Research graph
References from Genetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
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Activation of the p38 Mitogen-Activated Protein Kinase Mediates the Suppressive Effects of Type I Interferons and Transforming Growth Factor-Beta on Normal Hematopoiesis
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TLR4/CD14-mediated PI3K Activation Is an Essential Component of Interferon-Dependent VSV Resistance in Macrophages
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IFN-alpha2a Induces IP-10/CXCL10 and MIG/CXCL9 Production in Monocyte-Derived Dendritic Cells and Enhances Their Capacity to Attract and Stimulate CD8+ Effector T Cells
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Beta and -Gamma Induce CXCL9 and CXCL10 Secretion by Human Thyrocytes: Modulation by Peroxisome Proliferator-Activated Receptor-Gamma Agonists
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Interferon-alpha Counteracts the Angiogenic Switch and Reduces Tumor Cell Proliferation in a Spontaneous Model of Prostatic Cancer
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Interferon-alpha Resistance in Renal Carcinoma Cells Is Associated With Defective Induction of Signal Transducer and Activator of Transcription 1 Which Can Be Restored by a Supernatant of Phorbol 12-myristate 13-acetate Stimulated Peripheral Blood Mononuclear Cells
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Resistance to IFN-alpha-induced Apoptosis Is Linked to a Loss of STAT2
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Vascular Endothelial Growth Factor-Induced Elimination of the Type 1 Interferon Receptor Is Required for Efficient Angiogenesis
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Reconstruction of Gene Regulatory Modules From RNA Silencing of IFN-α Modulators: Experimental Set-Up and Inference Method
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A Regulatory microRNA Network Controls Endothelial Cell Phenotypic Switch During Sprouting Angiogenesis
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Identification of Key Genes and Pathways in Regulating Immune-induced Diseases of Dendritic Cells by Bioinformatic Analysis
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Type I Interferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors
2006 · External reference
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USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis
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Parsing the Interferon Transcriptional Network and Its Disease Associations
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UBP43 (USP18) Specifically Removes ISG15 From Conjugated Proteins
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Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling
2016 · External reference
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5
2013 · External reference
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
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IFIH1 Polymorphisms Are Significantly Associated With Type 1 Diabetes and IFIH1 Gene Expression in Peripheral Blood Mononuclear Cells
2009 · External reference
Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer
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CXC Chemokines in Angiogenesis
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The Guanylate Binding protein-1 GTPase Controls the Invasive and Angiogenic Capability of Endothelial Cells Through Inhibition of MMP-1 Expression
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Guanylate Binding protein-1 Inhibits Spreading and Migration of Endothelial Cells Through Induction of Integrin alpha4 Expression
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The Helical Domain of GBP-1 Mediates the Inhibition of Endothelial Cell Proliferation by Inflammatory Cytokines
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Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis
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Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- And Oxidative Stress-Related Signatures as Predictors and Correlates of Depression. Neuropsychopharmacology : official publication of the American College of
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Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells
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Overexpression of STAT1 Suppresses Angiogenesis Under Hypoxia by Regulating VEGF-A in Human Glioma Cells
2018 · External reference
