Research graph
References from Understanding APE1 cellular functions by the structural preference of exonuclease activities. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1038/emm.2014.42 · External reference
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
2017 · External reference
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1)
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Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1
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Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection
10.1371/journal.pone.0047974 · 2012 · External reference
Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
2004 · External reference
Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma
10.1038/s41598-017-10013-w · 2017 · External reference
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target
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Molecular and structural characterization of disease-associated APE1 polymorphisms
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AP Endonuclease 1 as a Key Enzyme in Repair of Apurinic/Apyrimidinic Sites
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Capturing snapshots of APE1 processing DNA damage
10.1038/nsmb.3105 · 2015 · External reference
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]
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Characterization of an endonuclease IV 3'-5' exonuclease activity
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Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis
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Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes
10.1074/jbc.m112.422774 · 2013 · External reference
10.1093/mutage/gel006
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APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
2021 · External reference
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
10.1038/s41467-017-02175-y · 2018 · External reference
Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs
10.1093/nar/gkl259 · 2006 · External reference
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Characterization of the apurinic endonuclease activity of Drosophila Rrp1
10.1021/bi00093a023 · 1993 · External reference
Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA
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The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae
10.1128/mcb.25.15.6380-6390.2005 · 2005 · External reference
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means
10.1016/s0921-8777(00)00028-8 · 2000 · External reference
Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damage
10.1371/journal.pone.0071535 · 2013 · External reference
Differential cleavage of oligonucleotides containing the benzene-derived adduct, 1, N6-benzetheno-dA, by the major human AP endonuclease HAP1 and Escherichia coli exonuclease III and endonuclease IV
10.1093/carcin/19.8.1339 · 1998 · External reference
Insight into mechanisms of 3'-5' exonuclease activity and removal of bulky 8,5'-cyclopurine adducts by apurinic/apyrimidinic endonucleases
10.1073/pnas.1305281110 · 2013 · External reference
Modulation of the 3'–>5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product
10.1074/jbc.m306065200 · 2003 · External reference
Cleavage of single- and double-stranded DNAs containing an abasic residue by Escherichia coli exonuclease III (AP endonuclease VI)
10.1093/nar/24.22.4572 · 1996 · External reference
10.1016/j.dnarep.2004.06.009
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10.1021/bi500676p
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10.1158/1541-7786.mcr-06-0329
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10.1016/j.jmb.2011.06.050
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10.1016/s0022-2836(03)00712-5
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Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III
10.1006/jmbi.2001.5382 · 2002 · External reference
AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop
2020 · External reference
AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis
10.1038/sj.emboj.7601593 · 2007 · External reference
Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1)
10.1021/bi0346190 · 2004 · External reference
The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks
10.1016/j.tox.2006.04.025 · 2006 · External reference
A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA
10.1074/jbc.m004082200 · 2000 · External reference
APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine
10.1093/nar/gki518 · 2005 · External reference
10.1074/jbc.271.48.30672
10.1074/jbc.271.48.30672 · External reference
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA
10.1016/j.dnarep.2004.01.010 · 2004 · External reference
Efficiency of exonucleolytic action of apurinic/apyrimidinic endonuclease 1 towards matched and mismatched dNMP at the 3' terminus of different oligomeric DNA structures correlates with thermal stability of DNA duplexes
10.1016/j.bbapap.2006.01.004 · 2006 · External reference
Human apurinic/apyrimidinic endonuclease 1 (APE1) has 3' RNA phosphatase and 3' exoribonuclease activities
10.1016/j.jmb.2014.12.001 · 2015 · External reference
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
10.1038/s41467-017-00842-8 · 2017 · External reference
RNA-cleaving properties of human apurinic/apyrimidinic endonuclease 1 (APE1)
2010 · External reference
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Quantitative characterization of protein-protein complexes involved in base excision DNA repair
10.1093/nar/gkv569 · 2015 · External reference
Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase beta in vivo
10.1073/pnas.1501101112 · 2015 · External reference
Trinucleotide repeats: a structural perspective
10.3389/fneur.2013.00076 · 2013 · External reference
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10.1016/j.tibs.2011.12.002
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AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
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Trinucleotide repeat instability via DNA base excision repair
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Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles
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The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway
10.1093/nar/gkh165 · 2004 · External reference
Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity
10.1371/journal.pone.0012241 · 2010 · External reference
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways
10.1371/journal.pone.0021039 · 2011 · External reference
Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway
10.1016/j.dnarep.2006.08.001 · 2007 · External reference
Coupling of the nucleotide incision and 3'–>5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences
2010 · External reference
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10.1016/j.mrrev.2020.108347 · External reference
Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2
10.3390/ijms19082389 · 2018 · External reference
10.1016/j.dnarep.2008.06.005
10.1016/j.dnarep.2008.06.005 · External reference
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration
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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
10.1038/ni885 · 2003 · External reference
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10.1074/jbc.m304914200 · External reference
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2001 · External reference
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The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death
10.1016/j.molcel.2006.06.005 · 2006 · External reference
TREX1 acts in degrading damaged DNA from drug-treated tumor cells
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3′–5′ exonuclease activity of human apurinic/apyrimidinic endonuclease 1 towards DNAs containing dNMP and their modified analogs at the 3′ end of single strand DNA break
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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
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High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA
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10.1016/j.molcel.2020.05.021
10.1016/j.molcel.2020.05.021 · External reference
Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells
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