Research graph
References from In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/sj.jid.5700683
10.1038/sj.jid.5700683 · External reference
10.1111/j.1751-1097.1977.tb07546.x
10.1111/j.1751-1097.1977.tb07546.x · External reference
10.1124/pr.58.4.2
10.1124/pr.58.4.2 · External reference
In vitro and in vivo studies disclosed the depigmenting effects of gallic acid: A novel skin lightening agent for hyperpigmentary skin diseases
10.1002/biof.1064 · 2013 · External reference
Development and validation of a modular, extensible docking program: DOCK 5
10.1007/s10822-006-9060-4 · 2006 · External reference
10.1056/nejmoa1614362
10.1056/nejmoa1614362 · External reference
Unresolved reference
External reference
Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach
10.1080/14756366.2019.1596904 · 2019 · External reference
10.1096/fj.06-6649rev
10.1096/fj.06-6649rev · External reference
Optimization of Flavonoid Extraction in Dendrobium officinale Leaves and Their Inhibitory Effects on Tyrosinase Activity
10.1155/2019/7849198 · 2019 · External reference
Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling
10.1038/srep07995 · 2015 · External reference
10.3390/ijms17040546
10.3390/ijms17040546 · External reference
Caffeic Acid Phenethyl Ester Inhibits Alpha-Melanocyte Stimulating Hormone-Induced Melanin Synthesis through Suppressing Transactivation Activity of Microphthalmia-Associated Transcription Factor
10.1021/np400129z · 2013 · External reference
Artopithecins A-D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities
10.1248/cpb.c18-00523 · 2018 · External reference
Effects of Selected Organo-sulfur Compounds on Melanin Formation
10.1021/jf9005824 · 2009 · External reference
Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol
10.1016/j.bmcl.2018.11.013 · 2019 · External reference
Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase
10.18632/oncotarget.20913 · 2017 · External reference
Safety assessment, biological effects, and mechanisms of Myrica rubra fruit extract for anti‐melanogenesis, anti‐oxidation, and free radical scavenging abilities on melanoma cells
10.1111/jocd.12505 · 2019 · External reference
10.3390/molecules201119656
10.3390/molecules201119656 · External reference
10.3390/molecules23102559
10.3390/molecules23102559 · External reference
Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation
10.1111/j.1464-5491.2006.01858.x · 2006 · External reference
10.1001/jama.285.19.2486
10.1001/jama.285.19.2486 · External reference
Bacterial tyrosinases and their applications
10.1016/j.procbio.2012.08.018 · 2012 · External reference
Le bleuissement et le noircissement des champignons
1895 · External reference
De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability
10.1021/acs.jmedchem.8b00737 · 2018 · External reference
Unresolved reference
External reference
Topical use of hydroquinone as a depigmenting agent
10.1001/jama.1965.03090220021006 · 1965 · External reference
10.3390/ijms10062440
10.3390/ijms10062440 · External reference
10.1111/j.2042-7158.1994.tb03253.x
10.1111/j.2042-7158.1994.tb03253.x · External reference
Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety
10.1016/j.bmc.2004.10.010 · 2005 · External reference
A novel synthetic compound, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-iminothiazolidin-4-one (MHY773) inhibits mushroom tyrosinase
10.1080/09168451.2018.1445518 · 2018 · External reference
The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold
10.1016/j.bmc.2018.05.047 · 2018 · External reference
10.2147/dddt.s131538
10.2147/dddt.s131538 · External reference
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl) acrylonitriles
2015 · External reference
10.1111/j.1365-2672.2006.02866.x
10.1111/j.1365-2672.2006.02866.x · External reference
10.1016/j.molonc.2012.07.003
10.1016/j.molonc.2012.07.003 · External reference
Unresolved reference
External reference
10.3390/ijms161226114
10.3390/ijms161226114 · External reference
Synthesis and in vitro anticancer activity of new 2-thioxo-oxazolidin-4-one derivatives
10.1016/j.pharep.2017.03.005 · 2017 · External reference
Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41
10.1016/j.bmcl.2011.08.081 · 2011 · External reference
Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors
10.1016/j.bmcl.2011.10.095 · 2012 · External reference
Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones
10.1016/j.ejmech.2005.06.002 · 2005 · External reference
Characterization of a small molecule inhibitor of melanogenesis that inhibits tyrosinase activity and scavenges nitric oxide (NO)
10.1016/j.bbagen.2013.06.002 · 2013 · External reference
MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress
10.1016/j.bmcl.2014.01.040 · 2014 · External reference
Benzylidene-linked thiohydantoin derivatives as inhibitors of tyrosinase and melanogenesis: importance of the β-phenyl-α,β-unsaturated carbonyl functionality
10.1039/c4md00171k · 2014 · External reference
Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor
10.1007/s12272-013-0184-5 · 2013 · External reference
10.1016/j.bmc.2015.11.015
10.1016/j.bmc.2015.11.015 · External reference
(Z)-2-(Benzo [d] thiazol-2-ylamino)-5-(substituted benzylidene) thiazol-4 (5H)-one Derivatives as Novel Tyrosinase Inhibitors
10.1248/bpb.b15-00300 · 2015 · External reference
Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4 dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP)
10.1016/j.bbagen.2012.03.018 · 2012 · External reference
Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384)
10.1016/j.bbagen.2012.01.001 · 2012 · External reference
Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives
10.1016/j.bmc.2019.04.020 · 2019 · External reference
The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)-β-phenyl-α,β-unsaturated carbonyl scaffold of an endomethylene type
10.1007/s00044-018-2267-9 · 2019 · External reference
10.1016/j.ejmech.2018.10.025
10.1016/j.ejmech.2018.10.025 · External reference
10.1016/j.bmc.2018.10.014
10.1016/j.bmc.2018.10.014 · External reference
C-13-Nmr Spectroscopy. 19. Structures of Addition-Products of Acetylene-Dicarboxylic Acid-Esters with Various Dinucleophiles - Application of C, H-Spin-Coupling Constants
10.1002/hlca.19780610207 · 1978 · External reference
UniProt: the universal protein knowledgebase
10.1093/nar/gkw1099 · 2016 · External reference
10.1002/anie.201704616
10.1002/anie.201704616 · External reference
Inhibitory Effects of Kurarinol, Kuraridinol, and Trifolirhizin from Sophora flavescens on Tyrosinase and Melanin Synthesis
10.1248/bpb.31.154 · 2008 · External reference
10.1002/(sici)1096-987x(19981115)19:14<1639::aid-jcc10>3.0.co;2-b
10.1002/(sici)1096-987x(19981115)19:14<1639::aid-jcc10>3.0.co;2-b · External reference
10.1021/jm051256o
10.1021/jm051256o · External reference
10.1016/j.bmc.2005.12.032
10.1016/j.bmc.2005.12.032 · External reference
A Novel Synthesized Tyrosinase Inhibitor: (E)-2-((2,4-Dihydroxyphenyl)diazenyl)phenyl 4-Methylbenzenesulfonate as an Azo-Resveratrol Analog
10.1271/bbb.120547 · 2013 · External reference
Melanogenesis Inhibition by Gallotannins from Chinese Galls in B16 Mouse Melanoma Cells
10.1248/bpb.32.1447 · 2009 · External reference
