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References from In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor. Local targets link to admitted publications; unresolved targets remain external evidence.
ChromoHub: a data hub for navigators of chromatin-mediated signalling
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The PHD finger: a versatile epigenome reader
2011 · External reference
PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks
2008 · External reference
The role of human bromodomains in chromatin biology and gene transcription
2009 · External reference
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
10.1038/s41589-019-0310-x · 2019 · External reference
PHD fingers: epigenetic effectors and potential drug targets
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Targeting ligandable pockets on plant homeodomain (PHD) zinc finger domains by a fragment-based approach
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Diverse functions of PHD fingers of the MLL/KMT2 subfamily
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NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory
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Nizp1, a Novel Multitype Zinc Finger Protein That Interacts with the NSD1 Histone Lysine Methyltransferase through a Unique C2HR Motif
10.1128/mcb.24.12.5184-5196.2004 · 2004 · External reference
Biochimica et Biophysica Acta The NIZP1 KRAB and C2HR domains cross-talk for transcriptional regulation
2010 · External reference
Covalent inhibition of NSD1 histone methyltransferase
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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
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Unresolved reference
External reference
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Unresolved reference
External reference
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Toward small-molecule inhibition of protein-protein interactions: general aspects and recent progress in targeting costimulatory and coinhibitory (immune checkpoint) interactions
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Characterization of ligand binding by saturation transfer difference NMR spectroscopy
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Topoisomerase II inhibitors in AML: past, present, and future
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