Research graph
References from Discovery of the EL-0052 as a potential anesthetic drug. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1111/ejn.12601
10.1111/ejn.12601 · External reference
Respiratory effects of etomidate
10.1093/bja/49.3.233 · 1977 · External reference
Using Etomidate and midazolam for screening colonoscopies results in more stable hemodynamic responses in patients of all ages
10.5009/gnl18514 · 2019 · External reference
Clinical analysis of propofol, etomidate and an admixture of etomidate and propofol for induction of general anaesthesia
10.5152/tjar.2019.53806 · 2019 · External reference
Adrenocortical suppression by a single induction dose of etomidate
10.1007/bf01711723 · 1984 · External reference
Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation
10.1210/jcem-59-6-1143 · 1984 · External reference
Duration of adrenal inhibition following a single dose of etomidate in critically ill patients
10.1007/s00134-007-0970-y · 2008 · External reference
Mortality amongst multiple trauma patients admitted to an intensive therapy unit
10.1111/j.1365-2044.1984.tb08885.x · 1984 · External reference
Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after noncardiac surgery
10.1213/ane.0b013e318299a516 · 2013 · External reference
Etomidate is associated with mortality and adrenal insufficiency in sepsis: A meta-analysis
10.1097/ccm.0b013e31825fec26 · 2012 · External reference
Pre-hospital emergent intubation in trauma patients: the influence of etomidate on mortality, morbidity and healthcare resource utilization
10.1186/s13049-019-0637-z · 2019 · External reference
Etomidate derivatives: Novel pharmaceutical agents in anesthesia
10.4103/0970-9185.222521 · 2017 · External reference
Carboetomidate: an analog of etomidate that interacts weakly with 11 beta-hydroxylase
10.1213/ane.0b013e31828b3637 · 2013 · External reference
Carboetomidate a pyrrole analog of etomidate designed not to suppress adrenocortical function
10.1097/aln.0b013e3181cf40ed · 2010 · External reference
Carboetomidate: Will it eliminate the etomidate debate?
10.1097/ccm.0b013e31823294c7 · 2012 · External reference
Methoxycarbonyl-etomidate a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression
10.1097/aln.0b013e3181ae63d1 · 2009 · External reference
Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite
10.1213/ane.0b013e318239c6ca · 2012 · External reference
Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects
10.1016/j.bja.2018.01.038 · 2018 · External reference
Advancing novel anesthetics pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs
10.1097/aln.0000000000000416 · 2014 · External reference
Anesthetic drug development: Novel drugs and new approaches
10.4103/2152-7806.109179 · 2013 · External reference
Metabolite-inactive etomidate analogues alleviating suppression on adrenal function in Beagle dogs
10.1016/j.ejps.2016.12.041 · 2017 · External reference
In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate
10.1213/ane.0b013e3182320559 · 2012 · External reference
A phase 1c trial comparing the efficacy and safety of a new aqueous formulation of alphaxalone with propofol
10.1213/ane.0000000000000856 · 2015 · External reference
Alphaxalone reformulated: a water-soluble intravenous anesthetic preparation in sulfobutyl-ether-beta-cyclodextrin
10.1213/ane.0000000000000559 · 2015 · External reference
10.1016/j.tips.2019.05.001
10.1016/j.tips.2019.05.001 · External reference
Computational approaches to anesthetic drug discovery
10.1016/j.tips.2019.09.001 · 2019 · External reference
Discovery of new inhibitors of transforming growth factor-beta type 1 receptor by utilizing docking and structure-activity relationship analysis
10.3390/ijms20174090 · 2019 · External reference
Novel transforming growth factor-beta receptor 1 antagonists through a pharmacophore-based virtual screening approach
10.3390/molecules23112824 · 2018 · External reference
Insights into receptor-based anesthetic pharmacophores and anesthetic-protein interactions
10.1016/bs.mie.2018.01.004 · 2018 · External reference
A newly developed anesthetic based on a unique chemical core
10.1073/pnas.1822076116 · 2019 · External reference
GABA(A) receptor signalling mechanisms revealed by structural pharmacology
10.1038/s41586-018-0832-5 · 2019 · External reference
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design
10.1074/jbc.ra118.006214 · 2019 · External reference
Identification of a gaba(a) receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog
10.1523/jneurosci.3467-06.2006 · 2006 · External reference
Competitive antagonism of etomidate action by diazepam in vitro GABA(A) receptor and in vivo zebrafish studies
10.1097/aln.0000000000003403 · 2020 · External reference
10.1038/nchembio.1340
10.1038/nchembio.1340 · External reference
10.1093/nar/gky1004
10.1093/nar/gky1004 · External reference
Detailed analysis of grid-based molecular docking: A case study of CDOCKER - A CHARMm-based MD docking algorithm
10.1002/jcc.10306 · 2003 · External reference
10.1002/1097-0134(20010501)43:2<113::aid-prot1023>3.0.co;2-t
10.1002/1097-0134(20010501)43:2<113::aid-prot1023>3.0.co;2-t · External reference
Linear scaling geometry optimisation and transition state search in hybrid delocalised internal coordinates
10.1039/a909486e · 2000 · External reference
Validation of the general purpose QUANTA 3.2/CHARMm force field
10.1002/jcc.540130714 · 1992 · External reference
pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
10.1021/acs.jmedchem.5b00104 · 2015 · External reference
10.1002/jcc.22885
10.1002/jcc.22885 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
Docking-based virtual screening of TβR1 inhibitors: evaluation of pose prediction and scoring functions
10.1186/s13065-020-00704-3 · 2020 · External reference
