Research graph
References from Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/s0092-8674(03)01077-8
10.1016/s0092-8674(03)01077-8 · External reference
10.1016/j.ceb.2009.01.028
10.1016/j.ceb.2009.01.028 · External reference
10.1016/j.molcel.2006.06.001
10.1016/j.molcel.2006.06.001 · External reference
10.1017/s1462399404007331
10.1017/s1462399404007331 · External reference
10.1038/362087a0
10.1038/362087a0 · External reference
10.1016/0092-8674(93)90404-e
10.1016/0092-8674(93)90404-e · External reference
Defining the Specificity Space of the Human Src Homology 2 Domain*
10.1074/mcp.m700312-mcp200 · 2008 · External reference
10.1016/b978-0-12-381268-1.00007-0
10.1016/b978-0-12-381268-1.00007-0 · External reference
10.1016/s0968-0004(03)00091-4
10.1016/s0968-0004(03)00091-4 · External reference
10.1016/s0092-8674(00)80938-1
10.1016/s0092-8674(00)80938-1 · External reference
10.1016/s0969-2126(98)00027-6
10.1016/s0969-2126(98)00027-6 · External reference
10.1074/jbc.270.7.2897
10.1074/jbc.270.7.2897 · External reference
10.1074/jbc.273.2.729
10.1074/jbc.273.2.729 · External reference
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
10.1056/nejmra1514296 · 2016 · External reference
10.1016/j.cellsig.2007.10.002
10.1016/j.cellsig.2007.10.002 · External reference
Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance
10.1007/s11154-013-9282-4 · 2014 · External reference
Molecular mechanism of SHP2 activation by PD-1 stimulation. Science
2020 · External reference
10.1073/pnas.1710437115
10.1073/pnas.1710437115 · External reference
10.1016/s0021-9258(17)36874-6
10.1016/s0021-9258(17)36874-6 · External reference
10.1038/352073a0
10.1038/352073a0 · External reference
10.1073/pnas.91.15.7335
10.1073/pnas.91.15.7335 · External reference
10.1128/mcb.14.1.509-517.1994
10.1128/mcb.14.1.509-517.1994 · External reference
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
1996 · External reference
10.1016/s1097-2765(01)00369-0
10.1016/s1097-2765(01)00369-0 · External reference
Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2
2013 · External reference
10.1021/bi9722913
10.1021/bi9722913 · External reference
10.1021/bi00003a039
10.1021/bi00003a039 · External reference
10.1021/bi051408h
10.1021/bi051408h · External reference
An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
10.1038/s41598-020-75409-7 · 2020 · External reference
10.1021/acs.jcim.0c00307
10.1021/acs.jcim.0c00307 · External reference
10.1016/0009-2614(80)80041-8
10.1016/0009-2614(80)80041-8 · External reference
Gradient-Tailored Water Suppression for 1H–15N HSQC Experiments Optimized to Retain Full Sensitivity
10.1006/jmra.1993.1098 · 1993 · External reference
10.1007/bf02192855
10.1007/bf02192855 · External reference
Relaxation-Rate Measurements for 15N–1H Groups with Pulsed-Field Gradients and Preservation of Coherence Pathways
10.1006/jmra.1994.1236 · 1994 · External reference
Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation
10.1021/bi00185a040 · 1994 · External reference
10.1021/bi00449a003
10.1021/bi00449a003 · External reference
10.1006/jmre.1998.1380
10.1006/jmre.1998.1380 · External reference
10.1016/0022-2364(91)90034-q
10.1016/0022-2364(91)90034-q · External reference
An NMR Experiment for the Accurate Measurement of Heteronuclear Spin-Lock Relaxation Rates
10.1021/ja0204776 · 2002 · External reference
Improved magnetization alignment schemes for spin-lock relaxation experiments
10.1007/s10858-006-9126-6 · 2007 · External reference
Solvent Saturation-Transfer Effects in Pulsed-Field-Gradient Heteronuclear Single-Quantum-Coherence (PFG-HSQC) Spectra of Polypeptides and Proteins
10.1006/jmrb.1993.1049 · 1993 · External reference
