Research graph
References from Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1002/ijc.31937
10.1002/ijc.31937 · External reference
10.1038/35021093
10.1038/35021093 · External reference
10.1126/science.3798106
10.1126/science.3798106 · External reference
10.1126/science.2470152
10.1126/science.2470152 · External reference
Resistance mechanisms to anti-HER2 therapies in HER2-positive breast cancer: Current knowledge, new research directions and therapeutic perspectives
10.1016/j.critrevonc.2019.05.001 · 2019 · External reference
10.1007/s00018-019-03340-w
10.1007/s00018-019-03340-w · External reference
Evaluating Trastuzumab in the treatment of HER2 positive breast cancer
2020 · External reference
Trastuzumab-associated cardiac events at 8 years of median follow-up in the Herceptin Adjuvant trial (BIG 1–01)
10.1200/jco.2013.53.9288 · 2014 · External reference
Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice
10.1016/j.breast.2020.04.005 · 2020 · External reference
10.2147/ijn.s596
10.2147/ijn.s596 · External reference
10.1080/1061186x.2017.1358729
10.1080/1061186x.2017.1358729 · External reference
10.1111/joim.12280
10.1111/joim.12280 · External reference
Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging
10.1042/bst0350061 · 2007 · External reference
10.1016/j.addr.2005.09.019
10.1016/j.addr.2005.09.019 · External reference
In vivo proinflammatory activity of generations 0–3 (G0–G3) polyamidoamine (PAMAM) nanoparticles
10.1007/s00011-016-0959-5 · 2016 · External reference
Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney
10.1016/j.ijpharm.2016.03.039 · 2016 · External reference
Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
10.1016/j.ijpharm.2010.05.030 · 2010 · External reference
Cationic polyamidoamine dendrimers as modulators of EGFR signaling in vitro and in vivo
10.1371/journal.pone.0132215 · 2015 · External reference
10.1016/j.ijpharm.2013.03.039
10.1016/j.ijpharm.2013.03.039 · External reference
Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction
10.1016/j.nano.2019.02.012 · 2019 · External reference
Multicomponent conjugates of anticancer drugs and monoclonal antibody with PAMAM dendrimers to increase efficacy of HER-2 positive breast cancer therapy
10.1007/s11095-019-2683-7 · 2019 · External reference
PAMAM/5-fluorouracil drug conjugate for targeting E6 and E7 oncoproteins in cervical cancer: a combined experimental/in silico approach
10.1039/c6ra26511a · 2017 · External reference
Effect of methotrexate conjugated PAMAM dendrimers on the viability of breast cancer cells
10.1063/1.5095929 · 2019 · External reference
Biotinylated PAMAM dendrimers for intracellular delivery of cisplatin to ovarian cancer: role of SMVT
2011 · External reference
Targeting human liver cancer cells with lactobionic acid-G(4)-PAMAM-FITC sorafenib loaded dendrimers
10.1016/j.ijpharm.2017.06.049 · 2017 · External reference
10.1155/2010/530130
10.1155/2010/530130 · External reference
Evaluating the gene-expression profiles of HeLa cancer cells treated with activated and nonactivated poly(amidoamine) dendrimers, and their DNA complexes
10.1021/mp900303s · 2010 · External reference
A Polyamidoamine dendrimer-based electrochemical immunosensor for label-free determination of epithelial cell adhesion molecule- expressing cancer cells
10.3390/s19081879 · 2019 · External reference
10.1016/j.cis.2018.06.005
10.1016/j.cis.2018.06.005 · External reference
10.3109/01480540903493507
10.3109/01480540903493507 · External reference
Mechanism of cell death induced by cationic dendrimers in RAW 264.7 murine macrophage-like cells
10.1211/0022357055803 · 2005 · External reference
Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations
10.1021/bm900683r · 2009 · External reference
Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells
10.1016/j.taap.2010.04.014 · 2010 · External reference
10.1016/j.aquatox.2013.01.020
10.1016/j.aquatox.2013.01.020 · External reference
10.1101/gad.13.15.1899
10.1101/gad.13.15.1899 · External reference
Naked poly(amidoamine) dendrimer nanoparticles exhibit intrinsic embryotoxicity during the early stages of normal development
10.1166/jbn.2020.2981 · 2020 · External reference
10.5402/2012/428062
10.5402/2012/428062 · External reference
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
10.1038/msb4100094 · 2006 · External reference
HER2-mTOR signaling-driven breast cancer cells require ER-associated degradation to survive
10.1126/scisignal.aaa6922 · 2015 · External reference
Role of JNK signaling in oral cancer: A mini review
10.1177/1010428317711659 · 2017 · External reference
An in vivo functional screen identifies JNK signaling as a modulator of chemotherapeutic response in breast cancer
10.1158/1535-7163.mct-16-0731 · 2017 · External reference
Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu
2000 · External reference
Outcome and Human Epithelial Growth Factor Receptor (HER) 1–4 status in invasive breast carcinomas with proliferation indices evaluated using bromodeoxyuridine (BrdU) labelling
10.1186/bcr783 · 2004 · External reference
10.1016/j.jconrel.2006.04.014
10.1016/j.jconrel.2006.04.014 · External reference
10.1016/j.nano.2014.08.004
10.1016/j.nano.2014.08.004 · External reference
10.1002/jps.24222
10.1002/jps.24222 · External reference
10.1021/bc700483s
10.1021/bc700483s · External reference
Stealth dendrimers for antiarrhythmic quinidine delivery
10.1007/s10856-007-3144-0 · 2007 · External reference
10.1038/nrd1033
10.1038/nrd1033 · External reference
PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats
10.1007/s11356-015-5022-5 · 2016 · External reference
Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer
10.1038/srep23179 · 2016 · External reference
10.3390/polym11091422
10.3390/polym11091422 · External reference
10.1211/jpp.61.08.0002
10.1211/jpp.61.08.0002 · External reference
PAMAM dendrimers augment inhibitory effects of curcumin on cancer cell proliferation: possible inhibition of telomerase
10.7314/apjcp.2013.14.11.6925 · 2013 · External reference