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References from Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. Local targets link to admitted publications; unresolved targets remain external evidence.
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis
10.1038/s41586-020-2600-6 · 2020 · External reference
Unresolved reference
External reference
Unresolved reference
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Unresolved reference
External reference
A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial
10.1186/s13063-020-04548-z · 2020 · External reference
10.1016/j.molimm.2019.07.030
10.1016/j.molimm.2019.07.030 · External reference
10.1038/s41573-019-0031-6
10.1038/s41573-019-0031-6 · External reference
New milestones ahead in complement-targeted therapy
10.1016/j.smim.2016.06.001 · 2016 · External reference
Unresolved reference
External reference
Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features
10.1096/fj.09-145631 · 2010 · External reference
Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract
10.1111/j.1365-2958.2010.07065.x · 2010 · External reference
10.1146/annurev.immunol.15.1.675
10.1146/annurev.immunol.15.1.675 · External reference
Streptococcal C5a peptidase is a highly specific endopeptidase
10.1128/iai.60.12.5219-5223.1992 · 1992 · External reference
Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase
10.1371/journal.ppat.1006493 · 2017 · External reference
Mechanism of action of the group A streptococcal C5a inactivator
10.1073/pnas.82.23.8144 · 1985 · External reference
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors
10.1073/pnas.91.4.1214 · 1994 · External reference
10.1038/sj.bjp.0707332
10.1038/sj.bjp.0707332 · External reference
Restricted ability of group B streptococcal C5a-ase to inactivate C5a prepared from different animal species
10.1128/iai.61.4.1421-1426.1993 · 1993 · External reference
10.1046/j.1432-1033.2002.03183.x
10.1046/j.1432-1033.2002.03183.x · External reference
10.1128/jb.182.11.3254-3258.2000
10.1128/jb.182.11.3254-3258.2000 · External reference
10.1074/jbc.m513408200
10.1074/jbc.m513408200 · External reference
Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation
1981 · External reference
A novel selective extracorporeal intervention in sepsis: immunoadsorption of endotoxin, interleukin 6, and complement-activating product 5a
10.1097/shk.0b013e31804f5921 · 2007 · External reference
Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients
10.1038/s41423-020-00551-1 · 2020 · External reference
Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins
10.1074/jbc.270.17.9862 · 1995 · External reference
Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor
10.1111/j.1432-1033.1994.tb18571.x · 1994 · External reference
Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase
10.1006/abio.1996.0238 · 1996 · External reference
Application of the Van Slyke-Cullen irreversible mechanism in the analysis of enzymatic progress curves
10.1016/j.ab.2009.06.040 · 2009 · External reference
Determination of receptor-ligand kinetic and equilibrium binding constants using surface plasmon resonance: application to the lck SH2 domain and phosphotyrosyl peptides
10.1021/jm00008a009 · 1995 · External reference
T3-sequencing: targeted characterization of the N- and C-termini of undigested proteins by mass spectrometry
10.1021/ac034362b · 2003 · External reference
Protein identification and analysis tools in the ExPASy server
1999 · External reference
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
10.1172/jci106462 · 1970 · External reference
Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts
10.4049/jimmunol.141.10.3570 · 1988 · External reference
Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg
10.4049/jimmunol.134.5.3325 · 1985 · External reference
10.1021/bi2002289
10.1021/bi2002289 · External reference
10.1021/cr800373w
10.1021/cr800373w · External reference
Imlifidase desensitization in crossmatch-positive, highly-sensitized kidney transplant recipients: Results of an international phase 2 trial (Highdes)
2020 · External reference
10.1128/iai.70.6.2869-2876.2002
10.1128/iai.70.6.2869-2876.2002 · External reference
10.1021/bi800089f
10.1021/bi800089f · External reference
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides
1999 · External reference
10.1016/j.csbj.2020.03.004 · Admitted local publication
Evidence for a large dispensable segment in the subtilisin-like catalytic domain of the Lactococcus lactis cell-envelope proteinase
10.1093/protein/7.8.991 · 1994 · External reference
Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera
10.1038/ncomms9322 · 2015 · External reference
10.1016/j.jmb.2008.12.074
10.1016/j.jmb.2008.12.074 · External reference