10.1023/a:1015385910220
10.1023/a:1015385910220 · External reference
Accurate Sampling of High-Frequency Motions in Proteins by Steady-State 15N−{1H} Nuclear Overhauser Effect Measurements in the Presence of Cross-Correlated Relaxation
10.1021/ja809526q · 2009 · External reference
10.1021/jp074793o
10.1021/jp074793o · External reference
10.1007/bf00197809
10.1007/bf00197809 · External reference
10.1002/prot.20449
10.1002/prot.20449 · External reference
Unresolved reference
External reference
10.1021/ja00381a009
10.1021/ja00381a009 · External reference
10.1021/ja00381a010
10.1021/ja00381a010 · External reference
10.1023/a:1008305808620
10.1023/a:1008305808620 · External reference
Predicting conformational entropy of bond vectors in proteins by networks of coupled rotators
10.1063/1.2969809 · 2008 · External reference
10.1021/ja902477s
10.1021/ja902477s · External reference
Unresolved reference
External reference
10.1006/jmbi.1993.1626
10.1006/jmbi.1993.1626 · External reference
10.1002/cpbi.3
10.1002/cpbi.3 · External reference
10.1016/j.softx.2015.06.001 · Admitted local publication
10.1002/jcc.20291
10.1002/jcc.20291 · External reference
10.1002/prot.22711
10.1002/prot.22711 · External reference
10.1002/jcc.20035
10.1002/jcc.20035 · External reference
ACPYPE-Antechamber python parser interface
10.1186/1756-0500-5-367 · 2012 · External reference
10.1063/1.445869
10.1063/1.445869 · External reference
10.1063/1.470117
10.1063/1.470117 · External reference
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h
10.1002/(sici)1096-987x(199709)18:12<1463::aid-jcc4>3.0.co;2-h · External reference
10.1002/jcc.540130805
10.1002/jcc.540130805 · External reference
10.1002/jcc.20035
10.1002/jcc.20035 · External reference
10.1063/1.328693
10.1063/1.328693 · External reference
10.1093/bioinformatics/btl461
10.1093/bioinformatics/btl461 · External reference
10.1016/j.bpj.2014.09.019
10.1016/j.bpj.2014.09.019 · External reference
10.1074/jbc.m115.702605
10.1074/jbc.m115.702605 · External reference
SH2 domains recognize specific phosphopeptide sequences
10.1016/0092-8674(93)90404-e · 1993 · External reference
SH2 Domains from Suppressor of Cytokine Signaling-3 and Protein Tyrosine Phosphatase SHP-2 Have Similar Binding Specificities
10.1021/bi0259507 · 2002 · External reference
10.1021/bi051408h
10.1021/bi051408h · External reference
Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains: CRITICAL ROLES OF RESIDUES BEYOND THE pY+3 POSITION *
10.1074/jbc.m601047200 · 2006 · External reference
Defining the Specificity Space of the Human Src Homology 2 Domain *
10.1074/mcp.m700312-mcp200 · 2008 · External reference
10.1038/nsb0796-586
10.1038/nsb0796-586 · External reference
10.1038/358646a0
10.1038/358646a0 · External reference
10.1016/j.celrep.2017.08.080
10.1016/j.celrep.2017.08.080 · External reference
Superbinder SH2 domains act as antagonists of cell signaling
10.1126/scisignal.2003021 · 2012 · External reference
10.1016/s0962-8924(01)02154-7
10.1016/s0962-8924(01)02154-7 · External reference
10.1016/j.yjsbx.2020.100026
10.1016/j.yjsbx.2020.100026 · External reference
10.1038/s42003-020-0845-0
10.1038/s42003-020-0845-0 · External reference
10.1016/j.molcel.2008.03.009
10.1016/j.molcel.2008.03.009 · External reference
10.1074/jbc.m504699200
10.1074/jbc.m504699200 · External reference
Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2
10.1002/prot.21050 · 2007 · External reference
10.1146/annurev.genom.6.080604.162305
10.1146/annurev.genom.6.080604.162305 · External reference
10.1093/hmg/ddn099
10.1093/hmg/ddn099 · External reference
10.1016/j.jmgm.2009.01.006
10.1016/j.jmgm.2009.01.006 · External reference
