/journal.pbio.3000154 · External reference
10.1016/j.ijpara.2008.05.016
10.1016/j.ijpara.2008.05.016 · External reference
10.1042/bj20050425
10.1042/bj20050425 · External reference
Cyclic GMP balance is critical for malaria parasite transmission from the mosquito to the mammalian host
10.1128/mbio.02330-14 · 2015 · External reference
10.1021/cb501004q
10.1021/cb501004q · External reference
ToxoDB: An integrated Toxoplasma gondii database resource
10.1093/nar/gkm981 · 2007 · External reference
10.1146/annurev.biochem.76.060305.150444
10.1146/annurev.biochem.76.060305.150444 · External reference
10.1038/s41573-019-0033-4
10.1038/s41573-019-0033-4 · External reference
10.1124/mol.65.2.267
10.1124/mol.65.2.267 · External reference
10.1016/j.chom.2015.09.006
10.1016/j.chom.2015.09.006 · External reference
10.1007/978-3-642-17969-3_4
10.1007/978-3-642-17969-3_4 · 2011 · External reference
Structural insight into substrate specificity of phosphodiesterase 10. Proceedings of the National Academy of SciencesStructural insight into substrate specificity of phosphodiesterase 10
10.1073/pnas.0700279104 · 2007 · External reference
10.1016/j.pharmthera.2005.07.003
10.1016/j.pharmthera.2005.07.003 · External reference
10.1042/bj20050057
10.1042/bj20050057 · External reference
10.1038/nn.2540
10.1038/nn.2540 · External reference
10.1085/jgp.201310959
10.1085/jgp.201310959 · External reference
10.1371/journal.pone.0168361
10.1371/journal.pone.0168361 · External reference
Tagging of weakly expressed Toxoplasma gondii calcium-related genes with high-affinity tags
10.1111/jeu.12626 · 2018 · External reference
Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes
2015 · External reference
A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division
10.1371/journal.ppat.1001094 · 2010 · External reference
Cyclic nucleotide phosphodiesterase superfamily
2007 · External reference
10.1073/pnas.0708850105
10.1073/pnas.0708850105 · External reference
The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10
10.1016/j.jmb.2007.05.060 · 2007 · External reference
10.1016/j.molcel.2004.07.005
10.1016/j.molcel.2004.07.005 · External reference
10.1016/j.cell.2016.08.019
10.1016/j.cell.2016.08.019 · External reference
MAEBL is essential for malarial sporozoite infection of the mosquito salivary gland
10.1084/jem.20011876 · 2002 · External reference
10.1111/cmi.12745
10.1111/cmi.12745 · External reference
10.1016/s0166-6851(02)00067-1
10.1016/s0166-6851(02)00067-1 · External reference
Cyclic nucleotide phosphodiesterases: New targets in the metabolic syndrome?
10.1016/j.pharmthera.2020.107475 · 2020 · External reference
cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis
10.1124/mol.111.076125 · 2012 · External reference
10.1093/femsre/fuz005
10.1093/femsre/fuz005 · External reference
10.1128/ec.00357-08
10.1128/ec.00357-08 · External reference
10.1128/ec.00358-08
10.1128/ec.00358-08 · External reference
Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene Use as a selectable marker for stable transformation
10.1074/jbc.271.24.14010 · 1996 · External reference
10.1038/nmeth.3365
10.1038/nmeth.3365 · External reference
10.1016/j.chom.2008.01.001
10.1016/j.chom.2008.01.001 · External reference
Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated
10.1016/j.jmb.2005.05.031 · 2005 · External reference
10.1111/mmi.14411
10.1111/mmi.14411 · External reference
Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth
10.1074/jbc.m501523200 · 2005 · External reference
Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria
10.1073/pnas.90.24.11703 · 1993 · External reference
10.1093/nar/gkw1105
10.1093/nar/gkw1105 · External reference
10.1093/bioinformatics/btv362
10.1093/bioinformatics/btv362 · External reference
A hidden Markov model for predicting transmembrane helices in protein sequences
1998 · External reference
10.1016/j.jmb.2004.03.016
10.1016/j.jmb.2004.03.016 · External reference
TMbase-A database of membrane spanning proteins segments
1993 · External reference
10.1093/nar/gkh454
10.1093/nar/gkh454 · External reference
SMART: recent updates, new developments and status in 2015
10.1093/nar/gku949 · 2014 · External reference
10.1093/nar/gky995
10.1093/nar/gky995 · External reference
TEXtopo: shaded membrane protein topology plots in LATEX2ε
10.1093/bioinformatics/16.11.1050 · 2000 · External reference
10.1093/molbev/msy096
10.1093/molbev/msy096 · External reference
10.1093/nar/gkz239
10.1093/nar/gkz239 · External reference
10.1093/nar/gky427
10.1093/nar/gky427 · External reference
10.1002/jcc.21334
10.1002/jcc.21334 · External reference
10.1002/jcc.20084
10.1002/jcc.20084 · External reference
